This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, R.
Right arrow Articles by Misra, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, R.
Right arrow Articles by Misra, V.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 09 1997, 5117-5126, Vol 17, No. 9
Copyright © 1997, American Society for Microbiology

Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor

R Lu, P Yang, P O'Hare and V Misra
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.

The human host cell factor (HCF) is expressed in a variety of adult and fetal tissues, and its gene is conserved in animals as diverse as mammals and insects. However, its only known function is to stabilize the herpes simplex virus virion transactivator VP16 in a complex with the cellular POU domain protein Oct-1 and cis-acting regulatory elements in promoters of immediate-early viral genes. To identify a cellular function for HCF, we used the yeast two-hybrid system to identify a cellular ligand for HCF. This protein, Luman, appears to be a cyclic AMP response element (CRE)-binding protein/activating transcription factor 1 protein of the basic leucine zipper superfamily. It binds CREs in vitro and activates CRE-containing promoters when transfected into COS7 cells. This activation of transcription was synergistically enhanced by the presence of CCAAT/enhancer-binding protein elements and inhibited by AP-1 elements in the promoter. In addition to a basic DNA binding domain, Luman possesses an unusually long leucine zipper and an acidic amino-terminal activation domain. These features in Luman are also present in what appear to be homologs in the mouse, Drosophila melanogaster, and Caenorhabditis elegans. Luman and VP16 appear to have similar mechanisms for binding HCF, as in vitro each competitively inhibited the binding of the other to HCF. In transfected cells, however, while VP16 strongly inhibited the ability of GAL-Luman to activate transcription from a GAL4 upstream activation sequence-containing promoter, Luman was unable to inhibit the activity of GAL-VP16. Luman appears to be a ubiquitous transcription factor, and its mRNA was detected in all human adult and fetal tissues examined. The possible role of HCF in regulating the function of this ubiquitous transcription factor is discussed.


This article has been cited by other articles:

  • Machida, Y. J., Machida, Y., Vashisht, A. A., Wohlschlegel, J. A., Dutta, A. (2009). The Deubiquitinating Enzyme BAP1 Regulates Cell Growth via Interaction with HCF-1. J. Biol. Chem. 284: 34179-34188 [Abstract] [Full Text]  
  • Whitlow, Z. W., Kristie, T. M. (2009). Recruitment of the Transcriptional Coactivator HCF-1 to Viral Immediate-Early Promoters during Initiation of Reactivation from Latency of Herpes Simplex Virus Type 1. J. Virol. 83: 9591-9595 [Abstract] [Full Text]  
  • Kolb, G., Kristie, T. M. (2008). Association of the Cellular Coactivator HCF-1 with the Golgi Apparatus in Sensory Neurons. J. Virol. 82: 9555-9563 [Abstract] [Full Text]  
  • Audas, T. E., Li, Y., Liang, G., Lu, R. (2008). A Novel Protein, Luman/CREB3 Reruitment Factor, Inhibits Luman Activation of the Unfolded Protein Response. Mol. Cell. Biol. 28: 3952-3966 [Abstract] [Full Text]  
  • Aicha, S. B., Lessard, J., Pelletier, M., Fournier, A., Calvo, E., Labrie, C. (2007). Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. Physiol. Genomics 31: 295-305 [Abstract] [Full Text]  
  • Jang, S.-W., Kim, Y. S., Kim, Y. R., Sung, H. J., Ko, J. (2007). Regulation of Human LZIP Expression by NF-{kappa}B and Its Involvement in Monocyte Cell Migration Induced by Lkn-1. J. Biol. Chem. 282: 11092-11100 [Abstract] [Full Text]  
  • Liang, G., Audas, T. E., Li, Y., Cockram, G. P., Dean, J. D., Martyn, A. C., Kokame, K., Lu, R. (2006). Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element. Mol. Cell. Biol. 26: 7999-8010 [Abstract] [Full Text]  
  • Vogel, J. L., Kristie, T. M. (2006). Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors. Proc. Natl. Acad. Sci. USA 103: 6817-6822 [Abstract] [Full Text]  
  • Stirling, J., O'Hare, P. (2006). CREB4, a Transmembrane bZip Transcription Factor and Potential New Substrate for Regulation and Cleavage by S1P. Mol. Biol. Cell 17: 413-426 [Abstract] [Full Text]  
  • Akhova, O., Bainbridge, M., Misra, V. (2005). The Neuronal Host Cell Factor-Binding Protein Zhangfei Inhibits Herpes Simplex Virus Replication. J. Virol. 79: 14708-14718 [Abstract] [Full Text]  
  • Adham, I. M., Eck, T. J., Mierau, K., Muller, N., Sallam, M. A., Paprotta, I., Schubert, S., Hoyer-Fender, S., Engel, W. (2005). Reduction of Spermatogenesis but Not Fertility in Creb3l4-Deficient Mice. Mol. Cell. Biol. 25: 7657-7664 [Abstract] [Full Text]  
  • Misra, V., Rapin, N., Akhova, O., Bainbridge, M., Korchinski, P. (2005). Zhangfei Is a Potent and Specific Inhibitor of the Host Cell Factor-binding Transcription Factor Luman. J. Biol. Chem. 280: 15257-15266 [Abstract] [Full Text]  
  • Chin, K.-T., Zhou, H.-J., Wong, C.-M., Lee, J. M.-F., Chan, C.-P., Qiang, B.-Q., Yuan, J.-G., Ng, I. O.-l., Jin, D.-Y. (2005). The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res 33: 1859-1873 [Abstract] [Full Text]  
  • Khurana, B., Kristie, T. M. (2004). A Protein Sequestering System Reveals Control of Cellular Programs by the Transcriptional Coactivator HCF-1. J. Biol. Chem. 279: 33673-33683 [Abstract] [Full Text]  
  • Luciano, R. L., Wilson, A. C. (2003). HCF-1 Functions as a Coactivator for the Zinc Finger Protein Krox20. J. Biol. Chem. 278: 51116-51124 [Abstract] [Full Text]  
  • Richie-Jannetta, R., Francis, S. H., Corbin, J. D. (2003). Dimerization of cGMP-dependent Protein Kinase I{beta} Is Mediated by an Extensive Amino-terminal Leucine Zipper Motif, and Dimerization Modulates Enzyme Function. J. Biol. Chem. 278: 50070-50079 [Abstract] [Full Text]  
  • Storlazzi, C. T., Mertens, F., Nascimento, A., Isaksson, M., Wejde, J., Brosjo, O., Mandahl, N., Panagopoulos, I. (2003). Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Hum Mol Genet 12: 2349-2358 [Abstract] [Full Text]  
  • Wysocka, J., Myers, M. P., Laherty, C. D., Eisenman, R. N., Herr, W. (2003). Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev. 17: 896-911 [Abstract] [Full Text]  
  • Piluso, D., Bilan, P., Capone, J. P. (2002). Host Cell Factor-1 Interacts with and Antagonizes Transactivation by the Cell Cycle Regulatory Factor Miz-1. J. Biol. Chem. 277: 46799-46808 [Abstract] [Full Text]  
  • Mahajan, S. S., Little, M. M., Vazquez, R., Wilson, A. C. (2002). Interaction of HCF-1 with a Cellular Nuclear Export Factor. J. Biol. Chem. 277: 44292-44299 [Abstract] [Full Text]  
  • Luciano, R. L., Wilson, A. C. (2002). An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP. Proc. Natl. Acad. Sci. USA 99: 13403-13408 [Abstract] [Full Text]  
  • Vinson, C., Myakishev, M., Acharya, A., Mir, A. A., Moll, J. R., Bonovich, M. (2002). Classification of Human B-ZIP Proteins Based on Dimerization Properties. Mol. Cell. Biol. 22: 6321-6335 [Full Text]  
  • Raggo, C., Rapin, N., Stirling, J., Gobeil, P., Smith-Windsor, E., O'Hare, P., Misra, V. (2002). Luman, the Cellular Counterpart of Herpes Simplex Virus VP16, Is Processed by Regulated Intramembrane Proteolysis. Mol. Cell. Biol. 22: 5639-5649 [Abstract] [Full Text]  
  • Stelzer, G., Don, J. (2002). Atce1: A Novel Mouse Cyclic Adenosine 3',5'-Monophosphate-Responsive Element-Binding Protein-Like Gene Exclusively Expressed in Postmeiotic Spermatids. Endocrinology 143: 1578-1588 [Abstract] [Full Text]  
  • Loiacono, C. M., Myers, R., Mitchell, W. J. (2002). Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice. J. Virol. 76: 2449-2459 [Abstract] [Full Text]  
  • Qi, H., Fillion, C., Labrie, Y., Grenier, J., Fournier, A., Berger, L., El-Alfy, M., Labrie, C. (2002). AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells. Cancer Res. 62: 721-733 [Abstract] [Full Text]  
  • Lee, S., Herr, W. (2001). Stabilization but Not the Transcriptional Activity of Herpes Simplex Virus VP16-Induced Complexes Is Evolutionarily Conserved among HCF Family Members. J. Virol. 75: 12402-12411 [Abstract] [Full Text]  
  • Tsavachidou, D., Podrzucki, W., Seykora, J., Berger, S. L. (2001). Gene Array Analysis Reveals Changes in Peripheral Nervous System Gene Expression following Stimuli That Result in Reactivation of Latent Herpes Simplex Virus Type 1: Induction of Transcription Factor Bcl-3. J. Virol. 75: 9909-9917 [Abstract] [Full Text]  
  • Omori, Y., Imai, J.-i., Watanabe, M., Komatsu, T., Suzuki, Y., Kataoka, K., Watanabe, S., Tanigami, A., Sugano, S. (2001). CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res 29: 2154-2162 [Abstract] [Full Text]  
  • Wilson, A. C., Boutros, M., Johnson, K. M., Herr, W. (2000). HCF-1 Amino- and Carboxy-Terminal Subunit Association through Two Separate Sets of Interaction Modules: Involvement of Fibronectin Type 3 Repeats. Mol. Cell. Biol. 20: 6721-6730 [Abstract] [Full Text]  
  • Luciano, R. L., Wilson, A. C. (2000). N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif. Proc. Natl. Acad. Sci. USA 10.1073/pnas.190062797v1 [Abstract] [Full Text]  
  • Vogel, J. L., Kristie, T. M. (2000). Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): A potential role for proteolytic regulation of coactivator function. Proc. Natl. Acad. Sci. USA 10.1073/pnas.160266697v1 [Abstract] [Full Text]  
  • Lu, R., Misra, V. (2000). Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. Nucleic Acids Res 28: 2446-2454 [Abstract] [Full Text]  
  • Scarr, R. B., Smith, M. R., Beddall, M., Sharp, P. A. (2000). A Novel 50-Kilodalton Fragment of Host Cell Factor 1 (C1) in G0 Cells. Mol. Cell. Biol. 20: 3568-3575 [Abstract] [Full Text]  
  • Mahajan, S. S., Wilson, A. C. (2000). Mutations in Host Cell Factor 1 Separate Its Role in Cell Proliferation from Recruitment of VP16 and LZIP. Mol. Cell. Biol. 20: 919-928 [Abstract] [Full Text]  
  • Ajuh, P. M., Browne, G. J., Hawkes, N. A., Cohen, P. T. W., Roberts, S. G. E., Lamond, A. I. (2000). Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex. Nucleic Acids Res 28: 678-686 [Abstract] [Full Text]  
  • Lu, R., Misra, V. (2000). Potential Role for Luman, the Cellular Homologue of Herpes Simplex Virus VP16 (alpha Gene trans-Inducing Factor), in Herpesvirus Latency. J. Virol. 74: 934-943 [Abstract] [Full Text]  
  • Chang, P.-K., Yu, J., Bhatnagar, D., Cleveland, T. E. (1999). The Carboxy-Terminal Portion of the Aflatoxin Pathway Regulatory Protein AFLR of Aspergillus parasiticus Activates GAL1::lacZ Gene Expression in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 65: 2508-2512 [Abstract] [Full Text]  
  • Johnson, K. M., Mahajan, S. S., Wilson, A. C. (1999). Herpes Simplex Virus Transactivator VP16 Discriminates between HCF-1 and a Novel Family Member, HCF-2. J. Virol. 73: 3930-3940 [Abstract] [Full Text]  
  • Liu, Y., Hengartner, M. O., Herr, W. (1999). Selected Elements of Herpes Simplex Virus Accessory Factor HCF Are Highly Conserved in Caenorhabditis elegans. Mol. Cell. Biol. 19: 909-915 [Abstract] [Full Text]  
  • Lu, R., Yang, P., Padmakumar, S., Misra, V. (1998). The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF. J. Virol. 72: 6291-6297 [Abstract] [Full Text]  
  • HERR, W. (1998). The Herpes Simplex Virus VP16-induced Complex: Mechanisms of Combinatorial Transcriptional Regulation. Cold Spring Harb Symp Quant Biol 63: 599-608 [Abstract]  
  • Freiman, R. N., Herr, W. (1997). Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. Genes Dev. 11: 3122-3127 [Abstract] [Full Text]  
  • Gassama-Diagne, A., Hullin-Matsuda, F., Li, R. Y., Nauze, M., Ragab, A., Pons, V., Delagebeaudeuf, C., Simon, M.-F., Fauvel, J., Chap, H. (2001). Enterophilins, a New Family of Leucine Zipper Proteins Bearing a B30.2 Domain and Associated with Enterocyte Differentiation. J. Biol. Chem. 276: 18352-18360 [Abstract] [Full Text]  
  • Zhou, H.-J., Wong, C.-M., Chen, J.-H., Qiang, B.-Q., Yuan, J.-G., Jin, D.-Y. (2001). Inhibition of LZIP-mediated Transcription through Direct Interaction with a Novel Host Cell Factor-like Protein. J. Biol. Chem. 276: 28933-28938 [Abstract] [Full Text]  
  • Vogel, J. L., Kristie, T. M. (2000). Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): A potential role for proteolytic regulation of coactivator function. Proc. Natl. Acad. Sci. USA 97: 9425-9430 [Abstract] [Full Text]  
  • Luciano, R. L., Wilson, A. C. (2000). N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif. Proc. Natl. Acad. Sci. USA 97: 10757-10762 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»