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Mol. Cell. Biol., 02 1995, 731-741, Vol 15, No. 2
Copyright © 1995, American Society for Microbiology

p34Cdc28-mediated control of Cln3 cyclin degradation

J Yaglom, MH Linskens, S Sadis, DM Rubin, B Futcher and D Finley
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.

Cln3 cyclin of the budding yeast Saccharomyces cerevisiae is a key regulator of Start, a cell cycle event in G1 phase at which cells become committed to division. The time of Start is sensitive to Cln3 levels, which in turn depend on the balance between synthesis and rapid degradation. Here we report that the breakdown of Cln3 is ubiquitin dependent and involves the ubiquitin-conjugating enzyme Cdc34 (Ubc3). The C-terminal tail of Cln3 functions as a transferable signal for degradation. Sequences important for Cln3 degradation are spread throughout the tail and consist largely of PEST elements, which have been previously suggested to target certain proteins for rapid turnover. The Cln3 tail also appears to contain multiple phosphorylation sites, and both phosphorylation and degradation of Cln3 are deficient in a cdc28ts mutant at the nonpermissive temperature. A point mutation at Ser-468, which lies within a Cdc28 kinase consensus site, causes approximately fivefold stabilization of a Cln3-beta- galactosidase fusion protein that contains a portion of the Cln3 tail and strongly reduces the phosphorylation of this protein. These data indicate that the degradation of Cln3 involves CDC28-dependent phosphorylation events.


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  • Galan, J., Cantegrit, B., Garnier, C., Namy, O., Haguenauer-tsapis, R. (1998). `ER degradation' of a mutant yeast plasma membrane protein by the ubiquitin-proteasome pathway. FASEB J. 12: 315-323 [Abstract] [Full Text]  
  • Patton, E. E., Willems, A. R., Sa, D., Kuras, L., Thomas, D., Craig, K. L., Tyers, M. (1998). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12: 692-705 [Abstract] [Full Text]  
  • Wang, X., Luo, H., Chen, H., Duguid, W., Wu, J. (1998). Role of Proteasomes in T Cell Activation and Proliferation. J. Immunol. 160: 788-801 [Abstract] [Full Text]  
  • Sanchez-Diaz, A, Gonzalez, I, Arellano, M, Moreno, S (1998). The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast. J. Cell Sci. 111: 843-851 [Abstract]  
  • Marchal, C., Haguenauer-Tsapis, R., Urban-Grimal, D. (1998). A PEST-Like Sequence Mediates Phosphorylation and Efficient Ubiquitination of Yeast Uracil Permease. Mol. Cell. Biol. 18: 314-321 [Abstract] [Full Text]  
  • Jeoung, D.-I., Oehlen, L. J. W. M., Cross, F. R. (1998). Cln3-Associated Kinase Activity in Saccharomyces cerevisiae Is Regulated by the Mating Factor Pathway. Mol. Cell. Biol. 18: 433-441 [Abstract] [Full Text]  
  • Gerlinger, U.-M., Gückel, R., Hoffmann, M., Wolf, D. H., Hilt, W. (1997). Yeast Cycloheximide-resistant crl Mutants Are Proteasome Mutants Defective in Protein Degradation. Mol. Biol. Cell 8: 2487-2499 [Abstract] [Full Text]  
  • Polymenis, M., Schmidt, E. V. (1997). Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev. 11: 2522-2531 [Abstract] [Full Text]  
  • Conner, E. M., Brand, S., Davis, J. M., Laroux, F. S., Palombella, V. J., Fuseler, J. W., Kang, D. Y., Wolf, R. E., Grisham, M. B. (1997). Proteasome Inhibition Attenuates Nitric Oxide Synthase Expression, VCAM-1 Transcription and the Development of Chronic Colitis. J. Pharmacol. Exp. Ther. 282: 1615-1622 [Abstract] [Full Text]  
  • Yu, C.-L., Burakoff, S. J. (1997). Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation. J. Biol. Chem. 272: 14017-14020 [Abstract] [Full Text]  
  • Diehl, J A, Zindy, F, Sherr, C J (1997). Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.. Genes Dev. 11: 957-972 [Abstract]  
  • Dembinska, M. E., Stanewsky, R., Hall, J. C., Rosbash, M. (1997). Circadian Cycling of a PERIOD-{beta}-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation. J Biol Rhythms 12: 157-172 [Abstract]  
  • Meerovitch, K., Wing, S., Goltzman, D. (1997). Preproparathyroid Hormone-related Protein, a Secreted Peptide, Is a Substrate for the Ubiquitin Proteolytic System. J. Biol. Chem. 272: 6706-6713 [Abstract] [Full Text]  
  • King, R. W., Deshaies, R. J., Peters, J.-M., Kirschner, M. W. (1996). How Proteolysis Drives the Cell Cycle. Science 274: 1652-1659 [Abstract] [Full Text]  
  • Hofmann, F, Martelli, F, Livingston, D M, Wang, Z (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.. Genes Dev. 10: 2949-2959 [Abstract]  
  • Hateboer, G, Kerkhoven, R M, Shvarts, A, Bernards, R, Beijersbergen, R L (1996). Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.. Genes Dev. 10: 2960-2970 [Abstract]  
  • Betting, J., Seufert, W. (1996). A Yeast Ubc9 Mutant Protein with Temperature-sensitive in Vivo Function Is Subject to Conditional Proteolysis by a Ubiquitin- and Proteasome-dependent Pathway. J. Biol. Chem. 271: 25790-25796 [Abstract] [Full Text]  
  • Hateboer, G., Hijmans, E. M., Nooij, J. B.D., Schlenker, S., Jentsch, S., Bernards, R. (1996). mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect. J. Biol. Chem. 271: 25906-25911 [Abstract] [Full Text]  
  • Kim, T. K., Maniatis, T. (1996). Regulation of Interferon-gamma -Activated STAT1 by the Ubiquitin-Proteasome Pathway. Science 273: 1717-1719 [Abstract] [Full Text]  
  • Clurman, B E, Sheaff, R J, Thress, K, Groudine, M, Roberts, J M (1996). Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.. Genes Dev. 10: 1979-1990 [Abstract]  
  • Stephen, A. G., Trausch-Azar, J. S., Ciechanover, A., Schwartz, A. L. (1996). The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner. J. Biol. Chem. 271: 15608-15614 [Abstract] [Full Text]  
  • Galan, J. M., Moreau, V., Andre, B., Volland, C., Haguenauer-Tsapis, R. (1996). Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease. J. Biol. Chem. 271: 10946-10952 [Abstract] [Full Text]  
  • Baboshina, O. V., Haas, A. L. (1996). Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2[IMAGE] and RAD6 Are Recognized by 26 S Proteasome Subunit 5. J. Biol. Chem. 271: 2823-2831 [Abstract] [Full Text]  
  • Deveraux, Q., van Nocker, S., Mahaffey, D., Vierstra, R., Rechsteiner, M. (1995). Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a. J. Biol. Chem. 270: 29660-29663 [Abstract] [Full Text]  
  • Huang, Y., Baker, R. T., Fischer-Vize, J. A. (1995). Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene. Science 270: 1828-1831 [Abstract]  
  • Banerjee, A., Deshaies, R. J., Chau, V. (1995). Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34. J. Biol. Chem. 270: 26209-26215 [Abstract] [Full Text]  
  • Laing, J. G., Beyer, E. C. (1995). The Gap Junction Protein Connexin43 Is Degraded via the Ubiquitin Proteasome Pathway. J. Biol. Chem. 270: 26399-26403 [Abstract] [Full Text]  
  • Schork, S. M., Thumm, M., Wolf, D. H. (1995). Catabolite Inactivation of Fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. J. Biol. Chem. 270: 26446-26450 [Abstract] [Full Text]  
  • Chen, Z, Hagler, J, Palombella, V J, Melandri, F, Scherer, D, Ballard, D, Maniatis, T (1995). Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.. Genes Dev. 9: 1586-1597 [Abstract]  
  • Hautbergue, G., Goguel, V. (2001). Activation of the Cyclin-dependent Kinase CTDK-I Requires the Heterodimerization of Two Unstable Subunits. J. Biol. Chem. 276: 8005-8013 [Abstract] [Full Text]  
  • Huber, A. H., Stewart, D. B., Laurents, D. V., Nelson, W. J., Weis, W. I. (2001). The Cadherin Cytoplasmic Domain Is Unstructured in the Absence of beta -Catenin. A POSSIBLE MECHANISM FOR REGULATING CADHERIN TURNOVER. J. Biol. Chem. 276: 12301-12309 [Abstract] [Full Text]  


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