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Molecular and Cellular Biology, September 1998, p. 5355-5363, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure

Helen Cho,1 George Orphanides,1 Xiaoqing Sun,1 Xiang-Jiao Yang,2 Vasily Ogryzko,2 Emma Lees,3 Yoshihiro Nakatani,2 and Danny Reinberg1,*

Howard Hughes Medical Institute, Division of Nucleic Acid Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 088541; DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 943043; and Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 208922

Received 13 May 1998/Accepted 16 June 1998

We have isolated a human RNA polymerase II complex that contains chromatin structure remodeling activity and histone acetyltransferase activity. This complex contains the Srb proteins, the Swi-Snf complex, and the histone acetyltransferases CBP and PCAF in addition to RNA polymerase II. Notably, the general transcription factors are absent from this complex. The complex was purified by two different methods: conventional chromatography and affinity chromatography using antibodies directed against CDK8, the human homolog of the yeast Srb10 protein. Protein interaction studies demonstrate a direct interaction between RNA polymerase II and the histone acetyltransferases p300 and PCAF. Importantly, p300 interacts specifically with the nonphosphorylated, initiation-competent form of RNA polymerase II. In contrast, PCAF interacts with the elongation-competent, phosphorylated form of RNA polymerase II.

* Corresponding author. Mailing address: Howard Hughes Medical Institute, Division of Nucleic Acid Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 663 Hoes Ln., Piscataway, NJ 08854-5635. Phone: (732) 235-4195. Fax: (732) 235-5294. E-mail: reinbedf{at}umdnj.edu.

Molecular and Cellular Biology, September 1998, p. 5355-5363, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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