This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hollenberg, S. M.
Right arrow Articles by Weintraub, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hollenberg, S. M.
Right arrow Articles by Weintraub, H.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 07 1995, 3813-3822, Vol 15, No. 7
Copyright © 1995, American Society for Microbiology

Identification of a new family of tissue-specific basic helix-loop- helix proteins with a two-hybrid system

SM Hollenberg, R Sternglanz, PF Cheng and H Weintraub
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.

With modified two-hybrid technology, we have isolated a member of a new family of basic helix-loop-helix (bHLH) transcription factors. Thing1 (Th1) was identified in a screen of a mouse embryo cDNA library as a partner for the Drosophila E protein daughterless. RNA in situ hybridization and reverse transcriptase-PCR demonstrate a stage- and tissue-specific distribution for the expression of Th1. Although tissue specific, the expression pattern of Th1 is fairly complex. During development, Th1 mRNA is widely expressed in extraembryonic tissues, portions of the heart, autonomic ganglia, the gut, and pharyngeal arches. At embryonic day 7.5 (E7.5), extraembryonic derivatives show robust Th1 expression. By E8.5, expression in the embryonic heart becomes detectable. During the next 2 days of development, the signal also includes gut and pharyngeal arches. Predominant expression at E13.5 is in neural crest derivatives, especially the autonomic nervous system and adrenal medulla. Expression of Th1 persists in the adult, in which it is localized to the smooth muscle cells of the gut. In vitro, Th1 protein recognizes a set of DNA sites that are more degenerate than has been determined for other bHLH factors, indicating a reduced binding specificity. Transient transfection of NIH 3T3 cells with GAL4- Th1 fusions reveals a repression activity mediated by the Th1 bHLH domain. In combination, these properties define Th1 as a new bHLH protein with a unique set of properties.


This article has been cited by other articles:

  • Bai, X.-H., Wang, D.-W., Kong, L., Zhang, Y., Luan, Y., Kobayashi, T., Kronenberg, H. M., Yu, X.-P., Liu, C.-j. (2009). ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor. Mol. Cell. Biol. 29: 4201-4219 [Abstract] [Full Text]  
  • Khelfaoui, M., Pavlowsky, A., Powell, A. D., Valnegri, P., Cheong, K. W., Blandin, Y., Passafaro, M., Jefferys, J. G.R., Chelly, J., Billuart, P. (2009). Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation. Hum Mol Genet 18: 2575-2583 [Abstract] [Full Text]  
  • Liu, N., Barbosa, A. C., Chapman, S. L., Bezprozvannaya, S., Qi, X., Richardson, J. A., Yanagisawa, H., Olson, E. N. (2009). DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development 136: 933-942 [Abstract] [Full Text]  
  • Aoh, Q. L., Castle, A. M., Hubbard, C. H., Katsumata, O., Castle, J. D. (2009). SCAMP3 Negatively Regulates Epidermal Growth Factor Receptor Degradation and Promotes Receptor Recycling. Mol. Biol. Cell 20: 1816-1832 [Abstract] [Full Text]  
  • Funato, N., Chapman, S. L., McKee, M. D., Funato, H., Morris, J. A., Shelton, J. M., Richardson, J. A., Yanagisawa, H. (2009). Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136: 615-625 [Abstract] [Full Text]  
  • Li, X., Su, V., Kurata, W. E., Jin, C., Lau, A. F. (2008). A Novel Connexin43-interacting Protein, CIP75, Which Belongs to the UbL-UBA Protein Family, Regulates the Turnover of Connexin43. J. Biol. Chem. 283: 5748-5759 [Abstract] [Full Text]  
  • Brady, T. L., Fuerst, P. G., Dick, R. A., Schmidt, C., Voytas, D. F. (2008). Retrotransposon Target Site Selection by Imitation of a Cellular Protein. Mol. Cell. Biol. 28: 1230-1239 [Abstract] [Full Text]  
  • Odell, A. F., Van Helden, D. F., Scott, J. L. (2008). The Spectrin Cytoskeleton Influences the Surface Expression and Activation of Human Transient Receptor Potential Channel 4 Channels. J. Biol. Chem. 283: 4395-4407 [Abstract] [Full Text]  
  • Glick, E., Zrachya, A., Levy, Y., Mett, A., Gidoni, D., Belausov, E., Citovsky, V., Gafni, Y. (2008). Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein. Proc. Natl. Acad. Sci. USA 105: 157-161 [Abstract] [Full Text]  
  • Strickfaden, S. C., Pryciak, P. M. (2008). Distinct Roles for Two G{alpha} G Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein. Mol. Biol. Cell 19: 181-197 [Abstract] [Full Text]  
  • Zaltsman, A., Yi, B.-Y., Krichevsky, A., Gafni, Y., Citovsky, V. (2007). Yeast-Plant Coupled Vector System for Identification of Nuclear Proteins. Plant Physiol. 145: 1264-1271 [Abstract] [Full Text]  
  • Goehring, A. S., Pedroja, B. S., Hinke, S. A., Langeberg, L. K., Scott, J. D. (2007). MyRIP Anchors Protein Kinase A to the Exocyst Complex. J. Biol. Chem. 282: 33155-33167 [Abstract] [Full Text]  
  • Dong, Y.-F., Soung, D. Y., Chang, Y., Enomoto-Iwamoto, M., Paris, M., O'Keefe, R. J., Schwarz, E. M., Drissi, H. (2007). Transforming Growth Factor-{beta} and Wnt Signals Regulate Chondrocyte Differentiation through Twist1 in a Stage-Specific Manner. Mol. Endocrinol. 21: 2805-2820 [Abstract] [Full Text]  
  • Howell, V. M., Jones, J. M., Bergren, S. K., Li, L., Billi, A. C., Avenarius, M. R., Meisler, M. H. (2007). Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum Mol Genet 16: 2506-2516 [Abstract] [Full Text]  
  • Ayyanathan, K., Peng, H., Hou, Z., Fredericks, W. J., Goyal, R. K., Langer, E. M., Longmore, G. D., Rauscher, F. J. III (2007). The Ajuba LIM Domain Protein Is a Corepressor for SNAG Domain Mediated Repression and Participates in Nucleocytoplasmic Shuttling. Cancer Res. 67: 9097-9106 [Abstract] [Full Text]  
  • Apponi, L. H., Kelly, S. M., Harreman, M. T., Lehner, A. N., Corbett, A. H., Valentini, S. R. (2007). An Interaction between Two RNA Binding Proteins, Nab2 and Pub1, Links mRNA Processing/Export and mRNA Stability. Mol. Cell. Biol. 27: 6569-6579 [Abstract] [Full Text]  
  • Firulli, B. A., Redick, B. A., Conway, S. J., Firulli, A. B. (2007). Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA Binding Affinities. J. Biol. Chem. 282: 27536-27546 [Abstract] [Full Text]  
  • D'Autreaux, F., Morikawa, Y., Cserjesi, P., Gershon, M. D. (2007). Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development 134: 2237-2249 [Abstract] [Full Text]  
  • Hong, S., Wang, L.-C., Gao, X., Kuo, Y.-L., Liu, B., Merling, R., Kung, H.-J., Shih, H.-M., Giam, C.-Z. (2007). Heptad Repeats Regulate Protein Phosphatase 2A Recruitment to I-{kappa}B Kinase {gamma}/NF-{kappa}B Essential Modulator and Are Targeted by Human T-lymphotropic Virus Type 1 Tax. J. Biol. Chem. 282: 12119-12126 [Abstract] [Full Text]  
  • Xu, K., Zhang, Y., Ilalov, K., Carlson, C. S., Feng, J. Q., Di Cesare, P. E., Liu, C.-j. (2007). Cartilage Oligomeric Matrix Protein Associates with Granulin-Epithelin Precursor (GEP) and Potentiates GEP-stimulated Chondrocyte Proliferation. J. Biol. Chem. 282: 11347-11355 [Abstract] [Full Text]  
  • Duval, D. L., Jonsen, M. D., Diamond, S. E., Murapa, P., Jean, A., Gutierrez-Hartmann, A. (2007). Differential Utilization of Transcription Activation Subdomains by Distinct Coactivators Regulates Pit-1 Basal and Ras Responsiveness. Mol. Endocrinol. 21: 172-185 [Abstract] [Full Text]  
  • Paterou, A., Walrad, P., Craddy, P., Fenn, K., Matthews, K. (2006). Identification and Stage-specific Association with the Translational Apparatus of TbZFP3, a CCCH Protein That Promotes Trypanosome Life-cycle Development. J. Biol. Chem. 281: 39002-39013 [Abstract] [Full Text]  
  • Schepsky, A., Bruser, K., Gunnarsson, G. J., Goodall, J., Hallsson, J. H., Goding, C. R., Steingrimsson, E., Hecht, A. (2006). The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression. Mol. Cell. Biol. 26: 8914-8927 [Abstract] [Full Text]  
  • Hamik, A., Wang, B., Jain, M. K. (2006). Transcriptional Regulators of Angiogenesis. Arterioscler. Thromb. Vasc. Bio. 26: 1936-1947 [Abstract] [Full Text]  
  • Chen, B.-S., Braud, S., Badger, J. D. II, Isaac, J. T. R., Roche, K. W. (2006). Regulation of NR1/NR2C N-Methyl-D-aspartate (NMDA) Receptors by Phosphorylation. J. Biol. Chem. 281: 16583-16590 [Abstract] [Full Text]  
  • Liu, C.-j., Kong, W., Xu, K., Luan, Y., Ilalov, K., Sehgal, B., Yu, S., Howell, R. D., Di Cesare, P. E. (2006). ADAMTS-12 Associates with and Degrades Cartilage Oligomeric Matrix Protein. J. Biol. Chem. 281: 15800-15808 [Abstract] [Full Text]  
  • Tanaka, T., Nishimura, D., Wu, R.-C., Amano, M., Iso, T., Kedes, L., Nishida, H., Kaibuchi, K., Hamamori, Y. (2006). Nuclear Rho Kinase, ROCK2, Targets p300 Acetyltransferase. J. Biol. Chem. 281: 15320-15329 [Abstract] [Full Text]  
  • Lin, C.-H., Tapscott, S. J., Olson, J. M. (2006). Congenital Hypothyroidism (Cretinism) in neuroD2-Deficient Mice.. Mol. Cell. Biol. 26: 4311-4315 [Abstract] [Full Text]  
  • Yoshiuchi, S., Yamamoto, T., Sakane, H., Kadota, J., Mochida, J., Asaka, M., Tanaka, K. (2006). Identification of Novel Mutations in ACT1 and SLA2 That Suppress the Actin-Cable-Overproducing Phenotype Caused by Overexpression of a Dominant Active Form of Bni1p in Saccharomyces cerevisiae. Genetics 173: 527-539 [Abstract] [Full Text]  
  • Liu, C.-j., Kong, W., Ilalov, K., Yu, S., Xu, K., Prazak, L., Fajardo, M., Sehgal, B., Di Cesare, P. E. (2006). ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J. 20: 988-990 [Abstract] [Full Text]  
  • Eulalio, A., Nunes-Correia, I., Carvalho, A. L., Faro, C., Citovsky, V., Salas, J., Salas, M. L., Simoes, S., de Lima, M. C. P. (2006). Nuclear Export of African Swine Fever Virus p37 Protein Occurs through Two Distinct Pathways and Is Mediated by Three Independent Signals. J. Virol. 80: 1393-1404 [Abstract] [Full Text]  
  • Beaudoin, J., Labbe, S. (2006). Copper Induces Cytoplasmic Retention of Fission Yeast Transcription Factor Cuf1. Eukaryot Cell 5: 277-292 [Abstract] [Full Text]  
  • Havecker, E. R., Gao, X., Voytas, D. F. (2005). The Sireviruses, a Plant-Specific Lineage of the Ty1/copia Retrotransposons, Interact with a Family of Proteins Related to Dynein Light Chain 8. Plant Physiol. 139: 857-868 [Abstract] [Full Text]  
  • Morin, S., Pozzulo, G., Robitaille, L., Cross, J., Nemer, M. (2005). MEF2-dependent Recruitment of the HAND1 Transcription Factor Results in Synergistic Activation of Target Promoters. J. Biol. Chem. 280: 32272-32278 [Abstract] [Full Text]  
  • Kawai-Kowase, K., Kumar, M. S., Hoofnagle, M. H., Yoshida, T., Owens, G. K. (2005). PIAS1 Activates the Expression of Smooth Muscle Cell Differentiation Marker Genes by Interacting with Serum Response Factor and Class I Basic Helix-Loop-Helix Proteins. Mol. Cell. Biol. 25: 8009-8023 [Abstract] [Full Text]  
  • Ueki, S., Citovsky, V. (2005). Identification of an interactor of cadmium ion-induced glycine-rich protein involved in regulation of callose levels in plant vasculature. Proc. Natl. Acad. Sci. USA 102: 12089-12094 [Abstract] [Full Text]  
  • Miller, J. P., Lo, R. S., Ben-Hur, A., Desmarais, C., Stagljar, I., Noble, W. S., Fields, S. (2005). Large-scale identification of yeast integral membrane protein interactions. Proc. Natl. Acad. Sci. USA 102: 12123-12128 [Abstract] [Full Text]  
  • Stribinskis, V., Heyman, H.-C., Ellis, S. R., Steffen, M. C., Martin, N. C. (2005). Rpm2p, a Component of Yeast Mitochondrial RNase P, Acts as a Transcriptional Activator in the Nucleus. Mol. Cell. Biol. 25: 6546-6558 [Abstract] [Full Text]  
  • Gonzalez-Cabo, P., Vazquez-Manrique, R. P., Garcia-Gimeno, M. A., Sanz, P., Palau, F. (2005). Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet 14: 2091-2098 [Abstract] [Full Text]  
  • Chen, M.-H., Tian, G.-W., Gafni, Y., Citovsky, V. (2005). Effects of Calreticulin on Viral Cell-to-Cell Movement. Plant Physiol. 138: 1866-1876 [Abstract] [Full Text]  
  • Pelletier, B., Trott, A., Morano, K. A., Labbe, S. (2005). Functional Characterization of the Iron-regulatory Transcription Factor Fep1 from Schizosaccharomyces pombe. J. Biol. Chem. 280: 25146-25161 [Abstract] [Full Text]  
  • McFadden, D. G., Barbosa, A. C., Richardson, J. A., Schneider, M. D., Srivastava, D., Olson, E. N. (2005). The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201 [Abstract] [Full Text]  
  • Hill, A. A., Riley, P. R. (2004). Differential Regulation of Hand1 Homodimer and Hand1-E12 Heterodimer Activity by the Cofactor FHL2. Mol. Cell. Biol. 24: 9835-9847 [Abstract] [Full Text]  
  • Bachmann, M., Hennemann, H., Xing, P. X., Hoffmann, I., Moroy, T. (2004). The Oncogenic Serine/Threonine Kinase Pim-1 Phosphorylates and Inhibits the Activity of Cdc25C-associated Kinase 1 (C-TAK1): A NOVEL ROLE FOR Pim-1 AT THE G2/M CELL CYCLE CHECKPOINT. J. Biol. Chem. 279: 48319-48328 [Abstract] [Full Text]  
  • Vascotto, F., Campagna, M., Visintin, M., Cattaneo, A., Burrone, O. R. (2004). Effects of intrabodies specific for rotavirus NSP5 during the virus replicative cycle. J. Gen. Virol. 85: 3285-3290 [Abstract] [Full Text]  
  • Forrest, S., McNamara, C. (2004). Id Family of Transcription Factors and Vascular Lesion Formation. Arterioscler. Thromb. Vasc. Bio. 24: 2014-2020 [Abstract] [Full Text]  
  • Wiggins, A. K., Wei, G., Doxakis, E., Wong, C., Tang, A. A., Zang, K., Luo, E. J., Neve, R. L., Reichardt, L. F., Huang, E. J. (2004). Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival. JCB 167: 257-267 [Abstract] [Full Text]  
  • Shandala, T., Gregory, S. L., Dalton, H. E., Smallhorn, M., Saint, R. (2004). Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development 131: 5053-5063 [Abstract] [Full Text]  
  • Wang, Y., Tzfira, T., Gaba, V., Citovsky, V., Palukaitis, P., Gal-On, A. (2004). Functional analysis of the Cucumber mosaic virus 2b protein: pathogenicity and nuclear localization. J. Gen. Virol. 85: 3135-3147 [Abstract] [Full Text]  
  • Eulalio, A., Nunes-Correia, I., Carvalho, A. L., Faro, C., Citovsky, V., Simoes, S., Pedroso de Lima, M. C. (2004). Two African Swine Fever Virus Proteins Derived from a Common Precursor Exhibit Different Nucleocytoplasmic Transport Activities. J. Virol. 78: 9731-9739 [Abstract] [Full Text]  
  • Wilson-Rawls, J., Rhee, J. M., Rawls, A. (2004). Paraxis Is a Basic Helix-Loop-Helix Protein That Positively Regulates Transcription through Binding to Specific E-box Elements. J. Biol. Chem. 279: 37685-37692 [Abstract] [Full Text]  
  • Wittmack, E. K., Rush, A. M., Craner, M. J., Goldfarb, M., Waxman, S. G., Dib-Hajj, S. D. (2004). Fibroblast Growth Factor Homologous Factor 2B: Association with Nav1.6 and Selective Colocalization at Nodes of Ranvier of Dorsal Root Axons. J. Neurosci. 24: 6765-6775 [Abstract] [Full Text]  
  • Owens, G. K., Kumar, M. S., Wamhoff, B. R. (2004). Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease. Physiol. Rev. 84: 767-801 [Abstract] [Full Text]  
  • Shirai, C., Takai, T., Nariai, M., Horigome, C., Mizuta, K. (2004). Ebp2p, the Yeast Homolog of Epstein-Barr Virus Nuclear Antigen 1-binding Protein 2, Interacts with Factors of Both the 60 S and the 40 S Ribosomal Subunit Assembly. J. Biol. Chem. 279: 25353-25358 [Abstract] [Full Text]  
  • Ploski, J. E., Shamsher, M. K., Radu, A. (2004). Paired-Type Homeodomain Transcription Factors Are Imported into the Nucleus by Karyopherin 13. Mol. Cell. Biol. 24: 4824-4834 [Abstract] [Full Text]  
  • Sanchez Garcia, J., Ciufo, L. F., Yang, X., Kearsey, S. E., MacNeill, S. A. (2004). The C-terminal zinc finger of the catalytic subunit of DNA polymerase {delta} is responsible for direct interaction with the B-subunit. Nucleic Acids Res 32: 3005-3016 [Abstract] [Full Text]  
  • Mangus, D. A., Smith, M. M., McSweeney, J. M., Jacobson, A. (2004). Identification of Factors Regulating Poly(A) Tail Synthesis and Maturation. Mol. Cell. Biol. 24: 4196-4206 [Abstract] [Full Text]  
  • Morikawa, Y., Cserjesi, P. (2004). Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development 131: 2195-2204 [Abstract] [Full Text]  
  • Chalazonitis, A., D'Autreaux, F., Guha, U., Pham, T. D., Faure, C., Chen, J. J., Roman, D., Kan, L., Rothman, T. P., Kessler, J. A., Gershon, M. D. (2004). Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset. J. Neurosci. 24: 4266-4282 [Abstract] [Full Text]  
  • Poveda, A., Pamblanco, M., Tafrov, S., Tordera, V., Sternglanz, R., Sendra, R. (2004). Hif1 Is a Component of Yeast Histone Acetyltransferase B, a Complex Mainly Localized in the Nucleus. J. Biol. Chem. 279: 16033-16043 [Abstract] [Full Text]  
  • Christian, M., Tullet, J. M. A., Parker, M. G. (2004). Characterization of Four Autonomous Repression Domains in the Corepressor Receptor Interacting Protein 140. J. Biol. Chem. 279: 15645-15651 [Abstract] [Full Text]  
  • Stebbins, J. L., Triezenberg, S. J. (2004). Identification, Mutational Analysis, and Coactivator Requirements of Two Distinct Transcriptional Activation Domains of the Saccharomyces cerevisiae Hap4 Protein. Eukaryot Cell 3: 339-347 [Abstract] [Full Text]  
  • Nery, F. C., Passos, D. O., Garcia, V. S., Kobarg, J. (2004). Ki-1/57 Interacts with RACK1 and Is a Substrate for the Phosphorylation by Phorbol 12-Myristate 13-Acetate-activated Protein Kinase C. J. Biol. Chem. 279: 11444-11455 [Abstract] [Full Text]  
  • Znaidi, S., Pelletier, B., Mukai, Y., Labbe, S. (2004). The Schizosaccharomyces pombe Corepressor Tup11 Interacts with the Iron-responsive Transcription Factor Fep1. J. Biol. Chem. 279: 9462-9474 [Abstract] [Full Text]  
  • Wei, C., Price, C. M. (2004). Cell Cycle Localization, Dimerization, and Binding Domain Architecture of the Telomere Protein cPot1. Mol. Cell. Biol. 24: 2091-2102 [Abstract] [Full Text]  
  • Matsunaga, M., Jaehning, J. A. (2004). A Mutation in the Yeast Mitochondrial Core RNA Polymerase, Rpo41, Confers Defects in Both Specificity Factor Interaction and Promoter Utilization. J. Biol. Chem. 279: 2012-2019 [Abstract] [Full Text]  
  • Nelson, B., Parsons, A. B., Evangelista, M., Schaefer, K., Kennedy, K., Ritchie, S., Petryshen, T. L., Boone, C. (2004). Fus1p Interacts With Components of the Hog1p Mitogen-Activated Protein Kinase and Cdc42p Morphogenesis Signaling Pathways to Control Cell Fusion During Yeast Mating. Genetics 166: 67-77 [Abstract] [Full Text]  
  • Rychlik, J. L., Gerbasi, V., Lewis, E. J. (2003). The Interaction between dHAND and Arix at the Dopamine {beta}-Hydroxylase Promoter Region Is Independent of Direct dHAND Binding to DNA. J. Biol. Chem. 278: 49652-49660 [Abstract] [Full Text]  
  • Giovannone, B., Lee, E., Laviola, L., Giorgino, F., Cleveland, K. A., Smith, R. J. (2003). Two Novel Proteins That Are Linked to Insulin-like Growth Factor (IGF-I) Receptors by the Grb10 Adapter and Modulate IGF-I Signaling. J. Biol. Chem. 278: 31564-31573 [Abstract] [Full Text]  
  • Guo, C. S., Degnin, C., Fiddler, T. A., Stauffer, D., Thayer, M. J. (2003). Regulation of MyoD Activity and Muscle Cell Differentiation by MDM2, pRb, and Sp1. J. Biol. Chem. 278: 22615-22622 [Abstract] [Full Text]  
  • Kaiser, F. J., Tavassoli, K., Van den Bemd, G.-J., Chang, G. T.G., Horsthemke, B., Moroy, T., Ludecke, H.-J. (2003). Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1. Hum Mol Genet 12: 1349-1358 [Abstract] [Full Text]  
  • Toi, H., Fujimura-Kamada, K., Irie, K., Takai, Y., Todo, S., Tanaka, K. (2003). She4p/Dim1p Interacts with the Motor Domain of Unconventional Myosins in the Budding Yeast, Saccharomyces cerevisiae. Mol. Biol. Cell 14: 2237-2249 [Abstract] [Full Text]  
  • Zhu, Y., Dai, J., Fuerst, P. G., Voytas, D. F. (2003). From the Cover: Controlling integration specificity of a yeast retrotransposon. Proc. Natl. Acad. Sci. USA 100: 5891-5895 [Abstract] [Full Text]  
  • Kumar, M. S., Hendrix, J. A., Johnson, A. D., Owens, G. K. (2003). Smooth Muscle {alpha}-Actin Gene Requires Two E-Boxes for Proper Expression In Vivo and Is a Target of Class I Basic Helix-Loop-Helix Proteins. Circ. Res. 92: 840-847 [Abstract] [Full Text]  
  • Kumar, M. S., Owens, G. K. (2003). Combinatorial Control of Smooth Muscle-Specific Gene Expression. Arterioscler. Thromb. Vasc. Bio. 23: 737-747 [Abstract] [Full Text]  
  • Edwards, S., Li, C. M., Levy, D. L., Brown, J., Snow, P. M., Campbell, J. L. (2003). Saccharomyces cerevisiae DNA Polymerase {varepsilon} and Polymerase {sigma} Interact Physically and Functionally, Suggesting a Role for Polymerase {varepsilon} in Sister Chromatid Cohesion. Mol. Cell. Biol. 23: 2733-2748 [Abstract] [Full Text]  
  • Sun, W., Wei, X., Kesavan, K., Garrington, T. P., Fan, R., Mei, J., Anderson, S. M., Gelfand, E. W., Johnson, G. L. (2003). MEK Kinase 2 and the Adaptor Protein Lad Regulate Extracellular Signal-Regulated Kinase 5 Activation by Epidermal Growth Factor via Src. Mol. Cell. Biol. 23: 2298-2308 [Abstract] [Full Text]  
  • Wysocka, J., Myers, M. P., Laherty, C. D., Eisenman, R. N., Herr, W. (2003). Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 17: 896-911 [Abstract] [Full Text]  
  • Muller, F., Rohrer, H. (2003). Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage. Development 129: 5707-5717 [Abstract] [Full Text]  
  • Tanaka, T., Chung, G. T. Y., Forster, A., Lobato, M. N., Rabbitts, T. H. (2003). De novo production of diverse intracellular antibody libraries. Nucleic Acids Res 31: e23-e23 [Abstract] [Full Text]  
  • Liu, C.-j., Dib-Hajj, S. D., Renganathan, M., Cummins, T. R., Waxman, S. G. (2003). Modulation of the Cardiac Sodium Channel Nav1.5 by Fibroblast Growth Factor Homologous Factor 1B. J. Biol. Chem. 278: 1029-1036 [Abstract] [Full Text]  
  • Eilers, A. L., Sundwall, E., Lin, M., Sullivan, A. A., Ayer, D. E. (2002). A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex. Mol. Cell. Biol. 22: 8514-8526 [Abstract] [Full Text]  
  • Nakamura, T., Komiya, M., Sone, K., Hirose, E., Gotoh, N., Morii, H., Ohta, Y., Mori, N. (2002). Grit, a GTPase-Activating Protein for the Rho Family, Regulates Neurite Extension through Association with the TrkA Receptor and N-Shc and CrkL/Crk Adapter Molecules. Mol. Cell. Biol. 22: 8721-8734 [Abstract] [Full Text]  
  • Andrulis, E. D., Zappulla, D. C., Ansari, A., Perrod, S., Laiosa, C. V., Gartenberg, M. R., Sternglanz, R. (2002). Esc1, a Nuclear Periphery Protein Required for Sir4-Based Plasmid Anchoring and Partitioning. Mol. Cell. Biol. 22: 8292-8301 [Abstract] [Full Text]  
  • Brackertz, M., Boeke, J., Zhang, R., Renkawitz, R. (2002). Two Highly Related p66 Proteins Comprise a New Family of Potent Transcriptional Repressors Interacting with MBD2 and MBD3. J. Biol. Chem. 277: 40958-40966 [Abstract] [Full Text]  
  • Hook, S. S., Orian, A., Cowley, S. M., Eisenman, R. N. (2002). Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc. Natl. Acad. Sci. USA 99: 13425-13430 [Abstract] [Full Text]  
  • Madani, N., Millette, R., Platt, E. J., Marin, M., Kozak, S. L., Bloch, D. B., Kabat, D. (2002). Implication of the Lymphocyte-Specific Nuclear Body Protein Sp140 in an Innate Response to Human Immunodeficiency Virus Type 1. J. Virol. 76: 11133-11138 [Abstract] [Full Text]  
  • Moraitis, A. N., Giguere, V., Thompson, C. C. (2002). Novel Mechanism of Nuclear Receptor Corepressor Interaction Dictated by Activation Function 2 Helix Determinants. Mol. Cell. Biol. 22: 6831-6841 [Abstract] [Full Text]  
  • Oliveira, C. C., Gonzales, F. A., Zanchin, N. I. T. (2002). Temperature-sensitive mutants of the exosome subunit Rrp43p show a deficiency in mRNA degradation and no longer interact with the exosome. Nucleic Acids Res 30: 4186-4198 [Abstract] [Full Text]  
  • Alto, N. M., Soderling, J., Scott, J. D. (2002). Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. JCB 158: 659-668 [Abstract] [Full Text]  
  • Tzfira, T., Vaidya, M., Citovsky, V. (2002). Increasing plant susceptibility to Agrobacterium infection by overexpression of the Arabidopsis nuclear protein VIP1. Proc. Natl. Acad. Sci. USA 99: 10435-10440 [Abstract] [Full Text]  
  • Desvoyes, B., Faure-Rabasse, S., Chen, M.-H., Park, J.-W., Scholthof, H. B. (2002). A Novel Plant Homeodomain Protein Interacts in a Functionally Relevant Manner with a Virus Movement Protein. Plant Physiol. 129: 1521-1532 [Abstract] [Full Text]  
  • Benecke, A., Gaudon, C., Garnier, J.-M., vom Baur, E., Chambon, P., Losson, R. (2002). ADA3-containing complexes associate with estrogen receptor alpha. Nucleic Acids Res 30: 2508-2514 [Abstract] [Full Text]  
  • Ferkey, D. M., Kimelman, D. (2002). Glycogen Synthase Kinase-3beta Mutagenesis Identifies a Common Binding Domain for GBP and Axin. J. Biol. Chem. 277: 16147-16152 [Abstract] [Full Text]  
  • Wasylyk, C., Schlumberger, S. E., Criqui-Filipe, P., Wasylyk, B. (2002). Sp100 Interacts with ETS-1 and Stimulates Its Transcriptional Activity. Mol. Cell. Biol. 22: 2687-2702 [Abstract] [Full Text]  
  • Seimiya, H., Smith, S. (2002). The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182). J. Biol. Chem. 277: 14116-14126 [Abstract] [Full Text]  
  • Dai, Y.-S., Cserjesi, P. (2002). The Basic Helix-Loop-Helix Factor, HAND2, Functions as a Transcriptional Activator by Binding to E-boxes as a Heterodimer. J. Biol. Chem. 277: 12604-12612 [Abstract] [Full Text]  
  • Yi, Z., Yokota, H., Torii, S., Aoki, T., Hosaka, M., Zhao, S., Takata, K., Takeuchi, T., Izumi, T. (2002). The Rab27a/Granuphilin Complex Regulates the Exocytosis of Insulin-Containing Dense-Core Granules. Mol. Cell. Biol. 22: 1858-1867 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»