This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stein, G. H.
Right arrow Articles by Reed, S. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stein, G. H.
Right arrow Articles by Reed, S. I.

 Previous Article  |  Next Article 

Mol. Cell. Biol., Jan 1998, 546-557, Vol 18, No. 1
Copyright © 1998, American Society for Microbiology

Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

V Dulic, GH Stein, DF Far and SI Reed
CNRS-UMR 134, Universite de Nice-Sophia Antipolis, Nice, France. dulic@vega.crbm.cnrs-mop.fr

Cell cycle arrest in G1 in response to ionizing radiation or senescence is believed to be provoked by inactivation of G1 cyclin-cyclin- dependent kinases (Cdks) by the Cdk inhibitor p21(Cip1/Waf1/Sdi1). We provide evidence that in addition to exerting negative control of the G1/S phase transition, p21 may play a role at the onset of mitosis. In nontransformed fibroblasts, p21 transiently reaccumulates in the nucleus near the G2/M-phase boundary, concomitant with cyclin B1 nuclear translocation, and associates with a fraction of cyclin A-Cdk and cyclin B1-Cdk complexes. Premitotic nuclear accumulation of cyclin B1 is not detectable in cells with low p21 levels, such as fibroblasts expressing the viral human papillomavirus type 16 E6 oncoprotein, which functionally inactivates p53, or in tumor-derived cells. Moreover, synchronized E6-expressing fibroblasts show accelerated entry into mitosis compared to wild-type cells and exhibit higher cyclin A- and cyclin B1-associated kinase activities. Finally, primary embryonic fibroblasts derived from p21-/- mice have significantly reduced numbers of premitotic cells with nuclear cyclin B1. These data suggest that p21 promotes a transient pause late in G2 that may contribute to the implementation of late cell cycle checkpoint controls.


This article has been cited by other articles:

  • Lopez, G., Liu, J., Ren, W., Wei, W., Wang, S., Lahat, G., Zhu, Q.-S., Bornmann, W. G., McConkey, D. J., Pollock, R. E., Lev, D. C. (2009). Combining PCI-24781, a Novel Histone Deacetylase Inhibitor, with Chemotherapy for the Treatment of Soft Tissue Sarcoma. Clin. Cancer Res. 15: 3472-3483 [Abstract] [Full Text]  
  • Moh, M. C., Zhang, T., Lee, L. H., Shen, S. (2008). Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells. Carcinogenesis 29: 2298-2305 [Abstract] [Full Text]  
  • Kim, Y., Starostina, N. G., Kipreos, E. T. (2008). The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev. 22: 2507-2519 [Abstract] [Full Text]  
  • Campregher, C, Luciani, M G, Gasche, C (2008). Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. Gut 57: 780-787 [Abstract] [Full Text]  
  • Wong, S. H. K., Shih, R. S. M., Schoene, N. W., Lei, K. Y. (2008). Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells. Am. J. Physiol. Cell Physiol. 294: C1342-C1349 [Abstract] [Full Text]  
  • Uddin, S., Ahmed, M., Bavi, P., El-Sayed, R., Al-Sanea, N., AbdulJabbar, A., Ashari, L. H., Alhomoud, S., Al-Dayel, F., Hussain, A. R., Al-Kuraya, K. S. (2008). Bortezomib (Velcade) Induces p27Kip1 Expression through S-Phase Kinase Protein 2 Degradation in Colorectal Cancer. Cancer Res. 68: 3379-3388 [Abstract] [Full Text]  
  • Manceau, M., Gros, J., Savage, K., Thome, V., McPherron, A., Paterson, B., Marcelle, C. (2008). Myostatin promotes the terminal differentiation of embryonic muscle progenitors. Genes Dev. 22: 668-681 [Abstract] [Full Text]  
  • Chen, Z., Place, R. F., Jia, Z.-J., Pookot, D., Dahiya, R., Li, L.-C. (2008). Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells. Molecular Cancer Therapeutics 7: 698-703 [Abstract] [Full Text]  
  • Jalota-Badhwar, A., Kaul-Ghanekar, R., Mogare, D., Boppana, R., Paknikar, K. M., Chattopadhyay, S. (2007). SMAR1-derived P44 Peptide Retains Its Tumor Suppressor Function through Modulation of p53. J. Biol. Chem. 282: 9902-9913 [Abstract] [Full Text]  
  • Zhang, J., Wang, S., Kern, S., Cui, X., Danner, R. L. (2007). Nitric Oxide Down-regulates Polo-like Kinase 1 through a Proximal Promoter Cell Cycle Gene Homology Region. J. Biol. Chem. 282: 1003-1009 [Abstract] [Full Text]  
  • Gong, Y., Yue, J., Wu, X., Wang, X., Wen, J., Lu, L., Peng, X., Qiang, B., Yuan, J. (2006). NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element. Nucleic Acids Res 34: 6158-6169 [Abstract] [Full Text]  
  • Staalesen, V., Knappskog, S., Chrisanthar, R., Nordgard, S. H., Lokkevik, E., Anker, G., Ostenstad, B., Lundgren, S., Risberg, T., Mjaaland, I., Gram, I. T., Kristensen, V. N., Borresen-Dale, A.-L., Lillehaug, J. R., Lonning, P. E. (2006). The Novel p21 Polymorphism p21G251A Is Associated with Locally Advanced Breast Cancer.. Clin. Cancer Res. 12: 6000-6004 [Abstract] [Full Text]  
  • Yun, J.-M., Kweon, M.-H., Kwon, H., Hwang, J.-K., Mukhtar, H. (2006). Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145. Carcinogenesis 27: 1454-1464 [Abstract] [Full Text]  
  • Bazzaro, M., Lee, M. K., Zoso, A., Stirling, W. L.H., Santillan, A., Shih, I.-M., Roden, R. B.S. (2006). Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis.. Cancer Res. 66: 3754-3763 [Abstract] [Full Text]  
  • Yang, J.-H., Hsia, T.-C., Kuo, H.-M., Chao, P.-D. L., Chou, C.-C., Wei, Y.-H., Chung, J.-G. (2006). INHIBITION OF LUNG CANCER CELL GROWTH BY QUERCETIN GLUCURONIDES VIA G2/M ARREST AND INDUCTION OF APOPTOSIS. Drug Metab. Dispos. 34: 296-304 [Abstract] [Full Text]  
  • Monzo, P., Gauthier, N. C., Keslair, F., Loubat, A., Field, C. M., Le Marchand-Brustel, Y., Cormont, M. (2005). Clues to CD2-associated Protein Involvement in Cytokinesis. Mol. Biol. Cell 16: 2891-2902 [Abstract] [Full Text]  
  • Munoz-Alonso, M. J., Acosta, J. C., Richard, C., Delgado, M. D., Sedivy, J., Leon, J. (2005). p21Cip1 and p27Kip1 Induce Distinct Cell Cycle Effects and Differentiation Programs in Myeloid Leukemia Cells. J. Biol. Chem. 280: 18120-18129 [Abstract] [Full Text]  
  • Jalota, A., Singh, K., Pavithra, L., Kaul-Ghanekar, R., Jameel, S., Chattopadhyay, S. (2005). Tumor Suppressor SMAR1 Activates and Stabilizes p53 through Its Arginine-Serine-rich Motif. J. Biol. Chem. 280: 16019-16029 [Abstract] [Full Text]  
  • Dash, B. C., El-Deiry, W. S. (2005). Phosphorylation of p21 in G2/M Promotes Cyclin B-Cdc2 Kinase Activity. Mol. Cell. Biol. 25: 3364-3387 [Abstract] [Full Text]  
  • Pizzoferrato, E., Liu, Y., Gambotto, A., Armstrong, M. J., Stang, M. T., Gooding, W. E., Alber, S. M., Shand, S. H., Watkins, S. C., Storkus, W. J., Yim, J. H. (2004). Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin. Cancer Res. 64: 8381-8388 [Abstract] [Full Text]  
  • Charrier-Savournin, F. B., Chateau, M.-T., Gire, V., Sedivy, J., Piette, J., Dulic, V. (2004). p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress. Mol. Biol. Cell 15: 3965-3976 [Abstract] [Full Text]  
  • Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duee, P.-H., Martel, P., Chaumontet, C. (2004). Diallyl disulfide (DADS) increases histone acetylation and p21waf1/cip1 expression in human colon tumor cell lines. Carcinogenesis 25: 1227-1236 [Abstract] [Full Text]  
  • Kikuchi, M., Harris, D. L., Obara, Y., Senoo, T., Joyce, N. C. (2004). p27kip1 Antisense-Induced Proliferative Activity of Rat Corneal Endothelial Cells. IOVS 45: 1763-1770 [Abstract] [Full Text]  
  • Staalesen, V., Leirvaag, B., Lillehaug, J. R., Lonning, P. E. (2004). Genetic and Epigenetic Changes in p21 and p21B Do Not Correlate with Resistance to Doxorubicin or Mitomycin and 5-Fluorouracil in Locally Advanced Breast Cancer. Clin. Cancer Res. 10: 3438-3443 [Abstract] [Full Text]  
  • Tintignac, L. A. J., Sirri, V., Leibovitch, M. P., Lecluse, Y., Castedo, M., Metivier, D., Kroemer, G., Leibovitch, S. A. (2004). Mutant MyoD Lacking Cdc2 Phosphorylation Sites Delays M-Phase Entry. Mol. Cell. Biol. 24: 1809-1821 [Abstract] [Full Text]  
  • Reed, S. E., Spruck, C. H., Sangfelt, O., van Drogen, F., Mueller-Holzner, E., Widschwendter, M., Zetterberg, A., Reed, S. I. (2004). Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in Cancer. Cancer Res. 64: 795-800 [Abstract] [Full Text]  
  • Barnes, B. J., Kellum, M. J., Pinder, K. E., Frisancho, J. A., Pitha, P. M. (2003). Interferon Regulatory Factor 5, a Novel Mediator of Cell Cycle Arrest and Cell Death. Cancer Res. 63: 6424-6431 [Abstract] [Full Text]  
  • Lapillonne, H., Konopleva, M., Tsao, T., Gold, D., McQueen, T., Sutherland, R. L., Madden, T., Andreeff, M. (2003). Activation of Peroxisome Proliferator-activated Receptor {gamma} by a Novel Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Growth Arrest and Apoptosis in Breast Cancer Cells. Cancer Res. 63: 5926-5939 [Abstract] [Full Text]  
  • Zeng, H., Davis, C. D. (2003). Down-Regulation of Proliferating Cell Nuclear Antigen Gene Expression Occurs during Cell Cycle Arrest Induced by Human Fecal Water in Colonic HT-29 Cells. J. Nutr. 133: 2682-2687 [Abstract] [Full Text]  
  • Shibata, M.-A., Kavanaugh, C., Shibata, E., Abe, H., Nguyen, P., Otsuki, Y., Trepel, J. B., Green, J. E. (2003). Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models. Carcinogenesis 24: 453-459 [Abstract] [Full Text]  
  • Pellikainen, M J, Pekola, T T, Ropponen, K M, Kataja, V V, Kellokoski, J K, Eskelinen, M J, Kosma, V-M (2003). p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis. J. Clin. Pathol. 56: 214-220 [Abstract] [Full Text]  
  • Huang, Z.-y., Wu, Y., Hedrick, N., Gutmann, D. H. (2003). T-Cadherin-Mediated Cell Growth Regulation Involves G2 Phase Arrest and Requires p21CIP1/WAF1 Expression. Mol. Cell. Biol. 23: 566-578 [Abstract] [Full Text]  
  • Takada, Y., Hachiya, M., Park, S.-H., Osawa, Y., Ozawa, T., Akashi, M. (2002). Role of Reactive Oxygen Species in Cells Overexpressing Manganese Superoxide Dismutase: Mechanism for Induction of Radioresistance. Mol Cancer Res 1: 137-146 [Abstract] [Full Text]  
  • Westbrook, T. F., Nguyen, D. X., Thrash, B. R., McCance, D. J. (2002). E7 Abolishes Raf-Induced Arrest via Mislocalization of p21Cip1. Mol. Cell. Biol. 22: 7041-7052 [Abstract] [Full Text]  
  • te Poele, R. H., Okorokov, A. L., Jardine, L., Cummings, J., Joel, S. P. (2002). DNA Damage Is Able to Induce Senescence in Tumor Cells in Vitro and in Vivo. Cancer Res. 62: 1876-1883 [Abstract] [Full Text]  
  • Baccini, V., Roy, L., Vitrat, N., Chagraoui, H., Sabri, S., Couedic, J.-P. L., Debili, N., Wendling, F., Vainchenker, W. (2001). Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes. Blood 98: 3274-3282 [Abstract] [Full Text]  
  • Op De Beeck, A., Sobczak-Thepot, J., Sirma, H., Bourgain, F., Brechot, C., Caillet-Fauquet, P. (2001). NS1- and Minute Virus of Mice-Induced Cell Cycle Arrest: Involvement of p53 and p21cip1. J. Virol. 75: 11071-11078 [Abstract] [Full Text]  
  • Ando, T., Kawabe, T., Ohara, H., Ducommun, B., Itoh, M., Okamoto, T. (2001). Involvement of the Interaction between p21 and Proliferating Cell Nuclear Antigen for the Maintenance of G2/M Arrest after DNA Damage. J. Biol. Chem. 276: 42971-42977 [Abstract] [Full Text]  
  • Santini, R. P., Myrand, S., Elferink, C., Reiners, J. J. Jr. (2001). Regulation of Cyp1a1 Induction by Dioxin as a Function of Cell Cycle Phase. J. Pharmacol. Exp. Ther. 299: 718-728 [Abstract] [Full Text]  
  • Rooney, R. J. (2001). Cell Cycle Attenuation by p120E4F Is Accompanied by Increased Mitotic Dysfunction. Cell Growth Differ. 12: 505-516 [Abstract] [Full Text]  
  • Andreassen, P. R., Lacroix, F. B., Lohez, O. D., Margolis, R. L. (2001). Neither p21WAF1 Nor 14-3-3{sigma} Prevents G2 Progression to Mitotic Catastrophe in Human Colon Carcinoma Cells after DNA Damage, But p21WAF1 Induces Stable G1 Arrest in Resulting Tetraploid Cells. Cancer Res. 61: 7660-7668 [Abstract] [Full Text]  
  • Baixeras, E., Jeay, S., Kelly, P. A., Postel-Vinay, M.-C. (2001). The Proliferative and Antiapoptotic Actions of Growth Hormone and Insulin-Like Growth Factor-1 Are Mediated through Distinct Signaling Pathways in the Pro-B Ba/F3 Cell Line. Endocrinology 142: 2968-2977 [Abstract] [Full Text]  
  • Upadhyay, S., Neburi, M., Chinni, S. R., Alhasan, S., Miller, F., Sarkar, F. H. (2001). Differential Sensitivity of Normal and Malignant Breast Epithelial Cells to Genistein Is Partly Mediated by p21WAF1. Clin. Cancer Res. 7: 1782-1789 [Abstract] [Full Text]  
  • Modestou, M., Puig-Antich, V., Korgaonkar, C., Eapen, A., Quelle, D. E. (2001). The Alternative Reading Frame Tumor Suppressor Inhibits Growth through p21-dependent and p21-independent Pathways. Cancer Res. 61: 3145-3150 [Abstract] [Full Text]  
  • Jeay, S., Sonenshein, G. E., Kelly, P. A., Postel-Vinay, M.-C., Baixeras, E. (2001). Growth Hormone Exerts Antiapoptotic and Proliferative Effects through Two Different Pathways Involving Nuclear Factor-{{kappa}}B and Phosphatidylinositol 3-Kinase. Endocrinology 142: 147-156 [Abstract] [Full Text]  
  • Matushansky, I., Radparvar, F., Skoultchi, A. I. (2000). Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1. Proc. Natl. Acad. Sci. USA 10.1073/pnas.250488697v1 [Abstract] [Full Text]  
  • Dulic, V., Beney, G.-E., Frebourg, G., Drullinger, L. F., Stein, G. H. (2000). Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts. Mol. Cell. Biol. 20: 6741-6754 [Abstract] [Full Text]  
  • de la Fuente, C., Santiago, F., Chong, S. Y., Deng, L., Mayhood, T., Fu, P., Stein, D., Denny, T., Coffman, F., Azimi, N., Mahieux, R., Kashanchi, F. (2000). Overexpression of p21waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2. J. Virol. 74: 7270-7283 [Abstract] [Full Text]  
  • Scott, M. T., Morrice, N., Ball, K. L. (2000). Reversible Phosphorylation at the C-terminal Regulatory Domain of p21Waf1/Cip1 Modulates Proliferating Cell Nuclear Antigen Binding. J. Biol. Chem. 275: 11529-11537 [Abstract] [Full Text]  
  • Badie, C., Itzhaki, J. E., Sullivan, M. J., Carpenter, A. J., Porter, A. C. G. (2000). Repression of CDK1 and Other Genes with CDE and CHR Promoter Elements during DNA Damage-Induced G2/M Arrest in Human Cells. Mol. Cell. Biol. 20: 2358-2366 [Abstract] [Full Text]  
  • McVean, M., Xiao, H., Isobe, K.-i., Pelling, J. C. (2000). Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes. Carcinogenesis 21: 633-639 [Abstract] [Full Text]  
  • Senderowicz, A. M., Sausville, E. A. (2000). Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators. JNCI J Natl Cancer Inst 92: 376-387 [Abstract] [Full Text]  
  • RIEDER, C.L., COLE, R. (2000). Microscopy-induced Radiation Damage, Microtubules, and Progression through the Terminal Stage of G2 (Prophase) in Vertebrate Somatic Cells. Cold Spring Harb Symp Quant Biol 65: 369-376 [Abstract]  
  • Park, J.-S., Carter, S., Reardon, D. B., Schmidt-Ullrich, R., Dent, P., Fisher, P. B. (1999). Roles for Basal and Stimulated p21Cip-1/WAF1/MDA6 Expression and Mitogen-activated Protein Kinase Signaling in Radiation-induced Cell Cycle Checkpoint Control in Carcinoma Cells. Mol. Biol. Cell 10: 4231-4246 [Abstract] [Full Text]  
  • Harrison, L. E., Wang, Q. M., Studzinski, G. P. (1999). Butyrate-Induced G2/M Block in Caco-2 Colon Cancer Cells is Associated with Decreased p34cdc2 Activity. Exp. Biol. Med. 222: 150-156 [Abstract] [Full Text]  
  • Furuno, N., den Elzen, N., Pines, J. (1999). Human Cyclin a Is Required for Mitosis until Mid Prophase. JCB 147: 295-306 [Abstract] [Full Text]  
  • Shapiro, G. I., Koestner, D. A., Matranga, C. B., Rollins, B. J. (1999). Flavopiridol Induces Cell Cycle Arrest and p53-independent Apoptosis in Non-Small Cell Lung Cancer Cell Lines. Clin. Cancer Res. 5: 2925-2938 [Abstract] [Full Text]  
  • Passalaris, T. M., Benanti, J. A., Gewin, L., Kiyono, T., Galloway, D. A. (1999). The G2 Checkpoint Is Maintained by Redundant Pathways. Mol. Cell. Biol. 19: 5872-5881 [Abstract] [Full Text]  
  • Adams, J., Palombella, V. J., Sausville, E. A., Johnson, J., Destree, A., Lazarus, D. D., Maas, J., Pien, C. S., Prakash, S., Elliott, P. J. (1999). Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents. Cancer Res. 59: 2615-2622 [Abstract] [Full Text]  
  • Sevilla, L., Aperlo, C., Dulic, V., Chambard, J. C., Boutonnet, C., Pasquier, O., Pognonec, P., Boulukos, K. E. (1999). The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-xL-Dependent Mechanism. Mol. Cell. Biol. 19: 2624-2634 [Abstract] [Full Text]  
  • Jones, J. M., Cui, X.-S., Medina, D., Donehower, L. A. (1999). Heterozygosity of p21WAF1/CIP1 Enhances Tumor Cell Proliferation and Cyclin D1-associated Kinase Activity in a Murine Mammary Cancer Model. Cell Growth Differ. 10: 213-222 [Abstract] [Full Text]  
  • Heerdt, B. G., Houston, M. A., Anthony, G. M., Augenlicht, L. H. (1999). Initiation of Growth Arrest and Apoptosis of MCF-7 Mammary Carcinoma Cells by Tributyrin, a Triglyceride Analogue of the Short-Chain Fatty Acid Butyrate,Is Associated with Mitochondrial Activity. Cancer Res. 59: 1584-1591 [Abstract] [Full Text]  
  • Stein, G. H., Drullinger, L. F., Soulard, A., Dulic, V. (1999). Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts. Mol. Cell. Biol. 19: 2109-2117 [Abstract] [Full Text]  
  • Coco Martin, J. M., Balkenende, A., Verschoor, T., Lallemand, F., Michalides, R. (1999). Cyclin D1 Overexpression Enhances Radiation-induced Apoptosis and Radiosensitivity in a Breast Tumor Cell Line. Cancer Res. 59: 1134-1140 [Abstract] [Full Text]  
  • Gutterman, J. U., Choubey, D. (1999). Retardation of Cell Proliferation after Expression of p202 Accompanies an Increase in p21WAF1/CIP1. Cell Growth Differ. 10: 93-100 [Abstract] [Full Text]  
  • Eskew, J. D., Vanacore, R. M., Sung, L., Morales, P. J., Smith, A. (1999). Cellular Protection Mechanisms against Extracellular Heme. HEME-HEMOPEXIN, BUT NOT FREE HEME, ACTIVATES THE N-TERMINAL c-Jun KINASE. J. Biol. Chem. 274: 638-648 [Abstract] [Full Text]  
  • Bastians, H., Townsley, F. M., Ruderman, J. V. (1998). The cyclin-dependent kinase inhibitor p27Kip1 induces N-terminal proteolytic cleavage of cyclin A. Proc. Natl. Acad. Sci. USA 95: 15374-15381 [Abstract] [Full Text]  
  • Hengst, L., Göpfert, U., Lashuel, H. A., Reed, S. I. (1998). Complete inhibition of Cdk/cyclin by one molecule of p21Cip1. Genes Dev. 12: 3882-3888 [Abstract] [Full Text]  
  • Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., Vogelstein, B. (1998). Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage. Science 282: 1497-1501 [Abstract] [Full Text]  
  • Cai, K., Dynlacht, B. D. (1998). Activity and nature of p21WAF1 complexes during the cell cycle. Proc. Natl. Acad. Sci. USA 95: 12254-12259 [Abstract] [Full Text]  
  • Patel, R, Bartosch, B, Blank, J. (1998). p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression. J. Cell Sci. 111: 2247-2255 [Abstract]  
  • Niculescu, A. B. III, Chen, X., Smeets, M., Hengst, L., Prives, C., Reed, S. I. (1998). Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication. Mol. Cell. Biol. 18: 629-643 [Abstract] [Full Text]  
  • Jin, S., Antinore, M. J., Lung, F.-D. T., Dong, X., Zhao, H., Fan, F., Colchagie, A. B., Blanck, P., Roller, P. P., Fornace, A. J. Jr., Zhan, Q. (2000). The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression. J. Biol. Chem. 275: 16602-16608 [Abstract] [Full Text]  
  • Coqueret, O., Gascan, H. (2000). Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21WAF1/CIP1/SDI1. J. Biol. Chem. 275: 18794-18800 [Abstract] [Full Text]  
  • McShea, A., Samuel, T., Eppel, J.-T., Galloway, D. A., Funk, J. O. (2000). Identification of CIP-1-associated Regulator of Cyclin B (CARB), a Novel p21-binding Protein Acting in the G2 Phase of the Cell Cycle. J. Biol. Chem. 275: 23181-23186 [Abstract] [Full Text]  
  • Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., Kambadur, R. (2000). Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation. J. Biol. Chem. 275: 40235-40243 [Abstract] [Full Text]  
  • Yang, Q., Manicone, A., Coursen, J. D., Linke, S. P., Nagashima, M., Forgues, M., Wang, X. W. (2000). Identification of a Functional Domain in a GADD45-mediated G2/M Checkpoint. J. Biol. Chem. 275: 36892-36898 [Abstract] [Full Text]  
  • Smits, V. A. J., Klompmaker, R., Vallenius, T., Rijksen, G., Makela, T. P., Medema, R. H. (2000). p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint. J. Biol. Chem. 275: 30638-30643 [Abstract] [Full Text]  
  • Khanna, S. J., Brown, R., Whetton, A. D., Ball, K. L., Dive, C. (2001). v-Abl Protein-tyrosine Kinase Up-regulates p21WAF-1 in Cell Cycle Arrested and Proliferating Myeloid Cells. J. Biol. Chem. 276: 11143-11150 [Abstract] [Full Text]  
  • Arima, N., Kao, C.-Y., Licht, T., Padmanabhan, R., Sasaguri, Y., Padmanabhan, R. (2001). Modulation of Cell Growth by the Hepatitis C Virus Nonstructural Protein NS5A. J. Biol. Chem. 276: 12675-12684 [Abstract] [Full Text]  
  • Ciciarello, M., Mangiacasale, R., Casenghi, M., Zaira Limongi, M., D'Angelo, M., Soddu, S., Lavia, P., Cundari, E. (2001). p53 Displacement from Centrosomes and p53-mediated G1 Arrest following Transient Inhibition of the Mitotic Spindle. J. Biol. Chem. 276: 19205-19213 [Abstract] [Full Text]  
  • Holmes-McNary, M. Q., Baldwin, A. S. Jr., Zeisel, S. H. (2001). Opposing Regulation of Choline Deficiency-induced Apoptosis by p53 and Nuclear Factor kappa B. J. Biol. Chem. 276: 41197-41204 [Abstract] [Full Text]  
  • Matushansky, I., Radparvar, F., Skoultchi, A. I. (2000). Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1. Proc. Natl. Acad. Sci. USA 97: 14317-14322 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»