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Mol Cell Biol, May 1998, p. 3034-3043, Vol. 18, No. 5
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Mutation in the Arabidopsis PASTICCINO1 Gene, Which Encodes a New FK506-Binding Protein-Like Protein, Has a Dramatic Effect on Plant Development

Paola Vittorioso,dagger Rachel Cowling, Jean-Denis Faure, Michel Caboche, and Catherine Bellini*

Laboratoire de Biologie Cellulaire, INRA-Centre de Versailles, 78026 Versailles Cedex, France

Received 22 August 1997/Returned for modification 2 October 1997/Accepted 16 February 1998

The pasticcino (pas) mutants of Arabidopsis thaliana are a new class of plant developmental mutants; members of this class show ectopic cell proliferation in cotyledons, extra layers of cells in the hypocotyl, and an abnormal apical meristem. This phenotype is correlated with both cell division and cell elongation defects. There are three complementation groups of pas mutants (pas1, pas2, and pas3, with, respectively 2, 1, and 4 alleles). Here we describe in more detail the pas1-1 allele, which was obtained by insertional mutagenesis. The PAS1 gene has been cloned and characterized; it encodes an immunophilin-like protein similar to the p59 FK506-binding protein (FKBP52). PAS1 is characterized by an FKBP-like domain and three tetratricopeptide repeat units. Although the presence of immunophilins in plants has already been demonstrated, the pas1-1 mutant represents the first inactivation of an FKBP-like gene in plants. PAS1 expression is altered in pas1 mutants and in the pas2 and pas3 mutants. The expression of the PAS1 gene is increased in the presence of cytokinins, a class of phytohormones originally discovered because of their ability to stimulate cell division. These results are of particular relevance as they show for the first time that an FKBP-like protein plays an important role in the control of plant development.

* Corresponding author. Mailing address: Laboratoire de Biologie Cellulaire, INRA-Centre de Versailles, Route de St. Cyr, 78026 Versailles Cedex, France. Phone: (33 1) 30833095. Fax: (33 1) 30833099. E-mail: bellini{at}versailles.inra.fr.

dagger Present address: Dipartimento di Genetica e Biologia Molecolare, Università di Roma "La Sapienza," 00185 Rome, Italy.

Mol Cell Biol, May 1998, p. 3034-3043, Vol. 18, No. 5
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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