This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fontes, J. D.
Right arrow Articles by Peterlin, B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fontes, J. D.
Right arrow Articles by Peterlin, B. M.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, January 1999, p. 941-947, Vol. 19, No. 1
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Interactions between the Class II Transactivator and CREB Binding Protein Increase Transcription of Major Histocompatibility Complex Class II Genes

Joseph D. Fontes, Satoshi Kanazawa, Dickson Jean, and B. Matija Peterlin*

Howard Hughes Medical Institute, Departments of Medicine, Immunology, and Microbiology, University of California San Francisco, San Francisco, California 94143-0703.

Received 10 June 1998/Returned for modification 13 August 1998/Accepted 14 October 1998

Class II major histocompatibility (class II) genes are regulated in a B-cell-specific and gamma interferon-inducible fashion. The master switch for the expression of these genes is the class II transactivator (CIITA). In this report, we demonstrate that one of the functions of CIITA is to recruit the CREB binding protein (CBP) to class II promoters. Not only functional but also specific binding interactions between CIITA and CBP were demonstrated. Moreover, a dominant negative form of CBP decreased the activity of class II promoters and levels of class II determinants on the surface of cells. Finally, the inhibition of class II gene expression by the glucocorticoid hormone could be attributed to the squelching of CBP by the glucocorticoid receptor. We conclude that CBP, a histone acetyltransferase, plays an important role in the transcription of class II genes.

* Corresponding author. Mailing address: Howard Hughes Medical Institute, Departments of Medicine, Immunology, and Microbiology, University of California San Francisco, San Francisco, CA 94143-0703. Phone: (415) 502-1902. Fax: (415) 502-1901. E-mail: matija{at}itsa.ucsf.edu.

Molecular and Cellular Biology, January 1999, p. 941-947, Vol. 19, No. 1
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Debierre-Grockiego, F., Molitor, N., Schwarz, R. T., Luder, C. G.K. (2009). Toxoplasma gondii glycosylphosphatidylinositols up-regulate major histocompatibility complex (MHC) molecule expression on primary murine macrophages. Innate Immunity 15: 25-32 [Abstract]  
  • Koues, O. I., Dudley, R. K., Truax, A. D., Gerhardt, D., Bhat, K. P., McNeal, S., Greer, S. F. (2008). Regulation of Acetylation at the Major Histocompatibility Complex Class II Proximal Promoter by the 19S Proteasomal ATPase Sug1. Mol. Cell. Biol. 28: 5837-5850 [Abstract] [Full Text]  
  • Voong, L. N., Slater, A. R., Kratovac, S., Cressman, D. E. (2008). Mitogen-activated Protein Kinase ERK1/2 Regulates the Class II Transactivator. J. Biol. Chem. 283: 9031-9039 [Abstract] [Full Text]  
  • Xu, Y., Harton, J. A., Smith, B. D. (2008). CIITA Mediates Interferon-{gamma} Repression of Collagen Transcription through Phosphorylation-dependent Interactions with Co-repressor Molecules. J. Biol. Chem. 283: 1243-1256 [Abstract] [Full Text]  
  • Bewry, N. N., Bolick, S. C. E., Wright, K. L., Harton, J. A. (2007). GTP-dependent Recruitment of CIITA to the Class II Major Histocompatibility Complex Promoter. J. Biol. Chem. 282: 26178-26184 [Abstract] [Full Text]  
  • Rybtsova, N., Leimgruber, E., Seguin-Estevez, Q., Dunand-Sauthier, I., Krawczyk, M., Reith, W. (2007). Transcription-coupled deposition of histone modifications during MHC class II gene activation. Nucleic Acids Res 35: 3431-3441 [Abstract] [Full Text]  
  • Drozina, G., Kohoutek, J., Nishiya, T., Peterlin, B. M. (2006). Sequential Modifications in Class II Transactivator Isoform 1 Induced by Lipopolysaccharide Stimulate Major Histocompatibility Complex Class II Transcription in Macrophages. J. Biol. Chem. 281: 39963-39970 [Abstract] [Full Text]  
  • Tosi, G., Pilotti, E., Mortara, L., Barbaro, A. D. L., Casoli, C., Accolla, R. S. (2006). Inhibition of human T cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y. Proc. Natl. Acad. Sci. USA 103: 12861-12866 [Abstract] [Full Text]  
  • Gialitakis, M., Kretsovali, A., Spilianakis, C., Kravariti, L., Mages, J., Hoffmann, R., Hatzopoulos, A. K., Papamatheakis, J. (2006). Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. Nucleic Acids Res 34: 765-772 [Abstract] [Full Text]  
  • Zika, E., Fauquier, L., Vandel, L., Ting, J. P.-Y. (2005). Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-{gamma}-inducible MHC-II gene expression. Proc. Natl. Acad. Sci. USA 102: 16321-16326 [Abstract] [Full Text]  
  • Wang, A. H., Gregoire, S., Zika, E., Xiao, L., Li, C. S., Li, H., Wright, K. L., Ting, J. P., Yang, X.-J. (2005). Identification of the Ankyrin Repeat Proteins ANKRA and RFXANK as Novel Partners of Class IIa Histone Deacetylases. J. Biol. Chem. 280: 29117-29127 [Abstract] [Full Text]  
  • Desfosses, Y., Solis, M., Sun, Q., Grandvaux, N., Van Lint, C., Burny, A., Gatignol, A., Wainberg, M. A., Lin, R., Hiscott, J. (2005). Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins. J. Virol. 79: 9180-9191 [Abstract] [Full Text]  
  • Gomez, J. A., Majumder, P., Nagarajan, U. M., Boss, J. M. (2005). X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function. J. Immunol. 175: 1030-1040 [Abstract] [Full Text]  
  • Wang, Y., Curry, H. M., Zwilling, B. S., Lafuse, W. P. (2005). Mycobacteria Inhibition of IFN-{gamma} Induced HLA-DR Gene Expression by Up-Regulating Histone Deacetylation at the Promoter Region in Human THP-1 Monocytic Cells. J. Immunol. 174: 5687-5694 [Abstract] [Full Text]  
  • Adamski, J., Benveniste, E. N. (2005). 17{beta}-Estradiol Activation of the c-Jun N-Terminal Kinase Pathway Leads to Down-Regulation of Class II Major Histocompatibility Complex Expression. Mol. Endocrinol. 19: 113-124 [Abstract] [Full Text]  
  • Xu, Y., Wang, L., Buttice, G., Sengupta, P. K., Smith, B. D. (2004). Major Histocompatibility Class II Transactivator (CIITA) Mediates Repression of Collagen (COL1A2) Transcription by Interferon {gamma} (IFN-{gamma}). J. Biol. Chem. 279: 41319-41332 [Abstract] [Full Text]  
  • Park, W. S., Bae, Y., Chung, D. H., Choi, Y.-L., Kim, B. K., Sung, Y. C., Choi, E. Y., Park, S. H., Jung, K. C. (2004). T cell expression of CIITA represses Th1 immunity. Int Immunol 16: 1355-1364 [Abstract] [Full Text]  
  • Muhlethaler-Mottet, A., Krawczyk, M., Masternak, K., Spilianakis, C., Kretsovali, A., Papamatheakis, J., Reith, W. (2004). The S Box of Major Histocompatibility Complex Class II Promoters Is a Key Determinant for Recruitment of the Transcriptional Co-activator CIITA. J. Biol. Chem. 279: 40529-40535 [Abstract] [Full Text]  
  • Adamski, J., Ma, Z., Nozell, S., Benveniste, E. N. (2004). 17{beta}-Estradiol Inhibits Class II Major Histocompatibility Complex (MHC) Expression: Influence on Histone Modifications and CBP Recruitment to the Class II MHC Promoter. Mol. Endocrinol. 18: 1963-1974 [Abstract] [Full Text]  
  • Blois, J. T., Mataraza, J. M., Mecklenbrauker, I., Tarakhovsky, A., Chiles, T. C. (2004). B Cell Receptor-induced cAMP-response Element-binding Protein Activation in B Lymphocytes Requires Novel Protein Kinase C{delta}. J. Biol. Chem. 279: 30123-30132 [Abstract] [Full Text]  
  • Osborne, A. R., Zhang, H., Fejer, G., Palubin, K. M., Niesen, M. I., Blanck, G. (2004). Oct-1 Maintains an Intermediate, Stable State of HLA-DRA Promoter Repression in Rb-defective Cells: AN Oct-1-CONTAINING REPRESSOSOME THAT PREVENTS NF-Y BINDING TO THE HLA-DRA PROMOTER. J. Biol. Chem. 279: 28911-28919 [Abstract] [Full Text]  
  • Nagarajan, U. M., Long, A. B., Harreman, M. T., Corbett, A. H., Boss, J. M. (2004). A Hierarchy of Nuclear Localization Signals Governs the Import of the Regulatory Factor X Complex Subunits and MHC Class II Expression. J. Immunol. 173: 410-419 [Abstract] [Full Text]  
  • Le Tulzo, Y., Pangault, C., Amiot, L., Guilloux, V., Tribut, O., Arvieux, C., Camus, C., Fauchet, R., Thomas, R., Drenou, B. (2004). Monocyte Human Leukocyte Antigen-DR Transcriptional Downregulation by Cortisol during Septic Shock. Am. J. Respir. Crit. Care Med. 169: 1144-1151 [Abstract] [Full Text]  
  • Casoli, C., De Lerma Barbaro, A., Pilotti, E., Bertazzoni, U., Tosi, G., Accolla, R. S. (2004). The MHC class II transcriptional activator (CIITA) inhibits HTLV-2 viral replication by blocking the function of the viral transactivator Tax-2. Blood 103: 995-1001 [Abstract] [Full Text]  
  • Xu, Y., Wang, L., Buttice, G., Sengupta, P. K., Smith, B. D. (2003). Interferon {gamma} Repression of Collagen (COL1A2) Transcription Is Mediated by the RFX5 Complex. J. Biol. Chem. 278: 49134-49144 [Abstract] [Full Text]  
  • Tzortzakaki, E., Spilianakis, C., Zika, E., Kretsovali, A., Papamatheakis, J. (2003). Steroid Receptor Coactivator 1 Links the Steroid and Interferon {gamma} Response Pathways. Mol. Endocrinol. 17: 2509-2518 [Abstract] [Full Text]  
  • Sisk, T. J., Nickerson, K., Kwok, R. P. S., Chang, C.-H. (2003). Phosphorylation of class II transactivator regulates its interaction ability and transactivation function. Int Immunol 15: 1195-1205 [Abstract] [Full Text]  
  • Zika, E., Greer, S. F., Zhu, X.-S., Ting, J. P.-Y. (2003). Histone Deacetylase 1/mSin3A Disrupts Gamma Interferon-Induced CIITA Function and Major Histocompatibility Complex Class II Enhanceosome Formation. Mol. Cell. Biol. 23: 3091-3102 [Abstract] [Full Text]  
  • Jabrane-Ferrat, N., Nekrep, N., Tosi, G., Esserman, L., Peterlin, B. M. (2003). MHC class II enhanceosome: how is the class II transactivator recruited to DNA-bound activators?. Int Immunol 15: 467-475 [Abstract] [Full Text]  
  • Raval, A., Weissman, J. D., Howcroft, T. K., Singer, D. S. (2003). The GTP-Binding Domain of Class II Transactivator Regulates Its Nuclear Export. J. Immunol. 170: 922-930 [Abstract] [Full Text]  
  • Nagarajan, U. M., Bushey, A., Boss, J. M. (2002). Modulation of Gene Expression by the MHC Class II Transactivator. J. Immunol. 169: 5078-5088 [Abstract] [Full Text]  
  • Mudhasani, R., Fontes, J. D. (2002). The Class II Transactivator Requires brahma-Related Gene 1 To Activate Transcription of Major Histocompatibility Complex Class II Genes. Mol. Cell. Biol. 22: 5019-5026 [Abstract] [Full Text]  
  • Sengupta, P. K., Fargo, J., Smith, B. D. (2002). The RFX Family Interacts at the Collagen (COL1A2) Start Site and Represses Transcription. J. Biol. Chem. 277: 24926-24937 [Abstract] [Full Text]  
  • Shao, L., Sperber, K. (2002). Impaired Regulation of HLA-DR Expression in Human Immunodeficiency Virus-Infected Monocytes. CVI 9: 739-746 [Full Text]  
  • Morris, A. C., Beresford, G. W., Mooney, M. R., Boss, J. M. (2002). Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation. Mol. Cell. Biol. 22: 4781-4791 [Abstract] [Full Text]  
  • Frontini, M., Imbriano, C., diSilvio, A., Bell, B., Bogni, A., Romier, C., Moras, D., Tora, L., Davidson, I., Mantovani, R. (2002). NF-Y Recruitment of TFIID, Multiple Interactions with Histone Fold TAFIIs. J. Biol. Chem. 277: 5841-5848 [Abstract] [Full Text]  
  • Holling, T. M., van der Stoep, N., Quinten, E., van den Elsen, P. J. (2002). Activated Human T Cells Accomplish MHC Class II Expression Through T Cell-Specific Occupation of Class II Transactivator Promoter III. J. Immunol. 168: 763-770 [Abstract] [Full Text]  
  • Gobin, S. J. P., van Zutphen, M., Westerheide, S. D., Boss, J. M., van den Elsen, P. J. (2001). The MHC-Specific Enhanceosome and Its Role in MHC Class I and {beta}2-Microglobulin Gene Transactivation. J. Immunol. 167: 5175-5184 [Abstract] [Full Text]  
  • Zhu, X.-S., Ting, J. P.-Y. (2001). A 36-Amino-Acid Region of CIITA Is an Effective Inhibitor of CBP: Novel Mechanism of Gamma Interferon-Mediated Suppression of Collagen {alpha}2(I) and Other Promoters. Mol. Cell. Biol. 21: 7078-7088 [Abstract] [Full Text]  
  • Harton, J. A., Zika, E., Ting, J. P.-Y. (2001). The Histone Acetyltransferase Domains of CREB-binding Protein (CBP) and p300/CBP-associated Factor Are Not Necessary for Cooperativity with the Class II Transactivator. J. Biol. Chem. 276: 38715-38720 [Abstract] [Full Text]  
  • Sisk, T. J., Roys, S., Chang, C.-H. (2001). Self-Association of CIITA and Its Transactivation Potential. Mol. Cell. Biol. 21: 4919-4928 [Abstract] [Full Text]  
  • Li, G., Harton, J. A., Zhu, X., Ting, J. P.-Y. (2001). Downregulation of CIITA Function by Protein Kinase A (PKA)-Mediated Phosphorylation: Mechanism of Prostaglandin E, Cyclic AMP, and PKA Inhibition of Class II Major Histocompatibility Complex Expression in Monocytic Lines. Mol. Cell. Biol. 21: 4626-4635 [Abstract] [Full Text]  
  • Kanazawa, S., Peterlin, B. M. (2001). Combinations of dominant-negative class II transactivator, p300 or CDK9 proteins block the expression of MHC II genes. Int Immunol 13: 951-958 [Abstract] [Full Text]  
  • Linhoff, M. W., Harton, J. A., Cressman, D. E., Martin, B. K., Ting, J. P.-Y. (2001). Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains. Mol. Cell. Biol. 21: 3001-3011 [Abstract] [Full Text]  
  • Gourley, T. S., Chang, C.-H. (2001). Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression. J. Immunol. 166: 2917-2921 [Abstract] [Full Text]  
  • Magner, W. J., Kazim, A. L., Stewart, C., Romano, M. A., Catalano, G., Grande, C., Keiser, N., Santaniello, F., Tomasi, T. B. (2000). Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors. J. Immunol. 165: 7017-7024 [Abstract] [Full Text]  
  • Spilianakis, C., Papamatheakis, J., Kretsovali, A. (2000). Acetylation by PCAF Enhances CIITA Nuclear Accumulation and Transactivation of Major Histocompatibility Complex Class II Genes. Mol. Cell. Biol. 20: 8489-8498 [Abstract] [Full Text]  
  • Hake, S. B., Masternak, K., Kammerbauer, C., Janzen, C., Reith, W., Steimle, V. (2000). CIITA Leucine-Rich Repeats Control Nuclear Localization, In Vivo Recruitment to the Major Histocompatibility Complex (MHC) Class II Enhanceosome, and MHC Class II Gene Transactivation. Mol. Cell. Biol. 20: 7716-7725 [Abstract] [Full Text]  
  • Ito, K., Barnes, P. J., Adcock, I. M. (2000). Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1beta -Induced Histone H4 Acetylation on Lysines 8 and 12. Mol. Cell. Biol. 20: 6891-6903 [Abstract] [Full Text]  
  • Harton, J. A., Ting, J. P.-Y. (2000). Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression. Mol. Cell. Biol. 20: 6185-6194 [Full Text]  
  • Sisk, T. J., Gourley, T., Roys, S., Chang, C.-H. (2000). MHC Class II Transactivator Inhibits IL-4 Gene Transcription by Competing with NF-AT to Bind the Coactivator CREB Binding Protein (CBP)/p300. J. Immunol. 165: 2511-2517 [Abstract] [Full Text]  
  • Zhu, X.-S., Linhoff, M. W., Li, G., Chin, K.-C., Maity, S. N., Ting, J. P.-Y. (2000). Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter. Mol. Cell. Biol. 20: 6051-6061 [Abstract] [Full Text]  
  • Taxman, D. J., Cressman, D. E., Ting, J. P.-Y. (2000). Identification of Class II Transcriptional Activator-Induced Genes by Representational Difference Analysis: Discoordinate Regulation of the DN{alpha}/DO{beta} Heterodimer. J. Immunol. 165: 1410-1416 [Abstract] [Full Text]  
  • Aittomaki, S., Pesu, M., Groner, B., Janne, O. A., Palvimo, J. J., Silvennoinen, O. (2000). Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fc{gamma} Receptor I in Monocytes. J. Immunol. 164: 5689-5697 [Abstract] [Full Text]  
  • Masternak, K., Muhlethaler-Mottet, A., Villard, J., Zufferey, M., Steimle, V., Reith, W. (2000). CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 14: 1156-1166 [Abstract] [Full Text]  
  • Saifuddin, M., Roebuck, K. A., Chang, C.-h., Ting, J. P. Y., Spear, G. T. (2000). Cutting Edge: Activation of HIV-1 Transcription by the MHC Class II Transactivator. J. Immunol. 164: 3941-3945 [Abstract] [Full Text]  
  • Nagarajan, U. M., Peijnenburg, A., Gobin, S. J. P., Boss, J. M., van den Elsen, P. J. (2000). Novel Mutations Within the RFX-B Gene and Partial Rescue of MHC and Related Genes Through Exogenous Class II Transactivator in RFX-B-Deficient Cells. J. Immunol. 164: 3666-3674 [Abstract] [Full Text]  
  • Boisvert, F.-M., Hendzel, M. J., Bazett-Jones, D. P. (2000). Promyelocytic Leukemia (Pml) Nuclear Bodies Are Protein Structures That Do Not Accumulate RNA. JCB 148: 283-292 [Abstract] [Full Text]  
  • Kretsovali, A., Spilianakis, C., Dimakopoulos, A., Makatounakis, T., Papamatheakis, J. (2001). Self-association of Class II Transactivator Correlates with Its Intracellular Localization and Transactivation. J. Biol. Chem. 276: 32191-32197 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»