MFR, a Putative Receptor Mediating the Fusion of Macrophages

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Molecular and Cellular Biology, November 1998, p. 6213-6223, Vol. 18, No. 11
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

MFR, a Putative Receptor Mediating the Fusion of Macrophages

Charles Saginario,¹ Hyacinth Sterling,¹^,² Cornelius Beckers,³ Ruji Kobayashi,⁴ Michele Solimena,⁵ Elisabetta Ullu,¹^,³ and Agnès Vignery¹^,²^,^*

Department of Cell Biology,¹ Department of Medicine, Section of Infectious Diseases,³ Department of Medicine, Section of Endocrinology,⁵ and Department of Orthopaedics and Rehabilitation,² Yale University School of Medicine, New Haven, Connecticut, and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York⁴

Received 26 March 1998/Returned for modification 15 July 1998/Accepted 31 July 1998

We had previously identified a macrophage surface protein whose expression is highly induced, transient, and specific, asit is restricted to actively fusing macrophages in vitro and invivo. This protein is recognized by monoclonal antibodies thatblock macrophage fusion. We have now purified this protein andcloned its corresponding cDNA. This protein belongs to the superfamilyof immunoglobulins and is similar to immune antigen receptorssuch as the T-cell receptor, B-cell receptor, and viral receptorssuch as CD4. We have therefore named this protein macrophage fusionreceptor (MFR). We show that the extracellular domain of MFR preventsfusion of macrophages in vitro and therefore propose that MFRbelongs to the fusion machinery of macrophages. MFR is identicalto SHPS-1 and BIT and is a homologue of P84, SIRP $alpha$ , and MyD-1,all of which have been recently cloned and implicated in cellsignaling and cell-cell interaction events.

^* Corresponding author. Mailing address: Yale University School of Medicine, Department of Orthopaedics and Rehabilitation,333 Cedar St., New Haven, CT 06510. Phone: (203) 785-5968. Fax:(203) 737-2701. E-mail: agnes.vignery{at}yale.edu.

Molecular and Cellular Biology, November 1998, p. 6213-6223, Vol. 18, No. 11
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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