This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lenczowski, J. M.
Right arrow Articles by Ashwell, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lenczowski, J. M.
Right arrow Articles by Ashwell, J. D.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 01 1997, 170-181, Vol 17, No. 1
Copyright © 1997, American Society for Microbiology

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

JM Lenczowski, L Dominguez, AM Eder, LB King, CM Zacharchuk and JD Ashwell
Laboratory of Immune Cell Biology, National Institutes of Health, Bethesda, Maryland 20892-1152, USA.

Cross-linking of Fas (CD95) induces apoptosis, a response that has been reported to depend upon the Ras activation pathway. Since many examples of apoptosis have been reported to involve AP-1 and/or the AP-1- activation pathway. Since many examples of apoptosis have been reported to involve AP-1 and/or the AP-1-activating enzyme Jun kinase (JNK), downstream effectors of Ras or Ras-like small GTP-binding proteins, we evaluated the role of these molecules in Fas-mediated apoptosis. Although cross-linking of Fas on Jurkat T cells did result in JNK activation, increased activity was observed relatively late, being detectable only after 60 min of stimulation. Expression of a dominant negative form of SEK1 that blocked Fas-mediated induction of JNK activity had no effect on Fas-mediated apoptosis. Furthermore, maximally effective concentrations of anti-Fas did not cause JNK activation if apoptosis was blocked by a cysteine protease inhibitor, suggesting that under these conditions, activation of JNK may be secondary to the stress of apoptosis rather than a direct result of Fas engagement. Despite the activation of JNK, there was no induction of AP- 1 activity as determined by gel shift assay or induction of an AP-1- responsive reporter. The lack of a requirement for AP-1 induction in Fas-mediated death was further substantiated with Jurkat cells that were stably transfected with a dominant negative cJun, TAM-67. While TAM-67 effectively prevented AP-1-dependent transcription of both the interleukin-2 and cJun genes, it had no effect on Fas-induced cell death, even at limiting levels of Fas signaling. Thus, induction of JNK activity in Jurkat cells by ligation of Fas at levels sufficient to cause cell death is likely a result, rather than a cause, of the apoptotic response, and AP-1 function is not required for Fas-induced apoptosis.


This article has been cited by other articles:

  • Bosque, A., Aguilo, J. I., Alava, M. A., Paz-Artal, E., Naval, J., Allende, L. M., Anel, A. (2007). The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling. Blood 109: 1627-1635 [Abstract] [Full Text]  
  • Schlezinger, J. J., Emberley, J. K., Sherr, D. H. (2006). Activation of Multiple Mitogen-Activated Protein Kinases in Pro/Pre-B Cells by GW7845, a Peroxisome Proliferator-Activated Receptor {gamma} Agonist, and Their Contribution to GW7845-Induced Apoptosis. Toxicol Sci 92: 433-444 [Abstract] [Full Text]  
  • Farley, N., Pedraza-Alva, G., Serrano-Gomez, D., Nagaleekar, V., Aronshtam, A., Krahl, T., Thornton, T., Rincon, M. (2006). p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8+ T Cells.. Mol. Cell. Biol. 26: 2118-2129 [Abstract] [Full Text]  
  • Heimlich, G., Cidlowski, J. A. (2006). Selective Role of Intracellular Chloride in the Regulation of the Intrinsic but Not Extrinsic Pathway of Apoptosis in Jurkat T-cells. J. Biol. Chem. 281: 2232-2241 [Abstract] [Full Text]  
  • Kang, Y. J. (2006). Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death. Toxicol Pathol 34: 58-66 [Abstract] [Full Text]  
  • Su, J.-L., Lin, M.-T., Hong, C.-C., Chang, C.-C., Shiah, S.-G., Wu, C.-W., Chen, S.-T., Chau, Y.-P., Kuo, M.-L. (2005). Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis 26: 1-10 [Abstract] [Full Text]  
  • Shrivastava, P., Pantano, C., Watkin, R., McElhinney, B., Guala, A., Poynter, M. L., Persinger, R. L., Budd, R., Janssen-Heininger, Y. (2004). Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase. Mol. Cell. Biol. 24: 6763-6772 [Abstract] [Full Text]  
  • Tamura, K., Noyama, T., Ishizawa, Y.-h., Takamatsu, N., Shiba, T., Ito, M. (2004). Xenopus Death Receptor-M1 and -M2, New Members of the Tumor Necrosis Factor Receptor Superfamily, Trigger Apoptotic Signaling by Differential Mechanisms. J. Biol. Chem. 279: 7629-7635 [Abstract] [Full Text]  
  • Sun, Y., Yuan, J., Liu, H., Shi, Z., Baker, K., Vuori, K., Wu, J., Feng, G.-S. (2004). Role of Gab1 in UV-Induced c-Jun NH2-Terminal Kinase Activation and Cell Apoptosis. Mol. Cell. Biol. 24: 1531-1539 [Abstract] [Full Text]  
  • Kurita-Ochiai, T., Amano, S., Fukushima, K., Ochiai, K. (2003). Cellular Events Involved in Butyric Acid-Induced T Cell Apoptosis. J. Immunol. 171: 3576-3584 [Abstract] [Full Text]  
  • Kim, K. H., Min, Y. K., Baik, J.-H., Lau, L. F., Chaqour, B., Chung, K. C. (2003). Expression of Angiogenic Factor Cyr61 during Neuronal Cell Death via the Activation of c-Jun N-terminal Kinase and Serum Response Factor. J. Biol. Chem. 278: 13847-13854 [Abstract] [Full Text]  
  • Krippner-Heidenreich, A., Tubing, F., Bryde, S., Willi, S., Zimmermann, G., Scheurich, P. (2002). Control of Receptor-induced Signaling Complex Formation by the Kinetics of Ligand/Receptor Interaction. J. Biol. Chem. 277: 44155-44163 [Abstract] [Full Text]  
  • Chen, H.-L., Demiralp, B., Schneider, A., Koh, A. J., Silve, C., Wang, C.-Y., McCauley, L. K. (2002). Parathyroid Hormone and Parathyroid Hormone-related Protein Exert Both Pro- and Anti-apoptotic Effects in Mesenchymal Cells. J. Biol. Chem. 277: 19374-19381 [Abstract] [Full Text]  
  • He, T., Stepulak, A., Holmstrom, T. H., Omary, M. B., Eriksson, J. E. (2002). The Intermediate Filament Protein Keratin 8 Is a Novel Cytoplasmic Substrate for c-Jun N-terminal Kinase. J. Biol. Chem. 277: 10767-10774 [Abstract] [Full Text]  
  • Ahn, J.-H., Park, S.-M., Cho, H.-S., Lee, M.-S., Yoon, J.-B., Vilcek, J., Lee, T. H. (2001). Non-apoptotic Signaling Pathways Activated by Soluble Fas Ligand in Serum-starved Human Fibroblasts. MITOGEN-ACTIVATED PROTEIN KINASES AND NF-kappa B-DEPENDENT GENE EXPRESSION. J. Biol. Chem. 276: 47100-47106 [Abstract] [Full Text]  
  • Ortiz, M. A., Lopez-Hernandez, F. J., Bayon, Y., Pfahl, M., Piedrafita, F. J. (2001). Retinoid-related Molecules Induce Cytochrome c Release and Apoptosis through Activation of c-Jun NH2-Terminal Kinase/p38 Mitogen-activated Protein Kinases. Cancer Res. 61: 8504-8512 [Abstract] [Full Text]  
  • Major, C. D., Wolf, B. A. (2001). Interleukin-1{beta} Stimulation of c-Jun NH2-Terminal Kinase Activity in Insulin-Secreting Cells: Evidence for Cytoplasmic Restriction. Diabetes 50: 2721-2728 [Abstract] [Full Text]  
  • Yoshii, S., Tanaka, M., Otsuki, Y., Fujiyama, T., Kataoka, H., Arai, H., Hanai, H., Sugimura, H. (2001). Involvement of Alpha-PAK-Interacting Exchange Factor in the PAK1-c-Jun NH2-Terminal Kinase 1 Activation and Apoptosis Induced by Benzo[a]pyrene. Mol. Cell. Biol. 21: 6796-6807 [Abstract] [Full Text]  
  • Ghose, A., Fleming, J., El-Bayoumy, K., Harrison, P. R. (2001). Enhanced Sensitivity of Human Oral Carcinomas to Induction of Apoptosis by Selenium Compounds: Involvement of Mitogen-activated Protein Kinase and Fas Pathways. Cancer Res. 61: 7479-7487 [Abstract] [Full Text]  
  • Chen, C.-Y., Juo, P., Liou, J. S., Li, C.-Q., Yu, Q., Blenis, J., Faller, D. V. (2001). The Recruitment of Fas-associated Death Domain/Caspase-8 in Ras-induced Apoptosis. Cell Growth Differ. 12: 297-306 [Abstract] [Full Text]  
  • Kyriakis, J. M., Avruch, J. (2001). Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation. Physiol. Rev. 81: 807-869 [Abstract] [Full Text]  
  • Lee, Z. H., Lee, S. E., Kwack, K., Yeo, W., Lee, T. H., Bae, S. S., Suh, P.-G., Kim, H.-H. (2001). Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells. J. Leukoc. Biol. 69: 490-496 [Abstract] [Full Text]  
  • Kunz, M., Ibrahim, S., Koczan, D., Thiesen, H.-J., Köhler, H. J., Acker, T., Plate, K. H., Ludwig, S., Rapp, U. R., Bröcker, E.-B., van Muijen, G. N. P., Flory, E., Gross, G. (2001). Activation of c-Jun NH2-Terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Is Critical for Hypoxia-induced Apoptosis of Human Malignant Melanoma. Cell Growth Differ. 12: 137-145 [Abstract] [Full Text]  
  • Takada, E., Toyota, H., Suzuki, J., Mizuguchi, J. (2001). Prevention of Anti-IgM-Induced Apoptosis Accompanying G1 Arrest in B Lymphoma Cells Overexpressing Dominant-Negative Mutant Form of c-Jun N-Terminal Kinase 1. J. Immunol. 166: 1641-1649 [Abstract] [Full Text]  
  • Villunger, A., Huang, D. C. S., Holler, N., Tschopp, J., Strasser, A. (2000). Fas Ligand-Induced c-Jun Kinase Activation in Lymphoid Cells Requires Extensive Receptor Aggregation But Is Independent of DAXX, and Fas-Mediated Cell Death Does Not Involve DAXX, RIP, or RAIDD. J. Immunol. 165: 1337-1343 [Abstract] [Full Text]  
  • Law, S. F., O'Neill, G. M., Fashena, S. J., Einarson, M. B., Golemis, E. A. (2000). The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites. Mol. Cell. Biol. 20: 5184-5195 [Abstract] [Full Text]  
  • Melino, G., Bernassola, F., Catani, M. V., Rossi, A., Corazzari, M., Sabatini, S., Vilbois, F., Green, D. R. (2000). Nitric Oxide Inhibits Apoptosis via AP-1-dependent CD95L Transactivation. Cancer Res. 60: 2377-2383 [Abstract] [Full Text]  
  • Yu, R., Mandlekar, S., Ruben, S., Ni, J., Kong, A-N. T. (2000). Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Androgen-independent Prostate Cancer Cells. Cancer Res. 60: 2384-2389 [Abstract] [Full Text]  
  • Okamoto, K., Kobayashi, T., Kobata, T., Hasunuma, T., Kato, T., Sumida, T., Nishioka, K. (2000). Fas-associated death domain protein is a Fas-mediated apoptosis modulator in synoviocytes. Rheumatology (Oxford) 39: 471-480 [Abstract] [Full Text]  
  • Zhang, J., Gao, J.-X., Salojin, K., Shao, Q., Grattan, M., Meagher, C., Laird, D. W., Delovitch, T. L. (2000). Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase. JEM 191: 1017-1030 [Abstract] [Full Text]  
  • Wollert, K. C., Heineke, J., Westermann, J., Ludde, M., Fiedler, B., Zierhut, W., Laurent, D., Bauer, M. K. A., Schulze-Osthoff, K., Drexler, H. (2000). The Cardiac Fas (APO-1/CD95) Receptor/Fas Ligand System : Relation to Diastolic Wall Stress in Volume-Overload Hypertrophy In Vivo and Activation of the Transcription Factor AP-1 in Cardiac Myocytes. Circulation 101: 1172-1178 [Abstract] [Full Text]  
  • Shinohara, H., Yagita, H., Ikawa, Y., Oyaizu, N. (2000). Fas Drives Cell Cycle Progression in Glioma Cells via Extracellular Signal-regulated Kinase Activation. Cancer Res. 60: 1766-1772 [Abstract] [Full Text]  
  • Kolbus, A., Herr, I., Schreiber, M., Debatin, K.-M., Wagner, E. F., Angel, P. (2000). c-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents. Mol. Cell. Biol. 20: 575-582 [Abstract] [Full Text]  
  • Juo, P., Sue-Ann Woo, M., Kuo, C. J., Signorelli, P., Biemann, H. P., Hannun, Y. A., Blenis, J. (1999). FADD Is Required for Multiple Signaling Events Downstream of the Receptor Fas. Cell Growth Differ. 10: 797-804 [Abstract] [Full Text]  
  • Rebollo, A., Martinez-A, C. (1999). Ras Proteins: Recent Advances and New Functions. Blood 94: 2971-2980 [Full Text]  
  • Liu, R., Itoh, T., Arai, K.-i., Watanabe, S. (1999). Two Distinct Signaling Pathways Downstream of Janus Kinase 2 Play Redundant Roles for Antiapoptotic Activity of Granulocyte-Macrophage Colony-stimulating Factor. Mol. Biol. Cell 10: 3959-3970 [Abstract] [Full Text]  
  • Hida, H., Nagano, S., Takeda, M., Soliven, B. (1999). Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes. J. Neurosci. 19: 7458-7467 [Abstract] [Full Text]  
  • King, L. B., Tolosa, E., Lenczowski, J. M., Lu, F., Lind, E. F., Hunziker, R., Petrie, H. T., Ashwell, J. D. (1999). A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4–CD8– to CD4+CD8+ thymocytes. Int Immunol 11: 1203-1216 [Abstract] [Full Text]  
  • Nagata, Y., Todokoro, K. (1999). Requirement of Activation of JNK and p38 for Environmental Stress-Induced Erythroid Differentiation and Apoptosis and of Inhibition of ERK for Apoptosis. Blood 94: 853-863 [Abstract] [Full Text]  
  • Chaudhary, P. M., Eby, M. T., Jasmin, A., Hood, L. (1999). Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs. J. Biol. Chem. 274: 19211-19219 [Abstract] [Full Text]  
  • Huang, C., Ma, W.-y., Li, J., Dong, Z. (1999). Arsenic Induces Apoptosis through a c-Jun NH2-Terminal Kinase-dependent, p53-independent Pathway. Cancer Res. 59: 3053-3058 [Abstract] [Full Text]  
  • Shifrin, V. I., Anderson, P. (1999). Trichothecene Mycotoxins Trigger a Ribotoxic Stress Response That Activates c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase and Induces Apoptosis. J. Biol. Chem. 274: 13985-13992 [Abstract] [Full Text]  
  • Assefa, Z., Vantieghem, A., Declercq, W., Vandenabeele, P., Vandenheede, J. R., Merlevede, W., de Witte, P., Agostinis, P. (1999). The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin. J. Biol. Chem. 274: 8788-8796 [Abstract] [Full Text]  
  • Matsuda, S., Minowa, A., Suzuki, S., Koyasu, S. (1999). Differential Activation of c-Jun NH2-Terminal Kinase and p38 Pathways During FTY720-Induced Apoptosis of T Lymphocytes That Is Suppressed by the Extracellular Signal-Regulated Kinase Pathway. J. Immunol. 162: 3321-3326 [Abstract] [Full Text]  
  • Abreu-Martin, M. T., Palladino, A. A., Faris, M., Carramanzana, N. M., Nel, A. E., Targan, S. R. (1999). Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G599-G605 [Abstract] [Full Text]  
  • Khélifa, T., Beck, W. T. (1999). Merbarone, a Catalytic Inhibitor of DNA Topoisomerase II, Induces Apoptosis in CEM Cells through Activation of ICE/CED-3-like Protease. Mol. Pharmacol. 55: 548-556 [Abstract] [Full Text]  
  • Chang, H. Y., Yang, X., Baltimore, D. (1999). Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation. Proc. Natl. Acad. Sci. USA 96: 1252-1256 [Abstract] [Full Text]  
  • Yu, W., Israel, K., Liao, Q. Y., Aldaz, C. M., Sanders, B. G., Kline, K. (1999). Vitamin E Succinate (VES) Induces Fas Sensitivity in Human Breast Cancer Cells: Role for Mr 43,000 Fas in VES-triggered Apoptosis. Cancer Res. 59: 953-961 [Abstract] [Full Text]  
  • Nishina, H, Vaz, C, Billia, P, Nghiem, M, Sasaki, T, De la Pompa, J., Furlonger, K, Paige, C, Hui, C, Fischer, K., Kishimoto, H, Iwatsubo, T, Katada, T, Woodgett, J., Penninger, J. (1999). Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126: 505-516 [Abstract]  
  • Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F.-X., Green, D. R., Karin, M. (1999). Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death. Mol. Cell. Biol. 19: 751-763 [Abstract] [Full Text]  
  • Muhlenbeck, F., Haas, E., Schwenzer, R., Schubert, G., Grell, M., Smith, C., Scheurich, P., Wajant, H. (1998). TRAIL/Apo2L Activates c-Jun NH2-terminal Kinase (JNK) via Caspase-dependent and Caspase-independent Pathways. J. Biol. Chem. 273: 33091-33098 [Abstract] [Full Text]  
  • Shrivastava, A., Manna, S. K., Ray, R., Aggarwal, B. B. (1998). Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors. J. Virol. 72: 9722-9728 [Abstract] [Full Text]  
  • Okubo, Y., Blakesley, V. A., Stannard, B., Gutkind, S., Le Roith, D. (1998). Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase. J. Biol. Chem. 273: 25961-25966 [Abstract] [Full Text]  
  • Nagata, Y., Takahashi, N., Davis, R. J., Todokoro, K. (1998). Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation. Blood 92: 1859-1869 [Abstract] [Full Text]  
  • Faris, M., Latinis, K. M., Kempiak, S. J., Koretzky, G. A., Nel, A. (1998). Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter. Mol. Cell. Biol. 18: 5414-5424 [Abstract] [Full Text]  
  • Bradham, C. A., Plumpe, J., Manns, M. P., Brenner, D. A., Trautwein, C. (1998). I. TNF-induced liver injury. Am. J. Physiol. Gastrointest. Liver Physiol. 275: G387-G392 [Abstract] [Full Text]  
  • Lee, J. R., Koretzky, G. A. (1998). Extracellular Signal-Regulated Kinase-2, But Not c-Jun NH2-Terminal Kinase, Activation Correlates with Surface IgM-Mediated Apoptosis in the WEHI 231 B Cell Line. J. Immunol. 161: 1637-1644 [Abstract] [Full Text]  
  • Hossain, A., Tsuchiya, S., Minegishi, M., Osada, M., Ikawa, S., Tezuka, F.-a., Kaji, M., Konno, T., Watanabe, M., Kikuchi, H. (1998). The Ah Receptor Is Not Involved in 2,3,7,8-Tetrachlorodibenzo- p-dioxin-mediated Apoptosis in Human Leukemic T Cell Lines. J. Biol. Chem. 273: 19853-19858 [Abstract] [Full Text]  
  • Kamada, S., Kusano, H., Fujita, H., Ohtsu, M., Koya, R. C., Kuzumaki, N., Tsujimoto, Y. (1998). A cloning method for caspase substrates that uses the yeast two-hybrid system: Cloning of the antiapoptotic gene gelsolin. Proc. Natl. Acad. Sci. USA 95: 8532-8537 [Abstract] [Full Text]  
  • Chen, C.-Y., Liou, J., Forman, L. W., Faller, D. V. (1998). Differential Regulation of Discrete Apoptotic Pathways by Ras. J. Biol. Chem. 273: 16700-16709 [Abstract] [Full Text]  
  • Graves, J. D., Draves, K. E., Craxton, A., Krebs, E. G., Clark, E. A. (1998). A Comparison of Signaling Requirements for Apoptosis of Human B Lymphocytes Induced by the B Cell Receptor and CD95/Fas. J. Immunol. 161: 168-174 [Abstract] [Full Text]  
  • Xu, F.-h., Sharma, S., Gardner, A., Tu, Y., Raitano, A., Sawyers, C., Lichtenstein, A. (1998). Interleukin-6-Induced Inhibition of Multiple Myeloma Cell Apoptosis: Support for the Hypothesis That Protection Is Mediated Via Inhibition of the JNK/SAPK Pathway. Blood 92: 241-251 [Abstract] [Full Text]  
  • Deak, J. C., Cross, J. V., Lewis, M., Qian, Y., Parrott, L. A., Distelhorst, C. W., Templeton, D. J. (1998). Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc. Natl. Acad. Sci. USA 95: 5595-5600 [Abstract] [Full Text]  
  • Roulston, A., Reinhard, C., Amiri, P., Williams, L. T. (1998). Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor alpha. J. Biol. Chem. 273: 10232-10239 [Abstract] [Full Text]  
  • Hsu, S.-C., Wu, C.-C., Luh, T.-Y., Chou, C.-K., Han, S.-H., Lai, M.-Z. (1998). Apoptotic Signal of Fas Is Not Mediated by Ceramide. Blood 91: 2658-2663 [Abstract] [Full Text]  
  • Franklin, C. C., Srikanth, S., Kraft, A. S. (1998). Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc. Natl. Acad. Sci. USA 95: 3014-3019 [Abstract] [Full Text]  
  • Utz, P. J., Hottelet, M., van Venrooij, W. J., Anderson, P. (1998). Association of Phosphorylated Serine/Arginine (SR) Splicing Factors With The U1-Small Ribonucleoprotein (snRNP) Autoantigen Complex Accompanies Apoptotic Cell Death. JEM 187: 547-560 [Abstract] [Full Text]  
  • Chen, Y.-R., Wang, W., Kong, A.-N. T., Tan, T.-H. (1998). Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates. J. Biol. Chem. 273: 1769-1775 [Abstract] [Full Text]  
  • Faris, M., Kokot, N., Latinis, K., Kasibhatla, S., Green, D. R., Koretzky, G. A., Nel, A. (1998). The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression. J. Immunol. 160: 134-144 [Abstract] [Full Text]  
  • Toyoshima, F., Moriguchi, T., Nishida, E. (1997). Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases. JCB 139: 1005-1015 [Abstract] [Full Text]  
  • Brenner, B., Koppenhoefer, U., Weinstock, C., Linderkamp, O., Lang, F., Gulbins, E. (1997). Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153. J. Biol. Chem. 272: 22173-22181 [Abstract] [Full Text]  
  • Thangaraju, M., Kaufmann, S. H., Couch, F. J. (2000). BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines. J. Biol. Chem. 275: 33487-33496 [Abstract] [Full Text]  
  • Yamamura, Y., Hua, X., Bergelson, S., Lodish, H. F. (2000). Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-beta -dependent Apoptosis. J. Biol. Chem. 275: 36295-36302 [Abstract] [Full Text]  
  • Diao, J., Khine, A. A., Sarangi, F., Hsu, E., Iorio, C., Tibbles, L. A., Woodgett, J. R., Penninger, J., Richardson, C. D. (2001). X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway. J. Biol. Chem. 276: 8328-8340 [Abstract] [Full Text]  
  • Faouzi, S., Burckhardt, B. E., Hanson, J. C., Campe, C. B., Schrum, L. W., Rippe, R. A., Maher, J. J. (2001). Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-kappa B-independent, Caspase-3-dependent Pathway. J. Biol. Chem. 276: 49077-49082 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»