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Mol. Cell. Biol., 02 1996, 694-703, Vol 16, No. 2
Copyright © 1996, American Society for Microbiology

Phosphorylation of CREB at Ser-133 induces complex formation with CREB- binding protein via a direct mechanism

D Parker, K Ferreri, T Nakajima, VJ LaMorte, R Evans, SC Koerber, C Hoeger and MR Montminy
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037, USA.

We have characterized a phosphoserine binding domain in the coactivator CREB-binding protein (CBP) which interacts with the protein kinase A- phosphorylated, and hence activated, form of the cyclic AMP-responsive factor CREB. The CREB binding domain, referred to as KIX, is alpha helical and binds to an unstructured kinase-inducible domain in CREB following phosphorylation of CREB at Ser-133. Phospho-Ser-133 forms direct contacts with residues in KIX, and these contacts are further stabilized by hydrophobic residues in the kinase-inducible domain which flank phospho-Ser-133. Like the src homology 2 (SH2) domains which bind phosphotyrosine-containing peptides, phosphoserine 133 appears to coordinate with a single arginine residue (Arg-600) in KIX which is conserved in the CBP-related protein P300. Since mutagenesis of Arg-600 to Gln severely reduces CREB-CBP complex formation, our results demonstrate that, as in the case of tyrosine kinase pathways, signal transduction through serine/threonine kinase pathways may also require protein interaction motifs which are capable of recognizing phosphorylated amino acids.


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  • Felinski, E. A., Kim, J., Lu, J., Quinn, P. G. (2001). Recruitment of an RNA Polymerase II Complex Is Mediated by the Constitutive Activation Domain in CREB, Independently of CREB Phosphorylation. Mol. Cell. Biol. 21: 1001-1010 [Abstract] [Full Text]  
  • Bernard, C., Sutter, A., Vinson, C., Ratineau, C., Chayvialle, J.-A., Cordier-Bussat, M. (2001). Peptones Stimulate Intestinal Cholecystokinin Gene Transcription via Cyclic Adenosine Monophosphate Response Element-Binding Factors. Endocrinology 142: 721-729 [Abstract] [Full Text]  
  • Shaywitz, A. J., Dove, S. L., Kornhauser, J. M., Hochschild, A., Greenberg, M. E. (2000). Magnitude of the CREB-Dependent Transcriptional Response Is Determined by the Strength of the Interaction between the Kinase-Inducible Domain of CREB and the KIX Domain of CREB-Binding Protein. Mol. Cell. Biol. 20: 9409-9422 [Abstract] [Full Text]  
  • Fimia, G. M., De Cesare, D., Sassone-Corsi, P. (2000). A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM. Mol. Cell. Biol. 20: 8613-8622 [Abstract] [Full Text]  
  • Giebler, H. A., Lemasson, I., Nyborg, J. K. (2000). p53 Recruitment of CREB Binding Protein Mediated through Phosphorylated CREB: a Novel Pathway of Tumor Suppressor Regulation. Mol. Cell. Biol. 20: 4849-4858 [Abstract] [Full Text]  
  • Takemaru, K.-I., Moon, R. T. (2000). The Transcriptional Coactivator Cbp Interacts with {beta}-Catenin to Activate Gene Expression. JCB 149: 249-254 [Abstract] [Full Text]  
  • Cardinaux, J.-R., Notis, J. C., Zhang, Q., Vo, N., Craig, J. C., Fass, D. M., Brennan, R. G., Goodman, R. H. (2000). Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation. Mol. Cell. Biol. 20: 1546-1552 [Abstract] [Full Text]  
  • Li, J, Lee, G., Van Doren, S., Walker, J. (2000). The FHA domain mediates phosphoprotein interactions. J. Cell Sci. 113: 4143-4149 [Abstract]  
  • Van Orden, K., Giebler, H. A., Lemasson, I., Gonzales, M., Nyborg, J. K. (1999). Binding of p53 to the KIX Domain of CREB Binding Protein. A POTENTIAL LINK TO HUMAN T-CELL LEUKEMIA VIRUS, TYPE I-ASSOCIATED LEUKEMOGENESIS. J. Biol. Chem. 274: 26321-26328 [Abstract] [Full Text]  
  • Parker, D., Rivera, M., Zor, T., Henrion-Caude, A., Radhakrishnan, I., Kumar, A., Shapiro, L. H., Wright, P. E., Montminy, M., Brindle, P. K. (1999). Role of Secondary Structure in Discrimination between Constitutive and Inducible Activators. Mol. Cell. Biol. 19: 5601-5607 [Abstract] [Full Text]  
  • Shenkar, R., Abraham, E. (1999). Mechanisms of Lung Neutrophil Activation After Hemorrhage or Endotoxemia: Roles of Reactive Oxygen Intermediates, NF-{kappa}B, and Cyclic AMP Response Element Binding Protein. J. Immunol. 163: 954-962 [Abstract] [Full Text]  
  • Li, J., Smith, G. P., Walker, J. C. (1999). Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96: 7821-7826 [Abstract] [Full Text]  
  • Seternes, O. M., Johansen, B., Moens, U. (1999). A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth Factor-Induced CREB (cAMP-Responsive Element-Binding Protein) Activation, Uncoupled from Serine 133 Phosphorylation in NIH 3T3 Cells. Mol. Endocrinol. 13: 1071-1083 [Abstract] [Full Text]  
  • Francis, A., Ragoczy, T., Gradoville, L., Heston, L., El-Guindy, A., Endo, Y., Miller, G. (1999). Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator. J. Virol. 73: 4543-4551 [Abstract] [Full Text]  
  • Fry, C. J., Pearson, A., Malinowski, E., Bartley, S. M., Greenblatt, J., Farnham, P. J. (1999). Activation of the Murine Dihydrofolate Reductase Promoter by E2F1. A REQUIREMENT FOR CBP RECRUITMENT. J. Biol. Chem. 274: 15883-15891 [Abstract] [Full Text]  
  • Wölfl, S., Martinez, C., Majzoub, J. A. (1999). Inducible Binding of Cyclic Adenosine 3',5'-Monophosphate (cAMP)-Responsive Element Binding Protein (CREB) to a cAMP-Responsive Promoter in Vivo. Mol. Endocrinol. 13: 659-669 [Abstract] [Full Text]  
  • Felinski, E. A., Quinn, P. G. (1999). The CREB Constitutive Activation Domain Interacts with TATA-binding Protein-associated Factor 110 (TAF110) through Specific Hydrophobic Residues in One of the Three Subdomains Required for Both Activation and TAF110 Binding. J. Biol. Chem. 274: 11672-11678 [Abstract] [Full Text]  
  • Zerby, D., Chen, C.-J., Poon, E., Lee, D., Shiekhattar, R., Lieberman, P. M. (1999). The Amino-Terminal C/H1 Domain of CREB Binding Protein Mediates Zta Transcriptional Activation of Latent Epstein-Barr Virus. Mol. Cell. Biol. 19: 1617-1626 [Abstract] [Full Text]  
  • Fontes, J. D., Kanazawa, S., Jean, D., Peterlin, B. M. (1999). Interactions between the Class II Transactivator and CREB Binding Protein Increase Transcription of Major Histocompatibility Complex Class II Genes. Mol. Cell. Biol. 19: 941-947 [Abstract] [Full Text]  
  • Kashanchi, F., Duvall, J. F., Kwok, R. P. S., Lundblad, J. R., Goodman, R. H., Brady, J. N. (1998). The Coactivator CBP Stimulates Human T-cell Lymphotrophic Virus Type I Tax Transactivation in Vitro. J. Biol. Chem. 273: 34646-34652 [Abstract] [Full Text]  
  • Colgin, M. A., Nyborg, J. K. (1998). The Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax Inhibits the Transcriptional Activity of c-Myb through Competition for the CREB Binding Protein. J. Virol. 72: 9396-9399 [Abstract] [Full Text]  
  • Baumann, M., Mischak, H., Dammeier, S., Kolch, W., Gires, O., Pich, D., Zeidler, R., Delecluse, H.-J., Hammerschmidt, W. (1998). Activation of the Epstein-Barr Virus Transcription Factor BZLF1 by 12-O-Tetradecanoylphorbol-13-Acetate-Induced Phosphorylation. J. Virol. 72: 8105-8114 [Abstract] [Full Text]  
  • Wu, X., Spiro, C., Owen, W. G., McMurray, C. T. (1998). cAMP Response Element-binding Protein Monomers Cooperatively Assemble to Form Dimers on DNA. J. Biol. Chem. 273: 20820-20827 [Abstract] [Full Text]  
  • Hegde, S. P., Kumar, A., Kurschner, C., Shapiro, L. H. (1998). c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation. Mol. Cell. Biol. 18: 2729-2737 [Abstract] [Full Text]  
  • Qiu, Y., Sharma, A., Stein, R. (1998). p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene. Mol. Cell. Biol. 18: 2957-2964 [Abstract] [Full Text]  
  • Yang, C., Shapiro, L. H., Rivera, M., Kumar, A., Brindle, P. K. (1998). A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions. Mol. Cell. Biol. 18: 2218-2229 [Abstract] [Full Text]  
  • Bex, F., Yin, M.-J., Burny, A., Gaynor, R. B. (1998). Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300. Mol. Cell. Biol. 18: 2392-2405 [Abstract] [Full Text]  
  • Shi, Y., Mello, C. (1998). A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 12: 943-955 [Abstract] [Full Text]  
  • Lenzmeier, B. A., Giebler, H. A., Nyborg, J. K. (1998). Human T-Cell Leukemia Virus Type 1 Tax Requires Direct Access to DNA for Recruitment of CREB Binding Protein to the Viral Promoter. Mol. Cell. Biol. 18: 721-731 [Abstract] [Full Text]  
  • Himmelmann, A., Riva, A., Wilson, G. L., Lucas, B. P., Thevenin, C., Kehrl, J. H. (1997). PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes. Blood 90: 3984-3995 [Abstract] [Full Text]  
  • Lee, B. H., Mathews, M. B. (1997). Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein. Proc. Natl. Acad. Sci. USA 94: 4481-4486 [Abstract] [Full Text]  
  • Nakajima, T, Uchida, C, Anderson, S F, Parvin, J D, Montminy, M (1997). Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.. Genes Dev. 11: 738-747 [Abstract]  
  • Shih, H.-m., Goldman, P. S., DeMaggio, A. J., Hollenberg, S. M., Goodman, R. H., Hoekstra, M. F. (1996). A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP. Proc. Natl. Acad. Sci. USA 93: 13896-13901 [Abstract] [Full Text]  
  • Brass, A L, Kehrli, E, Eisenbeis, C F, Storb, U, Singh, H (1996). Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.. Genes Dev. 10: 2335-2347 [Abstract]  
  • Thomas, M. J., Umayahara, Y., Shu, H., Centrella, M., Rotwein, P., McCarthy, T. L. (1996). Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts. J. Biol. Chem. 271: 21835-21841 [Abstract] [Full Text]  
  • Bisotto, S., Minorgan, S., Rehfuss, R. P. (1996). Identification and Characterization of a Novel Transcriptional Activation Domain in the CREB-binding Protein. J. Biol. Chem. 271: 17746-17750 [Abstract] [Full Text]  
  • Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B. M., Montminy, M., Evans, R. M. (2001). A Transcriptional Switch Mediated by Cofactor Methylation. Science 294: 2507-2511 [Abstract] [Full Text]  
  • Zhang, Y., Derynck, R. (2000). Transcriptional Regulation of the Transforming Growth Factor-beta -inducible Mouse Germ Line Ig alpha Constant Region Gene by Functional Cooperation of Smad, CREB, and AML Family Members. J. Biol. Chem. 275: 16979-16985 [Abstract] [Full Text]  
  • Waltner-Law, M., Daniels, M. C., Sutherland, C., Granner, D. K. (2000). NF-kappa B Inhibits Glucocorticoid and cAMP-mediated Expression of the Phosphoenolpyruvate Carboxykinase Gene. J. Biol. Chem. 275: 31847-31856 [Abstract] [Full Text]  
  • Newton, A. L., Sharpe, B. K., Kwan, A., Mackay, J. P., Crossley, M. (2000). The Transactivation Domain within Cysteine/Histidine-rich Region 1 of CBP Comprises Two Novel Zinc-binding Modules. J. Biol. Chem. 275: 15128-15134 [Abstract] [Full Text]  
  • Ostedgaard, L. S., Baldursson, O., Welsh, M. J. (2001). Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Its R Domain. J. Biol. Chem. 276: 7689-7692 [Full Text]  
  • Ostedgaard, L. S., Baldursson, O., Vermeer, D. W., Welsh, M. J., Robertson, A. D. (2000). A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution. Proc. Natl. Acad. Sci. USA 97: 5657-5662 [Abstract] [Full Text]  


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