Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

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Molecular and Cellular Biology, September 1998, p. 5121-5127, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

David Kadosh and Kevin Struhl^*

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115

Received 15 May 1998/Returned for modification 3 June 1998/Accepted 16 June 1998

Eukaryotic organisms contain a multiprotein complex that includes Rpd3 histone deacetylase and the Sin3 corepressor. The Sin3-Rpd3complex is recruited to promoters by specific DNA-binding proteins,whereupon it represses transcription. By directly analyzing thechromatin structure of a repressed promoter in yeast cells, wedemonstrate that transcriptional repression is associated withlocalized histone deacetylation. Specifically, we observe decreasedacetylation of histones H3 and H4 (preferentially lysines 5 and12) that depends on the DNA-binding repressor (Ume6), Sin3, andRpd3. Mapping experiments indicate that the domain of histonedeacetylation is highly localized, occurring over a range of oneto two nucleosomes. Taken together with previous observations,these results define a novel mechanism of transcriptional repressionwhich involves targeted recruitment of a histone-modifying activityand localized perturbation of chromatin structure.

^* Corresponding author. Mailing address: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School,Boston, MA 02115. Phone: (617) 432-2104. Fax: (617) 432-2529.E-mail: kevin{at}hms.harvard.edu.

Present address: Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.

Molecular and Cellular Biology, September 1998, p. 5121-5127, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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Williams, R. M., Primig, M., Washburn, B. K., Winzeler, E. A., Bellis, M., Sarrauste de Menthiere, C., Davis, R. W., Esposito, R. E. (2002). The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc. Natl. Acad. Sci. USA 99: 13431-13436 [Abstract] [Full Text]
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Pile, L. A., Schlag, E. M., Wassarman, D. A. (2002). The SIN3/RPD3 Deacetylase Complex Is Essential for G2 Phase Cell Cycle Progression and Regulation of SMRTER Corepressor Levels. Mol. Cell. Biol. 22: 4965-4976 [Abstract] [Full Text]
Bernstein, B. E., Humphrey, E. L., Erlich, R. L., Schneider, R., Bouman, P., Liu, J. S., Kouzarides, T., Schreiber, S. L. (2002). Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl. Acad. Sci. USA 99: 8695-8700 [Abstract] [Full Text]
Ricci, A. R., Genereaux, J., Brandl, C. J. (2002). Components of the SAGA Histone Acetyltransferase Complex Are Required for Repressed Transcription of ARG1 in Rich Medium. Mol. Cell. Biol. 22: 4033-4042 [Abstract] [Full Text]
Traven, A., Staresincic, L., Arneric, M., Sopta, M. (2002). The yeast protein Xtc1 functions as a direct transcriptional repressor. Nucleic Acids Res 30: 2358-2364 [Abstract] [Full Text]
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Katan-Khaykovich, Y., Struhl, K. (2002). Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors. Genes Dev. 16: 743-752 [Abstract] [Full Text]
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Nuthall, H. N., Husain, J., McLarren, K. W., Stifani, S. (2002). Role for Hes1-Induced Phosphorylation in Groucho-Mediated Transcriptional Repression. Mol. Cell. Biol. 22: 389-399 [Abstract] [Full Text]
Courey, A. J., Jia, S. (2001). Transcriptional repression: the long and the short of it. Genes Dev. 15: 2786-2796 [Full Text]
Fazzio, T. G., Kooperberg, C., Goldmark, J. P., Neal, C., Basom, R., Delrow, J., Tsukiyama, T. (2001). Widespread Collaboration of Isw2 and Sin3-Rpd3 Chromatin Remodeling Complexes in Transcriptional Repression. Mol. Cell. Biol. 21: 6450-6460 [Abstract] [Full Text]
Sugiyama, M., Nikawa, J.-I. (2001). The Saccharomyces cerevisiae Isw2p-Itc1p Complex Represses INO1 Expression and Maintains Cell Morphology. J. Bacteriol. 183: 4985-4993 [Abstract] [Full Text]
Khanna-Gupta, A., Zibello, T., Sun, H., Lekstrom-Himes, J., Berliner, N. (2001). C/EBPvarepsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut). Proc. Natl. Acad. Sci. USA 98: 8000-8005 [Abstract] [Full Text]
Yochum, G. S., Ayer, D. E. (2001). Pf1, a Novel PHD Zinc Finger Protein That Links the TLE Corepressor to the mSin3A-Histone Deacetylase Complex. Mol. Cell. Biol. 21: 4110-4118 [Abstract] [Full Text]
Kulish, D., Struhl, K. (2001). TFIIS Enhances Transcriptional Elongation through an Artificial Arrest Site In Vivo. Mol. Cell. Biol. 21: 4162-4168 [Abstract] [Full Text]
Deckert, J., Struhl, K. (2001). Histone Acetylation at Promoters Is Differentially Affected by Specific Activators and Repressors. Mol. Cell. Biol. 21: 2726-2735 [Abstract] [Full Text]
Rine, L. N. R. a. J. (2001). Conversion of a gene-specific repressor to a regional silencer. Genes Dev. 15: 955-967 [Abstract] [Full Text]
Wade, P. A. (2001). Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin. Hum Mol Genet 10: 693-698 [Abstract] [Full Text]
Wu, J., Carmen, A. A., Kobayashi, R., Suka, N., Grunstein, M. (2001). HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc. Natl. Acad. Sci. USA 10.1073/pnas.081560698v1 [Abstract] [Full Text]
Washburn, B. K., Esposito, R. E. (2001). Identification of the Sin3-Binding Site in Ume6 Defines a Two-Step Process for Conversion of Ume6 from a Transcriptional Repressor to an Activator in Yeast. Mol. Cell. Biol. 21: 2057-2069 [Abstract] [Full Text]
Gui, C.-Y., Dean, A. (2001). Acetylation of a Specific Promoter Nucleosome Accompanies Activation of the {varepsilon}-Globin Gene by {beta}-Globin Locus Control Region HS2. Mol. Cell. Biol. 21: 1155-1163 [Abstract] [Full Text]
Urnov, F. D., Wolffe, A. P. (2001). A Necessary Good: Nuclear Hormone Receptors and Their Chromatin Templates. Mol. Endocrinol. 15: 1-16 [Full Text]
Tie, F, Furuyama, T, Prasad-Sinha, J, Jane, E, Harte, P. (2001). The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128: 275-286 [Abstract]
Schübeler, D., Lorincz, M. C., Cimbora, D. M., Telling, A., Feng, Y.-Q., Bouhassira, E. E., Groudine, M. (2000). Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation. Mol. Cell. Biol. 20: 9103-9112 [Abstract] [Full Text]
Flores-Saaib, R. D., Courey, A. J. (2000). Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression. Nucleic Acids Res 28: 4189-4196 [Abstract] [Full Text]
Watson, A. D., Edmondson, D. G., Bone, J. R., Mukai, Y., Yu, Y., Du, W., Stillman, D. J., Roth, S. Y. (2000). Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 14: 2737-2744 [Abstract] [Full Text]
Zabel, M. D., Byrne, B. L., Weis, J. J., Weis, J. H. (2000). Cell-Specific Expression of the Murine CD21 Gene Depends on Accessibility of Promoter and Intronic Elements. J. Immunol. 165: 4437-4445 [Abstract] [Full Text]
Mai, X., Chou, S., Struhl, K. (2000). Preferential Accessibility of the Yeast his3 Promoter Is Determined by a General Property of the DNA Sequence, Not by Specific Elements. Mol. Cell. Biol. 20: 6668-6676 [Abstract] [Full Text]
Elkhaimi, M., Kaadige, M. R., Kamath, D., Jackson, J. C., Biliran Jr, H., Lopes, J. M. (2000). Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes. Nucleic Acids Res 28: 3160-3167 [Abstract] [Full Text]
Li, S., Aufiero, B., Schiltz, R. L., Walsh, M. J. (2000). Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Proc. Natl. Acad. Sci. USA 10.1073/pnas.130028697v1 [Abstract] [Full Text]
Elefant, F., Cooke, N. E., Liebhaber, S. A. (2000). Targeted Recruitment of Histone Acetyltransferase Activity to a Locus Control Region. J. Biol. Chem. 275: 13827-13834 [Abstract] [Full Text]
Graves, J. A., Henry, S. A. (2000). Regulation of the Yeast INO1 Gene: The Products of the INO2, INO4 and OPI1 Regulatory Genes Are Not Required for Repression in Response to Inositol. Genetics 154: 1485-1495 [Abstract] [Full Text]
Grimes, J. A., Nielsen, S. J., Battaglioli, E., Miska, E. A., Speh, J. C., Berry, D. L., Atouf, F., Holdener, B. C., Mandel, G., Kouzarides, T. (2000). The Co-repressor mSin3A Is a Functional Component of the REST-CoREST Repressor Complex. J. Biol. Chem. 275: 9461-9467 [Abstract] [Full Text]
Geisberg, J. V., Struhl, K. (2000). TATA-Binding Protein Mutants That Increase Transcription from Enhancerless and Repressed Promoters In Vivo. Mol. Cell. Biol. 20: 1478-1488 [Abstract] [Full Text]
Dorland, S., Deegenaars, M. L., Stillman, D. J. (2000). Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 Genes in Transcriptional Repression by SIN3. Genetics 154: 573-586 [Abstract] [Full Text]
Mottus, R., Sobel, R. E., Grigliatti, T. A. (2000). Mutational Analysis of a Histone Deacetylase in Drosophila melanogaster: Missense Mutations Suppress Gene Silencing Associated With Position Effect Variegation. Genetics 154: 657-668 [Abstract] [Full Text]
Kao, H.-Y., Downes, M., Ordentlich, P., Evans, R. M. (2000). Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 14: 55-66 [Abstract] [Full Text]
Mukai, Y., Matsuo, E., Roth, S. Y., Harashima, S. (1999). Conservation of Histone Binding and Transcriptional Repressor Functions in a Schizosaccharomyces pombe Tup1p Homolog. Mol. Cell. Biol. 19: 8461-8468 [Abstract] [Full Text]
Travers, A. (1999). Chromatin modification by DNA tracking. Proc. Natl. Acad. Sci. USA 96: 13634-13637 [Abstract] [Full Text]
Naruse, Y., Aoki, T., Kojima, T., Mori, N. (1999). Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc. Natl. Acad. Sci. USA 96: 13691-13696 [Abstract] [Full Text]
Choi, C. Y., Kim, Y. H., Kwon, H. J., Kim, Y. (1999). The Homeodomain Protein NK-3 Recruits Groucho and a Histone Deacetylase Complex to Repress Transcription. J. Biol. Chem. 274: 33194-33197 [Abstract] [Full Text]
Forrester, W. C., Fernández, L. A., Grosschedl, R. (1999). Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions. Genes Dev. 13: 3003-3014 [Abstract] [Full Text]
Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th'ng, J., Han, J., Yang, X.-J. (1999). HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor. Mol. Cell. Biol. 19: 7816-7827 [Abstract] [Full Text]
Zhang, J., Hu, X., Lazar, M. A. (1999). A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression. Mol. Cell. Biol. 19: 6448-6457 [Abstract] [Full Text]
Zabel, M. D., Weis, J. J., Weis, J. H. (1999). Lymphoid Transcription of the Murine CD21 Gene Is Positively Regulated by Histone Acetylation. J. Immunol. 163: 2697-2703 [Abstract] [Full Text]
Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., Reinberg, D. (1999). Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13: 1924-1935 [Abstract] [Full Text]
Burgess, S. M., Ajimura, M., Kleckner, N. (1999). GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast. Proc. Natl. Acad. Sci. USA 96: 6835-6840 [Abstract] [Full Text]
Krebs, J. E., Kuo, M.-H., Allis, C. D., Peterson, C. L. (1999). Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Genes Dev. 13: 1412-1421 [Abstract] [Full Text]
Wölfl, S., Martinez, C., Majzoub, J. A. (1999). Inducible Binding of Cyclic Adenosine 3',5'-Monophosphate (cAMP)-Responsive Element Binding Protein (CREB) to a cAMP-Responsive Promoter in Vivo. Mol. Endocrinol. 13: 659-669 [Abstract] [Full Text]
Fischle, W., Emiliani, S., Hendzel, M. J., Nagase, T., Nomura, N., Voelter, W., Verdin, E. (1999). A New Family of Human Histone Deacetylases Related to Saccharomyces cerevisiae HDA1p. J. Biol. Chem. 274: 11713-11720 [Abstract] [Full Text]
Li, S., Moy, L., Pittman, N., Shue, G., Aufiero, B., Neufeld, E. J., LeLeiko, N. S., Walsh, M. J. (1999). Transcriptional Repression of the Cystic Fibrosis Transmembrane Conductance Regulator Gene, Mediated by CCAAT Displacement Protein/cut Homolog, Is Associated with Histone Deacetylation. J. Biol. Chem. 274: 7803-7815 [Abstract] [Full Text]
Kehle, J., Beuchle, D., Treuheit, S., Christen, B., Kennison, J. A., Bienz, M., Müller, J. (1998). dMi-2, a Hunchback-Interacting Protein That Functions in Polycomb Repression. Science 282: 1897-1900 [Abstract] [Full Text]
Gelmetti, V., Zhang, J., Fanelli, M., Minucci, S., Pelicci, P. G., Lazar, M. A. (1998). Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO. Mol. Cell. Biol. 18: 7185-7191 [Abstract] [Full Text]
Bone, J. R., Roth, S. Y. (2001). Recruitment of the Yeast Tup1p-Ssn6p Repressor Is Associated with Localized Decreases in Histone Acetylation. J. Biol. Chem. 276: 1808-1813 [Abstract] [Full Text]
Myers, F. A., Evans, D. R., Clayton, A. L., Thorne, A. W., Crane-Robinson, C. (2001). Targeted and Extended Acetylation of Histones H4 and H3 at Active and Inactive Genes in Chicken Embryo Erythrocytes. J. Biol. Chem. 276: 20197-20205 [Abstract] [Full Text]
Loewith, R., Smith, J. S., Meijer, M., Williams, T. J., Bachman, N., Boeke, J. D., Young, D. (2001). Pho23 Is Associated with the Rpd3 Histone Deacetylase and Is Required for Its Normal Function in Regulation of Gene Expression and Silencing in Saccharomyces cerevisiae. J. Biol. Chem. 276: 24068-24074 [Abstract] [Full Text]
Fischle, W., Dequiedt, F., Fillion, M., Hendzel, M. J., Voelter, W., Verdin, E. (2001). Human HDAC7 Histone Deacetylase Activity Is Associated with HDAC3 in Vivo. J. Biol. Chem. 276: 35826-35835 [Abstract] [Full Text]
Wu, J., Carmen, A. A., Kobayashi, R., Suka, N., Grunstein, M. (2001). HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc. Natl. Acad. Sci. USA 98: 4391-4396 [Abstract] [Full Text]
Li, S., Aufiero, B., Schiltz, R. L., Walsh, M. J. (2000). Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP. Proc. Natl. Acad. Sci. USA 97: 7166-7171 [Abstract] [Full Text]

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