This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Moberg, K. Articles by Lees, J. A. Search for Related Content PubMed PubMed Citation Articles by Moberg, K. Articles by Lees, J. A.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 04 1996, 1436-1449, Vol 16, No. 4
Copyright © 1996, American Society for Microbiology

E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

K Moberg, MA Starz and JA Lees
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, USA.

The E2F transcription factor couples the coordinate expression of cell cycle proteins to their appropriate transition points. Its activity is controlled by the cell cycle regulators pRB, p107, and p130. These bind to E2F at defined but distinct stages of the cell cycle. Using specific antisera, we have identified the DP and E2F components of each of these species. Although present at very different levels, DP-1 and DP-2 are evenly distributed among each of these complexes. In contrast, the individual E2Fs have distinctly different binding profiles. Consistent with previous studies, E2F-1, E2F-2, and E2F-3 bind specifically to the retinoblastoma protein. In each case, their expression and DNA binding activity are restricted to post-G1/S fractions. Surprisingly, E2F-1 and E2F-3 make unequal contributions to the pRB-associated and free E2F activity, suggesting that these proteins perform different cell cycle functions. Most significantly, this study showed E2F-4 accounts for the vast majority of the endogenous E2F activity. In arrested cells, E2F-4 is sequestered by the p130 protein. However, as the cells pass the G1- to-S transition, the levels of pRB and p107 increase and E2F-4 now associates with both of these regulators. Despite this, a considerable amount of E2F-4 exists as free E2F. In G1 cells, this accounts for almost all of the free activity. Once the cells enter S phase, free E2F is composed of an equal mixture of E2F-4 and E2F-1.

This article has been cited by other articles:

• Ma, Y., Kurtyka, C. A., Boyapalle, S., Sung, S.-S., Lawrence, H., Guida, W., Cress, W. D. (2008). A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model. Cancer Res. 68: 6292-6299 [Abstract] [Full Text]  
• Xue, L., Nolla, H., Suzuki, A., Mak, T. W., Winoto, A. (2008). Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc. Natl. Acad. Sci. USA 105: 2022-2027 [Abstract] [Full Text]  
• Osborn, S. L., Sohn, S. J., Winoto, A. (2007). Constitutive Phosphorylation Mutation in Fas-associated Death Domain (FADD) Results in Early Cell Cycle Defects. J. Biol. Chem. 282: 22786-22792 [Abstract] [Full Text]  
• Ahuja, P., Sdek, P., MacLellan, W. R. (2007). Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration. Physiol. Rev. 87: 521-544 [Abstract] [Full Text]  
• Ory, B., Blanchard, F., Battaglia, S., Gouin, F., Redini, F., Heymann, D. (2007). Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translocation Independently of p53 and Retinoblastoma Status. Mol. Pharmacol. 71: 333-343 [Abstract] [Full Text]  
• Rodriguez, J. M., Glozak, M. A., Ma, Y., Cress, W. D. (2006). Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis. J. Biol. Chem. 281: 22729-22735 [Abstract] [Full Text]  
• Kinross, K. M., Clark, A. J., Iazzolino, R. M., Humbert, P. O. (2006). E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation. Blood 108: 886-895 [Abstract] [Full Text]  
• Cho, H. J., Kim, E. J., Lim, S. S., Kim, M. K., Sung, M.-K., Kim, J.-S., Park, J. H. Y. (2006). Trans-10,cis-12, Not cis-9,trans-11, Conjugated Linoleic Acid Inhibits G1-S Progression in HT-29 Human Colon Cancer Cells. J. Nutr. 136: 893-898 [Abstract] [Full Text]  
• Lu, X., Jung, J. i., Cho, H. J., Lim, D. Y., Lee, H. S., Chun, H. S., Kwon, D. Y., Park, J. H. (2005). Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J. Nutr. 135: 2884-2890 [Abstract] [Full Text]  
• Balciunaite, E., Spektor, A., Lents, N. H., Cam, H., te Riele, H., Scime, A., Rudnicki, M. A., Young, R., Dynlacht, B. D. (2005). Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells. Mol. Cell. Biol. 25: 8166-8178 [Abstract] [Full Text]  
• Parakati, R., DiMario, J. X. (2005). Dynamic Transcriptional Regulatory Complexes, Including E2F4, p107, p130, and Sp1, Control Fibroblast Growth Factor Receptor 1 Gene Expression during Myogenesis. J. Biol. Chem. 280: 21284-21294 [Abstract] [Full Text]  
• Russo, G., Zamparelli, A., Howard, C. M., Minimo, C., Bellan, C., Carillo, G., Califano, L., Leoncini, L., Giordano, A., Claudio, P. P. (2005). Expression of Cell Cycle-Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications. Clin. Cancer Res. 11: 3265-3273 [Abstract] [Full Text]  
• Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., Botchan, M. R. (2004). Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18: 2929-2940 [Abstract] [Full Text]  
• DuPree, E. L., Mazumder, S., Almasan, A. (2004). Genotoxic Stress Induces Expression of E2F4, Leading to Its Association with p130 in Prostate Carcinoma Cells. Cancer Res. 64: 4390-4393 [Abstract] [Full Text]  
• Aslanian, A., Iaquinta, P. J., Verona, R., Lees, J. A. (2004). Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 18: 1413-1422 [Abstract] [Full Text]  
• Savell, J., Ma, Y., Morrow, K. S., Jove, R., Olashaw, N., Moseley, P. L., Cress, W. D., Wharton, W. (2004). AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1. Molecular Cancer Therapeutics 3: 205-213 [Abstract] [Full Text]  
• Vuocolo, S., Purev, E., Zhang, D., Bartek, J., Hansen, K., Soprano, D. R., Soprano, K. J. (2003). Protein Phosphatase 2A Associates with Rb2/p130 and Mediates Retinoic Acid-induced Growth Suppression of Ovarian Carcinoma Cells. J. Biol. Chem. 278: 41881-41889 [Abstract] [Full Text]  
• Dimova, D. K., Stevaux, O., Frolov, M. V., Dyson, N. J. (2003). Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev. 17: 2308-2320 [Abstract] [Full Text]  
• Fingerle-Rowson, G., Petrenko, O., Metz, C. N., Forsthuber, T. G., Mitchell, R., Huss, R., Moll, U., Muller, W., Bucala, R. (2003). The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc. Natl. Acad. Sci. USA 100: 9354-9359 [Abstract] [Full Text]  
• Ma, Y., Yuan, J., Huang, M., Jove, R., Cress, W. D. (2003). Regulation of the Cyclin D3 Promoter by E2F1. J. Biol. Chem. 278: 16770-16776 [Abstract] [Full Text]  
• Landsberg, R. L., Sero, J. E., Danielian, P. S., Yuan, T. L., Lee, E. Y., Lees, J. A. (2003). The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proc. Natl. Acad. Sci. USA 100: 2456-2461 [Abstract] [Full Text]  
• Singh, R. P., Agarwal, C., Agarwal, R. (2003). Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 24: 555-563 [Abstract] [Full Text]  
• Polager, S., Ginsberg, D. (2003). E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress. J. Biol. Chem. 278: 1443-1449 [Abstract] [Full Text]  
• Lee, C., Chang, J. H., Lee, H. S., Cho, Y. (2002). Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 16: 3199-3212 [Abstract] [Full Text]  
• Catchpole, S., Tavner, F., Le Cam, L., Sardet, C., Watson, R. J. (2002). A B-myb Promoter Corepressor Site Facilitates in Vivo Occupation of the Adjacent E2F Site by p107{middle dot}E2F and p130{middle dot}E2F Complexes. J. Biol. Chem. 277: 39015-39024 [Abstract] [Full Text]  
• Botos, J., Smith, R. III, Kochevar, D. T. (2002). Retinoblastoma Function Is a Better Indicator of Cellular Phenotype in Cultured Breast Adenocarcinoma Cells than Retinoblastoma Expression. Exp. Biol. Med. 227: 354-362 [Abstract] [Full Text]  
• Cloud, J. E., Rogers, C., Reza, T. L., Ziebold, U., Stone, J. R., Picard, M. H., Caron, A. M., Bronson, R. T., Lees, J. A. (2002). Mutant Mouse Models Reveal the Relative Roles of E2F1 and E2F3 In Vivo. Mol. Cell. Biol. 22: 2663-2672 [Abstract] [Full Text]  
• Kops, G. J. P. L., Medema, R. H., Glassford, J., Essers, M. A. G., Dijkers, P. F., Coffer, P. J., Lam, E. W.-F., Burgering, B. M. T. (2002). Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors. Mol. Cell. Biol. 22: 2025-2036 [Abstract] [Full Text]  
• Luong, M. X., van der Meijden, C. M., Xing, D., Hesselton, R., Monuki, E. S., Jones, S. N., Lian, J. B., Stein, J. L., Stein, G. S., Neufeld, E. J., van Wijnen, A. J. (2002). Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility. Mol. Cell. Biol. 22: 1424-1437 [Abstract] [Full Text]  
• Chestukhin, A., Litovchick, L., Rudich, K., DeCaprio, J. A. (2002). Nucleocytoplasmic Shuttling of p130/RBL2: Novel Regulatory Mechanism. Mol. Cell. Biol. 22: 453-468 [Abstract] [Full Text]  
• Dimitrova, D. S., Berezney, R. (2002). The spatio-temporal organization of DNA replication sites is identical in primary, immortalized and transformed mammalian cells. J. Cell Sci. 115: 4037-4051 [Abstract] [Full Text]  
• Fan, G., Ma, X., Kren, B. T., Steer, C. J. (2002). Unbound E2F modulates TGF-{beta}1-induced apoptosis in HuH-7 cells. J. Cell Sci. 115: 3181-3191 [Abstract] [Full Text]  
• Zhu, J. W., Field, S. J., Gore, L., Thompson, M., Yang, H., Fujiwara, Y., Cardiff, R. D., Greenberg, M., Orkin, S. H., DeGregori, J. (2001). E2F1 and E2F2 Determine Thresholds for Antigen-Induced T-Cell Proliferation and Suppress Tumorigenesis. Mol. Cell. Biol. 21: 8547-8564 [Abstract] [Full Text]  
• Frolov, M. V., Huen, D. S., Stevaux, O., Dimova, D., Balczarek-Strang, K., Elsdon, M., Dyson, N. J. (2001). Functional antagonism between E2F family members. Genes Dev. 15: 2146-2160 [Abstract] [Full Text]  
• Ehmann, G. L., Burnett, H. A., Bachenheimer, S. L. (2001). Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication. J. Virol. 75: 7149-7160 [Abstract] [Full Text]  
• Ezhevsky, S. A., Ho, A., Becker-Hapak, M., Davis, P. K., Dowdy, S. F. (2001). Differential Regulation of Retinoblastoma Tumor Suppressor Protein by G1 Cyclin-Dependent Kinase Complexes In Vivo. Mol. Cell. Biol. 21: 4773-4784 [Abstract] [Full Text]  
• Huang, D., Jokela, M., Tuusa, J., Skog, S., Poikonen, K., Syvaoja, J. E. (2001). E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase {{epsilon}} B-subunit gene POLE2. Nucleic Acids Res 29: 2810-2821 [Abstract] [Full Text]  
• Waghray, A., Schober, M., Feroze, F., Yao, F., Virgin, J., Chen, Y. Q. (2001). Identification of Differentially Expressed Genes by Serial Analysis of Gene Expression in Human Prostate Cancer. Cancer Res. 61: 4283-4286 [Abstract] [Full Text]  
• Gaubatz, S., Lees, J. A., Lindeman, G. J., Livingston, D. M. (2001). E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner. Mol. Cell. Biol. 21: 1384-1392 [Abstract] [Full Text]  
• Ziebold, U., Reza, T., Caron, A., Lees, J. A. (2001). E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev. 15: 386-391 [Abstract] [Full Text]  
• Trimarchi, J. M., Fairchild, B., Wen, J., Lees, J. A. (2001). The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc. Natl. Acad. Sci. USA 10.1073/pnas.041597698v1 [Abstract] [Full Text]  
• Frey, M. R., Clark, J. A., Leontieva, O., Uronis, J. M., Black, A. R., Black, J. D. (2000). Protein Kinase C Signaling Mediates a Program of Cell Cycle Withdrawal in the Intestinal Epithelium. J. Cell Biol. 151: 763-778 [Abstract] [Full Text]  
• Wu, L., Goodwin, E. C., Naeger, L. K., Vigo, E., Galaktionov, K., Helin, K., DiMaio, D. (2000). E2F-Rb Complexes Assemble and Inhibit cdc25A Transcription in Cervical Carcinoma Cells following Repression of Human Papillomavirus Oncogene Expression. Mol. Cell. Biol. 20: 7059-7067 [Abstract] [Full Text]  
• Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M., Farnham, P. J. (2000). Target Gene Specificity of E2F and Pocket Protein Family Members in Living Cells. Mol. Cell. Biol. 20: 5797-5807 [Abstract] [Full Text]  
• Vairo, G., Soos, T. J., Upton, T. M., Zalvide, J., DeCaprio, J. A., Ewen, M. E., Koff, A., Adams, J. M. (2000). Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation. Mol. Cell. Biol. 20: 4745-4753 [Abstract] [Full Text]  
• Wang, D., Russell, J. L., Johnson, D. G. (2000). E2F4 and E2F1 Have Similar Proliferative Properties but Different Apoptotic and Oncogenic Properties In Vivo. Mol. Cell. Biol. 20: 3417-3424 [Abstract] [Full Text]  
• Scarr, R. B., Smith, M. R., Beddall, M., Sharp, P. A. (2000). A Novel 50-Kilodalton Fragment of Host Cell Factor 1 (C1) in G0 Cells. Mol. Cell. Biol. 20: 3568-3575 [Abstract] [Full Text]  
• McElroy, A. K., Dwarakanath, R. S., Spector, D. H. (2000). Dysregulation of Cyclin E Gene Expression in Human Cytomegalovirus-Infected Cells Requires Viral Early Gene Expression and Is Associated with Changes in the Rb-Related Protein p130. J. Virol. 74: 4192-4206 [Abstract] [Full Text]  
• Howard, C. M., Claudio, P. P., Antonio De Luca, , Stiegler, P., Jori, F. P., Safdar, N. M., Caputi, M., Khalili, K., Giordano, A. (2000). Inducible pRb2/p130 Expression and Growth-suppressive Mechanisms: Evidence of a pRb2/p130, p27Kip1, and Cyclin E Negative Feedback Regulatory Loop. Cancer Res. 60: 2737-2744 [Abstract] [Full Text]  
• Marzio, G., Wagener, C., Gutierrez, M. I., Cartwright, P., Helin, K., Giacca, M. (2000). E2F Family Members Are Differentially Regulated by Reversible Acetylation. J. Biol. Chem. 275: 10887-10892 [Abstract] [Full Text]  
• Nishikawa, N. S., Izumi, M., Uchida, H., Yokoi, M., Miyazawa, H., Hanaoka, F. (2000). Cloning and characterization of the 5'-upstream sequence governing the cell cycle-dependent transcription of mouse DNA polymerase {alpha} 68 kDa subunit gene. Nucleic Acids Res 28: 1525-1534 [Abstract] [Full Text]  
• Takahashi, Y., Rayman, J. B., Dynlacht, B. D. (2000). Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 14: 804-816 [Abstract] [Full Text]  
• Gill, R. M., Hamel, P. A. (2000). Subcellular Compartmentalization of E2F Family Members Is Required for Maintenance of the Postmitotic State in Terminally Differentiated Muscle. J. Cell Biol. 148: 1187-1202 [Abstract] [Full Text]  
• Koziczak, M., Krek, W., Nagamine, Y. (2000). Pocket Protein-Independent Repression of Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor 1 Gene Expression by E2F1. Mol. Cell. Biol. 20: 2014-2022 [Abstract] [Full Text]  
• Humbert, P. O., Verona, R., Trimarchi, J. M., Rogers, C., Dandapani, S., Lees, J. A. (2000). E2f3 is critical for normal cellular proliferation. Genes Dev. 14: 690-703 [Abstract] [Full Text]  
• Cinti, C., Leoncini, L., Nyongo, A., Ferrari, F., Lazzi, S., Bellan, C., Vatti, R., Zamparelli, A., Cevenini, G., osi, G. M. T, Claudio, P. P., Maraldi, N. M., Tosi, P., Giordano, A. (2000). Genetic Alterations of the Retinoblastoma-Related Gene RB2/p130 Identify Different Pathogenetic Mechanisms in and among Burkitt’s Lymphoma Subtypes. Am. J. Pathol. 156: 751-760 [Abstract] [Full Text]  
• Arata, Y., Fujita, M., Ohtani, K., Kijima, S., Kato, J.-y. (2000). Cdk2-dependent and -independent Pathways in E2F-mediated S Phase Induction. J. Biol. Chem. 275: 6337-6345 [Abstract] [Full Text]  
• Komatsu, N., Takeuchi, S., Ikezoe, T., Tasaka, T., Hatta, Y., Machida, H., Williamson, I. K., Bartram, C. R., Koeffler, H. P., Taguchi, H. (2000). Mutations of the E2F4 gene in hematological malignancies having microsatellite instability. Blood 95: 1509-1510 [Abstract] [Full Text]  
• Claudio, P. P., Fratta, L., Farina, F., Howard, C. M., Stassi, G., Numata, S.-i., Pacilio, C., Davis, A., Lavitrano, M., Volpe, M., Wilson, J. M., Trimarco, B., Giordano, A., Condorelli, G. (1999). Adenoviral RB2/p130 Gene Transfer Inhibits Smooth Muscle Cell Proliferation and Prevents Restenosis After Angioplasty. Circ. Res. 85: 1032-1039 [Abstract] [Full Text]  
• Persengiev, S. P., Kondova, I. I., Kilpatrick, D. L. (1999). E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation. Mol. Cell. Biol. 19: 6048-6056 [Abstract] [Full Text]  
• Erickson, S., Sangfelt, O., Castro, J., Heyman, M., Einhorn, S., Grandér, D. (1999). Interferon-{{alpha}} Inhibits Proliferation in Human T Lymphocytes by Abrogation of Interleukin 2-induced Changes in Cell Cycle-regulatory Proteins. Cell Growth Differ. 10: 575-582 [Abstract] [Full Text]  
• Brennan, P., Babbage, J. W., Thomas, G., Cantrell, D. (1999). p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes. Mol. Cell. Biol. 19: 4729-4738 [Abstract] [Full Text]  
• Smith-McCune, K., Kalman, D., Robbins, C., Shivakumar, S., Yuschenkoff, L., Bishop, J. M. (1999). Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Proc. Natl. Acad. Sci. USA 96: 6999-7004 [Abstract] [Full Text]  
• Spender, L. C., Cannell, E. J., Hollyoake, M., Wensing, B., Gawn, J. M., Brimmell, M., Packham, G., Farrell, P. J. (1999). Control of Cell Cycle Entry and Apoptosis in B Lymphocytes Infected by Epstein-Barr Virus. J. Virol. 73: 4678-4688 [Abstract] [Full Text]  
• Brown, V. D., Phillips, R. A., Gallie, B. L. (1999). Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity. Mol. Cell. Biol. 19: 3246-3256 [Abstract] [Full Text]  
• Lind, E. F., Wayne, J., Wang, Q.-Z., Staeva, T., Stolzer, A., Petrie, H. T. (1999). Bcl-2-Induced Changes in E2F Regulatory Complexes Reveal the Potential for Integrated Cell Cycle and Cell Death Functions. J. Immunol. 162: 5374-5379 [Abstract] [Full Text]  
• van der Sman, J., Thomas, N. S. B., Lam, E. W.-F. (1999). Modulation of E2F Complexes during G0 to S Phase Transition in Human Primary B-lymphocytes. J. Biol. Chem. 274: 12009-12016 [Abstract] [Full Text]  
• Di Fiore, B., Guarguaglini, G., Palena, A., Kerkhoven, R. M., Bernards, R., Lavia, P. (1999). Two E2F Sites Control Growth-regulated and Cell Cycle-regulated Transcription of the Htf9-a/RanBP1 Gene through Functionally Distinct Mechanisms. J. Biol. Chem. 274: 10339-10348 [Abstract] [Full Text]  
• Zheng, N., Fraenkel, E., Pabo, C. O., Pavletich, N. P. (1999). Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 13: 666-674 [Abstract] [Full Text]  
• Duro, D, Schulze, A, Vogt, B, Bartek, J, Mittnacht, S, Jansen-Durr, P (1999). Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8. J. Gen. Virol. 80: 549-555 [Abstract]  
• Iavarone, A., Massague, J. (1999). E2F and Histone Deacetylase Mediate Transforming Growth Factor beta  Repression of cdc25A during Keratinocyte Cell Cycle Arrest. Mol. Cell. Biol. 19: 916-922 [Abstract] [Full Text]  
• Hateboer, G., Wobst, A., Petersen, B. O., Le Cam, L., Vigo, E., Sardet, C., Helin, K. (1998). Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F. Mol. Cell. Biol. 18: 6679-6697 [Abstract] [Full Text]  
• Thomas, N. S. B., Pizzey, A. R., Tiwari, S., Williams, C. D., Yang, J. (1998). p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by alpha -Interferon. J. Biol. Chem. 273: 23659-23667 [Abstract] [Full Text]  
• Lemasson, I., Thebault, S., Sardet, C., Devaux, C., Mesnard, J.-M. (1998). Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line. J. Biol. Chem. 273: 23598-23604 [Abstract] [Full Text]  
• Gaubatz, S., Wood, J. G., Livingston, D. M. (1998). Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. USA 95: 9190-9195 [Abstract] [Full Text]  
• Prall, O. W. J., Rogan, E. M., Musgrove, E. A., Watts, C. K. W., Sutherland, R. L. (1998). c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry. Mol. Cell. Biol. 18: 4499-4508 [Abstract] [Full Text]  
• Shih, H. H., Tevosian, S. G., Yee, A. S. (1998). Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein. Mol. Cell. Biol. 18: 4732-4743 [Abstract] [Full Text]  
• Dyson, N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev. 12: 2245-2262 [Full Text]  
• Hoshikawa, Y., Mori, A., Amimoto, K., Iwabe, K., Hatakeyama, M. (1998). Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130. Proc. Natl. Acad. Sci. USA 95: 8574-8579 [Abstract] [Full Text]  
• Watanabe, G., Albanese, C., Lee, R. J., Reutens, A., Vairo, G., Henglein, B., Pestell, R. G. (1998). Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1. Mol. Cell. Biol. 18: 3212-3222 [Abstract] [Full Text]  
• Lindeman, G. J., Dagnino, L., Gaubatz, S., Xu, Y., Bronson, R. T., Warren, H. B., Livingston, D. M. (1998). A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev. 12: 1092-1098 [Abstract] [Full Text]  
• Trimarchi, J. M., Fairchild, B., Verona, R., Moberg, K., Andon, N., Lees, J. A. (1998). E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. USA 95: 2850-2855 [Abstract] [Full Text]  
• Dong, F., Cress, W. D. Jr., Agrawal, D., Pledger, W. J. (1998). The Role of Cyclin D3-dependent Kinase in the Phosphorylation of p130 in Mouse BALB/c 3T3 Fibroblasts. J. Biol. Chem. 273: 6190-6195 [Abstract] [Full Text]  
• Lundberg, A. S., Weinberg, R. A. (1998). Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes. Mol. Cell. Biol. 18: 753-761 [Abstract] [Full Text]  
• Mulligan, G. J., Wong, J., Jacks, T. (1998). p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB. Mol. Cell. Biol. 18: 206-220 [Abstract] [Full Text]  
• Ezhevsky, S. A., Nagahara, H., Vocero-Akbani, A. M., Gius, D. R., Wei, M. C., Dowdy, S. F. (1997). Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 94: 10699-10704 [Abstract] [Full Text]  
• Hauser, P. J., Agrawal, D., Chu, B., Pledger, W. J. (1997). p107 and p130 Associated Cyclin A Has Altered Substrate Specificity. J. Biol. Chem. 272: 22954-22959 [Abstract] [Full Text]  
• DeGregori, J., Leone, G., Miron, A., Jakoi, L., Nevins, J. R. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94: 7245-7250 [Abstract] [Full Text]  
• Williams, C. D., Linch, D. C., Watts, M. J., Thomas, N. S. B. (1997). Characterization of Cell Cycle Status and E2F Complexes in Mobilized CD34+ Cells Before and After Cytokine Stimulation. Blood 90: 194-203 [Abstract] [Full Text]  
• Helin, K., Holm, K., Niebuhr, A., Eiberg, H., Tommerup, N., Hougaard, S., Poulsen, H. S., Spang-Thomsen, M., Norgaard, P. (1997). Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc. Natl. Acad. Sci. USA 94: 6933-6938 [Abstract] [Full Text]  
• Hurford, R K, Cobrinik, D, Lee, M H, Dyson, N (1997). pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.. Genes Dev. 11: 1447-1463 [Abstract]  
• Lukas, J, Herzinger, T, Hansen, K, Moroni, M C, Resnitzky, D, Helin, K, Reed, S I, Bartek, J (1997). Cyclin E-induced S phase without activation of the pRb/E2F pathway.. Genes Dev. 11: 1479-1492 [Abstract]  
• Li, J.-M., Hu, P. P.-c., Shen, X., Yu, Y., Wang, X.-F. (1997). E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta  through E2F binding sites. Proc. Natl. Acad. Sci. USA 94: 4948-4953 [Abstract] [Full Text]  
• Lindeman, G. J., Gaubatz, S., Livingston, D. M., Ginsberg, D. (1997). The subcellular localization of E2F-4 is cell-cycle dependent. Proc. Natl. Acad. Sci. USA 94: 5095-5100 [Abstract] [Full Text]  
• Iwase, S., Furukawa, Y., Kikuchi, J., Nagai, M., Terui, Y., Nakamura, M., Yamada, H. (1997). Modulation of E2F Activity Is Linked to Interferon-induced Growth Suppression of Hematopoietic Cells. J. Biol. Chem. 272: 12406-12414 [Abstract] [Full Text]  
• Wells, J. M., Illenye, S., Magae, J., Wu, C.-L., Heintz, N. H. (1997). Accumulation of E2F-4·DP-1 DNA Binding Complexes Correlates with Induction of dhfr Gene Expression during the G1 to S Phase Transition. J. Biol. Chem. 272: 4483-4492 [Abstract] [Full Text]  
• Tevosian, S G, Shih, H H, Mendelson, K G, Sheppard, K A, Paulson, K E, Yee, A S (1997). HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.. Genes Dev. 11: 383-396 [Abstract]  
• Allen, K., de la Luna, S, Kerkhoven, R., Bernards, R, La Thangue, N. (1997). Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors. J. Cell Sci. 110: 2819-2831 [Abstract]  
• Hofmann, F, Martelli, F, Livingston, D M, Wang, Z (1996). The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.. Genes Dev. 10: 2949-2959 [Abstract]  
• Ashizawa, S., Nishizawa, H., Yamada, M., Higashi, H., Kondo, T., Ozawa, H., Kakita, A., Hatakeyama, M. (2001). Collective Inhibition of pRB Family Proteins by Phosphorylation in Cells with p16INK4a Loss or Cyclin E Overexpression. J. Biol. Chem. 276: 11362-11370 [Abstract] [Full Text]