This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dohlman, H. G.
Right arrow Articles by Thorner, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dohlman, H. G.
Right arrow Articles by Thorner, J.

 Previous Article  |  Next Article 

Mol. Cell. Biol., Sep 1996, 5194-5209, Vol 16, No. 9
Copyright © 1996, American Society for Microbiology

Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit)

HG Dohlman, J Song, D Ma, WE Courchesne and J Thorner
Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-0812, USA.

Sst2 is the prototype for the newly recognized RGS (for regulators of G- protein signaling) family. Cells lacking the pheromone-inducible SST2 gene product fail to resume growth after exposure to pheromone. Conversely, overproduction of Sst2 markedly enhanced the rate of recovery from pheromone-induced arrest in the long-term halo bioassay and detectably dampened signaling in a short-term assay of pheromone response (phosphorylation of Ste4, Gbeta subunit). When the GPA1 gene product (Galpha subunit) is absent, the pheromone response pathway is constitutively active and, consequently, growth ceases. Despite sustained induction of Sst2 (observed with specific anti-Sst2 antibodies), gpa1delta mutants remain growth arrested, indicating that the action of Sst2 requires the presence of Gpa1. The N-terminal domain (residues 3 to 307) of Sst2 (698 residues) has sequence similarity to the catalytic regions of bovine GTPase-activating protein and human neurofibromatosis tumor suppressor protein; segments in the C-terminal domain of Sst2 (between residues 417 and 685) are homologous to other RGS proteins. Both the N- and C-terminal domains were required for Sst2 function in vivo. Consistent with a role for Sst2 in binding to and affecting the activity of Gpa1, the majority of Sst2 was membrane associated and colocalized with Gpa1 at the plasma membrane, as judged by sucrose density gradient fractionation. Moreover, from cell extracts, Sst2 could be isolated in a complex with Gpa1 (expressed as a glutathione S-transferase fusion); this association withstood the detergent and salt conditions required for extraction of these proteins from cell membranes. Also, SST2+ cells expressing a GTPase-defective GPA1 mutant displayed an increased sensitivity to pheromone, whereas sst2 cells did not. These results demonstrate that Sst2 and Gpa1 interact physically and suggest that Sst2 is a direct negative regulator of Gpa1.


This article has been cited by other articles:

  • Strickfaden, S. C., Pryciak, P. M. (2008). Distinct Roles for Two G{alpha} G Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein. Mol. Biol. Cell 19: 181-197 [Abstract] [Full Text]  
  • Fang, W., Pei, Y., Bidochka, M. J. (2007). A regulator of a G protein signalling (RGS) gene, cag8, from the insect-pathogenic fungus Metarhizium anisopliae is involved in conidiation, virulence and hydrophobin synthesis. Microbiology 153: 1017-1025 [Abstract] [Full Text]  
  • Wang, Y., Dohlman, H. G. (2006). Regulation of G Protein and Mitogen-Activated Protein Kinase Signaling by Ubiquitination: Insights From Model Organisms. Circ. Res. 99: 1305-1314 [Abstract] [Full Text]  
  • Chasse, S. A., Flanary, P., Parnell, S. C., Hao, N., Cha, J. Y., Siderovski, D. P., Dohlman, H. G. (2006). Genome-Scale Analysis Reveals Sst2 as the Principal Regulator of Mating Pheromone Signaling in the Yeast Saccharomyces cerevisiae. Eukaryot Cell 5: 330-346 [Abstract] [Full Text]  
  • Mayrhofer, S., Poggeler, S. (2005). Functional Characterization of an {alpha}-Factor-Like Sordaria macrospora Peptide Pheromone and Analysis of Its Interaction with Its Cognate Receptor in Saccharomyces cerevisiae. Eukaryot Cell 4: 661-672 [Abstract] [Full Text]  
  • Hoffman, C. S. (2005). Except in Every Detail: Comparing and Contrasting G-Protein Signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryot Cell 4: 495-503 [Full Text]  
  • Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). Quantitative Phosphoproteomics Applied to the Yeast Pheromone Signaling Pathway. Mol. Cell. Proteomics 4: 310-327 [Abstract] [Full Text]  
  • Segers, G. C., Regier, J. C., Nuss, Donald. L. (2004). Evidence for a Role of the Regulator of G-Protein Signaling Protein CPRGS-1 in G{alpha} Subunit CPG-1-Mediated Regulation of Fungal Virulence, Conidiation, and Hydrophobin Synthesis in the Chestnut Blight Fungus Cryphonectria parasitica. Eukaryot Cell 3: 1454-1463 [Abstract] [Full Text]  
  • Jones, M. B., Siderovski, D. P., Hooks, S. B. (2004). The G{beta}{gamma} DIMER as a NOVEL SOURCE of SELECTIVITY in G-Protein Signaling: GGL-ing AT CONVENTION. Mol. Interv. 4: 200-214 [Abstract] [Full Text]  
  • Shi, G.-X., Harrison, K., Han, S.-B., Moratz, C., Kehrl, J. H. (2004). Toll-Like Receptor Signaling Alters the Expression of Regulator of G Protein Signaling Proteins in Dendritic Cells: Implications for G Protein-Coupled Receptor Signaling. J. Immunol. 172: 5175-5184 [Abstract] [Full Text]  
  • Cabrera-Vera, T. M., Vanhauwe, J., Thomas, T. O., Medkova, M., Preininger, A., Mazzoni, M. R., Hamm, H. E. (2003). Insights into G Protein Structure, Function, and Regulation. Endocr. Rev. 24: 765-781 [Abstract] [Full Text]  
  • Hao, N., Yildirim, N., Wang, Y., Elston, T. C., Dohlman, H. G. (2003). Regulators of G Protein Signaling and Transient Activation of Signaling: EXPERIMENTAL AND COMPUTATIONAL ANALYSIS REVEALS NEGATIVE AND POSITIVE FEEDBACK CONTROLS ON G PROTEIN ACTIVITY. J. Biol. Chem. 278: 46506-46515 [Abstract] [Full Text]  
  • Yi, T.-M., Kitano, H., Simon, M. I. (2003). A quantitative characterization of the yeast heterotrimeric G protein cycle. Proc. Natl. Acad. Sci. USA 100: 10764-10769 [Abstract] [Full Text]  
  • Chatterjee, T. K., Fisher, R. A. (2003). Mild Heat and Proteotoxic Stress Promote Unique Subcellular Trafficking and Nucleolar Accumulation of RGS6 and Other RGS Proteins: ROLE OF THE RGS DOMAIN IN STRESS-INDUCED TRAFFICKING OF RGS PROTEINS. J. Biol. Chem. 278: 30272-30282 [Abstract] [Full Text]  
  • Chen, C.-K., Eversole-Cire, P., Zhang, H., Mancino, V., Chen, Y.-J., He, W., Wensel, T. G., Simon, M. I. (2003). Instability of GGL domain-containing RGS proteins in mice lacking the G protein {beta}-subunit G{beta}5. Proc. Natl. Acad. Sci. USA 100: 6604-6609 [Abstract] [Full Text]  
  • Hooks, S. B., Waldo, G. L., Corbitt, J., Bodor, E. T., Krumins, A. M., Harden, T. K. (2003). RGS6, RGS7, RGS9, and RGS11 Stimulate GTPase Activity of Gi Family G-proteins with Differential Selectivity and Maximal Activity. J. Biol. Chem. 278: 10087-10093 [Abstract] [Full Text]  
  • Serikawa, K. A., Xu, X. L., MacKay, V. L., Law, G. L., Zong, Q., Zhao, L. P., Bumgarner, R., Morris, D. R. (2003). The Transcriptome and Its Translation during Recovery from Cell Cycle Arrest in Saccharomyces cerevisiae. Mol. Cell. Proteomics 2: 191-204 [Abstract] [Full Text]  
  • Blackwell, E., Halatek, I. M., Kim, H.-J. N., Ellicott, A. T., Obukhov, A. A., Stone, D. E. (2003). Effect of the Pheromone-Responsive G{alpha} and Phosphatase Proteins of Saccharomyces cerevisiae on the Subcellular Localization of the Fus3 Mitogen-Activated Protein Kinase. Mol. Cell. Biol. 23: 1135-1150 [Abstract] [Full Text]  
  • Yoon, S., Liu, Z., Eyobo, Y., Orth, K. (2003). Yersinia Effector YopJ Inhibits Yeast MAPK Signaling Pathways by an Evolutionarily Conserved Mechanism. J. Biol. Chem. 278: 2131-2135 [Abstract] [Full Text]  
  • Wang, Y., Ho, G., Zhang, J. J., Nieuwenhuijsen, B., Edris, W., Chanda, P. K., Young, K. H. (2002). Regulator of G Protein Signaling Z1 (RGSZ1) Interacts with Galpha i Subunits and Regulates Galpha i-mediated Cell Signaling. J. Biol. Chem. 277: 48325-48332 [Abstract] [Full Text]  
  • Zhang, Q., Pacheco, M. A, Doupnik, C. A (2002). Gating properties of girk channels activated by g{alpha}o- and G{alpha}i-Coupled Muscarinic m2 Receptors in Xenopus Oocytes: The Role of Receptor Precoupling in RGS Modulation. J. Physiol. 545: 355-373 [Abstract] [Full Text]  
  • Esch, R. K., Errede, B. (2002). Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism. Proc. Natl. Acad. Sci. USA 99: 9160-9165 [Abstract] [Full Text]  
  • Wang, Q., Liu, M., Mullah, B., Siderovski, D. P., Neubig, R. R. (2002). Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells. J. Biol. Chem. 277: 24949-24958 [Abstract] [Full Text]  
  • Burchett, S. A., Flanary, P., Aston, C., Jiang, L., Young, K. H., Uetz, P., Fields, S., Dohlman, H. G. (2002). Regulation of Stress Response Signaling by the N-terminal Dishevelled/EGL-10/Pleckstrin Domain of Sst2, a Regulator of G Protein Signaling in Saccharomyces cerevisiae. J. Biol. Chem. 277: 22156-22167 [Abstract] [Full Text]  
  • Nixon, A. B., Grenningloh, G., Casey, P. J. (2002). The Interaction of RGSZ1 with SCG10 Attenuates the Ability of SCG10 to Promote Microtubule Disassembly. J. Biol. Chem. 277: 18127-18133 [Abstract] [Full Text]  
  • Xu, B.-E, Skowronek, K. R., Kurjan, J. (2001). The N Terminus of Saccharomyces cerevisiae Sst2p Plays an RGS-Domain-Independent, Mpt5p-Dependent Role in Recovery From Pheromone Arrest. Genetics 159: 1559-1571 [Abstract] [Full Text]  
  • Zhong, H., Neubig, R. R. (2001). Regulator of G Protein Signaling Proteins: Novel Multifunctional Drug Targets. J. Pharmacol. Exp. Ther. 297: 837-845 [Abstract] [Full Text]  
  • Nagata, Y., Oda, M., Nakata, H., Shozaki, Y., Kozasa, T., Todokoro, K. (2001). A novel regulator of G-protein signaling bearing GAP activity for G{alpha}i and G{alpha}q in megakaryocytes. Blood 97: 3051-3060 [Abstract] [Full Text]  
  • Scheschonka, A., Dessauer, C. W., Sinnarajah, S., Chidiac, P., Shi, C.-S., Kehrl, J. H. (2000). RGS3 Is a GTPase-Activating Protein for Gialpha and Gqalpha and a Potent Inhibitor of Signaling by GTPase-Deficient Forms of Gqalpha and G11alpha. Mol. Pharmacol. 58: 719-728 [Abstract] [Full Text]  
  • Jeong, S.-W., Ikeda, S. R. (2000). Endogenous Regulator of G-Protein Signaling Proteins Modify N-Type Calcium Channel Modulation in Rat Sympathetic Neurons. J. Neurosci. 20: 4489-4496 [Abstract] [Full Text]  
  • Reif, K., Cyster, J. G. (2000). RGS Molecule Expression in Murine B Lymphocytes and Ability to Down-Regulate Chemotaxis to Lymphoid Chemokines ,2. J. Immunol. 164: 4720-4729 [Abstract] [Full Text]  
  • Garrison, T. R., Zhang, Y., Pausch, M., Apanovitch, D., Aebersold, R., Dohlman, H. G. (1999). Feedback Phosphorylation of an RGS Protein by MAP Kinase in Yeast. J. Biol. Chem. 274: 36387-36391 [Abstract] [Full Text]  
  • Denecke, B., Meyerdierks, A., Bottger, E. C. (1999). RGS1 Is Expressed in Monocytes and Acts as a GTPase-activating Protein for G-protein-coupled Chemoattractant Receptors. J. Biol. Chem. 274: 26860-26868 [Abstract] [Full Text]  
  • Mukhopadhyay, S., Ross, E. M. (1999). Rapid GTP binding and hydrolysis by Gq promoted by receptor and GTPase-activating proteins. Proc. Natl. Acad. Sci. USA 96: 9539-9544 [Abstract] [Full Text]  
  • Hajdu-Cronin, Y. M., Chen, W. J., Patikoglou, G., Koelle, M. R., Sternberg, P. W. (1999). Antagonism between Goalpha and Gqalpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goalpha signaling and regulates Gqalpha activity. Genes Dev. 13: 1780-1793 [Abstract] [Full Text]  
  • Chen, C., Seow, K. T., Guo, K., Yaw, L. P., Lin, S.-C. (1999). The Membrane Association Domain of RGS16 Contains Unique Amphipathic Features That Are Conserved in RGS4 and RGS5. J. Biol. Chem. 274: 19799-19806 [Abstract] [Full Text]  
  • Kim, E., Arnould, T., Sellin, L., Benzing, T., Comella, N., Kocher, O., Tsiokas, L., Sukhatme, V. P., Walz, G. (1999). Interaction between RGS7 and polycystin. Proc. Natl. Acad. Sci. USA 96: 6371-6376 [Abstract] [Full Text]  
  • Saitoh, O., Kubo, Y., Odagiri, M., Ichikawa, M., Yamagata, K., Sekine, T. (1999). RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents. J. Biol. Chem. 274: 9899-9904 [Abstract] [Full Text]  
  • Nern, A., Arkowitz, R. A. (1999). A Cdc24p-Far1p-G{beta}{gamma} Protein Complex Required for Yeast Orientation during Mating. JCB 144: 1187-1202 [Abstract] [Full Text]  
  • Zhang, Y., Neo, S. Y., Han, J., Yaw, L. P., Lin, S.-C. (1999). RGS16 Attenuates Galpha q-dependent p38 Mitogen-activated Protein Kinase Activation by Platelet-activating Factor. J. Biol. Chem. 274: 2851-2857 [Abstract] [Full Text]  
  • Dulin, N. O., Sorokin, A., Reed, E., Elliott, S., Kehrl, J. H., Dunn, M. J. (1999). RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Galpha 11. Mol. Cell. Biol. 19: 714-723 [Abstract] [Full Text]  
  • Melliti, K., Meza, U., Fisher, R., Adams, B. (1999). Regulators of G Protein Signaling Attenuate the G Protein-mediated Inhibition of N-Type Ca Channels. JGP 113: 97-110 [Abstract] [Full Text]  
  • Tseng, C.-C., Zhang, X.-Y. (1998). Role of Regulator of G Protein Signaling in Desensitization of the Glucose-Dependent Insulinotropic Peptide Receptor. Endocrinology 139: 4470-4475 [Abstract] [Full Text]  
  • Apanovitch, D. M., Iiri, T., Karasawa, T., Bourne, H. R., Dohlman, H. G. (1998). Second Site Suppressor Mutations of a GTPase-deficient G-Protein alpha -Subunit. SELECTIVE INHIBITION OF Gbeta gamma -MEDIATED SIGNALING. J. Biol. Chem. 273: 28597-28602 [Abstract] [Full Text]  
  • Bear, J. E., Rawls, J. F., Saxe, C. L. III (1998). SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium Development. JCB 142: 1325-1335 [Abstract] [Full Text]  
  • Druey, K. M., Sullivan, B. M., Brown, D., Fischer, E. R., Watson, N., Blumer, K. J., Gerfen, C. R., Scheschonka, A., Kehrl, J. H. (1998). Expression of GTPase-deficient Gialpha 2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane. J. Biol. Chem. 273: 18405-18410 [Abstract] [Full Text]  
  • Banuett, F. (1998). Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi. Microbiol. Mol. Biol. Rev. 62: 249-274 [Abstract] [Full Text]  
  • Grishin, A. V., Rothenberg, M., Downs, M. A., Blumer, K. J. (1998). Mot3, a Zn Finger Transcription Factor That Modulates Gene Expression and Attenuates Mating Pheromone Signaling in Saccharomyces cerevisiae. Genetics 149: 879-892 [Abstract] [Full Text]  
  • De Vries, L., Elenko, E., McCaffery, J. M., Fischer, T., Hubler, L., McQuistan, T., Watson, N., Farquhar, M. G. (1998). RGS-GAIP, a GTPase-activating Protein for Galpha i Heterotrimeric G Proteins, Is Located on Clathrin-coated Vesicles. Mol. Biol. Cell 9: 1123-1134 [Abstract] [Full Text]  
  • Cowan, C. W., Fariss, R. N., Sokal, I., Palczewski, K., Wensel, T. G. (1998). High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc. Natl. Acad. Sci. USA 95: 5351-5356 [Abstract] [Full Text]  
  • Stefan, C. J., Overton, M. C., Blumer, K. J. (1998). Mechanisms Governing the Activation and Trafficking of Yeast G Protein-coupled Receptors. Mol. Biol. Cell 9: 885-899 [Abstract] [Full Text]  
  • DiBello, P. R., Garrison, T. R., Apanovitch, D. M., Hoffman, G., Shuey, D. J., Mason, K., Cockett, M. I., Dohlman, H. G. (1998). Selective Uncoupling of RGS Action by a Single Point Mutation in the G Protein alpha -Subunit. J. Biol. Chem. 273: 5780-5784 [Abstract] [Full Text]  
  • Saugstad, J. A., Marino, M. J., Folk, J. A., Hepler, J. R., Conn, P. J. (1998). RGS4 Inhibits Signaling by Group I Metabotropic Glutamate Receptors. J. Neurosci. 18: 905-913 [Abstract] [Full Text]  
  • Erickson, J. R., Wu, J. J., Goddard, J. G., Tigyi, G., Kawanishi, K., Tomei, L. D., Kiefer, M. C. (1998). Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid. J. Biol. Chem. 273: 1506-1510 [Abstract] [Full Text]  
  • Gillen, K., Pausch, M, Dohlman, H. (1998). N-terminal domain of Gpa1 (G protein alpha) subunit) is sufficient for plasma membrane targeting in yeast Saccharomyces cerevisiae. J. Cell Sci. 111: 3235-3244 [Abstract]  
  • Heximer, S. P., Watson, N., Linder, M. E., Blumer, K. J., Hepler, J. R. (1997). RGS2/G0S8 is a selective inhibitor of Gqalpha  function. Proc. Natl. Acad. Sci. USA 94: 14389-14393 [Abstract] [Full Text]  
  • Ogier-Denis, E., Petiot, A., Bauvy, C., Codogno, P. (1997). Control of the Expression and Activity of the Galpha -interacting Protein (GAIP) in Human Intestinal Cells. J. Biol. Chem. 272: 24599-24603 [Abstract] [Full Text]  
  • Buckbinder, L., Velasco-Miguel, S., Chen, Y., Xu, N., Talbott, R., Gelbert, L., Gao, J., Seizinger, B. R., Gutkind, J. S., Kley, N. (1997). The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc. Natl. Acad. Sci. USA 94: 7868-7872 [Abstract] [Full Text]  
  • Yan, Y., Chi, P. P., Bourne, H. R. (1997). RGS4 Inhibits Gq-mediated Activation of Mitogen-activated Protein Kinase and Phosphoinositide Synthesis. J. Biol. Chem. 272: 11924-11927 [Abstract] [Full Text]  
  • Faurobert, E., Hurley, J. B. (1997). The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro. Proc. Natl. Acad. Sci. USA 94: 2945-2950 [Abstract] [Full Text]  
  • Chen, C., Zheng, B., Han, J., Lin, S.-C. (1997). Characterization of a Novel Mammalian RGS Protein That Binds to Galpha Proteins and Inhibits Pheromone Signaling in Yeast. J. Biol. Chem. 272: 8679-8685 [Abstract] [Full Text]  
  • Wang, J., Tu, Y., Woodson, J., Song, X., Ross, E. M. (1997). A GTPase-activating Protein for the G Protein Galpha z. IDENTIFICATION, PURIFICATION, AND MECHANISM OF ACTION. J. Biol. Chem. 272: 5732-5740 [Abstract] [Full Text]  
  • Dohlman, H. G., Thorner, J. (1997). RGS Proteins and Signaling by Heterotrimeric G Proteins. J. Biol. Chem. 272: 3871-3874 [Full Text]  
  • Cook, J G, Bardwell, L, Kron, S J, Thorner, J (1996). Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.. Genes Dev. 10: 2831-2848 [Abstract]  
  • Popov, S. G., Krishna, U. M., Falck, J. R., Wilkie, T. M. (2000). Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity. J. Biol. Chem. 275: 18962-18968 [Abstract] [Full Text]  
  • Hoffman, G. A., Garrison, T. R., Dohlman, H. G. (2000). Endoproteolytic Processing of Sst2, a Multidomain Regulator of G Protein Signaling in Yeast. J. Biol. Chem. 275: 37533-37541 [Abstract] [Full Text]  
  • Lan, K.-L., Zhong, H., Nanamori, M., Neubig, R. R. (2000). Rapid Kinetics of Regulator of G-protein Signaling (RGS)-mediated Galpha i and Galpha o Deactivation. Galpha SPECIFICITY OF RGS4 AND RGS7. J. Biol. Chem. 275: 33497-33503 [Abstract] [Full Text]  
  • Burgon, P. G., Lee, W. L., Nixon, A. B., Peralta, E. G., Casey, P. J. (2001). Phosphorylation and Nuclear Translocation of a Regulator of G Protein Signaling (RGS10). J. Biol. Chem. 276: 32828-32834 [Abstract] [Full Text]  
  • Oliveira-dos-Santos, A. J., Matsumoto, G., Snow, B. E., Bai, D., Houston, F. P., Whishaw, I. Q., Mariathasan, S., Sasaki, T., Wakeham, A., Ohashi, P. S., Roder, J. C., Barnes, C. A., Siderovski, D. P., Penninger, J. M. (2000). Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc. Natl. Acad. Sci. USA 97: 12272-12277 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»