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Molecular and Cellular Biology, September 1998, p. 5609-5619, Vol. 18, No. 9
Division of Neuroscience,
Received 19 November 1997/Returned for modification 4 January
1998/Accepted 25 June 1998
Expression of the fos family of transcription factors
is stimulated by growth factors that induce quiescent cells to reenter the cell cycle, but the cellular targets of the Fos family that regulate cell cycle reentry have not been identified. To address this
issue, mice that lack two members of the fos family,
c-fos and fosB, were derived. The
fosB
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Fos Family Members Induce Cell Cycle Entry by Activating
Cyclin D1
/
c-fos
/
mice are similar in phenotype to c-fos
/
mice but are 30% smaller. This decrease in size is consistent with an
abnormality in cell proliferation. Fibroblasts derived from
fosB
/
c-fos
/
mice were found to have a defect in proliferation that results at least
in part from a failure to induce cyclin D1 following serum-stimulated
cell cycle reentry. Although definitive evidence that c-Fos and FosB
directly induce cyclin D1 transcription will require further analysis,
these findings raise the possibility that c-Fos and FosB are either
direct or indirect transcriptional regulators of the cyclin D1 gene and
may function as a critical link between serum stimulation and cell
cycle progression.
*
Corresponding author. Mailing address: Division of
Neuroscience, Children's Hospital, Boston, MA 02115. Phone: (617)
355-8344. Fax: (617) 738-1542. E-mail:
greenberg{at}a1.tch.harvard.edu.
Molecular and Cellular Biology, September 1998, p. 5609-5619, Vol. 18, No. 9
0270-7306/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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