This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by John, S.
Right arrow Articles by Leonard, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by John, S.
Right arrow Articles by Leonard, W. J.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 03 1995, 1786-1796, Vol 15, No. 3

Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins

S John, RB Reeves, JX Lin, R Child, JM Leiden, CB Thompson and WJ Leonard
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.

The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). This element had maximal activity in lymphoid cells, paralleling the cell type specificity of Elf-1 expression. Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated. Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells. Elf-1 physically associated with HMG-I and with NF-kappa B p50 and c-Rel in vitro, suggesting that protein-protein interactions might functionally coordinate the actions of the upstream and downstream positive regulatory elements. This is the first report of a physical interaction between an Ets family member and NF-kappa B family proteins. These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins.


This article has been cited by other articles:

  • Akaboshi, S.-i., Watanabe, S., Hino, Y., Sekita, Y., Xi, Y., Araki, K., Yamamura, K.-i., Oshima, M., Ito, T., Baba, H., Nakao, M. (2009). HMGA1 Is Induced by Wnt/{beta}-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer. Am. J. Pathol. 175: 1675-1685 [Abstract] [Full Text]  
  • Liau, S.-S., Whang, E. (2008). HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma. Clin. Cancer Res. 14: 1470-1477 [Abstract] [Full Text]  
  • Fedele, M., Fidanza, V., Battista, S., Pentimalli, F., Klein-Szanto, A. J.P., Visone, R., De Martino, I., Curcio, A., Morisco, C., Del Vecchio, L., Baldassarre, G., Arra, C., Viglietto, G., Indolfi, C., Croce, C. M., Fusco, A. (2006). Haploinsufficiency of the hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice.. Cancer Res. 66: 2536-2543 [Abstract] [Full Text]  
  • Murua Escobar, H., Soller, J. T., Richter, A., Meyer, B., Winkler, S., Bullerdiek, J., Nolte, I. (2005). "Best Friends" Sharing the HMGA1 Gene: Comparison of the Human and Canine HMGA1 to Orthologous Other Species. J Hered 96: 777-781 [Abstract] [Full Text]  
  • Kim, H.-P., Kim, B.-G., Letterio, J., Leonard, W. J. (2005). Smad-dependent Cooperative Regulation of Interleukin 2 Receptor {alpha} Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-{beta}. J. Biol. Chem. 280: 34042-34047 [Abstract] [Full Text]  
  • Adair, J. E., Kwon, Y., Dement, G. A., Smerdon, M. J., Reeves, R. (2005). Inhibition of Nucleotide Excision Repair by High Mobility Group Protein HMGA1. J. Biol. Chem. 280: 32184-32192 [Abstract] [Full Text]  
  • O'Sullivan, A., Chang, H.-C., Yu, Q., Kaplan, M. H. (2004). STAT4 Is Required for Interleukin-12-induced Chromatin Remodeling of the CD25 Locus. J. Biol. Chem. 279: 7339-7345 [Abstract] [Full Text]  
  • Chen, X., Lechago, J., Ertan, A., Ergun, G., Verm, R., Bridges, M., Johnson, C., Woods, K., Meriano, F., Chirala, M., Younes, M. (2004). Expression of the High Mobility Group Proteins HMGI(Y) Correlates with Malignant Progression in Barrett's Metaplasia. Cancer Epidemiol. Biomarkers Prev. 13: 30-33 [Abstract] [Full Text]  
  • Borrmann, L., Schwanbeck, R., Heyduk, T., Seebeck, B., Rogalla, P., Bullerdiek, J., Wisniewski, J. R. (2003). High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Nucleic Acids Res 31: 6841-6851 [Abstract] [Full Text]  
  • McCarthy, K. M., McDevit, D., Andreucci, A., Reeves, R., Nikolajczyk, B. S. (2003). HMGA1 Co-activates Transcription in B Cells through Indirect Association with DNA. J. Biol. Chem. 278: 42106-42114 [Abstract] [Full Text]  
  • Beitzel, B., Bushman, F. (2003). Construction and analysis of cells lacking the HMGA gene family. Nucleic Acids Res 31: 5025-5032 [Abstract] [Full Text]  
  • Ferguson, M., Henry, P. A., Currie, R. A. (2003). Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. Nucleic Acids Res 31: 3123-3133 [Abstract] [Full Text]  
  • O'Reilly, D., Quinn, C. M., El-Shanawany, T., Gordon, S., Greaves, D. R. (2003). Multiple Ets Factors and Interferon Regulatory Factor-4 Modulate CD68 Expression in a Cell Type-specific Manner. J. Biol. Chem. 278: 21909-21919 [Abstract] [Full Text]  
  • Sugimoto, H., Sugimoto, S., Tatei, K., Obinata, H., Bakovic, M., Izumi, T., Vance, D. E. (2003). Identification of Ets-1 as an Important Transcriptional Activator of CTP:Phosphocholine Cytidylyltransferase {alpha} in COS-7 Cells and Co-activation with Transcriptional Enhancer Factor-4. J. Biol. Chem. 278: 19716-19722 [Abstract] [Full Text]  
  • Bouallaga, I., Teissier, S., Yaniv, M., Thierry, F. (2003). HMG-I(Y) and the CBP/p300 Coactivator Are Essential for Human Papillomavirus Type 18 Enhanceosome Transcriptional Activity. Mol. Cell. Biol. 23: 2329-2340 [Abstract] [Full Text]  
  • Quirk, C. C., Seachrist, D. D., Nilson, J. H. (2003). Embryonic Expression of the Luteinizing Hormone beta Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor. J. Biol. Chem. 278: 1680-1685 [Abstract] [Full Text]  
  • Yeh, J.-H., Spicuglia, S., Kumar, S., Sanchez-Sevilla, A., Ferrier, P., Imbert, J. (2002). Control of IL-2R{alpha} gene expression: structural changes within the proximal enhancer/core promoter during T-cell development. Nucleic Acids Res 30: 1944-1951 [Abstract] [Full Text]  
  • Han, S. B., Park, S. H., Jeon, Y. J., Kim, Y. K., Kim, H. M., Yang, K. H. (2001). Prodigiosin Blocks T Cell Activation by Inhibiting Interleukin-2Ralpha Expression and Delays Progression of Autoimmune Diabetes and Collagen-Induced Arthritis. J. Pharmacol. Exp. Ther. 299: 415-425 [Abstract] [Full Text]  
  • Takemoto, M., Shimamoto, T., Isegawa, Y., Yamanishi, K. (2001). The R3 Region, One of Three Major Repetitive Regions of Human Herpesvirus 6, Is a Strong Enhancer of Immediate-Early Gene U95. J. Virol. 75: 10149-10160 [Abstract] [Full Text]  
  • Fedele, M., Battista, S., Manfioletti, G., Croce, C. M., Giancotti, V., Fusco, A. (2001). Role of the high mobility group A proteins in human lipomas. Carcinogenesis 22: 1583-1591 [Abstract] [Full Text]  
  • Darville, M. I., Eizirik, D. L. (2001). Cytokine Induction of Fas Gene Expression in Insulin-Producing Cells Requires the Transcription Factors NF-{kappa}B and C/EBP. Diabetes 50: 1741-1748 [Abstract] [Full Text]  
  • Yeh, J.-H., Lecine, P., Nunes, J. A., Spicuglia, S., Ferrier, P., Olive, D., Imbert, J. (2001). Novel CD28-Responsive Enhancer Activated by CREB/ATF and AP-1 Families in the Human Interleukin-2 Receptor {alpha}-Chain Locus. Mol. Cell. Biol. 21: 4515-4527 [Abstract] [Full Text]  
  • Shi, M.-J., Park, S.-R., Kim, P.-H., Stavnezer, J. (2001). Roles of Ets proteins, NF-{{kappa}}B and nocodazole in regulating induction of transcription of mouse germline Ig {{alpha}} RNA by transforming growth factor-{beta}1. Int Immunol 13: 733-746 [Abstract] [Full Text]  
  • Melillo, R. M., Pierantoni, G. M., Scala, S., Battista, S., Fedele, M., Stella, A., De Biasio, M. C., Chiappetta, G., Fidanza, V., Condorelli, G., Santoro, M., Croce, C. M., Viglietto, G., Fusco, A. (2001). Critical Role of the HMGI(Y) Proteins in Adipocytic Cell Growth and Differentiation. Mol. Cell. Biol. 21: 2485-2495 [Abstract] [Full Text]  
  • Reeves, R., Edberg, D. D., Li, Y. (2001). Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells. Mol. Cell. Biol. 21: 575-594 [Abstract] [Full Text]  
  • Shannon, M. F., Coles, L. S., Attema, J., Diamond, P. (2001). The role of architectural transcription factors in cytokine gene transcription. J. Leukoc. Biol. 69: 21-32 [Abstract] [Full Text]  
  • Li, L., Yoder, K., Hansen, M. S. T., Olvera, J., Miller, M. D., Bushman, F. D. (2000). Retroviral cDNA Integration: Stimulation by HMG I Family Proteins. J. Virol. 74: 10965-10974 [Abstract] [Full Text]  
  • Henderson, A., Bunce, M., Siddon, N., Reeves, R., Tremethick, D. J. (2000). High-Mobility-Group Protein I Can Modulate Binding of Transcription Factors to the U5 Region of the Human Immunodeficiency Virus Type 1 Proviral Promoter. J. Virol. 74: 10523-10534 [Abstract] [Full Text]  
  • Wood, L. J., Maher, J. F., Bunton, T. E., Resar, L. M. S. (2000). The Oncogenic Properties of the HMG-I Gene Family. Cancer Res. 60: 4256-4261 [Abstract] [Full Text]  
  • Reeves, R., Leonard, W. J., Nissen, M. S. (2000). Binding of HMG-I(Y) Imparts Architectural Specificity to a Positioned Nucleosome on the Promoter of the Human Interleukin-2 Receptor alpha Gene. Mol. Cell. Biol. 20: 4666-4679 [Abstract] [Full Text]  
  • Abe, N., Watanabe, T., Masaki, T., Mori, T., Sugiyama, M., Uchimura, H., Fujioka, Y., Chiappetta, G., Fusco, A., Atomi, Y. (2000). Pancreatic Duct Cell Carcinomas Express High Levels of High Mobility Group I(Y) Proteins. Cancer Res. 60: 3117-3122 [Abstract] [Full Text]  
  • Himes, S. R., Reeves, R., Attema, J., Nissen, M., Li, Y., Shannon, M. F. (2000). The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell Proliferation. J. Immunol. 164: 3157-3168 [Abstract] [Full Text]  
  • Klotzbucher, M., Wasserfall, A., Fuhrmann, U. (1999). Misexpression of Wild-Type and Truncated Isoforms of the High-Mobility Group I Proteins HMGI-C and HMGI(Y) in Uterine Leiomyomas. Am. J. Pathol. 155: 1535-1542 [Abstract] [Full Text]  
  • Oettgen, P., Kas, K., Dube, A., Gu, X., Grall, F., Thamrongsak, U., Akbarali, Y., Finger, E., Boltax, J., Endress, G., Munger, K., Kunsch, C., Libermann, T. A. (1999). Characterization of ESE-2, a Novel ESE-1-related Ets Transcription Factor That Is Restricted to Glandular Epithelium and Differentiated Keratinocytes. J. Biol. Chem. 274: 29439-29452 [Abstract] [Full Text]  
  • Adler, H. T., Chinery, R., Wu, D. Y., Kussick, S. J., Payne, J. M., Fornace, A. J. Jr., Tkachuk, D. C. (1999). Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins. Mol. Cell. Biol. 19: 7050-7060 [Abstract] [Full Text]  
  • Nagpal, S., Ghosn, C., DiSepio, D., Molina, Y., Sutter, M., Klein, E. S., Chandraratna, R. A. S. (1999). Retinoid-dependent Recruitment of a Histone H1 Displacement Activity by Retinoic Acid Receptor. J. Biol. Chem. 274: 22563-22568 [Abstract] [Full Text]  
  • Zhang, X. M., Verdine, G. L. (1999). A Small Region in HMG I(Y) Is Critical for Cooperation with NF-kappa B on DNA. J. Biol. Chem. 274: 20235-20243 [Abstract] [Full Text]  
  • Dickinson, L. A., Trauger, J. W., Baird, E. E., Dervan, P. B., Graves, B. J., Gottesfeld, J. M. (1999). Inhibition of Ets-1 DNA Binding and Ternary Complex Formation between Ets-1, NF-kappa B, and DNA by a Designed DNA-binding Ligand. J. Biol. Chem. 274: 12765-12773 [Abstract] [Full Text]  
  • Rusterholz, C., Henrioud, P. C., Nabholz, M. (1999). Interleukin-2 (IL-2) Regulates the Accessibility of the IL-2-Responsive Enhancer in the IL-2 Receptor alpha  Gene to Transcription Factors. Mol. Cell. Biol. 19: 2681-2689 [Abstract] [Full Text]  
  • Kuprash, D. V., Udalova, I. A., Turetskaya, R. L., Kwiatkowski, D., Rice, N. R., Nedospasov, S. A. (1999). Similarities and Differences Between Human and Murine TNF Promoters in Their Response to Lipopolysaccharide. J. Immunol. 162: 4045-4052 [Abstract] [Full Text]  
  • Liou, H.-C., Jin, Z., Tumang, J., Andjelic, S., Smith, K. A., Liou, M.-L. (1999). c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 11: 361-371 [Abstract] [Full Text]  
  • Abe, N., Watanabe, T., Sugiyama, M., Uchimura, H., Chiappetta, G., Fusco, A., Atomi, Y. (1999). Determination of High Mobility Group I(Y) Expression Level in Colorectal Neoplasias: A Potential Diagnostic Marker. Cancer Res. 59: 1169-1174 [Abstract] [Full Text]  
  • Verhoef, K., Sanders, R. W., Fontaine, V., Kitajima, S., Berkhout, B. (1999). Evolution of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat Promoter by Conversion of an NF-kappa B Enhancer Element into a GABP Binding Site. J. Virol. 73: 1331-1340 [Abstract] [Full Text]  
  • Karantzoulis-Fegaras, F., Antoniou, H., Lai, S.-L. M., Kulkarni, G., D'Abreo, C., Wong, G. K. T., Miller, T. L., Chan, Y., Atkins, J., Wang, Y., Marsden, P. A. (1999). Characterization of the Human Endothelial Nitric-oxide Synthase Promoter. J. Biol. Chem. 274: 3076-3093 [Abstract] [Full Text]  
  • Ping, D., Boekhoudt, G. H., Rogers, E. M., Boss, J. M. (1999). Nuclear Factor-{kappa}B p65 Mediates the Assembly and Activation of the TNF-Responsive Element of the Murine Monocyte Chemoattractant-1 Gene. J. Immunol. 162: 727-734 [Abstract] [Full Text]  
  • LEONARD, W.J., IMADA, K., NAKAJIMA, H., PUEL, A., SOLDAINI, E., JOHN, S. (1999). Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus. Cold Spring Harb Symp Quant Biol 64: 417-424 [Abstract]  
  • Cotmore, S. F., Tattersall, P. (1998). High-Mobility Group 1/2 Proteins Are Essential for Initiating Rolling-Circle-Type DNA Replication at a Parvovirus Hairpin Origin. J. Virol. 72: 8477-8484 [Abstract] [Full Text]  
  • Bockamp, E.-O., Fordham, J. L., Gottgens, B., Murrell, A. M., Sanchez, M.-J., Green, A. R. (1998). Transcriptional Regulation of the Stem Cell Leukemia Gene by PU.1 and Elf-1. J. Biol. Chem. 273: 29032-29042 [Abstract] [Full Text]  
  • Schuh, K., Twardzik, T., Kneitz, B., Heyer, J., Schimpl, A., Serfling, E. (1998). The Interleukin 2 Receptor {alpha} Chain/CD25 Promoter Is a Target for Nuclear Factor of Activated T Cells. JEM 188: 1369-1373 [Abstract] [Full Text]  
  • Morton, C. C. (1998). Many Tumors and Many Genes : Genetics of Uterine Leiomyomata. Am. J. Pathol. 153: 1015-1020 [Full Text]  
  • Ji, Y.-S., Xu, Q., Schmedtje, J. F. Jr (1998). Hypoxia Induces High-Mobility-Group Protein I(Y) and Transcription of the Cyclooxygenase-2 Gene in Human Vascular Endothelium. Circ. Res. 83: 295-304 [Abstract] [Full Text]  
  • Frank, O., Schwanbeck, R., Wisniewski, J. R. (1998). Protein Footprinting Reveals Specific Binding Modes of a High Mobility Group Protein I to DNAs of Different Conformation. J. Biol. Chem. 273: 20015-20020 [Abstract] [Full Text]  
  • Rellahan, B. L., Jensen, J. P., Howcroft, T. K., Singer, D. S., Bonvini, E., Weissman, A. M. (1998). Elf-1 Regulates Basal Expression from the T Cell Antigen Receptor {zeta}-Chain Gene Promoter. J. Immunol. 160: 2794-2801 [Abstract] [Full Text]  
  • Gri, G., Savio, D., Trinchieri, G., Ma, X. (1998). Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFkappa B and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages. J. Biol. Chem. 273: 6431-6438 [Abstract] [Full Text]  
  • Amirand, C, Viari, A, Ballini, J., Rezaei, H, Beaujean, N, Jullien, D, Kas, E, Debey, P (1998). Three distinct sub-nuclear populations of HMG-I protein of different properties revealed by co-localization image analysis. J. Cell Sci. 111: 3551-3561 [Abstract]  
  • Currie, R. A. (1997). Functional Interaction between the DNA Binding Subunit Trimerization Domain of NF-Y and the High Mobility Group Protein HMG-I(Y). J. Biol. Chem. 272: 30880-30888 [Abstract] [Full Text]  
  • Arlotta, P., Rustighi, A., Mantovani, F., Manfioletti, G., Giancotti, V., Tell, G., Damante, G. (1997). High Mobility Group I Proteins Interfere with the Homeodomains Binding to DNA. J. Biol. Chem. 272: 29904-29910 [Abstract] [Full Text]  
  • Wang, D., Zamorano, J., Keegan, A. D., Boothby, M. (1997). HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor. J. Biol. Chem. 272: 25083-25090 [Abstract] [Full Text]  
  • Lopez, S., Reeves, R., Island, M.-L., Bandu, M.-T., Christeff, N., Doly, J., Navarro, S. (1997). Silencer Activity in the Interferon-A Gene Promoters. J. Biol. Chem. 272: 22788-22799 [Abstract] [Full Text]  
  • Tenen, D. G., Hromas, R., Licht, J. D., Zhang, D.-E. (1997). Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90: 489-519 [Full Text]  
  • Ma, X., Neurath, M., Gri, G., Trinchieri, G. (1997). Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter. J. Biol. Chem. 272: 10389-10395 [Abstract] [Full Text]  
  • Serdobova, I., Pla, M., Reichenbach, P., Sperisen, P., Ghysdael, J., Wilson, A., Freeman, J., Nabholz, M. (1997). Elf-1 Contributes to the Function of the Complex Interleukin (IL)-2-responsive Enhancer in the Mouse IL-2 Receptor {alpha} Gene. JEM 185: 1211-1222 [Abstract] [Full Text]  
  • Ascherman, D. P., Migone, T.-S., Friedmann, M. C., Leonard, W. J. (1997). Interleukin-2 (IL-2)-mediated Induction of the IL-2 Receptor alpha Chain Gene. CRITICAL ROLE OF TWO FUNCTIONALLY REDUNDANT TYROSINE RESIDUES IN THE IL-2 RECEPTOR beta CHAIN CYTOPLASMIC DOMAIN AND SUGGESTION THAT THESE RESIDUES MEDIATE MORE THAN STAT5 ACTIVATION. J. Biol. Chem. 272: 8704-8709 [Abstract] [Full Text]  
  • Cogswell, P. C., Mayo, M. W., Baldwin, A. S. Jr. (1997). Involvement of Egr-1/RelA Synergy in Distinguishing T Cell Activation from Tumor Necrosis Factor-{alpha}-induced NF-{kappa}B1 Transcription. JEM 185: 491-498 [Abstract] [Full Text]  
  • Klein-Hessling, S., Schneider, G., Heinfling, A., Chuvpilo, S., Serfling, E. (1996). HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells. Proc. Natl. Acad. Sci. USA 93: 15311-15316 [Abstract] [Full Text]  
  • Akbarali, Y., Oettgen, P., Boltax, J., Libermann, T. A. (1996). ELF-1 Interacts with and Transactivates the IgH Enhancer pi Site. J. Biol. Chem. 271: 26007-26012 [Abstract] [Full Text]  
  • Fu, G. K., Markovitz, D. M. (1996). Purification of the pets Factor. A NUCLEAR PROTEIN THAT BINDS TO THE INDUCIBLE TG-RICH ELEMENT OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 2ENHANCER. J. Biol. Chem. 271: 19599-19605 [Abstract] [Full Text]  
  • Khachigian, L. M., Williams, A. J., Collins, T. (1995). Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells. J. Biol. Chem. 270: 27679-27686 [Abstract] [Full Text]  
  • Wang, D.-Z., Ray, P., Boothby, M. (1995). Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin. J. Biol. Chem. 270: 22924-22932 [Abstract] [Full Text]  
  • Ogram, S. A., Reeves, R. (1995). Differential Regulation of a Multipromoter Gene. J. Biol. Chem. 270: 14235-14242 [Abstract] [Full Text]  
  • Sperisen, P., Wang, S. M., Soldaini, E., Pla, M., Rusterholz, C., Bucher, P., Corthésy, P., Reichenbach, P., Nabholz, M. (1995). Mouse Interleukin-2 Receptor [IMAGE] Gene Expression. J. Biol. Chem. 270: 10743-10753 [Abstract] [Full Text]  
  • Arlotta, P., Tai, A. K.-F., Manfioletti, G., Clifford, C., Jay, G., Ono, S. J. (2000). Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas. J. Biol. Chem. 275: 14394-14400 [Abstract] [Full Text]  
  • Piekielko, A., Drung, A., Rogalla, P., Schwanbeck, R., Heyduk, T., Gerharz, M., Bullerdiek, J., Wisniewski, J. R. (2001). Distinct Organization of DNA Complexes of Various HMGI/Y Family Proteins and Their Modulation upon Mitotic Phosphorylation. J. Biol. Chem. 276: 1984-1992 [Abstract] [Full Text]  
  • Laumonnier, Y., Nadaud, S., Agrapart, M., Soubrier, F. (2000). Characterization of an Upstream Enhancer Region in the Promoter of the Human Endothelial Nitric-oxide Synthase Gene. J. Biol. Chem. 275: 40732-40741 [Abstract] [Full Text]  
  • Lewis, R. T., Andreucci, A., Nikolajczyk, B. S. (2001). PU.1-mediated Transcription Is Enhanced by HMG-I(Y)-dependent Structural Mechanisms. J. Biol. Chem. 276: 9550-9557 [Abstract] [Full Text]  
  • Caslini, C., Shilatifard, A., Yang, L., Hess, J. L. (2000). The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Proc. Natl. Acad. Sci. USA 97: 2797-2802 [Abstract] [Full Text]  
  • Baldassarre, G., Fedele, M., Battista, S., Vecchione, A., Klein-Szanto, A. J. P., Santoro, M., Waldmann, T. A., Azimi, N., Croce, C. M., Fusco, A. (2001). Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proc. Natl. Acad. Sci. USA 98: 7970-7975 [Abstract] [Full Text]  
  • Conze, D., Krahl, T., Kennedy, N., Weiss, L., Lumsden, J., Hess, P., Flavell, R. A., Le Gros, G., Davis, R. J., Rincon, M. (2002). c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation. JEM 195: 811-823 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»