This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hsu, S.-C.
Right arrow Articles by Grosschedl, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsu, S.-C.
Right arrow Articles by Grosschedl, R.

 Previous Article  |  Next Article 

Mol Cell Biol, August 1998, p. 4807-4818, Vol. 18, No. 8
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Modulation of Transcriptional Regulation by LEF-1 in Response to Wnt-1 Signaling and Association with beta -Catenin

Shu-Chi Hsu, Juan Galceran, and Rudolf Grosschedl*

Howard Hughes Medical Institute, Departments of Microbiology and Biochemistry, University of California, San Francisco, California 94143-0414

Received 10 March 1998/Returned for modification 14 April 1998/Accepted 26 May 1998

Wnt signaling is thought to be mediated via interactions between beta -catenin and members of the LEF-1/TCF family of transcription factors. Here we study the mechanism of transcriptional regulation by LEF-1 in response to a Wnt-1 signal under conditions of endogenous beta -catenin in NIH 3T3 cells, and we examine whether association with beta -catenin is obligatory for the function of LEF-1. We find that Wnt-1 signaling confers transcriptional activation potential upon LEF-1 by association with beta -catenin in the nucleus. By mutagenesis, we identified specific residues in LEF-1 important for interaction with beta -catenin, and we delineated two transcriptional activation domains in beta -catenin whose function is augmented in specific association with LEF-1. Finally, we show that a Wnt-1 signal and beta -catenin association are not required for the architectural function of LEF-1 in the regulation of the T-cell receptor alpha  enhancer, which involves association of LEF-1 with a different cofactor, ALY. Thus, LEF-1 can assume diverse regulatory functions by association with different proteins.


* Corresponding author. Mailing address: Howard Hughes Medical Institute, Departments of Microbiology and Biochemistry, University of California, San Francisco, CA 94143-0414. Phone: (415) 476-6954. Fax: (415) 476-8201. E-mail: rgross{at}itsa.ucsf.edu.


Mol Cell Biol, August 1998, p. 4807-4818, Vol. 18, No. 8
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Westenskow, P., Piccolo, S., Fuhrmann, S. (2009). {beta}-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development 136: 2505-2510 [Abstract] [Full Text]  
  • Fuhrmann, S., Riesenberg, A. N., Mathiesen, A. M., Brown, E. C., Vetter, M. L., Brown, N. L. (2009). Characterization of a Transient TCF/LEF-Responsive Progenitor Population in the Embryonic Mouse Retina. IOVS 50: 432-440 [Abstract] [Full Text]  
  • Gao, X., Wen, J., Zhang, L., Li, X., Ning, Y., Meng, A., Chen, Y.-G. (2008). Dapper1 Is a Nucleocytoplasmic Shuttling Protein That Negatively Modulates Wnt Signaling in the Nucleus. J. Biol. Chem. 283: 35679-35688 [Abstract] [Full Text]  
  • Kennell, J. A., Gerin, I., MacDougald, O. A., Cadigan, K. M. (2008). The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. USA 105: 15417-15422 [Abstract] [Full Text]  
  • Wang, K., Zhang, Y., Li, X., Chen, L., Wang, H., Wu, J., Zheng, J., Wu, D. (2008). Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism. J. Biol. Chem. 283: 23371-23375 [Abstract] [Full Text]  
  • Boman, B. M., Huang, E. (2008). Human Colon Cancer Stem Cells: A New Paradigm in Gastrointestinal Oncology. JCO 26: 2828-2838 [Abstract] [Full Text]  
  • Sustmann, C., Flach, H., Ebert, H., Eastman, Q., Grosschedl, R. (2008). Cell-Type-Specific Function of BCL9 Involves a Transcriptional Activation Domain That Synergizes with {beta}-Catenin. Mol. Cell. Biol. 28: 3526-3537 [Abstract] [Full Text]  
  • Tran, H., Hamada, F., Schwarz-Romond, T., Bienz, M. (2008). Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22: 528-542 [Abstract] [Full Text]  
  • Wu, W., Xu, R. F., Xiao, L., Xu, H., Gao, G. (2008). Expression of the -Catenin Gene in the Skin of Embryonic Geese During Feather Bud Development. Poult. Sci. 87: 204-211 [Abstract] [Full Text]  
  • Amen, M., Liu, X., Vadlamudi, U., Elizondo, G., Diamond, E., Engelhardt, J. F., Amendt, B. A. (2007). PITX2 and {beta}-Catenin Interactions Regulate Lef-1 Isoform Expression. Mol. Cell. Biol. 27: 7560-7573 [Abstract] [Full Text]  
  • Tang, L.-Y., Deng, N., Wang, L.-S., Dai, J., Wang, Z.-L., Jiang, X.-S., Li, S.-J., Li, L., Sheng, Q.-H., Wu, D.-Q., Li, L., Zeng, R. (2007). Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network: Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction. Mol. Cell. Proteomics 6: 1952-1967 [Abstract] [Full Text]  
  • Wei, Q., Yokota, C., Semenov, M. V., Doble, B., Woodgett, J., He, X. (2007). R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and beta-Catenin Signaling. J. Biol. Chem. 282: 15903-15911 [Abstract] [Full Text]  
  • Mertz, J. A., Kobayashi, R., Dudley, J. P. (2007). ALY Is a Common Coactivator of RUNX1 and c-Myb on the Type B Leukemogenic Virus Enhancer. J. Virol. 81: 3503-3513 [Abstract] [Full Text]  
  • Diamond, E., Amen, M., Hu, Q., Espinoza, H. M., Amendt, B. A. (2006). Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2. Nucleic Acids Res 34: 5951-5965 [Abstract] [Full Text]  
  • Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., Buckingham, M., Cossu, G. (2006). The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133: 3723-3732 [Abstract] [Full Text]  
  • Zhang, L., Gao, X., Wen, J., Ning, Y., Chen, Y.-G. (2006). Dapper 1 Antagonizes Wnt Signaling by Promoting Dishevelled Degradation. J. Biol. Chem. 281: 8607-8612 [Abstract] [Full Text]  
  • Ghogomu, S. M., van Venrooy, S., Ritthaler, M., Wedlich, D., Gradl, D. (2006). HIC-5 Is a Novel Repressor of Lymphoid Enhancer Factor/T-cell Factor-driven Transcription. J. Biol. Chem. 281: 1755-1764 [Abstract] [Full Text]  
  • Park, C. H., Hahm, E. R., Lee, J. H., Jung, K. C., Rhee, H. S., Yang, C. H. (2005). Ionomycin downregulates {beta}-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis 26: 1929-1933 [Abstract] [Full Text]  
  • Ouchi, Y., Tabata, Y., Arai, K.-i., Watanabe, S. (2005). Negative regulation of retinal-neurite extension by {beta}-catenin signaling pathway. J. Cell Sci. 118: 4473-4483 [Abstract] [Full Text]  
  • Nakamura, Y., Nawata, M., Wakitani, S. (2005). Expression Profiles and Functional Analyses of Wnt-Related Genes in Human Joint Disorders. Am. J. Pathol. 167: 97-105 [Abstract] [Full Text]  
  • Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., Wu, D. (2005). Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling. J. Biol. Chem. 280: 19883-19887 [Abstract] [Full Text]  
  • Howcroft, T. K., Weissman, J. D., Gegonne, A., Singer, D. S. (2005). A T Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression. J. Immunol. 174: 2106-2115 [Abstract] [Full Text]  
  • Jansson, E. A., Are, A., Greicius, G., Kuo, I-C., Kelly, D., Arulampalam, V., Pettersson, S. (2005). The Wnt/{beta}-catenin signaling pathway targets PPAR{gamma} activity in colon cancer cells. Proc. Natl. Acad. Sci. USA 102: 1460-1465 [Abstract] [Full Text]  
  • Galceran, J., Sustmann, C., Hsu, S.-C., Folberth, S., Grosschedl, R. (2004). LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18: 2718-2723 [Abstract] [Full Text]  
  • Roth, W., Sustmann, C., Kieslinger, M., Gilmozzi, A., Irmer, D., Kremmer, E., Turck, C., Grosschedl, R. (2004). PIASy-Deficient Mice Display Modest Defects in IFN and Wnt Signaling. J. Immunol. 173: 6189-6199 [Abstract] [Full Text]  
  • Kokubu, C., Heinzmann, U., Kokubu, T., Sakai, N., Kubota, T., Kawai, M., Wahl, M. B., Galceran, J., Grosschedl, R., Ozono, K., Imai, K. (2004). Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131: 5469-5480 [Abstract] [Full Text]  
  • Quelo, I., Gauthier, C., Hannigan, G. E., Dedhar, S., St-Arnaud, R. (2004). Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator {alpha}-NAC and Its Coactivation Potency. J. Biol. Chem. 279: 43893-43899 [Abstract] [Full Text]  
  • Driskell, R. R., Liu, X., Luo, M., Filali, M., Zhou, W., Abbott, D., Cheng, N., Moothart, C., Sigmund, C. D., Engelhardt, J. F. (2004). Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L752-L763 [Abstract] [Full Text]  
  • Billottet, C., Elkhatib, N., Thiery, J.-P., Jouanneau, J. (2004). Targets of Fibroblast Growth Factor 1 (FGF-1) and FGF-2 Signaling Involved in the Invasive and Tumorigenic Behavior of Carcinoma Cells. Mol. Biol. Cell 15: 4725-4734 [Abstract] [Full Text]  
  • Guo, R.-J., Huang, E., Ezaki, T., Patel, N., Sinclair, K., Wu, J., Klein, P., Suh, E.-R., Lynch, J. P. (2004). Cdx1 Inhibits Human Colon Cancer Cell Proliferation by Reducing {beta}-Catenin/T-cell Factor Transcriptional Activity. J. Biol. Chem. 279: 36865-36875 [Abstract] [Full Text]  
  • Otero, J. J., Fu, W., Kan, L., Cuadra, A. E., Kessler, J. A. (2004). {beta}-Catenin signaling is required for neural differentiation of embryonic stem cells. Development 131: 3545-3557 [Abstract] [Full Text]  
  • Maye, P., Zheng, J., Li, L., Wu, D. (2004). Multiple Mechanisms for Wnt11-mediated Repression of the Canonical Wnt Signaling Pathway. J. Biol. Chem. 279: 24659-24665 [Abstract] [Full Text]  
  • El-Tanani, M., Platt-Higgins, A., Rudland, P. S., Campbell, F. C. (2004). Ets Gene PEA3 Cooperates with {beta}-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription. J. Biol. Chem. 279: 20794-20806 [Abstract] [Full Text]  
  • Goodall, J., Martinozzi, S., Dexter, T. J., Champeval, D., Carreira, S., Larue, L., Goding, C. R. (2004). Brn-2 Expression Controls Melanoma Proliferation and Is Directly Regulated by {beta}-Catenin. Mol. Cell. Biol. 24: 2915-2922 [Abstract] [Full Text]  
  • Goodall, J., Wellbrock, C., Dexter, T. J., Roberts, K., Marais, R., Goding, C. R. (2004). The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation. Mol. Cell. Biol. 24: 2923-2931 [Abstract] [Full Text]  
  • Townsley, F. M., Thompson, B., Bienz, M. (2004). Pygopus Residues Required for its Binding to Legless Are Critical for Transcription and Development. J. Biol. Chem. 279: 5177-5183 [Abstract] [Full Text]  
  • Li, F.-Q., Person, R. E., Takemaru, K.-I., Williams, K., Meade-White, K., Ozsahin, A. H., Gungor, T., Moon, R. T., Horwitz, M. (2004). Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor {alpha} Regulation of ELA2. J. Biol. Chem. 279: 2873-2884 [Abstract] [Full Text]  
  • Cong, F., Schweizer, L., Chamorro, M., Varmus, H. (2003). Requirement for a Nuclear Function of {beta}-Catenin in Wnt Signaling. Mol. Cell. Biol. 23: 8462-8470 [Abstract] [Full Text]  
  • Jordan, B. K., Shen, J. H.-C., Olaso, R., Ingraham, H. A., Vilain, E. (2003). Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/{beta}-catenin synergy. Proc. Natl. Acad. Sci. USA 100: 10866-10871 [Abstract] [Full Text]  
  • Shin, H. S., Lee, H. J., Nishida, M., Lee, M.-S., Tamura, R., Yamashita, S., Matsuzawa, Y., Lee, I.-K., Koh, G. Y. (2003). Betacellulin and Amphiregulin Induce Upregulation of Cyclin D1 and DNA Synthesis Activity Through Differential Signaling Pathways in Vascular Smooth Muscle Cells. Circ. Res. 93: 302-310 [Abstract] [Full Text]  
  • Ioannidis, V., Kunz, B., Tanamachi, D. M., Scarpellino, L., Held, W. (2003). Initiation and Limitation of Ly-49A NK Cell Receptor Acquisition by T Cell Factor-1. J. Immunol. 171: 769-775 [Abstract] [Full Text]  
  • Grueneberg, D. A., Pablo, L., Hu, K.-Q., August, P., Weng, Z., Papkoff, J. (2003). A Functional Screen in Human Cells Identifies UBF2 as an RNA Polymerase II Transcription Factor That Enhances the {beta}-Catenin Signaling Pathway. Mol. Cell. Biol. 23: 3936-3950 [Abstract] [Full Text]  
  • Haq, S., Michael, A., Andreucci, M., Bhattacharya, K., Dotto, P., Walters, B., Woodgett, J., Kilter, H., Force, T. (2003). Stabilization of beta -catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc. Natl. Acad. Sci. USA 100: 4610-4615 [Abstract] [Full Text]  
  • Kahler, R. A., Westendorf, J. J. (2003). Lymphoid Enhancer Factor-1 and beta -Catenin Inhibit Runx2-dependent Transcriptional Activation of the Osteocalcin Promoter. J. Biol. Chem. 278: 11937-11944 [Abstract] [Full Text]  
  • Baek, S. H., Kioussi, C., Briata, P., Wang, D., Nguyen, H. D., Ohgi, K. A., Glass, C. K., Wynshaw-Boris, A., Rose, D. W., Rosenfeld, M. G. (2003). Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc. Natl. Acad. Sci. USA 100: 3245-3250 [Abstract] [Full Text]  
  • Yang, J., Tan, C., Darken, R. S., Wilson, P. A., Klein, P. S. (2003). {beta}-Catenin/Tcf-regulated transcription prior to the midblastula transition. Development 129: 5743-5752 [Abstract] [Full Text]  
  • Siegfried, K. R., Kimble, J. (2003). POP-1 controls axis formation during early gonadogenesis in C. elegans. Development 129: 443-453 [Abstract] [Full Text]  
  • Hecht, A., Stemmler, M. P. (2003). Identification of a Promoter-specific Transcriptional Activation Domain at the C Terminus of the Wnt Effector Protein T-cell Factor 4. J. Biol. Chem. 278: 3776-3785 [Abstract] [Full Text]  
  • Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kuhl, M., Behrens, J., von der Mark, K., Starzinski-Powitz, A., Wixler, V. (2002). The LIM-only protein FHL2 interacts with {beta}-catenin and promotes differentiation of mouse myoblasts. JCB 159: 113-122 [Abstract] [Full Text]  
  • Jin, Z.-X., Kishi, H., Wei, X.-C., Matsuda, T., Saito, S., Muraguchi, A. (2002). Lymphoid Enhancer-Binding Factor-1 Binds and Activates the Recombination-Activating Gene-2 Promoter Together with c-Myb and Pax-5 in Immature B Cells. J. Immunol. 169: 3783-3792 [Abstract] [Full Text]  
  • Filali, M., Cheng, N., Abbott, D., Leontiev, V., Engelhardt, J. F. (2002). Wnt-3A/beta -Catenin Signaling Induces Transcription from the LEF-1 Promoter. J. Biol. Chem. 277: 33398-33410 [Abstract] [Full Text]  
  • DasGupta, R., Rhee, H., Fuchs, E. (2002). A developmental conundrum: a stabilized form of {beta}-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells. JCB 158: 331-344 [Abstract] [Full Text]  
  • Christian, S. L., Sims, P. V., Gold, M. R. (2002). The B Cell Antigen Receptor Regulates the Transcriptional Activator {beta}-Catenin Via Protein Kinase C-Mediated Inhibition of Glycogen Synthase Kinase-3. J. Immunol. 169: 758-769 [Abstract] [Full Text]  
  • Henderson, B. R., Galea, M., Schuechner, S., Leung, L. (2002). Lymphoid Enhancer Factor-1 Blocks Adenomatous Polyposis Coli-mediated Nuclear Export and Degradation of beta -Catenin. REGULATION BY HISTONE DEACETYLASE 1. J. Biol. Chem. 277: 24258-24264 [Abstract] [Full Text]  
  • Monga, S. P. S., Mars, W. M., Pediaditakis, P., Bell, A., Mule, K., Bowen, W. C., Wang, X., Zarnegar, R., Michalopoulos, G. K. (2002). Hepatocyte Growth Factor Induces Wnt-independent Nuclear Translocation of {beta}-Catenin after Met-{beta}-Catenin Dissociation in Hepatocytes. Cancer Res. 62: 2064-2071 [Abstract] [Full Text]  
  • Briggs, M. W., Li, Z., Sacks, D. B. (2002). IQGAP1-mediated Stimulation of Transcriptional Co-activation by beta -Catenin Is Modulated by Calmodulin. J. Biol. Chem. 277: 7453-7465 [Abstract] [Full Text]  
  • Li, L., Mao, J., Sun, L., Liu, W., Wu, D. (2002). Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled. J. Biol. Chem. 277: 5977-5981 [Abstract] [Full Text]  
  • Tutter, A. V., Fryer, C. J., Jones, K. A. (2001). Chromatin-specific regulation of LEF-1-beta -catenin transcription activation and inhibition in vitro. Genes Dev. 15: 3342-3354 [Abstract] [Full Text]  
  • Chen, W., Hu, L. A., Semenov, M. V., Yanagawa, S., Kikuchi, A., Lefkowitz, R. J., Miller, W. E. (2001). beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. USA 10.1073/pnas.211572798v1 [Abstract] [Full Text]  
  • Sachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., Grosschedl, R. (2001). PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15: 3088-3103 [Abstract] [Full Text]  
  • Ross, D. A., Kadesch, T. (2001). The Notch Intracellular Domain Can Function as a Coactivator for LEF-1. Mol. Cell. Biol. 21: 7537-7544 [Abstract] [Full Text]  
  • Lamberti, C., Lin, K.-M., Yamamoto, Y., Verma, U., Verma, I. M., Byers, S., Gaynor, R. B. (2001). Regulation of beta -Catenin Function by the Ikappa B Kinases. J. Biol. Chem. 276: 42276-42286 [Abstract] [Full Text]  
  • Woodgett, J. R. (2001). Judging a Protein by More Than Its Name: GSK-3. Sci Signal 2001: re12-re12 [Abstract] [Full Text]  
  • Natarajan, L., Witwer, N. E., Eisenmann, D. M. (2001). The Divergent Caenorhabditis elegans {beta}-Catenin Proteins BAR-1, WRM-1 and HMP-2 Make Distinct Protein Interactions but Retain Functional Redundancy in Vivo. Genetics 159: 159-172 [Abstract] [Full Text]  
  • Galceran, J., Hsu, S.-C., Grosschedl, R. (2001). Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression. Proc. Natl. Acad. Sci. USA 10.1073/pnas.151258098v1 [Abstract] [Full Text]  
  • Gottardi, C. J., Wong, E., Gumbiner, B. M. (2001). E-Cadherin Suppresses Cellular Transformation by Inhibiting {beta}-Catenin Signaling in an Adhesion-Independent Manner. JCB 153: 1049-1060 [Abstract] [Full Text]  
  • Kunz, B., Held, W. (2001). Positive and Negative Roles of the Trans-Acting T Cell Factor-1 for the Acquisition of Distinct Ly-49 MHC Class I Receptors by NK Cells. J. Immunol. 166: 6181-6187 [Abstract] [Full Text]  
  • Fearnhead, N. S., Britton, M. P., Bodmer, W. F. (2001). The ABC of APC. Hum Mol Genet 10: 721-733 [Abstract] [Full Text]  
  • Simcha, I., Kirkpatrick, C., Sadot, E., Shtutman, M., Polevoy, G., Geiger, B., Peifer, M., Ben-Ze'ev, A. (2001). Cadherin Sequences That Inhibit {beta}-Catenin Signaling: A Study in Yeast and Mammalian Cells. Mol. Biol. Cell 12: 1177-1188 [Abstract] [Full Text]  
  • Letamendia, A., Labbe, E., Attisano, L. (2001). Transcriptional Regulation by Smads: Crosstalk between the TGF-{beta} and Wnt Pathways. JBJS 83: S31-39 [Abstract] [Full Text]  
  • Yan, D., Wallingford, J. B., Sun, T.-Q., Nelson, A. M., Sakanaka, C., Reinhard, C., Harland, R. M., Fantl, W. J., Williams, L. T. (2001). Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc. Natl. Acad. Sci. USA 98: 3802-3807 [Abstract] [Full Text]  
  • Letamendia, A., Labbe, E., Attisano, L. (2001). Transcriptional Regulation by Smads: Crosstalk between the TGF-{beta} and Wnt Pathways. JBJS 83: S31-S39 [Abstract] [Full Text]  
  • Chen, S., Guttridge, D. C., You, Z., Zhang, Z., Fribley, A., Mayo, M. W., Kitajewski, J., Wang, C.-Y. (2001). WNT-1 Signaling Inhibits Apoptosis by Activating {beta}-Catenin/T Cell Factor-Mediated Transcription. JCB 152: 87-96 [Abstract] [Full Text]  
  • Goichberg, P, Shtutman, M, Ben-Ze'ev, A, Geiger, B (2001). Recruitment of (&bgr;)-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction. J. Cell Sci. 114: 1309-1319 [Abstract]  
  • Lo Muzio, L. (2001). A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis. CROBM 12: 152-165 [Abstract] [Full Text]  
  • Sun, Y., Kolligs, F. T., Hottiger, M. O., Mosavin, R., Fearon, E. R., Nabel, G. J. (2000). Regulation of beta -catenin transformation by the p300 transcriptional coactivator. Proc. Natl. Acad. Sci. USA 10.1073/pnas.220158597v1 [Abstract] [Full Text]  
  • Playford, M. P., Bicknell, D., Bodmer, W. F., Macaulay, V. M. (2000). Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin. Proc. Natl. Acad. Sci. USA 10.1073/pnas.210394297v1 [Abstract] [Full Text]  
  • Kim, K., Pang, K. M., Evans, M., Hay, E. D. (2000). Overexpression of beta -Catenin Induces Apoptosis Independent of Its Transactivation Function with LEF-1 or the Involvement of Major G1 Cell Cycle Regulators. Mol. Biol. Cell 11: 3509-3523 [Abstract] [Full Text]  
  • Billin, A. N., Thirlwell, H., Ayer, D. E. (2000). beta -Catenin-Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator. Mol. Cell. Biol. 20: 6882-6890 [Abstract] [Full Text]  
  • Tago, K.-i., Nakamura, T., Nishita, M., Hyodo, J., Nagai, S.-i., Murata, Y., Adachi, S., Ohwada, S., Morishita, Y., Shibuya, H., Akiyama, T. (2000). Inhibition of Wnt signaling by ICAT, a novel beta -catenin-interacting protein. Genes Dev. 14: 1741-1749 [Abstract] [Full Text]  
  • Labbé, E., Letamendia, A., Attisano, L. (2000). Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and Wnt pathways. Proc. Natl. Acad. Sci. USA 10.1073/pnas.150152697v1 [Abstract] [Full Text]  
  • Zhurinsky, J., Shtutman, M., Ben-Ze'ev, A. (2000). Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by beta -Catenin and Plakoglobin. Mol. Cell. Biol. 20: 4238-4252 [Abstract] [Full Text]  
  • Kolligs, F. T., Kolligs, B., Hajra, K. M., Hu, G., Tani, M., Cho, K. R., Fearon, E. R. (2000). gamma -Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta -catenin. Genes Dev. 14: 1319-1331 [Abstract] [Full Text]  
  • Szuts, D., Bienz, M. (2000). LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator. Proc. Natl. Acad. Sci. USA 97: 5351-5356 [Abstract] [Full Text]  
  • Takemaru, K.-I., Moon, R. T. (2000). The Transcriptional Coactivator Cbp Interacts with {beta}-Catenin to Activate Gene Expression. JCB 149: 249-254 [Abstract] [Full Text]  
  • Yahata, T., de Caestecker, M. P., Lechleider, R. J., Andriole, S., Roberts, A. B., Isselbacher, K. J., Shioda, T. (2000). The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors. J. Biol. Chem. 275: 8825-8834 [Abstract] [Full Text]  
  • Zhurinsky, J, Shtutman, M, Ben-Ze'ev, A (2000). Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J. Cell Sci. 113: 3127-3139 [Abstract]  
  • Behrens, J (2000). Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J. Cell Sci. 113: 911-919 [Abstract]  
  • Galceran, J, Miyashita-Lin, E., Devaney, E, Rubenstein, J., Grosschedl, R (2000). Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 127: 469-482 [Abstract]  
  • Yuan, H., Mao, J., Li, L., Wu, D. (1999). Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation. J. Biol. Chem. 274: 30419-30423 [Abstract] [Full Text]  
  • Moriguchi, T., Kawachi, K., Kamakura, S., Masuyama, N., Yamanaka, H., Matsumoto, K., Kikuchi, A., Nishida, E. (1999). Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates. J. Biol. Chem. 274: 30957-30962 [Abstract] [Full Text]  
  • Fry, C. J., Farnham, P. J. (1999). Context-dependent Transcriptional Regulation. J. Biol. Chem. 274: 29583-29586 [Full Text]  
  • Ohto, H., Kamada, S., Tago, K., Tominaga, S.-I., Ozaki, H., Sato, S., Kawakami, K. (1999). Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya. Mol. Cell. Biol. 19: 6815-6824 [Abstract] [Full Text]  
  • Klymkowsky, M. W., Williams, B. O., Barish, G. D., Varmus, H. E., Vourgourakis, Y. E. (1999). Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling. Mol. Biol. Cell 10: 3151-3169 [Abstract] [Full Text]  
  • Kolligs, F. T., Hu, G., Dang, C. V., Fearon, E. R. (1999). Neoplastic Transformation of RK3E by Mutant beta -Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression. Mol. Cell. Biol. 19: 5696-5706 [Abstract] [Full Text]  
  • Hecht, A., Litterst, C. M., Huber, O., Kemler, R. (1999). Functional Characterization of Multiple Transactivating Elements in beta -Catenin, Some of Which Interact with the TATA-binding Protein in Vitro. J. Biol. Chem. 274: 18017-18025 [Abstract] [Full Text]  
  • Prieve, M. G., Waterman, M. L. (1999). Nuclear Localization and Formation of beta -Catenin-Lymphoid Enhancer Factor 1 Complexes Are Not Sufficient for Activation of Gene Expression. Mol. Cell. Biol. 19: 4503-4515 [Abstract] [Full Text]  
  • Caca, K., Kolligs, F. T., Ji, X., Hayes, M., Qian, J.-m., Yahanda, A., Rimm, D. L., Costa, J., Fearon, E. R. (1999). {beta}- and {{gamma}}-Catenin Mutations, but not E-Cadherin Inactivation, Underlie T-Cell Factor/Lymphoid Enhancer Factor Transcriptional Deregulation in Gastric and Pancreatic Cancer. Cell Growth Differ. 10: 369-376 [Abstract] [Full Text]