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Mol Cell Biol, August 1998, p. 4488-4498, Vol. 18, No. 8
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast

Kappei Tsukahara, Hanako Yamamoto, and Hiroto Okayama*

Department of Biochemistry and Molecular Biology, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113, Japan

Received 5 March 1998/Returned for modification 8 April 1998/Accepted 8 May 1998

The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1+, encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1+ causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1+ is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113, Japan. Phone: 81-3-5689-0876. Fax: 81-3-3815-1490. E-mail: okayama{at}m.u-tokyo.ac.jp.

Mol Cell Biol, August 1998, p. 4488-4498, Vol. 18, No. 8
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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