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Molecular and Cellular Biology, November 1998, p. 6595-6604, Vol. 18, No. 11
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Physical and Functional Interactions between Type I Transforming Growth Factor beta  Receptors and Balpha , a WD-40 Repeat Subunit of Phosphatase 2A

Irene Griswold-Prenner,1,2,dagger Craig Kamibayashi,3 E. Miko Maruoka,1 Marc C. Mumby,3 and Rik Derynck1,2,4,*

Departments of Growth and Development1 and Anatomy4 and Programs in Cell Biology and Developmental Biology,2 University of California at San Francisco, San Francisco, California 94143-0640, and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 752353

Received 29 January 1998/Returned for modification 12 March 1998/Accepted 20 August 1998

We have previously shown that a WD-40 repeat protein, TRIP-1, associates with the type II transforming growth factor beta  (TGF-beta ) receptor. In this report, we show that another WD-40 repeat protein, the Balpha subunit of protein phosphatase 2A, associates with the cytoplasmic domain of type I TGF-beta receptors. This association depends on the kinase activity of the type I receptor, is increased by coexpression of the type II receptor, which is known to phosphorylate and activate the type I receptor, and allows the type I receptor to phosphorylate Balpha . Furthermore, Balpha enhances the growth inhibition activity of TGF-beta in a receptor-dependent manner. Because Balpha has been characterized as a regulator of phosphatase 2A activity, our observations suggest possible functional interactions between the TGF-beta receptor complex and the regulation of protein phosphatase 2A.

* Corresponding author. Mailing address: Department of Growth and Development, University of California at San Francisco, San Francisco, CA 94143-0640. Phone: (415) 476 7322. Fax: (415) 476 1499. E-mail: derynck{at}itsa.ucsf.edu.

dagger Present address: Athena Neurosciences, South San Francisco, CA 94080.

Molecular and Cellular Biology, November 1998, p. 6595-6604, Vol. 18, No. 11
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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