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Mol. Cell. Biol., 12 1996, 6887-6899, Vol 16, No. 12
Copyright © 1996, American Society for Microbiology

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain- containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

Y Fujioka, T Matozaki, T Noguchi, A Iwamatsu, T Yamao, N Takahashi, M Tsuda, T Takada and M Kasuga
Second Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Japan.

Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src homology 2 (SH2) domains play important roles in growth factor and cytokine signal transduction pathways. A protein of approximately 115 to 120 kDa that interacts with SHP-1 and SHP-2 was purified from v-src-transformed rat fibroblasts (SR-3Y1 cells), and the corresponding cDNA was cloned. The predicted amino acid sequence of the encoded protein, termed SHPS-1 (SHP substrate 1), suggests that it is a glycosylated receptor-like protein with three immunoglobulin-like domains in its extracellular region and four YXX(L/V/I) motifs, potential tyrosine phosphorylation and SH2-domain binding sites, in its cytoplasmic region. Various mitogens, including serum, insulin, and lysophosphatidic acid, or cell adhesion induced tyrosine phosphorylation of SHPS-1 and its subsequent association with SHP-2 in cultured cells. Thus, SHPS-1 may be a direct substrate for both tyrosine kinases, such as the insulin receptor kinase or Src, and a specific docking protein for SH2-domain-containing PTPases. In addition, we suggest that SHPS-1 may be a potential substrate for SHP-2 and may function in both growth factor- and cell adhesion-induced cell signaling.


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  • Maroun, C. R., Naujokas, M. A., Holgado-Madruga, M., Wong, A. J., Park, M. (2000). The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase. Mol. Cell. Biol. 20: 8513-8525 [Abstract] [Full Text]  
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  • Elbaz, N., Bedecs, K., Masson, M., Sutren, M., Strosberg, A. D., Nahmias, C. (2000). Functional Trans-inactivation of Insulin Receptor Kinase by Growth-Inhibitory Angiotensin II AT2 Receptor. Mol. Endocrinol. 14: 795-804 [Abstract] [Full Text]  
  • Babic, I., Schallhorn, A., Lindberg, F. P., Jirik, F. R. (2000). SHPS-1 Induces Aggregation of Ba/F3 Pro-B Cells Via an Interaction with CD47. J. Immunol. 164: 3652-3658 [Abstract] [Full Text]  
  • Zhao, R., Zhao, Z. J. (2000). Dissecting the Interaction of SHP-2 with PZR, an Immunoglobulin Family Protein Containing Immunoreceptor Tyrosine-based Inhibitory Motifs. J. Biol. Chem. 275: 5453-5459 [Abstract] [Full Text]  
  • O'Reilly, A. M., Pluskey, S., Shoelson, S. E., Neel, B. G. (2000). Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps. Mol. Cell. Biol. 20: 299-311 [Abstract] [Full Text]  
  • Kim, S.-O., Houtman, J. C. D., Jiang, J., Ruppert, J. M., Bertics, P. J., Frank, S. J. (1999). Growth Hormone-induced Alteration in ErbB-2 Phosphorylation Status in 3T3-F442A Fibroblasts. J. Biol. Chem. 274: 36015-36024 [Abstract] [Full Text]  
  • Seiffert, M., Cant, C., Chen, Z., Rappold, I., Brugger, W., Kanz, L., Brown, E. J., Ullrich, A., Buhring, H.-J. (1999). Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47. Blood 94: 3633-3643 [Abstract] [Full Text]  
  • Lienard, H., Bruhns, P., Malbec, O., Fridman, W. H., Daeron, M. (1999). Signal Regulatory Proteins Negatively Regulate Immunoreceptor-dependent Cell Activation. J. Biol. Chem. 274: 32493-32499 [Abstract] [Full Text]  
  • Maegawa, H., Hasegawa, M., Sugai, S., Obata, T., Ugi, S., Morino, K., Egawa, K., Fujita, T., Sakamoto, T., Nishio, Y., Kojima, H., Haneda, M., Yasuda, H., Kikkawa, R., Kashiwagi, A. (1999). Expression of a Dominant Negative SHP-2 in Transgenic Mice Induces Insulin Resistance. J. Biol. Chem. 274: 30236-30243 [Abstract] [Full Text]  
  • Lee, Y.-J., Streuli, C. H. (1999). Extracellular Matrix Selectively Modulates the Response of Mammary Epithelial Cells to Different Soluble Signaling Ligands. J. Biol. Chem. 274: 22401-22408 [Abstract] [Full Text]  
  • Kim, H., Baumann, H. (1999). Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells. Mol. Cell. Biol. 19: 5326-5338 [Abstract] [Full Text]  
  • Qu, C.-K., Yu, W.-M., Azzarelli, B., Feng, G.-S. (1999). Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc. Natl. Acad. Sci. USA 96: 8528-8533 [Abstract] [Full Text]  
  • DeMali, K. A., Balciunaite, E., Kazlauskas, A. (1999). Integrins Enhance Platelet-derived Growth Factor (PDGF)-dependent Responses by Altering the Signal Relay Enzymes That Are Recruited to the PDGF beta Receptor. J. Biol. Chem. 274: 19551-19558 [Abstract] [Full Text]  
  • Tang, H., Zhao, Z. J., Huang, X.-Y., Landon, E. J., Inagami, T. (1999). Fyn Kinase-directed Activation of SH2 Domain-containing Protein-tyrosine Phosphatase SHP-2 by Gi Protein-coupled Receptors in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 274: 12401-12407 [Abstract] [Full Text]  
  • Oh, E.-S., Gu, H., Saxton, T. M., Timms, J. F., Hausdorff, S., Frevert, E. U., Kahn, B. B., Pawson, T., Neel, B. G., Thomas, S. M. (1999). Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2. Mol. Cell. Biol. 19: 3205-3215 [Abstract] [Full Text]  
  • Saxton, T. M., Pawson, T. (1999). Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. Proc. Natl. Acad. Sci. USA 96: 3790-3795 [Abstract] [Full Text]  
  • Bruhns, P., Marchetti, P., Fridman, W. H., Vivier, E., Daeron, M. (1999). Differential Roles of N- and C-Terminal Immunoreceptor Tyrosine-Based Inhibition Motifs During Inhibition of Cell Activation by Killer Cell Inhibitory Receptors. J. Immunol. 162: 3168-3175 [Abstract] [Full Text]  
  • Nishida, K., Yoshida, Y., Itoh, M., Fukada, T., Ohtani, T., Shirogane, T., Atsumi, T., Takahashi-Tezuka, M., Ishihara, K., Hibi, M., Hirano, T. (1999). Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors. Blood 93: 1809-1816 [Abstract] [Full Text]  
  • You, M., Yu, D.-H., Feng, G.-S. (1999). Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway. Mol. Cell. Biol. 19: 2416-2424 [Abstract] [Full Text]  
  • Gadina, M., Sudarshan, C., O'Shea, J. J. (1999). IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3'-Kinase, and Grb2. J. Immunol. 162: 2081-2086 [Abstract] [Full Text]  
  • Blasioli, J., Paust, S., Thomas, M. L. (1999). Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22. J. Biol. Chem. 274: 2303-2307 [Abstract] [Full Text]  
  • Jiang, P., Lagenaur, C. F., Narayanan, V. (1999). Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule. J. Biol. Chem. 274: 559-562 [Abstract] [Full Text]  
  • Huber, M., Izzi, L., Grondin, P., Houde, C., Kunath, T., Veillette, A., Beauchemin, N. (1999). The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells. J. Biol. Chem. 274: 335-344 [Abstract] [Full Text]  
  • Zhao, Z. J., Zhao, R. (1998). Purification and Cloning of PZR, a Binding Protein and Putative Physiological Substrate of Tyrosine Phosphatase SHP-2. J. Biol. Chem. 273: 29367-29372 [Abstract] [Full Text]  


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