This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haft, C. R.
Right arrow Articles by Taylor, S. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haft, C. R.
Right arrow Articles by Taylor, S. I.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, December 1998, p. 7278-7287, Vol. 18, No. 12
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors

Carol Renfrew Haft,1,* Maria de la Luz Sierra,1 Valarie A. Barr,1 Daniel H. Haft,2 and Simeon I. Taylor1

Diabetes Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 and National Biomedical Research Foundation, Washington, D.C.2

Received 31 December 1997/Returned for modification 6 March 1998/Accepted 8 September 1998

Sorting nexin 1 (SNX1) is a protein that binds to the epidermal growth factor (EGF) receptor and is proposed to play a role in directing EGF receptors to lysosomes for degradation (R. C. Kurten, D. L. Cadena, and G. N. Gill, Science 272:1008-1010, 1996). We have obtained full-length cDNAs and deduced the amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4). In addition, we identified a presumed splice variant isoform of SNX1 (SNX1A). These molecules contain a conserved domain of ~100 amino acids, which was termed the phox homology (PX) domain. Human SNX1 (522 amino acids), SNX1A (457 amino acids), SNX2 (519 amino acids), SNX3 (162 amino acids), and SNX4 (450 amino acids) are part of a larger family of hydrophilic molecules including proteins identified in Caenorhabditis elegans and Saccharomyces cerevisiae. Despite their hydrophilic nature, the sorting nexins are found partially associated with cellular membranes. They are widely expressed, although the tissue distribution of each sorting nexin mRNA varies. When expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SNX1A, SNX2, and SNX4 coimmunoprecipitated with receptor tyrosine kinases for EGF, platelet-derived growth factor, and insulin. These sorting nexins also associated with the long isoform of the leptin receptor but not with the short and medium isoforms. Interestingly, endogenous COS7 transferrin receptors associated exclusively with SNX1 and SNX1A, while SNX3 was not found to associate with any of the receptors studied. Our demonstration of a large conserved family of sorting nexins that interact with a variety of receptor types suggests that these proteins may be involved in several stages of intracellular trafficking in mammalian cells.

* Corresponding author. Mailing address: National Institutes of Health, Building 10, Room 8S-235A, 10 Center Dr. MSC-1770, Bethesda, MD 20892-1770. Phone: (301) 402-1629. Fax: (301) 402-0573. E-mail: carol_haft{at}nih.gov.

Molecular and Cellular Biology, December 1998, p. 7278-7287, Vol. 18, No. 12
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Katz, M. E., Evans, C. J., Heagney, E. E., vanKuyk, P. A., Kelly, J. M., Cheetham, B. F. (2009). Mutations in Genes Encoding Sorting Nexins Alter Production ofIntracellular and Extracellular Proteases in Aspergillus nidulans. Genetics 181: 1239-1247 [Abstract] [Full Text]  
  • Du, J. X., Bialkowska, A. B., McConnell, B. B., Yang, V. W. (2008). SUMOylation Regulates Nuclear Localization of Kruppel-like Factor 5. J. Biol. Chem. 283: 31991-32002 [Abstract] [Full Text]  
  • Raymond, A.-A., de Peredo, A. G., Stella, A., Ishida-Yamamoto, A., Bouyssie, D., Serre, G., Monsarrat, B., Simon, M. (2008). Lamellar Bodies of Human Epidermis: Proteomics Characterization by High Throughput Mass Spectrometry and Possible Involvement of CLIP-170 in their Trafficking/Secretion. Mol. Cell. Proteomics 7: 2151-2175 [Abstract] [Full Text]  
  • Cavet, M. E., Pang, J., Yin, G., Berk, B. C. (2008). An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 22: 3607-3616 [Abstract] [Full Text]  
  • Lee, J., Retamal, C., Cuitino, L., Caruano-Yzermans, A., Shin, J.-E., van Kerkhof, P., Marzolo, M.-P., Bu, G. (2008). Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes. J. Biol. Chem. 283: 11501-11508 [Abstract] [Full Text]  
  • Acevedo, N., Ding, J., Smith, G. D (2007). Insulin Signaling in Mouse Oocytes. Biol. Reprod. 77: 872-879 [Abstract] [Full Text]  
  • Muller, J., Mettbach, U., Menzel, D., Samaj, J. (2007). Molecular Dissection of Endosomal Compartments in Plants. Plant Physiol. 145: 293-304 [Full Text]  
  • Bujny, M. V., Popoff, V., Johannes, L., Cullen, P. J. (2007). The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network. J. Cell Sci. 120: 2010-2021 [Abstract] [Full Text]  
  • Rojas, R., Kametaka, S., Haft, C. R., Bonifacino, J. S. (2007). Interchangeable but Essential Functions of SNX1 and SNX2 in the Association of Retromer with Endosomes and the Trafficking of Mannose 6-Phosphate Receptors. Mol. Cell. Biol. 27: 1112-1124 [Abstract] [Full Text]  
  • Wassmer, T., Attar, N., Bujny, M. V., Oakley, J., Traer, C. J., Cullen, P. J. (2007). A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer. J. Cell Sci. 120: 45-54 [Abstract] [Full Text]  
  • Nguyen, L. N., Holdren, M. S., Nguyen, A. P., Furuya, M. H., Bianchini, M., Levy, E., Mordoh, J., Liu, A., Guncay, G. D., Campbell, J. S., Parks, W. T. (2006). Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis. Clin. Cancer Res. 12: 6952-6959 [Abstract] [Full Text]  
  • Gullapalli, A., Wolfe, B. L., Griffin, C. T., Magnuson, T., Trejo, J. (2006). An Essential Role for SNX1 in Lysosomal Sorting of Protease-activated Receptor-1: Evidence for Retromer-, Hrs-, and Tsg101-independent Functions of Sorting Nexins. Mol. Biol. Cell 17: 1228-1238 [Abstract] [Full Text]  
  • Lindmo, K., Stenmark, H. (2006). Regulation of membrane traffic by phosphoinositide 3-kinases. J. Cell Sci. 119: 605-614 [Abstract] [Full Text]  
  • Nakada-Tsukui, K., Saito-Nakano, Y., Ali, V., Nozaki, T. (2005). A Retromerlike Complex Is a Novel Rab7 Effector That Is Involved in the Transport of the Virulence Factor Cysteine Protease in the Enteric Protozoan Parasite Entamoeba histolytica. Mol. Biol. Cell 16: 5294-5303 [Abstract] [Full Text]  
  • Griffin, C. T., Trejo, J., Magnuson, T. (2005). Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc. Natl. Acad. Sci. USA 102: 15173-15177 [Abstract] [Full Text]  
  • Carlton, J. G., Bujny, M. V., Peter, B. J., Oorschot, V. M. J., Rutherford, A., Arkell, R. S., Klumperman, J., McMahon, H. T., Cullen, P. J. (2005). Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. J. Cell Sci. 118: 4527-4539 [Abstract] [Full Text]  
  • Zhong, Q., Watson, M. J., Lazar, C. S., Hounslow, A. M., Waltho, J. P., Gill, G. N. (2005). Determinants of the Endosomal Localization of Sorting Nexin 1. Mol. Biol. Cell 16: 2049-2057 [Abstract] [Full Text]  
  • Heydorn, A., Sondergaard, B. P., Ersboll, B., Holst, B., Nielsen, F. C., Haft, C. R., Whistler, J., Schwartz, T. W. (2004). A Library of 7TM Receptor C-terminal Tails: INTERACTIONS WITH THE PROPOSED POST-ENDOCYTIC SORTING PROTEINS ERM-BINDING PHOSPHOPROTEIN 50 (EBP50), N-ETHYLMALEIMIDE-SENSITIVE FACTOR (NSF), SORTING NEXIN 1 (SNX1), AND G PROTEIN-COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN (GASP). J. Biol. Chem. 279: 54291-54303 [Abstract] [Full Text]  
  • Lim, K.-P., Hong, W. (2004). Human Nischarin/Imidazoline Receptor Antisera-selected Protein Is Targeted to the Endosomes by a Combined Action of a PX Domain and a Coiled-coil Region. J. Biol. Chem. 279: 54770-54782 [Abstract] [Full Text]  
  • Merino-Trigo, A., Kerr, M. C., Houghton, F., Lindberg, A., Mitchell, C., Teasdale, R. D., Gleeson, P. A. (2004). Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. J. Cell Sci. 117: 6413-6424 [Abstract] [Full Text]  
  • Zheng, B., Lavoie, C., Tang, T.-D., Ma, P., Meerloo, T., Beas, A., Farquhar, M. G. (2004). Regulation of Epidermal Growth Factor Receptor Degradation by Heterotrimeric G{alpha}s Protein. Mol. Biol. Cell 15: 5538-5550 [Abstract] [Full Text]  
  • Choi, J. H., Hong, W.-P., Kim, M. J., Kim, J. H., Ryu, S. H., Suh, P.-G. (2004). Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J. Cell Sci. 117: 4209-4218 [Abstract] [Full Text]  
  • Roth, M. G. (2004). Phosphoinositides in Constitutive Membrane Traffic. Physiol. Rev. 84: 699-730 [Abstract] [Full Text]  
  • Bard, M. P., Hegmans, J. P., Hemmes, A., Luider, T. M., Willemsen, R., Severijnen, L.-A. A., van Meerbeeck, J. P., Burgers, S. A., Hoogsteden, H. C., Lambrecht, B. N. (2004). Proteomic Analysis of Exosomes Isolated from Human Malignant Pleural Effusions. Am. J. Respir. Cell Mol. Bio. 31: 114-121 [Abstract] [Full Text]  
  • Koga, T., Onishi, M., Nakamura, Y., Hirata, A., Nakamura, T., Shimoda, C., Iwaki, T., Takegawa, K., Fukui, Y. (2004). Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. GENES CELLS 9: 561-574 [Abstract] [Full Text]  
  • Gullapalli, A., Garrett, T. A., Paing, M. M., Griffin, C. T., Yang, Y., Trejo, J. (2004). A Role for Sorting Nexin 2 in Epidermal Growth Factor Receptor Down-regulation: Evidence for Distinct Functions of Sorting Nexin 1 and 2 in Protein Trafficking. Mol. Biol. Cell 15: 2143-2155 [Abstract] [Full Text]  
  • Burden, J. J., Sun, X.-M., Garcia, A. B. G., Soutar, A. K. (2004). Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17. J. Biol. Chem. 279: 16237-16245 [Abstract] [Full Text]  
  • Seaman, M. N.J. (2004). Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. JCB 165: 111-122 [Abstract] [Full Text]  
  • Arighi, C. N., Hartnell, L. M., Aguilar, R. C., Haft, C. R., Bonifacino, J. S. (2004). Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. JCB 165: 123-133 [Abstract] [Full Text]  
  • Nilsen, T., Slagsvold, T., Skjerpen, C. S., Brech, A., Stenmark, H., Olsnes, S. (2004). Peroxisomal Targeting as a Tool for Assaying Protein-Protein Interactions in the Living Cell: CYTOKINE-INDEPENDENT SURVIVAL KINASE (CISK) BINDS PDK-1 IN VIVO IN A PHOSPHORYLATION-DEPENDENT MANNER. J. Biol. Chem. 279: 4794-4801 [Abstract] [Full Text]  
  • Zhou, C.-Z., Li de La Sierra-Gallay, I., Quevillon-Cheruel, S., Collinet, B., Minard, P., Blondeau, K., Henckes, G., Aufrere, R., Leulliot, N., Graille, M., Sorel, I., Savarin, P., de la Torre, F., Poupon, A., Janin, J., van Tilbeurgh, H. (2003). Crystal Structure of the Yeast Phox Homology (PX) Domain Protein Grd19p Complexed to Phosphatidylinositol-3-phosphate. J. Biol. Chem. 278: 50371-50376 [Abstract] [Full Text]  
  • Trejo, J. (2003). Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking. J. Pharmacol. Exp. Ther. 307: 437-442 [Abstract] [Full Text]  
  • Vanoosthuyse, V., Tichtinsky, G., Dumas, C., Gaude, T., Cock, J. M. (2003). Interaction of Calmodulin, a Sorting Nexin and Kinase-Associated Protein Phosphatase with the Brassica oleracea S Locus Receptor Kinase. Plant Physiol. 133: 919-929 [Abstract] [Full Text]  
  • Petiot, A., Faure, J., Stenmark, H., Gruenberg, J. (2003). PI3P signaling regulates receptor sorting but not transport in the endosomal pathway. JCB 162: 971-979 [Abstract] [Full Text]  
  • Hanson, B. J., Hong, W. (2003). Evidence for a Role of SNX16 in Regulating Traffic between the Early and Later Endosomal Compartments. J. Biol. Chem. 278: 34617-34630 [Abstract] [Full Text]  
  • Leprince, C., Le Scolan, E., Meunier, B., Fraisier, V., Brandon, N., De Gunzburg, J., Camonis, J. (2003). Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J. Cell Sci. 116: 1937-1948 [Abstract] [Full Text]  
  • Ago, T., Kuribayashi, F., Hiroaki, H., Takeya, R., Ito, T., Kohda, D., Sumimoto, H. (2003). Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc. Natl. Acad. Sci. USA 100: 4474-4479 [Abstract] [Full Text]  
  • Koch, T., Brandenburg, L.-O., Schulz, S., Liang, Y., Klein, J., Hollt, V. (2003). ADP-ribosylation Factor-dependent Phospholipase D2 Activation Is Required for Agonist-induced {micro}-Opioid Receptor Endocytosis. J. Biol. Chem. 278: 9979-9985 [Abstract] [Full Text]  
  • Lal, S. K., Giroux, M. J., Brendel, V., Vallejos, C. E., Hannah, L. C. (2003). The Maize Genome Contains a Helitron Insertion. Plant Cell 15: 381-391 [Abstract] [Full Text]  
  • Cozier, G. E., Carlton, J., McGregor, A. H., Gleeson, P. A., Teasdale, R. D., Mellor, H., Cullen, P. J. (2002). The Phox Homology (PX) Domain-dependent, 3-Phosphoinositide-mediated Association of Sorting Nexin-1 with an Early Sorting Endosomal Compartment Is Required for Its Ability to Regulate Epidermal Growth Factor Receptor Degradation. J. Biol. Chem. 277: 48730-48736 [Abstract] [Full Text]  
  • Vervoort, V S, Viljoen, D, Smart, R, Suthers, G, DuPont, B R, Abbott, A, Schwartz, C E (2002). Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype. J. Med. Genet. 39: 893-899 [Abstract] [Full Text]  
  • Pennisi, P. A., Barr, V., Nunez, N. P., Stannard, B., Le Roith, D. (2002). Reduced Expression of Insulin-like Growth Factor I Receptors in MCF-7 Breast Cancer Cells Leads to a More Metastatic Phenotype. Cancer Res. 62: 6529-6537 [Abstract] [Full Text]  
  • Burda, P., Padilla, S. M., Sarkar, S., Emr, S. D. (2002). Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J. Cell Sci. 115: 3889-3900 [Abstract] [Full Text]  
  • Schwarz, D. G., Griffin, C. T., Schneider, E. A., Yee, D., Magnuson, T. (2002). Genetic Analysis of Sorting Nexins 1 and 2 Reveals a Redundant and Essential Function in Mice. Mol. Biol. Cell 13: 3588-3600 [Abstract] [Full Text]  
  • Hayashi, S., Okada, T., Igarashi, N., Fujita, T., Jahangeer, S., Nakamura, S.-i. (2002). Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein. J. Biol. Chem. 277: 33319-33324 [Abstract] [Full Text]  
  • Nice, D. C., Sato, T. K., Stromhaug, P. E., Emr, S. D., Klionsky, D. J. (2002). Cooperative Binding of the Cytoplasm to Vacuole Targeting Pathway Proteins, Cvt13 and Cvt20, to Phosphatidylinositol 3-Phosphate at the Pre-autophagosomal Structure Is Required for Selective Autophagy. J. Biol. Chem. 277: 30198-30207 [Abstract] [Full Text]  
  • Seaman, M. N.J., Williams, H. P. (2002). Identification of the Functional Domains of Yeast Sorting Nexins Vps5p and Vps17p. Mol. Biol. Cell 13: 2826-2840 [Abstract] [Full Text]  
  • Wang, Y., Zhou, Y., Szabo, K., Haft, C. R., Trejo, J. (2002). Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1. Mol. Biol. Cell 13: 1965-1976 [Abstract] [Full Text]  
  • Zhong, Q., Lazar, C. S., Tronchere, H., Sato, T., Meerloo, T., Yeo, M., Songyang, Z., Emr, S. D., Gill, G. N. (2002). Endosomal localization and function of sorting nexin 1. Proc. Natl. Acad. Sci. USA 99: 6767-6772 [Abstract] [Full Text]  
  • Ellson, C. D., Andrews, S., Stephens, L. R., Hawkins, P. T. (2002). The PX domain: a new phosphoinositide-binding module. J. Cell Sci. 115: 1099-1105 [Abstract] [Full Text]  
  • Sato, T. K., Overduin, M., Emr, S. D. (2001). Location, Location, Location: Membrane Targeting Directed by PX Domains. Science 294: 1881-1885 [Abstract] [Full Text]  
  • Zheng, B., Ma, Y.-C., Ostrom, R. S., Lavoie, C., Gill, G. N., Insel, P. A., Huang, X.-Y., Farquhar, M. G. (2001). RGS-PX1, a GAP for Galpha s and Sorting Nexin in Vesicular Trafficking. Science 294: 1939-1942 [Abstract] [Full Text]  
  • Yu, J. W., Lemmon, M. A. (2001). All Phox Homology (PX) Domains from Saccharomyces cerevisiae Specifically Recognize Phosphatidylinositol 3-Phosphate. J. Biol. Chem. 276: 44179-44184 [Abstract] [Full Text]  
  • Worby, C. A., Simonson-Leff, N., Clemens, J. C., Kruger, R. P., Muda, M., Dixon, J. E. (2001). The Sorting Nexin, DSH3PX1, Connects the Axonal Guidance Receptor, Dscam, to the Actin Cytoskeleton. J. Biol. Chem. 276: 41782-41789 [Abstract] [Full Text]  
  • Xu, J., Liu, D., Gill, G., Songyang, Z. (2001). Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. JCB 154: 699-706 [Abstract] [Full Text]  
  • Fuchs, U., Rehkamp, G., Haas, O. A., Slany, R., Konig, M., Bojesen, S., Bohle, R. M., Damm-Welk, C., Ludwig, W.-D., Harbott, J., Borkhardt, A. (2001). The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc. Natl. Acad. Sci. USA 10.1073/pnas.121433898v1 [Abstract] [Full Text]  
  • Kurten, R., Eddington, A., Chowdhury, P, Smith, R., Davidson, A., Shank, B. (2001). Self-assembly and binding of a sorting nexin to sorting endosomes. J. Cell Sci. 114: 1743-1756 [Abstract]  
  • Iwami, K.-i., Matsuguchi, T., Masuda, A., Kikuchi, T., Musikacharoen, T., Yoshikai, Y. (2000). Cutting Edge: Naturally Occurring Soluble Form of Mouse Toll-Like Receptor 4 Inhibits Lipopolysaccharide Signaling. J. Immunol. 165: 6682-6686 [Abstract] [Full Text]  
  • Haft, C. R., Sierra, M. d. l. L., Bafford, R., Lesniak, M. A., Barr, V. A., Taylor, S. I. (2000). Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes. Mol. Biol. Cell 11: 4105-4116 [Abstract] [Full Text]  
  • Brown, M. P. S., Grundy, W. N., Lin, D., Cristianini, N., Sugnet, C. W., Furey, T. S., Ares, M. Jr., Haussler, D. (2000). Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc. Natl. Acad. Sci. USA 97: 262-267 [Abstract] [Full Text]  
  • Howard, L., Nelson, K. K., Maciewicz, R. A., Blobel, C. P. (1999). Interaction of the Metalloprotease Disintegrins MDC9 and MDC15 with Two SH3 Domain-containing Proteins, Endophilin I and SH3PX1. J. Biol. Chem. 274: 31693-31699 [Abstract] [Full Text]  
  • Chin, L.-S., Raynor, M. C., Wei, X., Chen, H.-Q., Li, L. (2001). Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor. J. Biol. Chem. 276: 7069-7078 [Abstract] [Full Text]  
  • Phillips, S. A., Barr, V. A., Haft, D. H., Taylor, S. I., Haft, C. R. (2001). Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking. J. Biol. Chem. 276: 5074-5084 [Abstract] [Full Text]  
  • Parks, W. T., Frank, D. B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M. P., McNally, J. G., Reddi, A., Taylor, S. I., Roberts, A. B., Wang, T., Lechleider, R. J. (2001). Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-beta Family of Receptor Serine-Threonine Kinases. J. Biol. Chem. 276: 19332-19339 [Abstract] [Full Text]  
  • Shiina, T., Kawasaki, A., Nagao, T., Kurose, H. (2000). Interaction with beta -Arrestin Determines the Difference in Internalization Behavior between beta 1- and beta 2-Adrenergic Receptors. J. Biol. Chem. 275: 29082-29090 [Abstract] [Full Text]  
  • Fuchs, U., Rehkamp, G., Haas, O. A., Slany, R., Konig, M., Bojesen, S., Bohle, R. M., Damm-Welk, C., Ludwig, W.-D., Harbott, J., Borkhardt, A. (2001). The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc. Natl. Acad. Sci. USA 98: 8756-8761 [Abstract] [Full Text]  
  • Jones, S. M., Foreman, S. K., Shank, B. B., Kurten, R. C. (2002). EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain. Am. J. Physiol. Cell Physiol. 282: C420-C433 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»