This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vuori, K.
Right arrow Articles by Ruoslahti, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vuori, K.
Right arrow Articles by Ruoslahti, E.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 06 1996, 2606-2613, Vol 16, No. 6
Copyright © 1996, American Society for Microbiology

Introduction of p130cas signaling complex formation upon integrin- mediated cell adhesion: a role for Src family kinases

K Vuori, H Hirai, S Aizawa and E Ruoslahti
La Jolla Cancer Research Center, Burnham Institute, California 92037, USA.

Integrin-mediated cell adhesion triggers intracellular signaling cascades, including tyrosine phosphorylation of intracellular proteins. Among these are the focal adhesion proteins p130cas (Cas) and focal adhesion kinase (FAK). Here we identify the kinase(s) mediating integrin-induced Cas phosphorylation and characterize protein-protein interactions mediated by phosphorylated Cas. We found that expression of a constitutively active FAK in fibroblasts results in a consecutive tyrosine phosphorylation of Cas. This effect required the autophosphorylation site of FAK, which is a binding site for Src family kinases. Integrin-mediated phosphorylation of Cas was not, however, compromised in fibroblasts lacking FAK. In contrast, adhesion-induced tyrosine phosphorylation of Cas was reduced in cells lacking Src, whereas enhanced phosphorylation of Cas was observed Csk- cells, in which Src kinases are activated. These results suggest that Src kinases are responsible for the integrin-mediated tyrosine phosphorylation of Cas. FAK seems not to be necessary for phosphorylation of Cas, but when autophosphorylated, FAK may recruit Src family kinases to phosphorylate Cas. Cas was found to form complexes with Src homology 2 (SH2) domain- containing signaling molecules, such as the SH2/SH3 adapter protein Crk, following integrin-induced tyrosine phosphorylation. Guanine nucleotide exchange factors C3G and Sos were found in the Cas-Crk complex upon integrin ligand binding. These observations suggest that Cas serves as a docking protein and may transduce signals to downstream signaling pathways following integrin-mediated cell adhesion.


This article has been cited by other articles:

  • Liu, Z., Adams, H. C. III, Whitehead, I. P. (2009). The Rho-specific Guanine Nucleotide Exchange Factor Dbs Regulates Breast Cancer Cell Migration. J. Biol. Chem. 284: 15771-15780 [Abstract] [Full Text]  
  • Tang, D. D. (2009). p130 Crk-Associated Substrate (CAS) in Vascular Smooth Muscle. J CARDIOVASC PHARMACOL THER 14: 89-98 [Abstract]  
  • Leung, E. L.-H., Tam, I. Y.-S., Tin, V. P.-C., Chua, D. T.-T., Sihoe, A. D.-L., Cheng, L.-C., Ho, J. C.-M., Chung, L.-P., Wong, M. P. (2009). Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy. Mol Cancer Res 7: 923-932 [Abstract] [Full Text]  
  • Park, A. Y. J., Shen, T.-L., Chien, S., Guan, J.-L. (2009). Role of Focal Adhesion Kinase Ser-732 Phosphorylation in Centrosome Function during Mitosis. J. Biol. Chem. 284: 9418-9425 [Abstract] [Full Text]  
  • Milano, V., Piao, Y., LaFortune, T., de Groot, J. (2009). Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Molecular Cancer Therapeutics 8: 394-406 [Abstract] [Full Text]  
  • Ta, H. Q., Thomas, K. S., Schrecengost, R. S., Bouton, A. H. (2008). A Novel Association between p130Cas and Resistance to the Chemotherapeutic Drug Adriamycin in Human Breast Cancer Cells. Cancer Res. 68: 8796-8804 [Abstract] [Full Text]  
  • Smith, H. W., Marra, P., Marshall, C. J. (2008). uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. JCB 182: 777-790 [Abstract] [Full Text]  
  • Tang, D. D., Anfinogenova, Y. (2008). Physiologic Properties and Regulation of the Actin Cytoskeleton in Vascular Smooth Muscle. J CARDIOVASC PHARMACOL THER 13: 130-140 [Abstract]  
  • Carlucci, A., Gedressi, C., Lignitto, L., Nezi, L., Villa-Moruzzi, E., Avvedimento, E. V., Gottesman, M., Garbi, C., Feliciello, A. (2008). Protein-tyrosine Phosphatase PTPD1 Regulates Focal Adhesion Kinase Autophosphorylation and Cell Migration. J. Biol. Chem. 283: 10919-10929 [Abstract] [Full Text]  
  • Tazaki, T., Miyazaki, K., Hiyama, E., Nakamoto, T., Sakai, R., Yamasaki, N., Honda, Z.-i., Noda, M., Miyasaka, N., Sueda, T., Honda, H. (2008). Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice.. GENES CELLS 13: 145-157 [Abstract] [Full Text]  
  • Desai, L. P., Sinclair, S. E., Chapman, K. E., Hassid, A., Waters, C. M. (2007). High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L769-L778 [Abstract] [Full Text]  
  • Shen, Y., Khusial, P. R., Li, X., Ichikawa, H., Moreno, A. P., Goldberg, G. S. (2007). Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43. J. Biol. Chem. 282: 18914-18921 [Abstract] [Full Text]  
  • Galliher, A. J., Schiemann, W. P. (2007). Src Phosphorylates Tyr284 in TGF-{beta} Type II Receptor and Regulates TGF-{beta} Stimulation of p38 MAPK during Breast Cancer Cell Proliferation and Invasion. Cancer Res. 67: 3752-3758 [Abstract] [Full Text]  
  • McGarrigle, D., Shan, D., Yang, S., Huang, X.-Y. (2006). Role of Tyrosine Kinase Csk in G Protein-coupled Receptor- and Receptor Tyrosine Kinase-induced Fibroblast Cell Migration. J. Biol. Chem. 281: 10583-10588 [Abstract] [Full Text]  
  • Ballestrem, C., Erez, N., Kirchner, J., Kam, Z., Bershadsky, A., Geiger, B. (2006). Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J. Cell Sci. 119: 866-875 [Abstract] [Full Text]  
  • Dadke, D., Jarnik, M., Pugacheva, E. N., Singh, M. K., Golemis, E. A. (2006). Deregulation of HEF1 Impairs M-Phase Progression by Disrupting the RhoA Activation Cycle. Mol. Biol. Cell 17: 1204-1217 [Abstract] [Full Text]  
  • Tzima, E. (2006). Role of Small GTPases in Endothelial Cytoskeletal Dynamics and the Shear Stress Response. Circ. Res. 98: 176-185 [Abstract] [Full Text]  
  • Shen, Y., Jia, Z., Nagele, R. G., Ichikawa, H., Goldberg, G. S. (2006). Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells. Cancer Res. 66: 1543-1552 [Abstract] [Full Text]  
  • Zhang, Z., Lin, S.-Y., Neel, B. G., Haimovich, B. (2006). Phosphorylated {alpha}-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase{middle dot}Src Complex and Promote Cell Migration. J. Biol. Chem. 281: 1746-1754 [Abstract] [Full Text]  
  • Katoh, H., Hiramoto, K., Negishi, M. (2006). Activation of Rac1 by RhoG regulates cell migration. J. Cell Sci. 119: 56-65 [Abstract] [Full Text]  
  • Gelkop, S., Gish, G. D., Babichev, Y., Pawson, T., Isakov, N. (2005). T Cell Activation-Induced CrkII Binding to the Zap70 Protein Tyrosine Kinase Is Mediated by Lck-Dependent Phosphorylation of Zap70 Tyrosine 315. J. Immunol. 175: 8123-8132 [Abstract] [Full Text]  
  • Koga, S., Yogo, K., Yoshikawa, K., Samori, H., Goto, M., Uchida, T., Ishida, N., Takeya, T. (2005). Physical and Functional Association of c-Src and Adhesion and Degranulation Promoting Adaptor Protein (ADAP) in Osteoclastogenesis in Vitro. J. Biol. Chem. 280: 31564-31571 [Abstract] [Full Text]  
  • Shen, T.-L., Park, A. Y.-J., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R. A., Gu, H., Guan, J.-L. (2005). Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. JCB 169: 941-952 [Abstract] [Full Text]  
  • Briknarova, K., Nasertorabi, F., Havert, M. L., Eggleston, E., Hoyt, D. W., Li, C., Olson, A. J., Vuori, K., Ely, K. R. (2005). The Serine-rich Domain from Crk-associated Substrate (p130cas) Is a Four-helix Bundle. J. Biol. Chem. 280: 21908-21914 [Abstract] [Full Text]  
  • Brabek, J., Constancio, S. S., Siesser, P. F., Shin, N.-Y., Pozzi, A., Hanks, S. K. (2005). Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells. Mol Cancer Res 3: 307-315 [Abstract] [Full Text]  
  • Rodrigues, S. P., Fathers, K. E., Chan, G., Zuo, D., Halwani, F., Meterissian, S., Park, M. (2005). CrkI and CrkII Function as Key Signaling Integrators for Migration and Invasion of Cancer Cells. Mol Cancer Res 3: 183-194 [Abstract] [Full Text]  
  • Kiely, P. A., Leahy, M., O'Gorman, D., O'Connor, R. (2005). RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251. J. Biol. Chem. 280: 7624-7633 [Abstract] [Full Text]  
  • Pratt, S. J., Epple, H., Ward, M., Feng, Y., Braga, V. M., Longmore, G. D. (2005). The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. JCB 168: 813-824 [Abstract] [Full Text]  
  • Fujita, H., Fukuhara, S., Sakurai, A., Yamagishi, A., Kamioka, Y., Nakaoka, Y., Masuda, M., Mochizuki, N. (2005). Local Activation of Rap1 Contributes to Directional Vascular Endothelial Cell Migration Accompanied by Extension of Microtubules on Which RAPL, a Rap1-associating Molecule, Localizes. J. Biol. Chem. 280: 5022-5031 [Abstract] [Full Text]  
  • Yang, C. C., Ogawa, H., Dwinell, M. B., McCole, D. F., Eckmann, L., Kagnoff, M. F. (2005). Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. Am. J. Physiol. Cell Physiol. 288: C321-C328 [Abstract] [Full Text]  
  • Iwahara, T., Akagi, T., Fujitsuka, Y., Hanafusa, H. (2004). CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas. Proc. Natl. Acad. Sci. USA 101: 17693-17698 [Abstract] [Full Text]  
  • Dail, M., Kalo, M. S., Seddon, J. A., Cote, J.-F., Vuori, K., Pasquale, E. B. (2004). SHEP1 Function in Cell Migration Is Impaired by a Single Amino Acid Mutation That Disrupts Association with the Scaffolding Protein Cas but Not with Ras GTPases. J. Biol. Chem. 279: 41892-41902 [Abstract] [Full Text]  
  • Schroter, R. H., Lier, S., Holz, A., Bogdan, S., Klambt, C., Beck, L., Renkawitz-Pohl, R. (2004). kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila. Development 131: 4501-4509 [Abstract] [Full Text]  
  • Shin, N.-Y., Dise, R. S., Schneider-Mergener, J., Ritchie, M. D., Kilkenny, D. M., Hanks, S. K. (2004). Subsets of the Major Tyrosine Phosphorylation Sites in Crk-associated Substrate (CAS) Are Sufficient to Promote Cell Migration. J. Biol. Chem. 279: 38331-38337 [Abstract] [Full Text]  
  • Armulik, A., Velling, T., Johansson, S. (2004). The Integrin {beta}1 Subunit Transmembrane Domain Regulates Phosphatidylinositol 3-Kinase-dependent Tyrosine Phosphorylation of Crk-associated Substrate. Mol. Biol. Cell 15: 2558-2567 [Abstract] [Full Text]  
  • Gustavsson, A., Yuan, M., Fallman, M. (2004). Temporal Dissection of {beta}1-Integrin Signaling Indicates a Role for p130Cas-Crk in Filopodia Formation. J. Biol. Chem. 279: 22893-22901 [Abstract] [Full Text]  
  • Sanders, M. A., Basson, M. D. (2004). Collagen IV regulates Caco-2 migration and ERK activation via {alpha}1{beta}1- and {alpha}2{beta}1-integrin-dependent Src kinase activation. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G547-G557 [Abstract] [Full Text]  
  • Cabodi, S., Moro, L., Baj, G., Smeriglio, M., Di Stefano, P., Gippone, S., Surico, N., Silengo, L., Turco, E., Tarone, G., Defilippi, P. (2004). p130Cas interacts with estrogen receptor {alpha} and modulates non-genomic estrogen signaling in breast cancer cells. J. Cell Sci. 117: 1603-1611 [Abstract] [Full Text]  
  • Yin, G., Haendeler, J., Yan, C., Berk, B. C. (2004). GIT1 Functions as a Scaffold for MEK1-Extracellular Signal-Regulated Kinase 1 and 2 Activation by Angiotensin II and Epidermal Growth Factor. Mol. Cell. Biol. 24: 875-885 [Abstract] [Full Text]  
  • Vial, D., Oliver, C., Jamur, M. C., Pastor, M. V. D., da Silva Trindade, E., Berenstein, E., Zhang, J., Siraganian, R. P. (2003). Alterations in Granule Matrix and Cell Surface of Focal Adhesion Kinase-Deficient Mast Cells. J. Immunol. 171: 6178-6186 [Abstract] [Full Text]  
  • Moissoglu, K., Gelman, I. H. (2003). v-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts. J. Biol. Chem. 278: 47946-47959 [Abstract] [Full Text]  
  • Goldberg, G. S., Alexander, D. B., Pellicena, P., Zhang, Z.-Y., Tsuda, H., Miller, W. T. (2003). Src Phosphorylates Cas on Tyrosine 253 to Promote Migration of Transformed Cells. J. Biol. Chem. 278: 46533-46540 [Abstract] [Full Text]  
  • Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Schmidt, B. L., Atakilit, A., Chen, B., Ellis, D., Ramos, D. M. (2003). {alpha}v{beta}6-Fyn Signaling Promotes Oral Cancer Progression. J. Biol. Chem. 278: 41646-41653 [Abstract] [Full Text]  
  • Abassi, Y. A., Rehn, M., Ekman, N., Alitalo, K., Vuori, K. (2003). p130Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration. J. Biol. Chem. 278: 35636-35643 [Abstract] [Full Text]  
  • Bialkowska, K., Zaffran, Y., Meyer, S. C., Fox, J. E. B. (2003). 14-3-3{zeta} Mediates Integrin-induced Activation of Cdc42 and Rac: PLATELET GLYCOPROTEIN Ib-IX REGULATES INTEGRIN-INDUCED SIGNALING BY SEQUESTERING 14-3-3{zeta}. J. Biol. Chem. 278: 33342-33350 [Abstract] [Full Text]  
  • Riggins, R. B., Quilliam, L. A., Bouton, A. H. (2003). Synergistic Promotion of c-Src Activation and Cell Migration by Cas and AND-34/BCAR3. J. Biol. Chem. 278: 28264-28273 [Abstract] [Full Text]  
  • Woodring, P. J., Hunter, T., Wang, J. Y. J. (2003). Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J. Cell Sci. 116: 2613-2626 [Abstract] [Full Text]  
  • DeMali, K. A., Burridge, K. (2003). Coupling membrane protrusion and cell adhesion. J. Cell Sci. 116: 2389-2397 [Abstract] [Full Text]  
  • Kodama, H., Fukuda, K., Takahashi, E., Tahara, S., Tomita, Y., Ieda, M., Kimura, K., Owada, K. M., Vuori, K., Ogawa, S. (2003). Selective Involvement of p130Cas/Crk/Pyk2/c-Src in Endothelin-1-Induced JNK Activation. Hypertension 41: 1372-1379 [Abstract] [Full Text]  
  • Ritch, P. A., Carroll, S. L., Sontheimer, H. (2003). Neuregulin-1 Enhances Motility and Migration of Human Astrocytic Glioma Cells. J. Biol. Chem. 278: 20971-20978 [Abstract] [Full Text]  
  • Li, L., Guris, D. L., Okura, M., Imamoto, A. (2003). Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases. Mol. Cell. Biol. 23: 2883-2892 [Abstract] [Full Text]  
  • Parsons, J. T. (2003). Focal adhesion kinase: the first ten years. J. Cell Sci. 116: 1409-1416 [Abstract] [Full Text]  
  • Medley, Q. G., Buchbinder, E. G., Tachibana, K., Ngo, H., Serra-Pages, C., Streuli, M. (2003). Signaling between Focal Adhesion Kinase and Trio. J. Biol. Chem. 278: 13265-13270 [Abstract] [Full Text]  
  • Riggins, R. B., DeBerry, R. M., Toosarvandani, M. D., Bouton, A. H. (2003). Src-Dependent Association of Cas and p85 Phosphatidylinositol 3'-Kinase in v-crk-Transformed Cells. Mol Cancer Res 1: 428-437 [Abstract] [Full Text]  
  • Zeng, L., Si, X., Yu, W.-P., Le, H. T., Ng, K. P., Teng, R. M.H., Ryan, K., Wang, D. Z.-M., Ponniah, S., Pallen, C. J. (2003). PTP{alpha} regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. JCB 160: 137-146 [Abstract] [Full Text]  
  • Nagashima, K.-I., Endo, A., Ogita, H., Kawana, A., Yamagishi, A., Kitabatake, A., Matsuda, M., Mochizuki, N. (2002). Adaptor Protein Crk Is Required for Ephrin-B1-induced Membrane Ruffling and Focal Complex Assembly of Human Aortic Endothelial Cells. Mol. Biol. Cell 13: 4231-4242 [Abstract] [Full Text]  
  • Tai, L.-K., Okuda, M., Abe, J.-i., Yan, C., Berk, B. C. (2002). Fluid Shear Stress Activates Proline-Rich Tyrosine Kinase via Reactive Oxygen Species-Dependent Pathway. Arterioscler. Thromb. Vasc. Bio. 22: 1790-1796 [Abstract] [Full Text]  
  • Abbi, S., Ueda, H., Zheng, C., Cooper, L. A., Zhao, J., Christopher, R., Guan, J.-L. (2002). Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200. Mol. Biol. Cell 13: 3178-3191 [Abstract] [Full Text]  
  • Kim, J.-T., Joo, C.-K. (2002). Involvement of Cell-Cell Interactions in the Rapid Stimulation of Cas Tyrosine Phosphorylation and Src Kinase Activity by Transforming Growth Factor-beta 1. J. Biol. Chem. 277: 31938-31948 [Abstract] [Full Text]  
  • Huang, J., Hamasaki, H., Nakamoto, T., Honda, H., Hirai, H., Saito, M., Takato, T., Sakai, R. (2002). Differential Regulation of Cell Migration, Actin Stress Fiber Organization, and Cell Transformation by Functional Domains of Crk-associated Substrate. J. Biol. Chem. 277: 27265-27272 [Abstract] [Full Text]  
  • Nakamura, I., Kadono, Y., Takayanagi, H., Jimi, E., Miyazaki, T., Oda, H., Nakamura, K., Tanaka, S., Rodan, G. A., Duong, L. T. (2002). IL-1 Regulates Cytoskeletal Organization in Osteoclasts Via TNF Receptor-Associated Factor 6/c-Src Complex. J. Immunol. 168: 5103-5109 [Abstract] [Full Text]  
  • Cary, L. A., Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. (2002). Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading. Mol. Cell. Biol. 22: 2427-2440 [Abstract] [Full Text]  
  • Kira, M., Sano, S., Takagi, S., Yoshikawa, K., Takeda, J., Itami, S. (2002). STAT3 Deficiency in Keratinocytes Leads to Compromised Cell Migration through Hyperphosphorylation of p130cas. J. Biol. Chem. 277: 12931-12936 [Abstract] [Full Text]  
  • Kim, J., Feldman, R. A. (2002). Activated Fes Protein Tyrosine Kinase Induces Terminal Macrophage Differentiation of Myeloid Progenitors (U937 Cells) and Activation of the Transcription Factor PU.1. Mol. Cell. Biol. 22: 1903-1918 [Abstract] [Full Text]  
  • Moro, L., Dolce, L., Cabodi, S., Bergatto, E., Erba, E. B., Smeriglio, M., Turco, E., Retta, S. F., Giuffrida, M. G., Venturino, M., Godovac-Zimmermann, J., Conti, A., Schaefer, E., Beguinot, L., Tacchetti, C., Gaggini, P., Silengo, L., Tarone, G., Defilippi, P. (2002). Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines. J. Biol. Chem. 277: 9405-9414 [Abstract] [Full Text]  
  • Yi, J., Kloeker, S., Jensen, C. C., Bockholt, S., Honda, H., Hirai, H., Beckerle, M. C. (2002). Members of the Zyxin Family of LIM Proteins Interact with Members of the p130Cas Family of Signal Transducers. J. Biol. Chem. 277: 9580-9589 [Abstract] [Full Text]  
  • Cho, S. Y., Klemke, R. L. (2002). Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. JCB 156: 725-736 [Abstract] [Full Text]  
  • Li, L., Okura, M., Imamoto, A. (2002). Focal Adhesions Require Catalytic Activity of Src Family Kinases To Mediate Integrin-Matrix Adhesion. Mol. Cell. Biol. 22: 1203-1217 [Abstract] [Full Text]  
  • Lawrenson, I. D., Wimmer-Kleikamp, S. H., Lock, P., Schoenwaelder, S. M., Down, M., Boyd, A. W., Alewood, P. F., Lackmann, M. (2002). Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J. Cell Sci. 115: 1059-1072 [Abstract] [Full Text]  
  • Ruest, P. J., Shin, N.-Y., Polte, T. R., Zhang, X., Hanks, S. K. (2001). Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src. Mol. Cell. Biol. 21: 7641-7652 [Abstract] [Full Text]  
  • Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P., Schlaepfer, D. D. (2001). Inhibition of Focal Adhesion Kinase Expression or Activity Disrupts Epidermal Growth Factor-stimulated Signaling Promoting the Migration of Invasive Human Carcinoma Cells. Cancer Res. 61: 7079-7090 [Abstract] [Full Text]  
  • Welsch, T., Endlich, N., Kriz, W., Endlich, K. (2001). CD2AP and p130Cas localize to different F-actin structures in podocytes. Am. J. Physiol. Renal Physiol. 281: F769-F777 [Abstract] [Full Text]  
  • Gerthoffer, W. T., Gunst, S. J. (2001). Signal Transduction in Smooth Muscle: Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J. Appl. Physiol. 91: 963-972 [Abstract] [Full Text]  
  • Lu, Z., Jiang, G., Blume-Jensen, P., Hunter, T. (2001). Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase. Mol. Cell. Biol. 21: 4016-4031 [Abstract] [Full Text]  
  • Kapur, R., Cooper, R., Zhang, L., Williams, D. A. (2001). Cross-talk between {alpha}4{beta}1/{alpha}5{beta}1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways. Blood 97: 1975-1981 [Abstract] [Full Text]  
  • Prosper, F., Verfaillie, C. M. (2001). Regulation of hematopoiesis through adhesion receptors. J. Leukoc. Biol. 69: 307-316 [Abstract] [Full Text]  
  • Harrington, E. O., Smeglin, A., Newton, J., Ballard, G., Rounds, S. (2001). Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L342-L353 [Abstract] [Full Text]  
  • Xing, L., Ge, C., Zeltser, R., Maskevitch, G., Mayer, B. J., Alexandropoulos, K. (2000). c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase. Mol. Cell. Biol. 20: 7363-7377 [Abstract] [Full Text]  
  • Burnham, M. R., Bruce-Staskal, P. J., Harte, M. T., Weidow, C. L., Ma, A., Weed, S. A., Bouton, A. H. (2000). Regulation of c-SRC Activity and Function by the Adapter Protein CAS. Mol. Cell. Biol. 20: 5865-5878 [Abstract] [Full Text]  
  • Wennerberg, K., Armulik, A., Sakai, T., Karlsson, M., Fässler, R., Schaefer, E. M., Mosher, D. F., Johansson, S. (2000). The Cytoplasmic Tyrosines of Integrin Subunit beta 1 Are Involved in Focal Adhesion Kinase Activation. Mol. Cell. Biol. 20: 5758-5765 [Abstract] [Full Text]  
  • Yano, H., Uchida, H., Iwasaki, T., Mukai, M., Akedo, H., Nakamura, K., Hashimoto, S., Sabe, H. (2000). Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 97: 9076-9081 [Abstract] [Full Text]  
  • Buensuceso, C. S., O'Toole, T. E. (2000). The Association of CRKII with C3G Can be Regulated by Integrins and Defines a Novel Means to Regulate the Mitogen-activated Protein Kinases. J. Biol. Chem. 275: 13118-13125 [Abstract] [Full Text]  
  • Yoshizumi, M., Abe, J.-i., Haendeler, J., Huang, Q., Berk, B. C. (2000). Src and Cas Mediate JNK Activation but Not ERK1/2 and p38 Kinases by Reactive Oxygen Species. J. Biol. Chem. 275: 11706-11712 [Abstract] [Full Text]  
  • Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W., Feller, S. M. (2000). Signaling of Hepatocyte Growth Factor/Scatter Factor (HGF) to the Small GTPase Rap1 via the Large Docking Protein Gab1 and the Adapter Protein CRKL. J. Biol. Chem. 275: 10772-10778 [Abstract] [Full Text]  
  • Lai, J.-F., Kao, S.-C., Jiang, S.-T., Tang, M.-J., Chan, P.-C., Chen, H.-C. (2000). Involvement of Focal Adhesion Kinase in Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells. J. Biol. Chem. 275: 7474-7480 [Abstract] [Full Text]  
  • Nakamoto, T., Yamagata, T., Sakai, R., Ogawa, S., Honda, H., Ueno, H., Hirano, N., Yazaki, Y., Hirai, H. (2000). CIZ, a Zinc Finger Protein That Interacts with p130cas and Activates the Expression of Matrix Metalloproteinases. Mol. Cell. Biol. 20: 1649-1658 [Abstract] [Full Text]  
  • Weyant, M. J., Carothers, A. M., Bertagnolli, M. E., Bertagnolli, M. M. (2000). Colon Cancer Chemopreventive Drugs Modulate Integrin-mediated Signaling Pathways. Clin. Cancer Res. 6: 949-956 [Abstract] [Full Text]  
  • Spencer, K. S.R., Graus-Porta, D., Leng, J., Hynes, N. E., Klemke, R. L. (2000). ErbB2 Is Necessary for Induction of Carcinoma Cell Invasion by Erbb Family Receptor Tyrosine Kinases. JCB 148: 385-397 [Abstract] [Full Text]  
  • Brinkman, A., van der Flier, S., Kok, E. M., Dorssers, L. C. J. (2000). BCAR1, a Human Homologue of the Adapter Protein p130Cas, and Antiestrogen Resistance in Breast Cancer Cells. JNCI J Natl Cancer Inst 92: 112-120 [Abstract] [Full Text]  
  • Flier, S. v. d., Brinkman, A., Look, M. P., Kok, E. M., Meijer-van Gelder, M. E., Klijn, J. G. M., Dorssers, L. C. J., Foekens, J. A. (2000). Bcar1/p130Cas Protein and Primary Breast Cancer: Prognosis and Response to Tamoxifen Treatment. JNCI J Natl Cancer Inst 92: 120-127 [Abstract] [Full Text]  
  • Wang, D, Grammer, J., Cobbs, C., Stewart, J., Liu, Z, Rhoden, R, Hecker, T., Ding, Q, Gladson, C. (2000). p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J. Cell Sci. 113: 4221-4230 [Abstract]  
  • Tamura, M., Gu, J., Tran, H., Yamada, K. M. (1999). PTEN Gene and Integrin Signaling in Cancer. JNCI J Natl Cancer Inst 91: 1820-1828 [Abstract] [Full Text]  
  • Tapia, J. A., Ferris, H. A., Jensen, R. T., Garcia, L. J. (1999). Cholecystokinin Activates PYK2/CAKbeta by a Phospholipase C-dependent Mechanism and Its Association with the Mitogen-activated Protein Kinase Signaling Pathway in Pancreatic Acinar Cells. J. Biol. Chem. 274: 31261-31271 [Abstract] [Full Text]  
  • Hakak, Y., Martin, G. S. (1999). Cas Mediates Transcriptional Activation of the Serum Response Element by Src. Mol. Cell. Biol. 19: 6953-6962 [Abstract] [Full Text]  
  • Schaller, M. D., Hildebrand, J. D., Parsons, J. T. (1999). Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases. Mol. Biol. Cell 10: 3489-3505 [Abstract] [Full Text]  
  • Okuda, M., Takahashi, M., Suero, J., Murry, C. E., Traub, O., Kawakatsu, H., Berk, B. C. (1999). Shear Stress Stimulation of p130cas Tyrosine Phosphorylation Requires Calcium-dependent c-Src Activation. J. Biol. Chem. 274: 26803-26809 [Abstract] [Full Text]  
  • Cheresh, D. A., Leng, J., Klemke, R. L. (1999). Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells. JCB 146: 1107-1116 [Abstract] [Full Text]  
  • Zhang, Z., Hernandez-Lagunas, L., Horne, W. C., Baron, R. (1999). Cytoskeleton-dependent Tyrosine Phosphorylation of the p130Cas Family Member HEF1 Downstream of the G Protein-coupled Calcitonin Receptor. CALCITONIN INDUCES THE ASSOCIATION OF HEF1, PAXILLIN, AND FOCAL ADHESION KINASE. J. Biol. Chem. 274: 25093-25098 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»