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Molecular and Cellular Biology, January 1999, p. 567-576, Vol. 19, No. 1
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3' End

James R. Mitchell, Jeffrey Cheng, and Kathleen Collins*

Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3204

Received 31 August 1998/Returned for modification 8 October 1998/Accepted 20 October 1998

Simple sequence repeat telomeric DNA is maintained by a specialized reverse transcriptase, telomerase. The integral RNA subunit of telomerase contains a template region that determines the sequence added to chromosome ends. Aside from providing the template, little is known about the role of the telomerase RNA. In addition, no hypotheses have been suggested to account for the striking evolutionary divergence in size and sequence between telomerase RNAs of ciliates, yeasts, and mammals. We show that the two- to threefold increase in size of the mammalian telomerase RNAs relative to ciliate telomerase RNAs is due to the presence of an extra domain resembling a box H/ACA small nucleolar RNA (snoRNA). The human telomerase RNA (hTR) H/ACA domain is essential in vivo for hTR accumulation, hTR 3' end processing, and telomerase activity. By substituting the U64 box H/ACA snoRNA for the hTR H/ACA domain, we demonstrate that a heterologous snoRNA can function to promote chimeric RNA accumulation and 3' end processing but not telomerase activity. In addition, we show that maturation of full-length hTR and its assembly into active telomerase occur from an mRNA promoter-driven RNA polymerase II transcript but not from a U6 snRNA promoter-driven RNA polymerase III transcript. Finally, we show that a small percentage of hTR is associated with nucleoli. These results have implications for the biogenesis and structure of hTR and the human telomerase ribonucleoprotein complex. They also expand the structural and functional diversity of the box H/ACA snoRNA motif.

* Corresponding author. Mailing address: Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720-3204. Phone: (510) 643-1598. Fax: (510) 642-6062. E-mail: kcollins{at}socrates.berkeley.edu.

Molecular and Cellular Biology, January 1999, p. 567-576, Vol. 19, No. 1
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Yang, P. K., Rotondo, G., Porras, T., Legrain, P., Chanfreau, G. (2002). The Shq1p{middle dot}Naf1p Complex Is Required for Box H/ACA Small Nucleolar Ribonucleoprotein Particle Biogenesis. J. Biol. Chem. 277: 45235-45242 [Abstract] [Full Text]  
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  • Cong, Y.-S., Wright, W. E., Shay, J. W. (2002). Human Telomerase and Its Regulation. Microbiol. Mol. Biol. Rev. 66: 407-425 [Abstract] [Full Text]  
  • Gerbi, S. A., Lange, T. S. (2002). All Small Nuclear RNAs (snRNAs) of the [U4/U6.U5] Tri-snRNP Localize to Nucleoli; Identification of the Nucleolar Localization Element of U6 snRNA. Mol. Biol. Cell 13: 3123-3137 [Abstract] [Full Text]  
  • Bachand, F., Boisvert, F.-M., Cote, J., Richard, S., Autexier, C. (2002). The Product of the Survival of Motor Neuron (SMN) Gene is a Human Telomerase-associated Protein. Mol. Biol. Cell 13: 3192-3202 [Abstract] [Full Text]  
  • Etheridge, K. T., Banik, S. S. R., Armbruster, B. N., Zhu, Y., Terns, R. M., Terns, M. P., Counter, C. M. (2002). The Nucleolar Localization Domain of the Catalytic Subunit of Human Telomerase. J. Biol. Chem. 277: 24764-24770 [Abstract] [Full Text]  
  • Miller, M. C., Collins, K. (2002). Telomerase recognizes its template by using an adjacent RNA motif. Proc. Natl. Acad. Sci. USA 99: 6585-6590 [Abstract] [Full Text]  
  • Mergny, J.-L., Riou, J.-F., Mailliet, P., Teulade-Fichou, M.-P., Gilson, E. (2002). Natural and pharmacological regulation of telomerase. Nucleic Acids Res 30: 839-865 [Abstract] [Full Text]  
  • Antal, M., Boros, E., Solymosy, F., Kiss, T. (2002). Analysis of the structure of human telomerase RNA in vivo. Nucleic Acids Res 30: 912-920 [Abstract] [Full Text]  
  • Chen, J.-L., Opperman, K. K., Greider, C. W. (2002). A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res 30: 592-597 [Abstract] [Full Text]  
  • Beattie, T. L., Zhou, W., Robinson, M. O., Harrington, L. (2001). Functional Multimerization of the Human Telomerase Reverse Transcriptase. Mol. Cell. Biol. 21: 6151-6160 [Abstract] [Full Text]  
  • Bachand, F., Triki, I., Autexier, C. (2001). Human telomerase RNA-protein interactions. Nucleic Acids Res 29: 3385-3393 [Abstract] [Full Text]  
  • Kim, M. M., Rivera, M. A., Botchkina, I. L., Shalaby, R., Thor, A. D., Blackburn, E. H. (2001). From the Cover: A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc. Natl. Acad. Sci. USA 98: 7982-7987 [Abstract] [Full Text]  
  • Henras, A., Dez, C., Noaillac-Depeyre, J., Henry, Y., Caizergues-Ferrer, M. (2001). Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p. Nucleic Acids Res 29: 2733-2746 [Abstract] [Full Text]  
  • Sachsinger, J., Gonzalez-Suarez, E., Samper, E., Heicappell, R., Muller, M., Blasco, Maria. A. (2001). Telomerase Inhibition in RenCa, a Murine Tumor Cell Line with Short Telomeres, by Overexpression of a Dominant Negative mTERT Mutant, Reveals Fundamental Differences in Telomerase Regulation between Human and Murine Cells. Cancer Res. 61: 5580-5586 [Abstract] [Full Text]  
  • Shay, J. W., Zou, Y., Hiyama, E., Wright, W. E. (2001). Telomerase and cancer. Hum Mol Genet 10: 677-685 [Abstract] [Full Text]  
  • Bachand, F., Autexier, C. (2001). Functional Regions of Human Telomerase Reverse Transcriptase and Human Telomerase RNA Required for Telomerase Activity and RNA-Protein Interactions. Mol. Cell. Biol. 21: 1888-1897 [Abstract] [Full Text]  
  • Lai, C. K., Mitchell, J. R., Collins, K. (2001). RNA Binding Domain of Telomerase Reverse Transcriptase. Mol. Cell. Biol. 21: 990-1000 [Abstract] [Full Text]  
  • Dez, C., Henras, A., Faucon, B., Lafontaine, D. L. J., Caizergues-Ferrer, M., Henry, Y. (2001). Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p. Nucleic Acids Res 29: 598-603 [Abstract] [Full Text]  
  • Kickhoefer, V. A., Liu, Y., Kong, L. B., Snow, B. E., Stewart, P. L., Harrington, L., Rome, L. H. (2001). The Telomerase/Vault-Associated Protein Tep1 Is Required for Vault RNA Stability and Its Association with the Vault Particle. JCB 152: 157-164 [Abstract] [Full Text]  
  • GERBI, S.A., BOROVJAGIN, A.V., EZROKHI, M., LANGE, T.S. (2001). Ribosome Biogenesis: Role of Small Nucleolar RNA in Maturation of Eukaryotic rRNA. Cold Spring Harb Symp Quant Biol 66: 575-590 [Abstract]  
  • Pogacic, V., Dragon, F., Filipowicz, W. (2000). Human H/ACA Small Nucleolar RNPs and Telomerase Share Evolutionarily Conserved Proteins NHP2 and NOP10. Mol. Cell. Biol. 20: 9028-9040 [Abstract] [Full Text]  
  • Ford, L. P., Suh, J. M., Wright, W. E., Shay, J. W. (2000). Heterogeneous Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component of Human Telomerase. Mol. Cell. Biol. 20: 9084-9091 [Abstract] [Full Text]  
  • Michienzi, A., Cagnon, L., Bahner, I., Rossi, J. J. (2000). Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA. Proc. Natl. Acad. Sci. USA 97: 8955-8960 [Abstract] [Full Text]  
  • Lange, T. S., Gerbi, S. A. (2000). Transient Nucleolar Localization Of U6 Small Nuclear RNA In Xenopus Laevis Oocytes. Mol. Biol. Cell 11: 2419-2428 [Abstract] [Full Text]  
  • Lewis, J. D., Tollervey, D. (2000). Like Attracts Like: Getting RNA Processing Together in the Nucleus. Science 288: 1385-1389 [Abstract] [Full Text]  
  • Tzfati, Y., Fulton, T. B., Roy, J., Blackburn, E. H. (2000). Template Boundary in a Yeast Telomerase Specified by RNA Structure. Science 288: 863-867 [Abstract] [Full Text]  
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