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Mol. Cell. Biol., 06 1995, 3424-3429, Vol 15, No. 6
Copyright © 1995, American Society for Microbiology

The BTB domain of bric a brac mediates dimerization in vitro [retracted by Chen W, Zollman S, Couderc JL, Laski FA. In: Mol Cell Biol 1997 Nov;17(11):6772]

W Chen, S Zollman, JL Couderc and FA Laski
Department of Biology, University of California, Los Angeles 90024, USA.

The gene bric a brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins. In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro. In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify amino acids within this region that are required for binding.


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