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Mol Cell Biol, May 1998, p. 2553-2558, Vol. 18, No. 5
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Stat3 Activation Is Required for Cellular Transformation by v-src

Jacqueline F. Bromberg,1 Curt M. Horvath,1 Daniel Besser,2 Wyndham W. Lathem,1 and James E. Darnell Jr.1,*

Laboratory of Molecular Cell Biology1 and Laboratory of Molecular Oncology,2 The Rockefeller University, New York, New York 10021-6399

Received 16 September 1997/Returned for modification 13 November 1997/Accepted 29 January 1998

Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.

* Corresponding author. Mailing address: Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Ave., New York, NY 10021-6399. Phone: (212) 327-8791. Fax: (212) 327-8801. E-mail: darnell{at}rockvax.rockefeller.edu.

Mol Cell Biol, May 1998, p. 2553-2558, Vol. 18, No. 5
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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  • Richardson, C., Fielding, C., Rowe, M., Brennan, P. (2003). Epstein-Barr Virus Regulates STAT1 through Latent Membrane Protein 1. J. Virol. 77: 4439-4443 [Abstract] [Full Text]  
  • Clevenger, C. V., Furth, P. A., Hankinson, S. E., Schuler, L. A. (2003). The Role of Prolactin in Mammary Carcinoma. Endocr. Rev. 24: 1-27 [Abstract] [Full Text]  
  • Dolled-Filhart, M., Camp, R. L., Kowalski, D. P., Smith, B. L., Rimm, D. L. (2003). Tissue Microarray Analysis of Signal Transducers and Activators of Transcription 3 (Stat3) and Phospho-Stat3 (Tyr705) in Node-negative Breast Cancer Shows Nuclear Localization Is Associated with a Better Prognosis. Clin. Cancer Res. 9: 594-600 [Abstract] [Full Text]  
  • Barre, B., Avril, S., Coqueret, O. (2003). Opposite Regulation of Myc and p21waf1 Transcription by STAT3 Proteins. J. Biol. Chem. 278: 2990-2996 [Abstract] [Full Text]  
  • Kloth, M. T., Laughlin, K. K., Biscardi, J. S., Boerner, J. L., Parsons, S. J., Silva, C. M. (2003). STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor. J. Biol. Chem. 278: 1671-1679 [Abstract] [Full Text]  
  • Krause, A., Scaletta, N., Ji, J.-D., Ivashkiv, L. B. (2002). Rheumatoid Arthritis Synoviocyte Survival Is Dependent on Stat3. J. Immunol. 169: 6610-6616 [Abstract] [Full Text]  
  • Mora, L. B., Buettner, R., Seigne, J., Diaz, J., Ahmad, N., Garcia, R., Bowman, T., Falcone, R., Fairclough, R., Cantor, A., Muro-Cacho, C., Livingston, S., Karras, J., Pow-Sang, J., Jove, R. (2002). Constitutive Activation of Stat3 in Human Prostate Tumors and Cell Lines: Direct Inhibition of Stat3 Signaling Induces Apoptosis of Prostate Cancer Cells. Cancer Res. 62: 6659-6666 [Abstract] [Full Text]  
  • Schreiner, S. J., Schiavone, A. P., Smithgall, T. E. (2002). Activation of STAT3 by the Src Family Kinase Hck Requires a Functional SH3 Domain. J. Biol. Chem. 277: 45680-45687 [Abstract] [Full Text]  
  • Ren, Z., Schaefer, T. S. (2002). ErbB-2 Activates Stat3alpha in a Src- and JAK2-dependent Manner. J. Biol. Chem. 277: 38486-38493 [Abstract] [Full Text]  
  • Yoshida, T., Hanada, T., Tokuhisa, T., Kosai, K.-i., Sata, M., Kohara, M., Yoshimura, A. (2002). Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation. JEM 196: 641-653 [Abstract] [Full Text]  
  • Peng, B., Sutherland, K. D., Sum, E. Y. M., Olayioye, M., Wittlin, S., Tang, T. K., Lindeman, G. J., Visvader, J. E. (2002). CPAP Is a Novel Stat5-Interacting Cofactor that Augments Stat5-Mediated Transcriptional Activity. Mol. Endocrinol. 16: 2019-2033 [Abstract] [Full Text]  
  • Sato, K.-i., Nagao, T., Kakumoto, M., Kimoto, M., Otsuki, T., Iwasaki, T., Tokmakov, A. A., Owada, K., Fukami, Y. (2002). Adaptor Protein Shc Is an Isoform-specific Direct Activator of the Tyrosine Kinase c-Src. J. Biol. Chem. 277: 29568-29576 [Abstract] [Full Text]  
  • Dong, S., Tweardy, D. J. (2002). Interactions of STAT5b-RARalpha , a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood 99: 2637-2646 [Abstract] [Full Text]  
  • Buettner, R., Mora, L. B., Jove, R. (2002). Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention. Clin. Cancer Res. 8: 945-954 [Abstract] [Full Text]  
  • Nguyen, K. T., Zong, C. S., Uttamsingh, S., Sachdev, P., Bhanot, M., Le, M.-T., Chan, J. L.-K., Wang, L.-H. (2002). The Role of Phosphatidylinositol 3-Kinase, Rho Family GTPases, and STAT3 in Ros-induced Cell Transformation. J. Biol. Chem. 277: 11107-11115 [Abstract] [Full Text]  
  • Giraud, S., Bienvenu, F., Avril, S., Gascan, H., Heery, D. M., Coqueret, O. (2002). Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a. J. Biol. Chem. 277: 8004-8011 [Abstract] [Full Text]  
  • Chang, Y.-J., Holtzman, M. J., Chen, C.-C. (2002). Interferon-gamma -induced Epithelial ICAM-1 Expression and Monocyte Adhesion. INVOLVEMENT OF PROTEIN KINASE C-DEPENDENT c-Src TYROSINE KINASE ACTIVATION PATHWAY. J. Biol. Chem. 277: 7118-7126 [Abstract] [Full Text]  
  • Gwack, Y., Hwang, S., Lim, C., Won, Y. S., Lee, C. H., Choe, J. (2002). Kaposi's Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3. J. Biol. Chem. 277: 6438-6442 [Abstract] [Full Text]  
  • Osugi, T., Oshima, Y., Fujio, Y., Funamoto, M., Yamashita, A., Negoro, S., Kunisada, K., Izumi, M., Nakaoka, Y., Hirota, H., Okabe, M., Yamauchi-Takihara, K., Kawase, I., Kishimoto, T. (2002). Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart. J. Biol. Chem. 277: 6676-6681 [Abstract] [Full Text]  
  • Skinnider, B. F., Elia, A. J., Gascoyne, R. D., Patterson, B., Trumper, L., Kapp, U., Mak, T. W. (2002). Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 99: 618-626 [Abstract] [Full Text]  


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