Previous Article | Next Article 
Mol Cell Biol, February 1998, p. 967-977, Vol. 18, No. 2
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
A Dominant-Negative Inhibitor of CREB Reveals that It Is a
General Mediator of Stimulus-Dependent Transcription of
c-fos
Sohyun
Ahn,1
Michelle
Olive,2
Seema
Aggarwal,1
Dmitry
Krylov,2
David D.
Ginty,1,* and
Charles
Vinson2,*
Laboratory of Biochemistry, National Cancer
Institute, National Institutes of Health, Bethesda, Maryland
20892,2 and
Department of Neuroscience,
The Johns Hopkins University School of Medicine, Baltimore, Maryland
212051
Received 7 July 1997/Returned for modification 5 September
1997/Accepted 20 November 1997
Several studies have characterized the upstream regulatory region
of c-fos, and identified cis-acting elements
termed the cyclic AMP (cAMP) response elements (CREs) that are critical
for c-fos transcription in response to a variety of
extracellular stimuli. Although several transcription factors can bind
to CREs in vitro, the identity of the transcription factor(s) that
activates the c-fos promoter via the CRE in vivo remains
unclear. To help identify the trans-acting factors that
regulate stimulus-dependent transcription of c-fos via the
CREs, dominant-negative (D-N) inhibitor proteins that function by
preventing DNA binding of B-ZIP proteins in a dimerization
domain-dependent fashion were developed. A D-N inhibitor of CREB,
termed A-CREB, was constructed by fusing a designed acidic amphipathic
extension onto the N terminus of the CREB leucine zipper domain. The
acidic extension of A-CREB interacts with the basic region of CREB
forming a coiled-coil extension of the leucine zipper and thus prevents
the basic region of wild-type CREB from binding to DNA. Other D-N
inhibitors generated in a similar manner with the dimerization domains
of Fos, Jun, C/EBP, ATF-2, or VBP did not block CREB DNA binding
activity, nor did they inhibit transcriptional activation of a minimal
promoter containing a single CRE in PC12 cells. A-CREB inhibited
activation of CRE-mediated transcription evoked by three distinct
stimuli: forskolin, which increases intracellular cAMP; membrane
depolarization, which promotes Ca2+ influx; and nerve
growth factor (NGF). A-CREB completely inhibited cAMP-mediated, but
only partially inhibited Ca2+- and NGF-mediated,
transcription of a reporter gene containing 750 bp of the native
c-fos promoter. Moreover, glutamate induction of
c-fos expression in primary cortical neurons was dependent on CREB. In contrast, induction of c-fos transcription by
UV light was not inhibited by A-CREB. Lastly, A-CREB attenuated NGF
induction of morphological differentiation in PC12 cells. These results suggest that CREB or its closely related family members are general mediators of stimulus-dependent transcription of c-fos and
are required for at least some of the long-term actions of NGF.
*
Corresponding author. Mailing address for David D. Ginty: Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205-2185. Phone: (410) 614-9494. Fax: (410) 614-8423. E-mail:
david_ginty{at}qmail.bs.jhu.edu. Mailing address for
Charles Vinson: Building 37, Room 4D06, Laboratory of Biochemistry,
National Cancer Institute, National Institutes of Health, Bethesda, MD
20892. Phone: (301) 496-8753. Fax: (301) 402-3095. E-mail:
VinsonC{at}dc37a.nci.nih.gov.
This article has been cited by other articles:
-
Jancic, D., Lopez de Armentia, M., Valor, L. M., Olivares, R., Barco, A.
(2009). Inhibition of cAMP Response Element-Binding Protein Reduces Neuronal Excitability and Plasticity, and Triggers Neurodegeneration. Cereb Cortex
19: 2535-2547
[Abstract]
[Full Text]
-
Jeng, Y.-J., Soloff, M. S.
(2009). Characterization of the Cyclic Adenosine Monophosphate Target Site in the Oxytocin Receptor Gene in Rabbit Amnion. Biol. Reprod.
81: 473-479
[Abstract]
[Full Text]
-
Seoane, A., Massey, P. V., Keen, H., Bashir, Z. I., Brown, M. W.
(2009). L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes. J. Neurosci.
29: 9534-9544
[Abstract]
[Full Text]
-
Siddiq, A., Aminova, L. R., Troy, C. M., Suh, K., Messer, Z., Semenza, G. L., Ratan, R. R.
(2009). Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways. J. Neurosci.
29: 8828-8838
[Abstract]
[Full Text]
-
Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F. H., Song, H., Lie, D. C.
(2009). GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus. J. Neurosci.
29: 7966-7977
[Abstract]
[Full Text]
-
Rozenberg, J., Rishi, V., Orosz, A., Moitra, J., Glick, A., Vinson, C.
(2009). Inhibition of CREB Function in Mouse Epidermis Reduces Papilloma Formation. Mol Cancer Res
7: 654-664
[Abstract]
[Full Text]
-
Merot, Y., Ferriere, F., Gailhouste, L., Huet, G., Percevault, F., Saligaut, C., Flouriot, G.
(2009). Different Outcomes of Unliganded and Liganded Estrogen Receptor-{alpha} on Neurite Outgrowth in PC12 Cells. Endocrinology
150: 200-211
[Abstract]
[Full Text]
-
Siu, Y.-T., Ching, Y.-P., Jin, D.-Y.
(2008). Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation. Mol. Biol. Cell
19: 4750-4761
[Abstract]
[Full Text]
-
Chen, Y.-L., Jian, M.-H., Lin, C.-C., Kang, J.-C., Chen, S.-P., Lin, P.-C., Hung, P.-J., Chen, J.-R., Chang, W.-L., Lin, S.-Z., Harn, H.-J.
(2008). The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy. Mol. Pharmacol.
74: 1046-1058
[Abstract]
[Full Text]
-
Meyuhas, R., Pikarsky, E., Tavor, E., Klar, A., Abramovitch, R., Hochman, J., Lago, T. G., Honigman, A.
(2008). A Key Role for Cyclic AMP-Responsive Element Binding Protein in Hypoxia-Mediated Activation of the Angiogenesis Factor CCN1 (CYR61) in Tumor Cells. Mol Cancer Res
6: 1397-1409
[Abstract]
[Full Text]
-
Ciccone, N. A., Lacza, C. T., Hou, M. Y., Gregory, S. J., Kam, K.-Y., Xu, S., Kaiser, U. B.
(2008). A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene. Mol. Endocrinol.
22: 1908-1923
[Abstract]
[Full Text]
-
Simonetti, M., Giniatullin, R., Fabbretti, E.
(2008). Mechanisms Mediating the Enhanced Gene Transcription of P2X3 Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons. J. Biol. Chem.
283: 18743-18752
[Abstract]
[Full Text]
-
Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., Impey, S.
(2008). An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc. Natl. Acad. Sci. USA
105: 9093-9098
[Abstract]
[Full Text]
-
Schubert, S. W., Abendroth, A., Kilian, K., Vogler, T., Mayr, B., Knerr, I., Hashemolhosseini, S.
(2008). bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa/Gcm1 in trophoblast cells. Nucleic Acids Res
36: 3834-3846
[Abstract]
[Full Text]
-
Kim, C., Wilcox-Adelman, S., Sano, Y., Tang, W.-J., Collier, R. J., Park, J. M.
(2008). From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc. Natl. Acad. Sci. USA
105: 6150-6155
[Abstract]
[Full Text]
-
Wang, O., Cai, K., Pang, S., Wang, T., Qi, D., Zhu, Q., Ni, Z., Le, Y.
(2008). Mechanisms of Glucose-Induced Expression of Pancreatic-Derived Factor in Pancreatic {beta}-Cells. Endocrinology
149: 672-680
[Abstract]
[Full Text]
-
Jalvy, S., Renault, M.-A., Leen, L. L. S., Belloc, I., Bonnet, J., Gadeau, A.-P., Desgranges, C.
(2007). Autocrine expression of osteopontin contributes to PDGF-mediated arterial smooth muscle cell migration. Cardiovasc Res
75: 738-747
[Abstract]
[Full Text]
-
Chepurny, O. G., Holz, G. G.
(2007). A Novel Cyclic Adenosine Monophosphate Responsive Luciferase Reporter Incorporating a Nonpalindromic Cyclic Adenosine Monophosphate Response Element Provides Optimal Performance for Use in G Protein Coupled Receptor Drug Discovery Efforts. J Biomol Screen
12: 740-746
[Abstract]
-
Kim, H.-P., Leonard, W. J.
(2007). CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. JEM
204: 1543-1551
[Abstract]
[Full Text]
-
Jalvy, S., Renault, M.-A., Lam Shang Leen, L., Belloc, I., Reynaud, A., Gadeau, A.-P., Desgranges, C.
(2007). CREB Mediates UTP-Directed Arterial Smooth Muscle Cell Migration and Expression of the Chemotactic Protein Osteopontin via Its Interaction with Activator Protein-1 Sites. Circ. Res.
100: 1292-1299
[Abstract]
[Full Text]
-
Rohas, L. M., St-Pierre, J., Uldry, M., Jager, S., Handschin, C., Spiegelman, B. M.
(2007). A fundamental system of cellular energy homeostasis regulated by PGC-1{alpha}. Proc. Natl. Acad. Sci. USA
104: 7933-7938
[Abstract]
[Full Text]
-
Broderick, K. E., Zhang, T., Rangaswami, H., Zeng, Y., Zhao, X., Boss, G. R., Pilz, R. B.
(2007). Guanosine 3',5'-Cyclic Monophosphate (cGMP)/cGMP-Dependent Protein Kinase Induce Interleukin-6 Transcription in Osteoblasts. Mol. Endocrinol.
21: 1148-1162
[Abstract]
[Full Text]
-
Yao, M., Stenzel-Poore, M., Denver, R. J.
(2007). Structural and Functional Conservation of Vertebrate Corticotropin-Releasing Factor Genes: Evidence for a Critical Role for a Conserved Cyclic AMP Response Element. Endocrinology
148: 2518-2531
[Abstract]
[Full Text]
-
Sher, N., Yivgi-Ohana, N., Orly, J.
(2007). Transcriptional Regulation of the Cholesterol Side Chain Cleavage Cytochrome P450 Gene (CYP11A1) Revisited: Binding of GATA, Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activating Protein (AP)-1 Proteins to a Distal Novel Cluster of cis-Regulatory Elements Potentiates AP-2 and Steroidogenic Factor-1-Dependent Gene Expression in the Rodent Placenta and Ovary. Mol. Endocrinol.
21: 948-962
[Abstract]
[Full Text]
-
Chen, C., Cheng, X., Dieter, M. Z., Tanaka, Y., Klaassen, C. D.
(2007). Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression. Mol. Pharmacol.
71: 1159-1164
[Abstract]
[Full Text]
-
Pedersen, K. B., Zhang, P., Doumen, C., Charbonnet, M., Lu, D., Newgard, C. B., Haycock, J. W., Lange, A. J., Scott, D. K.
(2007). The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. Am. J. Physiol. Endocrinol. Metab.
292: E788-E801
[Abstract]
[Full Text]
-
Kim, S., Yamazaki, M., Shevde, N. K., Pike, J. W.
(2007). Transcriptional Control of Receptor Activator of Nuclear Factor-{kappa}B Ligand by the Protein Kinase A Activator Forskolin and the Transmembrane Glycoprotein 130-Activating Cytokine, Oncostatin M, Is Exerted through Multiple Distal Enhancers. Mol. Endocrinol.
21: 197-214
[Abstract]
[Full Text]
-
Je, H.-S., Yang, F., Zhou, J., Lu, B.
(2006). Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms. JCB
175: 1029-1042
[Abstract]
[Full Text]
-
Song, H., Ki, S. H., Kim, S. G., Moon, A.
(2006). Activating Transcription Factor 2 Mediates Matrix Metalloproteinase-2 Transcriptional Activation Induced by p38 in Breast Epithelial Cells. Cancer Res.
66: 10487-10496
[Abstract]
[Full Text]
-
Grant, C., Jain, P., Nonnemacher, M., Flaig, K. E., Irish, B., Ahuja, J., Alexaki, A., Alefantis, T., Wigdahl, B.
(2006). AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. J. Leukoc. Biol.
80: 640-650
[Abstract]
[Full Text]
-
Siu, Y.-T., Chin, K.-T., Siu, K.-L., Yee Wai Choy, E., Jeang, K.-T., Jin, D.-Y.
(2006). TORC1 and TORC2 Coactivators Are Required for Tax Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeats. J. Virol.
80: 7052-7059
[Abstract]
[Full Text]
-
Min, J., Jin, Y.-M., Moon, J.-S., Sung, M.-S., Ahn Jo, S., Jo, I.
(2006). Hypoxia-Induced Endothelial NO Synthase Gene Transcriptional Activation Is Mediated Through the Tax-Responsive Element in Endothelial Cells. Hypertension
47: 1189-1196
[Abstract]
[Full Text]
-
Dworet, J. H., Meinkoth, J. L.
(2006). Interference with 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein Stimulates Apoptosis through Aberrant Cell Cycle Progression and Checkpoint Activation. Mol. Endocrinol.
20: 1112-1120
[Abstract]
[Full Text]
-
Ichiki, T.
(2006). Role of cAMP Response Element Binding Protein in Cardiovascular Remodeling: Good, Bad, or Both?. Arterioscler. Thromb. Vasc. Bio.
26: 449-455
[Abstract]
[Full Text]
-
Le Goff, W., Zheng, P., Brubaker, G., Smith, J. D.
(2006). Identification of the cAMP-Responsive Enhancer of the Murine ABCA1 Gene: Requirement for CREB1 and STAT3/4 Elements. Arterioscler. Thromb. Vasc. Bio.
26: 527-533
[Abstract]
[Full Text]
-
Zhang, J., Bui, T. N., Xiang, J., Lin, A.
(2006). Cyclic AMP Inhibits p38 Activation via CREB-Induced Dynein Light Chain. Mol. Cell. Biol.
26: 1223-1234
[Abstract]
[Full Text]
-
Wang, J., Shannon, M. F., Young, I. G.
(2006). A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes. Int Immunol
18: 313-323
[Abstract]
[Full Text]
-
Cao, W., Collins, Q. F., Becker, T. C., Robidoux, J., Lupo, E. G. Jr., Xiong, Y., Daniel, K. W., Floering, L., Collins, S.
(2005). p38 Mitogen-activated Protein Kinase Plays a Stimulatory Role in Hepatic Gluconeogenesis. J. Biol. Chem.
280: 42731-42737
[Abstract]
[Full Text]
-
Lee, J., Kim, C.-H., Simon, D. K., Aminova, L. R., Andreyev, A. Y., Kushnareva, Y. E., Murphy, A. N., Lonze, B. E., Kim, K.-S., Ginty, D. D., Ferrante, R. J., Ryu, H., Ratan, R. R.
(2005). Mitochondrial Cyclic AMP Response Element-binding Protein (CREB) Mediates Mitochondrial Gene Expression and Neuronal Survival. J. Biol. Chem.
280: 40398-40401
[Abstract]
[Full Text]
-
Chen, S., Ji, M., Paris, M., Hullinger, R. L., Andrisani, O. M.
(2005). The cAMP Pathway Regulates Both Transcription and Activity of the Paired Homeobox Transcription Factor Phox2a Required for Development of Neural Crest-derived and Central Nervous System-derived Catecholaminergic Neurons. J. Biol. Chem.
280: 41025-41036
[Abstract]
[Full Text]
-
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H., Impey, S.
(2005). From The Cover: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA
102: 16426-16431
[Abstract]
[Full Text]
-
Giachino, C., De Marchis, S., Giampietro, C., Parlato, R., Perroteau, I., Schutz, G., Fasolo, A., Peretto, P.
(2005). cAMP Response Element-Binding Protein Regulates Differentiation and Survival of Newborn Neurons in the Olfactory Bulb. J. Neurosci.
25: 10105-10118
[Abstract]
[Full Text]
-
Contestabile, A., Fila, T., Bartesaghi, R., Ciani, E.
(2005). Cyclic AMP-mediated Regulation of Transcription Factor Lot1 Expression in Cerebellar Granule Cells. J. Biol. Chem.
280: 33541-33551
[Abstract]
[Full Text]
-
Warburton, E. C., Glover, C. P. J., Massey, P. V., Wan, H., Johnson, B., Bienemann, A., Deuschle, U., Kew, J. N. C., Aggleton, J. P., Bashir, Z. I., Uney, J., Brown, M. W.
(2005). cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory. J. Neurosci.
25: 6296-6303
[Abstract]
[Full Text]
-
Ji, M., Andrisani, O. M.
(2005). High-Level Activation of Cyclic AMP Signaling Attenuates Bone Morphogenetic Protein 2-Induced Sympathoadrenal Lineage Development and Promotes Melanogenesis in Neural Crest Cultures. Mol. Cell. Biol.
25: 5134-5145
[Abstract]
[Full Text]
-
Liby, K., Hock, T., Yore, M. M., Suh, N., Place, A. E., Risingsong, R., Williams, C. R., Royce, D. B., Honda, T., Honda, Y., Gribble, G. W., Hill-Kapturczak, N., Agarwal, A., Sporn, M. B.
(2005). The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling. Cancer Res.
65: 4789-4798
[Abstract]
[Full Text]
-
Butcher, G. Q., Lee, B., Cheng, H.-Y. M., Obrietan, K.
(2005). Light Stimulates MSK1 Activation in the Suprachiasmatic Nucleus via a PACAP-ERK/MAP Kinase-Dependent Mechanism. J. Neurosci.
25: 5305-5313
[Abstract]
[Full Text]
-
Yeagley, D., Quinn, P. G.
(2005). 3',5'-Cyclic Adenosine Monophosphate Response Element-Binding Protein and CCAAT Enhancer-Binding Protein Are Dispensable for Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Transcription and for Its Synergistic Induction by Protein Kinase A and Glucocorticoids. Mol. Endocrinol.
19: 913-924
[Abstract]
[Full Text]
-
Yoshida, T., Mishina, M.
(2005). Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation. J. Neurosci.
25: 3067-3079
[Abstract]
[Full Text]
-
Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J. R., Emerson, B., Hogenesch, J. B., Unterman, T., Young, R. A., Montminy, M.
(2005). Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl. Acad. Sci. USA
102: 4459-4464
[Abstract]
[Full Text]
-
Plotkin, L. I., Aguirre, J. I., Kousteni, S., Manolagas, S. C., Bellido, T.
(2005). Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation. J. Biol. Chem.
280: 7317-7325
[Abstract]
[Full Text]
-
Lee, B., Butcher, G. Q., Hoyt, K. R., Impey, S., Obrietan, K.
(2005). Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133. J. Neurosci.
25: 1137-1148
[Abstract]
[Full Text]
-
Gautier-Stein, A., Mithieux, G., Rajas, F.
(2005). A Distal Region Involving Hepatocyte Nuclear Factor 4{alpha} and CAAT/Enhancer Binding Protein Markedly Potentiates the Protein Kinase A Stimulation of the Glucose-6-Phosphatase Promoter. Mol. Endocrinol.
19: 163-174
[Abstract]
[Full Text]
-
Mynard, V., Latchoumanin, O., Guignat, L., Devin-Leclerc, J., Bertagna, X., Barre, B., Fagart, J., Coqueret, O., Catelli, M. G.
(2004). Synergistic Signaling by Corticotropin-Releasing Hormone and Leukemia Inhibitory Factor Bridged by Phosphorylated 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein at the Nur Response Element (NurRE)-Signal Transducers and Activators of Transcription (STAT) Element of the Proopiomelanocortin Promoter. Mol. Endocrinol.
18: 2997-3010
[Abstract]
[Full Text]
-
Canon, E., Cosgaya, J. M., Scsucova, S., Aranda, A.
(2004). Rapid Effects of Retinoic Acid on CREB and ERK Phosphorylation in Neuronal Cells. Mol. Biol. Cell
15: 5583-5592
[Abstract]
[Full Text]
-
Fukuchi, M., Tabuchi, A., Tsuda, M.
(2004). Activity-dependent Transcriptional Activation and mRNA Stabilization for Cumulative Expression of Pituitary Adenylate Cyclase-activating Polypeptide mRNA Controlled by Calcium and cAMP Signals in Neurons. J. Biol. Chem.
279: 47856-47865
[Abstract]
[Full Text]
-
Chun, J. T., Di Dato, V., D'Andrea, B., Zannini, M., Di Lauro, R.
(2004). The CRE-Like Element Inside the 5'-Upstream Region of the Rat Sodium/Iodide Symporter Gene Interacts with Diverse Classes of b-Zip Molecules that Regulate Transcriptional Activities through Strong Synergy with Pax-8. Mol. Endocrinol.
18: 2817-2829
[Abstract]
[Full Text]
-
Xu, X., Zhang, W., Kone, B. C.
(2004). CREB trans-activates the murine H+-K+-ATPase {alpha}2-subunit gene. Am. J. Physiol. Cell Physiol.
287: C903-C911
[Abstract]
[Full Text]
-
Nguyen, T. L.-A., Calomme, C., Wijmeersch, G., Nizet, S., Veithen, E., Portetelle, D., de Launoit, Y., Burny, A., Van Lint, C.
(2004). Deacetylase Inhibitors and the Viral Transactivator TaxBLV Synergistically Activate Bovine Leukemia Virus Gene Expression via a cAMP-responsive Element- and cAMP-responsive Element-binding Protein-dependent Mechanism. J. Biol. Chem.
279: 35025-35036
[Abstract]
[Full Text]
-
Park, E. Y., Cho, I. J., Kim, S. G.
(2004). Transactivation of the PPAR-Responsive Enhancer Module in Chemopreventive Glutathione S-Transferase Gene by the Peroxisome Proliferator-Activated Receptor-{gamma} and Retinoid X Receptor Heterodimer. Cancer Res.
64: 3701-3713
[Abstract]
[Full Text]
-
Simon, J., Arthur, C., Fong, A. L., Dwyer, J. M., Davare, M., Reese, E., Obrietan, K., Impey, S.
(2004). Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins. J. Neurosci.
24: 4324-4332
[Abstract]
[Full Text]
-
Sawka-Verhelle, D., Escoubet-Lozach, L., Fong, A. L., Hester, K. D., Herzig, S., Lebrun, P., Glass, C. K.
(2004). PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation. J. Biol. Chem.
279: 17772-17784
[Abstract]
[Full Text]
-
Inada, A., Hamamoto, Y., Tsuura, Y., Miyazaki, J.-i., Toyokuni, S., Ihara, Y., Nagai, K., Yamada, Y., Bonner-Weir, S., Seino, Y.
(2004). Overexpression of Inducible Cyclic AMP Early Repressor Inhibits Transactivation of Genes and Cell Proliferation in Pancreatic {beta} Cells. Mol. Cell. Biol.
24: 2831-2841
[Abstract]
[Full Text]
-
Chen, H.-C., Feener, E. P.
(2004). MEK1,2 response element mediates angiotensin II--stimulated plasminogen activator inhibitor-1 promoter activation. Blood
103: 2636-2644
[Abstract]
[Full Text]
-
Gustin, J. A., Pincheira, R., Mayo, L. D., Ozes, O. N., Kessler, K. M., Baerwald, M. R., Korgaonkar, C. K., Donner, D. B.
(2004). Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Am. J. Physiol. Cell Physiol.
286: C547-C555
[Abstract]
[Full Text]
-
Zhang, J.-W., Klemm, D. J., Vinson, C., Lane, M. D.
(2004). Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein {beta} Gene during Adipogenesis. J. Biol. Chem.
279: 4471-4478
[Abstract]
[Full Text]
-
Frigo, D. E., Tang, Y., Beckman, B. S., Scandurro, A. B., Alam, J., Burow, M. E., McLachlan, J. A.
(2004). Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis
25: 249-261
[Abstract]
[Full Text]
-
Bellido, T., Ali, A. A., Plotkin, L. I., Fu, Q., Gubrij, I., Roberson, P. K., Weinstein, R. S., O'Brien, C. A., Manolagas, S. C., Jilka, R. L.
(2003). Proteasomal Degradation of Runx2 Shortens Parathyroid Hormone-induced Anti-apoptotic Signaling in Osteoblasts: A PUTATIVE EXPLANATION FOR WHY INTERMITTENT ADMINISTRATION IS NEEDED FOR BONE ANABOLISM. J. Biol. Chem.
278: 50259-50272
[Abstract]
[Full Text]
-
Hahm, S. H., Chen, Y., Vinson, C., Eiden, L. E.
(2003). A Calcium-Initiated Signaling Pathway Propagated through Calcineurin and cAMP Response Element-Binding Protein Activates Proenkephalin Gene Transcription after Depolarization. Mol. Pharmacol.
64: 1503-1511
[Abstract]
[Full Text]
-
Cho, I. J., Kim, S. G.
(2003). Oltipraz Inhibits 3-Methylcholanthrene Induction of CYP1A1 by CCAAT/Enhancer-binding Protein Activation. J. Biol. Chem.
278: 44103-44112
[Abstract]
[Full Text]
-
Fass, D. M., Butler, J. E. F., Goodman, R. H.
(2003). Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes. J. Biol. Chem.
278: 43014-43019
[Abstract]
[Full Text]
-
Lee, M. G., Pedersen, P. L.
(2003). Glucose Metabolism in Cancer: IMPORTANCE OF TRANSCRIPTION FACTOR-DNA INTERACTIONS WITHIN A SHORT SEGMENT OF THE PROXIMAL REGION OF THE TYPE II HEXOKINASE PROMOTER. J. Biol. Chem.
278: 41047-41058
[Abstract]
[Full Text]
-
Tucholski, J., Johnson, G. V. W.
(2003). Tissue Transglutaminase Directly Regulates Adenylyl Cyclase Resulting in Enhanced cAMP-response Element-binding Protein (CREB) Activation. J. Biol. Chem.
278: 26838-26843
[Abstract]
[Full Text]
-
Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R. N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., Montminy, M.
(2003). cAMP promotes pancreatic {beta}-cell survival via CREB-mediated induction of IRS2. Genes Dev.
17: 1575-1580
[Abstract]
[Full Text]
-
Chen, Y., Zhuang, S., Cassenaer, S., Casteel, D. E., Gudi, T., Boss, G. R., Pilz, R. B.
(2003). Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-{beta}. Mol. Cell. Biol.
23: 4066-4082
[Abstract]
[Full Text]
-
Bedogni, B., Pani, G., Colavitti, R., Riccio, A., Borrello, S., Murphy, M., Smith, R., Eboli, M. L., Galeotti, T.
(2003). Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival. J. Biol. Chem.
278: 16510-16519
[Abstract]
[Full Text]
-
Magenta, A., Cenciarelli, C., De Santa, F., Fuschi, P., Martelli, F., Caruso, M., Felsani, A.
(2003). MyoD Stimulates RB Promoter Activity via the CREB/p300 Nuclear Transduction Pathway. Mol. Cell. Biol.
23: 2893-2906
[Abstract]
[Full Text]
-
Farini, D., Puglianiello, A., Mammi, C., Siracusa, G., Moretti, C.
(2003). Dual Effect of Pituitary Adenylate Cyclase Activating Polypeptide on Prostate Tumor LNCaP Cells: Short- and Long-Term Exposure Affect Proliferation and Neuroendocrine Differentiation. Endocrinology
144: 1631-1643
[Abstract]
[Full Text]
-
Alam, J., Killeen, E., Gong, P., Naquin, R., Hu, B., Stewart, D., Ingelfinger, J. R., Nath, K. A.
(2003). Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am. J. Physiol. Renal Physiol.
284: F743-F752
[Abstract]
[Full Text]
-
Kang, K. W., Park, E. Y., Kim, S. G.
(2003). Activation of CCAAT/enhancer-binding protein {beta} by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis
24: 475-482
[Abstract]
[Full Text]
-
Cho, Y. H., Lee, C. H., Kim, S. G.
(2003). Potentiation of Lipopolysaccharide-Inducible Cyclooxygenase 2 Expression by C2-Ceramide via c-Jun N-Terminal Kinase-Mediated Activation of CCAAT/Enhancer Binding Protein beta in Macrophages. Mol. Pharmacol.
63: 512-523
[Abstract]
[Full Text]
-
Bai, J., Nakamura, H., Kwon, Y.-W., Hattori, I., Yamaguchi, Y., Kim, Y.-C., Kondo, N., Oka, S.-i., Ueda, S., Masutani, H., Yodoi, J.
(2003). Critical Roles of Thioredoxin in Nerve Growth Factor-Mediated Signal Transduction and Neurite Outgrowth in PC12 Cells. J. Neurosci.
23: 503-509
[Abstract]
[Full Text]
-
Kang, K. W., Cho, I. J., Lee, C. H., Kim, S. G.
(2003). Essential Role of Phosphatidylinositol 3-Kinase-Dependent CCAAT/Enhancer Binding Protein {beta} Activation in the Induction of Glutathione S-Transferase by Oltipraz. JNCI J Natl Cancer Inst
95: 53-66
[Abstract]
[Full Text]
-
Fu, Q., Jilka, R. L., Manolagas, S. C., O'Brien, C. A.
(2002). Parathyroid Hormone Stimulates Receptor Activator of NFkappa B Ligand and Inhibits Osteoprotegerin Expression via Protein Kinase A Activation of cAMP-response Element-binding Protein. J. Biol. Chem.
277: 48868-48875
[Abstract]
[Full Text]
-
Raychowdhury, R., Schafer, G., Fleming, J., Rosewicz, S., Wiedenmann, B., Wang, T. C., Hocker, M.
(2002). Interaction of Early Growth Response Protein 1 (Egr-1), Specificity Protein 1 (Sp1), and Cyclic Adenosine 3'5'-Monophosphate Response Element Binding Protein (CREB) at a Proximal Response Element Is Critical for Gastrin-Dependent Activation of the Chromogranin A Promoter. Mol. Endocrinol.
16: 2802-2818
[Abstract]
[Full Text]
-
Boulon, S., Dantonel, J.-C., Binet, V., Vie, A., Blanchard, J.-M., Hipskind, R. A., Philips, A.
(2002). Oct-1 Potentiates CREB-Driven Cyclin D1 Promoter Activation via a Phospho-CREB- and CREB Binding Protein-Independent Mechanism. Mol. Cell. Biol.
22: 7769-7779
[Abstract]
[Full Text]
-
Louet, J.-F., Hayhurst, G., Gonzalez, F. J., Girard, J., Decaux, J.-F.
(2002). The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4alpha and cAMP-response Element-binding Protein (CREB). J. Biol. Chem.
277: 37991-38000
[Abstract]
[Full Text]
-
Vinson, C., Myakishev, M., Acharya, A., Mir, A. A., Moll, J. R., Bonovich, M.
(2002). Classification of Human B-ZIP Proteins Based on Dimerization Properties. Mol. Cell. Biol.
22: 6321-6335
[Full Text]
-
Cheng, H.-C., Shih, H.-M., Chern, Y.
(2002). Essential Role of cAMP-response Element-binding Protein Activation by A2A Adenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade. J. Biol. Chem.
277: 33930-33942
[Abstract]
[Full Text]
-
Beier, F., LuValle, P.
(2002). The Cyclin D1 and Cyclin A Genes Are Targets of Activated PTH/PTHrP Receptors in Jansen's Metaphyseal Chondrodysplasia. Mol. Endocrinol.
16: 2163-2173
[Abstract]
[Full Text]
-
Chepurny, O. G., Hussain, M. A., Holz, G. G.
(2002). Exendin-4 as a Stimulator of Rat Insulin I Gene Promoter Activity via bZIP/CRE Interactions Sensitive to Serine/Threonine Protein Kinase Inhibitor Ro 31-8220. Endocrinology
143: 2303-2313
[Abstract]
[Full Text]
-
Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P., Arthur, J. S. C.
(2002). MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts. Mol. Cell. Biol.
22: 2871-2881
[Abstract]
[Full Text]
-
Moll, J. R., Acharya, A., Gal, J., Mir, A. A., Vinson, C.
(2002). Magnesium is required for specific DNA binding of the CREB B-ZIP domain. Nucleic Acids Res
30: 1240-1246
[Abstract]
[Full Text]
-
Zentrich, E., Han, S.-Y., Pessoa-Brandao, L., Butterfield, L., Heasley, L. E.
(2002). Collaboration of JNKs and ERKs in Nerve Growth Factor Regulation of the Neurofilament Light Chain Promoter in PC12 Cells. J. Biol. Chem.
277: 4110-4118
[Abstract]
[Full Text]
-
Manna, P. R., Dyson, M. T., Eubank, D. W., Clark, B. J., Lalli, E., Sassone-Corsi, P., Zeleznik, A. J., Stocco, D. M.
(2002). Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein Family. Mol. Endocrinol.
16: 184-199
[Abstract]
[Full Text]
-
Beier, F., Ali, Z., Mok, D., Taylor, A. C., Leask, T., Albanese, C., Pestell, R. G., LuValle, P.
(2001). TGFbeta and PTHrP Control Chondrocyte Proliferation by Activating Cyclin D1 Expression. Mol. Biol. Cell
12: 3852-3863
[Abstract]
[Full Text]