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Molecular and Cellular Biology, October 1999, p. 7011-7019, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27Kip1 Activity

Tateki Tsutsui,1,2,dagger Bahar Hesabi,1,2 David S. Moons,1,2 Pier Paolo Pandolfi,3 Kimberly S. Hansel,1,2 Andrew Koff,4 and Hiroaki Kiyokawa1,2,4,*

Department of Molecular Genetics1 and Division of Developmental Therapeutics, Cancer Center,2 University of Illinois College of Medicine, Chicago, Illinois 60607, and Department of Human Genetics3 and Molecular Biology Program,4 Memorial Sloan-Kettering Cancer Center, New York, New York 10021

Received 6 April 1999/Returned for modification 5 May 1999/Accepted 20 July 1999

The mechanism by which cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression is not entirely clear. Cyclin D/CDK4 appears to initiate phosphorylation of retinoblastoma protein (Rb) leading to inactivation of the S-phase-inhibitory action of Rb. However, cyclin D/CDK4 has been postulated to act in a noncatalytic manner to regulate the cyclin E/CDK2-inhibitory activity of p27Kip1 by sequestration. In this study we investigated the roles of CDK4 in cell cycle regulation by targeted disruption of the mouse CDK4 gene. CDK4-/- mice survived embryogenesis and showed growth retardation and reproductive dysfunction associated with hypoplastic seminiferous tubules in the testis and perturbed corpus luteum formation in the ovary. These phenotypes appear to be opposite to those of p27-deficient mice such as gigantism and gonadal hyperplasia. A majority of CDK4-/- mice developed diabetes mellitus by 6 weeks, associated with degeneration of pancreatic islets. Fibroblasts from CDK4-/- mouse embryos proliferated similarly to wild-type embryonic fibroblasts under conditions that promote continuous growth. However, quiescent CDK4-/- fibroblasts exhibited a substantial (~6-h) delay in S-phase entry after serum stimulation. This cell cycle perturbation by CDK4 disruption was associated with increased binding of p27 to cyclin E/CDK2 and diminished activation of CDK2 accompanied by impaired Rb phosphorylation. Importantly, fibroblasts from CDK4-/- p27-/- embryos displayed partially restored kinetics of the G0-S transition, indicating the significance of the sequestration of p27 by CDK4. These results suggest that at least part of CDK4's participation in the rate-limiting mechanism for the G0-S transition consists of controlling p27 activity.

* Corresponding author. Mailing address: 900 S. Ashland Ave., MC 669, Chicago, IL 60607. Phone: (312) 355-1601. Fax: (312) 413-0353. E-mail: kiyokawa{at}uic.edu.

dagger Present address: Department of Obstetrics and Gynecology, Osaka University Medical School, Osaka 565, Japan.

Molecular and Cellular Biology, October 1999, p. 7011-7019, Vol. 19, No. 10
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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