This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahn, S.
Right arrow Articles by Vinson, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahn, S.
Right arrow Articles by Vinson, C.

 Previous Article  |  Next Article 

Mol Cell Biol, February 1998, p. 967-977, Vol. 18, No. 2
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

Sohyun Ahn,1 Michelle Olive,2 Seema Aggarwal,1 Dmitry Krylov,2 David D. Ginty,1,* and Charles Vinson2,*

Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892,2 and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 212051

Received 7 July 1997/Returned for modification 5 September 1997/Accepted 20 November 1997

Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos transcription in response to a variety of extracellular stimuli. Although several transcription factors can bind to CREs in vitro, the identity of the transcription factor(s) that activates the c-fos promoter via the CRE in vivo remains unclear. To help identify the trans-acting factors that regulate stimulus-dependent transcription of c-fos via the CREs, dominant-negative (D-N) inhibitor proteins that function by preventing DNA binding of B-ZIP proteins in a dimerization domain-dependent fashion were developed. A D-N inhibitor of CREB, termed A-CREB, was constructed by fusing a designed acidic amphipathic extension onto the N terminus of the CREB leucine zipper domain. The acidic extension of A-CREB interacts with the basic region of CREB forming a coiled-coil extension of the leucine zipper and thus prevents the basic region of wild-type CREB from binding to DNA. Other D-N inhibitors generated in a similar manner with the dimerization domains of Fos, Jun, C/EBP, ATF-2, or VBP did not block CREB DNA binding activity, nor did they inhibit transcriptional activation of a minimal promoter containing a single CRE in PC12 cells. A-CREB inhibited activation of CRE-mediated transcription evoked by three distinct stimuli: forskolin, which increases intracellular cAMP; membrane depolarization, which promotes Ca2+ influx; and nerve growth factor (NGF). A-CREB completely inhibited cAMP-mediated, but only partially inhibited Ca2+- and NGF-mediated, transcription of a reporter gene containing 750 bp of the native c-fos promoter. Moreover, glutamate induction of c-fos expression in primary cortical neurons was dependent on CREB. In contrast, induction of c-fos transcription by UV light was not inhibited by A-CREB. Lastly, A-CREB attenuated NGF induction of morphological differentiation in PC12 cells. These results suggest that CREB or its closely related family members are general mediators of stimulus-dependent transcription of c-fos and are required for at least some of the long-term actions of NGF.

* Corresponding author. Mailing address for David D. Ginty: Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205-2185. Phone: (410) 614-9494. Fax: (410) 614-8423. E-mail: david_ginty{at}qmail.bs.jhu.edu. Mailing address for Charles Vinson: Building 37, Room 4D06, Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 496-8753. Fax: (301) 402-3095. E-mail: VinsonC{at}dc37a.nci.nih.gov.




This article has been cited by other articles:

  • Jancic, D., Lopez de Armentia, M., Valor, L. M., Olivares, R., Barco, A. (2009). Inhibition of cAMP Response Element-Binding Protein Reduces Neuronal Excitability and Plasticity, and Triggers Neurodegeneration. Cereb Cortex 19: 2535-2547 [Abstract] [Full Text]  
  • Jeng, Y.-J., Soloff, M. S. (2009). Characterization of the Cyclic Adenosine Monophosphate Target Site in the Oxytocin Receptor Gene in Rabbit Amnion. Biol. Reprod. 81: 473-479 [Abstract] [Full Text]  
  • Seoane, A., Massey, P. V., Keen, H., Bashir, Z. I., Brown, M. W. (2009). L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes. J. Neurosci. 29: 9534-9544 [Abstract] [Full Text]  
  • Siddiq, A., Aminova, L. R., Troy, C. M., Suh, K., Messer, Z., Semenza, G. L., Ratan, R. R. (2009). Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways. J. Neurosci. 29: 8828-8838 [Abstract] [Full Text]  
  • Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F. H., Song, H., Lie, D. C. (2009). GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus. J. Neurosci. 29: 7966-7977 [Abstract] [Full Text]  
  • Rozenberg, J., Rishi, V., Orosz, A., Moitra, J., Glick, A., Vinson, C. (2009). Inhibition of CREB Function in Mouse Epidermis Reduces Papilloma Formation. Mol Cancer Res 7: 654-664 [Abstract] [Full Text]  
  • Merot, Y., Ferriere, F., Gailhouste, L., Huet, G., Percevault, F., Saligaut, C., Flouriot, G. (2009). Different Outcomes of Unliganded and Liganded Estrogen Receptor-{alpha} on Neurite Outgrowth in PC12 Cells. Endocrinology 150: 200-211 [Abstract] [Full Text]  
  • Siu, Y.-T., Ching, Y.-P., Jin, D.-Y. (2008). Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation. Mol. Biol. Cell 19: 4750-4761 [Abstract] [Full Text]  
  • Chen, Y.-L., Jian, M.-H., Lin, C.-C., Kang, J.-C., Chen, S.-P., Lin, P.-C., Hung, P.-J., Chen, J.-R., Chang, W.-L., Lin, S.-Z., Harn, H.-J. (2008). The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy. Mol. Pharmacol. 74: 1046-1058 [Abstract] [Full Text]  
  • Meyuhas, R., Pikarsky, E., Tavor, E., Klar, A., Abramovitch, R., Hochman, J., Lago, T. G., Honigman, A. (2008). A Key Role for Cyclic AMP-Responsive Element Binding Protein in Hypoxia-Mediated Activation of the Angiogenesis Factor CCN1 (CYR61) in Tumor Cells. Mol Cancer Res 6: 1397-1409 [Abstract] [Full Text]  
  • Ciccone, N. A., Lacza, C. T., Hou, M. Y., Gregory, S. J., Kam, K.-Y., Xu, S., Kaiser, U. B. (2008). A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene. Mol. Endocrinol. 22: 1908-1923 [Abstract] [Full Text]  
  • Simonetti, M., Giniatullin, R., Fabbretti, E. (2008). Mechanisms Mediating the Enhanced Gene Transcription of P2X3 Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons. J. Biol. Chem. 283: 18743-18752 [Abstract] [Full Text]  
  • Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., Impey, S. (2008). An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc. Natl. Acad. Sci. USA 105: 9093-9098 [Abstract] [Full Text]  
  • Schubert, S. W., Abendroth, A., Kilian, K., Vogler, T., Mayr, B., Knerr, I., Hashemolhosseini, S. (2008). bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cells. Nucleic Acids Res 36: 3834-3846 [Abstract] [Full Text]  
  • Kim, C., Wilcox-Adelman, S., Sano, Y., Tang, W.-J., Collier, R. J., Park, J. M. (2008). From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc. Natl. Acad. Sci. USA 105: 6150-6155 [Abstract] [Full Text]  
  • Wang, O., Cai, K., Pang, S., Wang, T., Qi, D., Zhu, Q., Ni, Z., Le, Y. (2008). Mechanisms of Glucose-Induced Expression of Pancreatic-Derived Factor in Pancreatic {beta}-Cells. Endocrinology 149: 672-680 [Abstract] [Full Text]  
  • Jalvy, S., Renault, M.-A., Leen, L. L. S., Belloc, I., Bonnet, J., Gadeau, A.-P., Desgranges, C. (2007). Autocrine expression of osteopontin contributes to PDGF-mediated arterial smooth muscle cell migration. Cardiovasc Res 75: 738-747 [Abstract] [Full Text]  
  • Chepurny, O. G., Holz, G. G. (2007). A Novel Cyclic Adenosine Monophosphate Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance for Use in G Protein Coupled Receptor Drug Discovery Efforts. J Biomol Screen 12: 740-746 [Abstract]  
  • Kim, H.-P., Leonard, W. J. (2007). CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. JEM 204: 1543-1551 [Abstract] [Full Text]  
  • Jalvy, S., Renault, M.-A., Lam Shang Leen, L., Belloc, I., Reynaud, A., Gadeau, A.-P., Desgranges, C. (2007). CREB Mediates UTP-Directed Arterial Smooth Muscle Cell Migration and Expression of the Chemotactic Protein Osteopontin via Its Interaction with Activator Protein-1 Sites. Circ. Res. 100: 1292-1299 [Abstract] [Full Text]  
  • Rohas, L. M., St-Pierre, J., Uldry, M., Jager, S., Handschin, C., Spiegelman, B. M. (2007). A fundamental system of cellular energy homeostasis regulated by PGC-1{alpha}. Proc. Natl. Acad. Sci. USA 104: 7933-7938 [Abstract] [Full Text]  
  • Broderick, K. E., Zhang, T., Rangaswami, H., Zeng, Y., Zhao, X., Boss, G. R., Pilz, R. B. (2007). Guanosine 3',5'-Cyclic Monophosphate (cGMP)/cGMP-Dependent Protein Kinase Induce Interleukin-6 Transcription in Osteoblasts. Mol. Endocrinol. 21: 1148-1162 [Abstract] [Full Text]  
  • Yao, M., Stenzel-Poore, M., Denver, R. J. (2007). Structural and Functional Conservation of Vertebrate Corticotropin-Releasing Factor Genes: Evidence for a Critical Role for a Conserved Cyclic AMP Response Element. Endocrinology 148: 2518-2531 [Abstract] [Full Text]  
  • Sher, N., Yivgi-Ohana, N., Orly, J. (2007). Transcriptional Regulation of the Cholesterol Side Chain Cleavage Cytochrome P450 Gene (CYP11A1) Revisited: Binding of GATA, Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activating Protein (AP)-1 Proteins to a Distal Novel Cluster of cis-Regulatory Elements Potentiates AP-2 and Steroidogenic Factor-1-Dependent Gene Expression in the Rodent Placenta and Ovary. Mol. Endocrinol. 21: 948-962 [Abstract] [Full Text]  
  • Chen, C., Cheng, X., Dieter, M. Z., Tanaka, Y., Klaassen, C. D. (2007). Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression. Mol. Pharmacol. 71: 1159-1164 [Abstract] [Full Text]  
  • Pedersen, K. B., Zhang, P., Doumen, C., Charbonnet, M., Lu, D., Newgard, C. B., Haycock, J. W., Lange, A. J., Scott, D. K. (2007). The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. Am. J. Physiol. Endocrinol. Metab. 292: E788-E801 [Abstract] [Full Text]  
  • Kim, S., Yamazaki, M., Shevde, N. K., Pike, J. W. (2007). Transcriptional Control of Receptor Activator of Nuclear Factor-{kappa}B Ligand by the Protein Kinase A Activator Forskolin and the Transmembrane Glycoprotein 130-Activating Cytokine, Oncostatin M, Is Exerted through Multiple Distal Enhancers. Mol. Endocrinol. 21: 197-214 [Abstract] [Full Text]  
  • Je, H.-S., Yang, F., Zhou, J., Lu, B. (2006). Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms. JCB 175: 1029-1042 [Abstract] [Full Text]  
  • Song, H., Ki, S. H., Kim, S. G., Moon, A. (2006). Activating Transcription Factor 2 Mediates Matrix Metalloproteinase-2 Transcriptional Activation Induced by p38 in Breast Epithelial Cells. Cancer Res. 66: 10487-10496 [Abstract] [Full Text]  
  • Grant, C., Jain, P., Nonnemacher, M., Flaig, K. E., Irish, B., Ahuja, J., Alexaki, A., Alefantis, T., Wigdahl, B. (2006). AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. J. Leukoc. Biol. 80: 640-650 [Abstract] [Full Text]  
  • Siu, Y.-T., Chin, K.-T., Siu, K.-L., Yee Wai Choy, E., Jeang, K.-T., Jin, D.-Y. (2006). TORC1 and TORC2 Coactivators Are Required for Tax Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeats. J. Virol. 80: 7052-7059 [Abstract] [Full Text]  
  • Min, J., Jin, Y.-M., Moon, J.-S., Sung, M.-S., Ahn Jo, S., Jo, I. (2006). Hypoxia-Induced Endothelial NO Synthase Gene Transcriptional Activation Is Mediated Through the Tax-Responsive Element in Endothelial Cells. Hypertension 47: 1189-1196 [Abstract] [Full Text]  
  • Dworet, J. H., Meinkoth, J. L. (2006). Interference with 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein Stimulates Apoptosis through Aberrant Cell Cycle Progression and Checkpoint Activation. Mol. Endocrinol. 20: 1112-1120 [Abstract] [Full Text]  
  • Ichiki, T. (2006). Role of cAMP Response Element Binding Protein in Cardiovascular Remodeling: Good, Bad, or Both?. Arterioscler. Thromb. Vasc. Bio. 26: 449-455 [Abstract] [Full Text]  
  • Le Goff, W., Zheng, P., Brubaker, G., Smith, J. D. (2006). Identification of the cAMP-Responsive Enhancer of the Murine ABCA1 Gene: Requirement for CREB1 and STAT3/4 Elements. Arterioscler. Thromb. Vasc. Bio. 26: 527-533 [Abstract] [Full Text]  
  • Zhang, J., Bui, T. N., Xiang, J., Lin, A. (2006). Cyclic AMP Inhibits p38 Activation via CREB-Induced Dynein Light Chain. Mol. Cell. Biol. 26: 1223-1234 [Abstract] [Full Text]  
  • Wang, J., Shannon, M. F., Young, I. G. (2006). A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes. Int Immunol 18: 313-323 [Abstract] [Full Text]  
  • Cao, W., Collins, Q. F., Becker, T. C., Robidoux, J., Lupo, E. G. Jr., Xiong, Y., Daniel, K. W., Floering, L., Collins, S. (2005). p38 Mitogen-activated Protein Kinase Plays a Stimulatory Role in Hepatic Gluconeogenesis. J. Biol. Chem. 280: 42731-42737 [Abstract] [Full Text]  
  • Lee, J., Kim, C.-H., Simon, D. K., Aminova, L. R., Andreyev, A. Y., Kushnareva, Y. E., Murphy, A. N., Lonze, B. E., Kim, K.-S., Ginty, D. D., Ferrante, R. J., Ryu, H., Ratan, R. R. (2005). Mitochondrial Cyclic AMP Response Element-binding Protein (CREB) Mediates Mitochondrial Gene Expression and Neuronal Survival. J. Biol. Chem. 280: 40398-40401 [Abstract] [Full Text]  
  • Chen, S., Ji, M., Paris, M., Hullinger, R. L., Andrisani, O. M. (2005). The cAMP Pathway Regulates Both Transcription and Activity of the Paired Homeobox Transcription Factor Phox2a Required for Development of Neural Crest-derived and Central Nervous System-derived Catecholaminergic Neurons. J. Biol. Chem. 280: 41025-41036 [Abstract] [Full Text]  
  • Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H., Impey, S. (2005). From The Cover: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 102: 16426-16431 [Abstract] [Full Text]  
  • Giachino, C., De Marchis, S., Giampietro, C., Parlato, R., Perroteau, I., Schutz, G., Fasolo, A., Peretto, P. (2005). cAMP Response Element-Binding Protein Regulates Differentiation and Survival of Newborn Neurons in the Olfactory Bulb. J. Neurosci. 25: 10105-10118 [Abstract] [Full Text]  
  • Contestabile, A., Fila, T., Bartesaghi, R., Ciani, E. (2005). Cyclic AMP-mediated Regulation of Transcription Factor Lot1 Expression in Cerebellar Granule Cells. J. Biol. Chem. 280: 33541-33551 [Abstract] [Full Text]  
  • Warburton, E. C., Glover, C. P. J., Massey, P. V., Wan, H., Johnson, B., Bienemann, A., Deuschle, U., Kew, J. N. C., Aggleton, J. P., Bashir, Z. I., Uney, J., Brown, M. W. (2005). cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory. J. Neurosci. 25: 6296-6303 [Abstract] [Full Text]  
  • Ji, M., Andrisani, O. M. (2005). High-Level Activation of Cyclic AMP Signaling Attenuates Bone Morphogenetic Protein 2-Induced Sympathoadrenal Lineage Development and Promotes Melanogenesis in Neural Crest Cultures. Mol. Cell. Biol. 25: 5134-5145 [Abstract] [Full Text]  
  • Liby, K., Hock, T., Yore, M. M., Suh, N., Place, A. E., Risingsong, R., Williams, C. R., Royce, D. B., Honda, T., Honda, Y., Gribble, G. W., Hill-Kapturczak, N., Agarwal, A., Sporn, M. B. (2005). The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res. 65: 4789-4798 [Abstract] [Full Text]  
  • Butcher, G. Q., Lee, B., Cheng, H.-Y. M., Obrietan, K. (2005). Light Stimulates MSK1 Activation in the Suprachiasmatic Nucleus via a PACAP-ERK/MAP Kinase-Dependent Mechanism. J. Neurosci. 25: 5305-5313 [Abstract] [Full Text]  
  • Yeagley, D., Quinn, P. G. (2005). 3',5'-Cyclic Adenosine Monophosphate Response Element-Binding Protein and CCAAT Enhancer-Binding Protein Are Dispensable for Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Transcription and for Its Synergistic Induction by Protein Kinase A and Glucocorticoids. Mol. Endocrinol. 19: 913-924 [Abstract] [Full Text]  
  • Yoshida, T., Mishina, M. (2005). Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation. J. Neurosci. 25: 3067-3079 [Abstract] [Full Text]  
  • Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J. R., Emerson, B., Hogenesch, J. B., Unterman, T., Young, R. A., Montminy, M. (2005). Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl. Acad. Sci. USA 102: 4459-4464 [Abstract] [Full Text]  
  • Plotkin, L. I., Aguirre, J. I., Kousteni, S., Manolagas, S. C., Bellido, T. (2005). Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation. J. Biol. Chem. 280: 7317-7325 [Abstract] [Full Text]  
  • Lee, B., Butcher, G. Q., Hoyt, K. R., Impey, S., Obrietan, K. (2005). Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133. J. Neurosci. 25: 1137-1148 [Abstract] [Full Text]  
  • Gautier-Stein, A., Mithieux, G., Rajas, F. (2005). A Distal Region Involving Hepatocyte Nuclear Factor 4{alpha} and CAAT/Enhancer Binding Protein Markedly Potentiates the Protein Kinase A Stimulation of the Glucose-6-Phosphatase Promoter. Mol. Endocrinol. 19: 163-174 [Abstract] [Full Text]  
  • Mynard, V., Latchoumanin, O., Guignat, L., Devin-Leclerc, J., Bertagna, X., Barre, B., Fagart, J., Coqueret, O., Catelli, M. G. (2004). Synergistic Signaling by Corticotropin-Releasing Hormone and Leukemia Inhibitory Factor Bridged by Phosphorylated 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein at the Nur Response Element (NurRE)-Signal Transducers and Activators of Transcription (STAT) Element of the Proopiomelanocortin Promoter. Mol. Endocrinol. 18: 2997-3010 [Abstract] [Full Text]  
  • Canon, E., Cosgaya, J. M., Scsucova, S., Aranda, A. (2004). Rapid Effects of Retinoic Acid on CREB and ERK Phosphorylation in Neuronal Cells. Mol. Biol. Cell 15: 5583-5592 [Abstract] [Full Text]  
  • Fukuchi, M., Tabuchi, A., Tsuda, M. (2004). Activity-dependent Transcriptional Activation and mRNA Stabilization for Cumulative Expression of Pituitary Adenylate Cyclase-activating Polypeptide mRNA Controlled by Calcium and cAMP Signals in Neurons. J. Biol. Chem. 279: 47856-47865 [Abstract] [Full Text]  
  • Chun, J. T., Di Dato, V., D'Andrea, B., Zannini, M., Di Lauro, R. (2004). The CRE-Like Element Inside the 5'-Upstream Region of the Rat Sodium/Iodide Symporter Gene Interacts with Diverse Classes of b-Zip Molecules that Regulate Transcriptional Activities through Strong Synergy with Pax-8. Mol. Endocrinol. 18: 2817-2829 [Abstract] [Full Text]  
  • Xu, X., Zhang, W., Kone, B. C. (2004). CREB trans-activates the murine H+-K+-ATPase {alpha}2-subunit gene. Am. J. Physiol. Cell Physiol. 287: C903-C911 [Abstract] [Full Text]  
  • Nguyen, T. L.-A., Calomme, C., Wijmeersch, G., Nizet, S., Veithen, E., Portetelle, D., de Launoit, Y., Burny, A., Van Lint, C. (2004). Deacetylase Inhibitors and the Viral Transactivator TaxBLV Synergistically Activate Bovine Leukemia Virus Gene Expression via a cAMP-responsive Element- and cAMP-responsive Element-binding Protein-dependent Mechanism. J. Biol. Chem. 279: 35025-35036 [Abstract] [Full Text]  
  • Park, E. Y., Cho, I. J., Kim, S. G. (2004). Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor-{gamma} and Retinoid X Receptor Heterodimer. Cancer Res. 64: 3701-3713 [Abstract] [Full Text]  
  • Simon, J., Arthur, C., Fong, A. L., Dwyer, J. M., Davare, M., Reese, E., Obrietan, K., Impey, S. (2004). Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins. J. Neurosci. 24: 4324-4332 [Abstract] [Full Text]  
  • Sawka-Verhelle, D., Escoubet-Lozach, L., Fong, A. L., Hester, K. D., Herzig, S., Lebrun, P., Glass, C. K. (2004). PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation. J. Biol. Chem. 279: 17772-17784 [Abstract] [Full Text]  
  • Inada, A., Hamamoto, Y., Tsuura, Y., Miyazaki, J.-i., Toyokuni, S., Ihara, Y., Nagai, K., Yamada, Y., Bonner-Weir, S., Seino, Y. (2004). Overexpression of Inducible Cyclic AMP Early Repressor Inhibits Transactivation of Genes and Cell Proliferation in Pancreatic {beta} Cells. Mol. Cell. Biol. 24: 2831-2841 [Abstract] [Full Text]  
  • Chen, H.-C., Feener, E. P. (2004). MEK1,2 response element mediates angiotensin II--stimulated plasminogen activator inhibitor-1 promoter activation. Blood 103: 2636-2644 [Abstract] [Full Text]  
  • Gustin, J. A., Pincheira, R., Mayo, L. D., Ozes, O. N., Kessler, K. M., Baerwald, M. R., Korgaonkar, C. K., Donner, D. B. (2004). Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Am. J. Physiol. Cell Physiol. 286: C547-C555 [Abstract] [Full Text]  
  • Zhang, J.-W., Klemm, D. J., Vinson, C., Lane, M. D. (2004). Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein {beta} Gene during Adipogenesis. J. Biol. Chem. 279: 4471-4478 [Abstract] [Full Text]  
  • Frigo, D. E., Tang, Y., Beckman, B. S., Scandurro, A. B., Alam, J., Burow, M. E., McLachlan, J. A. (2004). Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis 25: 249-261 [Abstract] [Full Text]  
  • Bellido, T., Ali, A. A., Plotkin, L. I., Fu, Q., Gubrij, I., Roberson, P. K., Weinstein, R. S., O'Brien, C. A., Manolagas, S. C., Jilka, R. L. (2003). Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts: A PUTATIVE EXPLANATION FOR WHY INTERMITTENT ADMINISTRATION IS NEEDED FOR BONE ANABOLISM. J. Biol. Chem. 278: 50259-50272 [Abstract] [Full Text]  
  • Hahm, S. H., Chen, Y., Vinson, C., Eiden, L. E. (2003). A Calcium-Initiated Signaling Pathway Propagated through Calcineurin and cAMP Response Element-Binding Protein Activates Proenkephalin Gene Transcription after Depolarization. Mol. Pharmacol. 64: 1503-1511 [Abstract] [Full Text]  
  • Cho, I. J., Kim, S. G. (2003). Oltipraz Inhibits 3-Methylcholanthrene Induction of CYP1A1 by CCAAT/Enhancer-binding Protein Activation. J. Biol. Chem. 278: 44103-44112 [Abstract] [Full Text]  
  • Fass, D. M., Butler, J. E. F., Goodman, R. H. (2003). Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes. J. Biol. Chem. 278: 43014-43019 [Abstract] [Full Text]  
  • Lee, M. G., Pedersen, P. L. (2003). Glucose Metabolism in Cancer: IMPORTANCE OF TRANSCRIPTION FACTOR-DNA INTERACTIONS WITHIN A SHORT SEGMENT OF THE PROXIMAL REGION OF THE TYPE II HEXOKINASE PROMOTER. J. Biol. Chem. 278: 41047-41058 [Abstract] [Full Text]  
  • Tucholski, J., Johnson, G. V. W. (2003). Tissue Transglutaminase Directly Regulates Adenylyl Cyclase Resulting in Enhanced cAMP-response Element-binding Protein (CREB) Activation. J. Biol. Chem. 278: 26838-26843 [Abstract] [Full Text]  
  • Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R. N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., Montminy, M. (2003). cAMP promotes pancreatic {beta}-cell survival via CREB-mediated induction of IRS2. Genes Dev. 17: 1575-1580 [Abstract] [Full Text]  
  • Chen, Y., Zhuang, S., Cassenaer, S., Casteel, D. E., Gudi, T., Boss, G. R., Pilz, R. B. (2003). Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-{beta}. Mol. Cell. Biol. 23: 4066-4082 [Abstract] [Full Text]  
  • Bedogni, B., Pani, G., Colavitti, R., Riccio, A., Borrello, S., Murphy, M., Smith, R., Eboli, M. L., Galeotti, T. (2003). Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival. J. Biol. Chem. 278: 16510-16519 [Abstract] [Full Text]  
  • Magenta, A., Cenciarelli, C., De Santa, F., Fuschi, P., Martelli, F., Caruso, M., Felsani, A. (2003). MyoD Stimulates RB Promoter Activity via the CREB/p300 Nuclear Transduction Pathway. Mol. Cell. Biol. 23: 2893-2906 [Abstract] [Full Text]  
  • Farini, D., Puglianiello, A., Mammi, C., Siracusa, G., Moretti, C. (2003). Dual Effect of Pituitary Adenylate Cyclase Activating Polypeptide on Prostate Tumor LNCaP Cells: Short- and Long-Term Exposure Affect Proliferation and Neuroendocrine Differentiation. Endocrinology 144: 1631-1643 [Abstract] [Full Text]  
  • Alam, J., Killeen, E., Gong, P., Naquin, R., Hu, B., Stewart, D., Ingelfinger, J. R., Nath, K. A. (2003). Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am. J. Physiol. Renal Physiol. 284: F743-F752 [Abstract] [Full Text]  
  • Kang, K. W., Park, E. Y., Kim, S. G. (2003). Activation of CCAAT/enhancer-binding protein {beta} by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis 24: 475-482 [Abstract] [Full Text]  
  • Cho, Y. H., Lee, C. H., Kim, S. G. (2003). Potentiation of Lipopolysaccharide-Inducible Cyclooxygenase 2 Expression by C2-Ceramide via c-Jun N-Terminal Kinase-Mediated Activation of CCAAT/Enhancer Binding Protein beta in Macrophages. Mol. Pharmacol. 63: 512-523 [Abstract] [Full Text]  
  • Bai, J., Nakamura, H., Kwon, Y.-W., Hattori, I., Yamaguchi, Y., Kim, Y.-C., Kondo, N., Oka, S.-i., Ueda, S., Masutani, H., Yodoi, J. (2003). Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells. J. Neurosci. 23: 503-509 [Abstract] [Full Text]  
  • Kang, K. W., Cho, I. J., Lee, C. H., Kim, S. G. (2003). Essential Role of Phosphatidylinositol 3-Kinase-Dependent CCAAT/Enhancer Binding Protein {beta} Activation in the Induction of Glutathione S-Transferase by Oltipraz. JNCI J Natl Cancer Inst 95: 53-66 [Abstract] [Full Text]  
  • Fu, Q., Jilka, R. L., Manolagas, S. C., O'Brien, C. A. (2002). Parathyroid Hormone Stimulates Receptor Activator of NFkappa B Ligand and Inhibits Osteoprotegerin Expression via Protein Kinase A Activation of cAMP-response Element-binding Protein. J. Biol. Chem. 277: 48868-48875 [Abstract] [Full Text]  
  • Raychowdhury, R., Schafer, G., Fleming, J., Rosewicz, S., Wiedenmann, B., Wang, T. C., Hocker, M. (2002). Interaction of Early Growth Response Protein 1 (Egr-1), Specificity Protein 1 (Sp1), and Cyclic Adenosine 3'5'-Monophosphate Response Element Binding Protein (CREB) at a Proximal Response Element Is Critical for Gastrin-Dependent Activation of the Chromogranin A Promoter. Mol. Endocrinol. 16: 2802-2818 [Abstract] [Full Text]  
  • Boulon, S., Dantonel, J.-C., Binet, V., Vie, A., Blanchard, J.-M., Hipskind, R. A., Philips, A. (2002). Oct-1 Potentiates CREB-Driven Cyclin D1 Promoter Activation via a Phospho-CREB- and CREB Binding Protein-Independent Mechanism. Mol. Cell. Biol. 22: 7769-7779 [Abstract] [Full Text]  
  • Louet, J.-F., Hayhurst, G., Gonzalez, F. J., Girard, J., Decaux, J.-F. (2002). The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4alpha and cAMP-response Element-binding Protein (CREB). J. Biol. Chem. 277: 37991-38000 [Abstract] [Full Text]  
  • Vinson, C., Myakishev, M., Acharya, A., Mir, A. A., Moll, J. R., Bonovich, M. (2002). Classification of Human B-ZIP Proteins Based on Dimerization Properties. Mol. Cell. Biol. 22: 6321-6335 [Full Text]  
  • Cheng, H.-C., Shih, H.-M., Chern, Y. (2002). Essential Role of cAMP-response Element-binding Protein Activation by A2A Adenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade. J. Biol. Chem. 277: 33930-33942 [Abstract] [Full Text]  
  • Beier, F., LuValle, P. (2002). The Cyclin D1 and Cyclin A Genes Are Targets of Activated PTH/PTHrP Receptors in Jansen's Metaphyseal Chondrodysplasia. Mol. Endocrinol. 16: 2163-2173 [Abstract] [Full Text]  
  • Chepurny, O. G., Hussain, M. A., Holz, G. G. (2002). Exendin-4 as a Stimulator of Rat Insulin I Gene Promoter Activity via bZIP/CRE Interactions Sensitive to Serine/Threonine Protein Kinase Inhibitor Ro 31-8220. Endocrinology 143: 2303-2313 [Abstract] [Full Text]  
  • Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S. C. (2002). MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts. Mol. Cell. Biol. 22: 2871-2881 [Abstract] [Full Text]  
  • Moll, J. R., Acharya, A., Gal, J., Mir, A. A., Vinson, C. (2002). Magnesium is required for specific DNA binding of the CREB B-ZIP domain. Nucleic Acids Res 30: 1240-1246 [Abstract] [Full Text]  
  • Zentrich, E., Han, S.-Y., Pessoa-Brandao, L., Butterfield, L., Heasley, L. E. (2002). Collaboration of JNKs and ERKs in Nerve Growth Factor Regulation of the Neurofilament Light Chain Promoter in PC12 Cells. J. Biol. Chem. 277: 4110-4118 [Abstract] [Full Text]  
  • Manna, P. R., Dyson, M. T., Eubank, D. W., Clark, B. J., Lalli, E., Sassone-Corsi, P., Zeleznik, A. J., Stocco, D. M. (2002). Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein Family. Mol. Endocrinol. 16: 184-199 [Abstract] [Full Text]  
  • Beier, F., Ali, Z., Mok, D., Taylor, A. C., Leask, T., Albanese, C., Pestell, R. G., LuValle, P. (2001). TGFbeta and PTHrP Control Chondrocyte Proliferation by Activating Cyclin D1 Expression. Mol. Biol. Cell 12: 3852-3863 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»