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Mol. Cell. Biol., 06 1996, 3066-3073, Vol 16, No. 6
Copyright © 1996, American Society for Microbiology

Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression

O Hobert, B Jallal and A Ullrich
Department of Molecular Biology, Max-Planck-Institut fur Biochemie, Martinsried, Germany.

The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.


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