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Molecular and Cellular Biology, December 1999, p. 8083-8093, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae

Shu-Chun Teng and Virginia A. Zakian*

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

Received 24 May 1999/Returned for modification 29 June 1999/Accepted 25 August 1999

Many Saccharomyces telomeres bear one or more copies of the repetitive Y' element followed by ~350 bp of telomerase-generated C1-3A/TG1-3 repeats. Although most cells lacking a gene required for the telomerase pathway die after 50 to 100 cell divisions, survivors arise spontaneously in such cultures. These survivors have one of two distinct patterns of telomeric DNA (V. Lundblad and E. H. Blackburn, Cell 73:347-360, 1993). The more common of the two patterns, seen in type I survivors, is tandem amplification of Y' followed by very short tracts of C1-3A/TG1-3 DNA. By determining the structure of singly tagged telomeres, chromosomes in type II survivors were shown to end in very long and heterogeneous-length tracts of C1-3A/TG1-3 DNA, with some telomeres having 12 kb or more of C1-3A/TG1-3 repeats. Maintenance of these long telomeres required the continuous presence of Rad52p. Whereas type I survivors often converted to the type II structure of telomeric DNA, the type II pattern was maintained for at least 250 cell divisions. However, during outgrowth, the structure of type II telomeres was dynamic, displaying gradual shortening as well as other structural changes that could be explained by continuous gene conversion events with other telomeres. Although most type II survivors had a growth rate similar to that of telomerase-proficient cells, their telomeres slowly returned to wild-type lengths when telomerase was reintroduced. The very long and heterogeneous-length telomeres characteristic of type II survivors in Saccharomyces are reminiscent of the telomeres in immortal human cell lines and tumors that maintain telomeric DNA in the absence of telomerase.

* Corresponding author. Mailing address: Department of Molecular Biology, Princeton University, Princeton, NJ 08544. Phone: (609) 258-6770. Fax: (609) 258-1701. E-mail: vzakian{at}molbio.princeton.edu.

Molecular and Cellular Biology, December 1999, p. 8083-8093, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Yu, E. Y., Steinberg-Neifach, O., Dandjinou, A. T., Kang, F., Morrison, A. J., Shen, X., Lue, N. F. (2007). Regulation of Telomere Structure and Functions by Subunits of the INO80 Chromatin Remodeling Complex. Mol. Cell. Biol. 27: 5639-5649 [Abstract] [Full Text]  
  • Grandin, N., Charbonneau, M. (2007). Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA. Nucleic Acids Res 35: 822-838 [Abstract] [Full Text]  
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  • d'Adda di Fagagna, F., Teo, S.-H., Jackson, S. P. (2004). Functional links between telomeres and proteins of the DNA-damage response. Genes Dev. 18: 1781-1799 [Abstract] [Full Text]  
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  • Edmonds, D., Breitkreutz, B.-J., Harrington, L. (2004). A genome-wide telomere screen in yeast: The long and short of it all. Proc. Natl. Acad. Sci. USA 101: 9515-9516 [Full Text]  
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  • Underwood, D. H., Carroll, C., McEachern, M. J. (2004). Genetic Dissection of the Kluyveromyces lactis Telomere and Evidence for Telomere Capping Defects in TER1 Mutants with Long Telomeres. Eukaryot Cell 3: 369-384 [Abstract] [Full Text]  
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  • Bertuch, A. A., Lundblad, V. (2004). EXO1 Contributes to Telomere Maintenance in Both Telomerase-Proficient and Telomerase-Deficient Saccharomyces cerevisiae. Genetics 166: 1651-1659 [Abstract] [Full Text]  
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  • Scholes, D. T., Kenny, A. E., Gamache, E. R., Mou, Z., Curcio, M. J. (2003). Activation of a LTR-retrotransposon by telomere erosion. Proc. Natl. Acad. Sci. USA 100: 15736-15741 [Abstract] [Full Text]  
  • Grandin, N., Charbonneau, M. (2003). Mitotic Cyclins Regulate Telomeric Recombination in Telomerase-Deficient Yeast Cells. Mol. Cell. Biol. 23: 9162-9177 [Abstract] [Full Text]  
  • Tsukamoto, M., Yamashita, K., Miyazaki, T., Shinohara, M., Shinohara, A. (2003). The N-Terminal DNA-Binding Domain of Rad52 Promotes RAD51-Independent Recombination in Saccharomyces cerevisiae. Genetics 165: 1703-1715 [Abstract] [Full Text]  
  • Lydall, D. (2003). Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways. J. Cell Sci. 116: 4057-4065 [Abstract] [Full Text]  
  • Natarajan, S., Groff-Vindman, C., McEachern, M. J. (2003). Factors Influencing the Recombinational Expansion and Spread of Telomeric Tandem Arrays in Kluyveromyces lactis. Eukaryot Cell 2: 1115-1127 [Abstract] [Full Text]  
  • Kibe, T., Tomita, K., Matsuura, A., Izawa, D., Kodaira, T., Ushimaru, T., Uritani, M., Ueno, M. (2003). Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer. Nucleic Acids Res 31: 5054-5063 [Abstract] [Full Text]  
  • Lowell, J. E., Roughton, A. I., Lundblad, V., Pillus, L. (2003). Telomerase-Independent Proliferation Is Influenced by Cell Type in Saccharomyces cerevisiae. Genetics 164: 909-921 [Abstract] [Full Text]  
  • Grandin, N., Charbonneau, M. (2003). The Rad51 Pathway of Telomerase-Independent Maintenance of Telomeres Can Amplify TG1-3 Sequences in yku and cdc13 Mutants of Saccharomyces cerevisiae. Mol. Cell. Biol. 23: 3721-3734 [Abstract] [Full Text]  
  • Wu, G., Jiang, X., Lee, W.-H., Chen, P.-L. (2003). Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1. Cancer Res. 63: 2589-2595 [Abstract] [Full Text]  
  • Hahn, W. C. (2003). Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. JCO 21: 2034-2043 [Abstract] [Full Text]  
  • Gallego, M. E., Jalut, N., White, C. I. (2003). Telomerase Dependence of Telomere Lengthening in ku80 Mutant Arabidopsis. Plant Cell 15: 782-789 [Abstract] [Full Text]  
  • IJpma, A. S., Greider, C. W. (2003). Short Telomeres Induce a DNA Damage Response in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 987-1001 [Abstract] [Full Text]  
  • Friedman, K. L., Heit, J. J., Long, D. M., Cech, T. R. (2003). N-terminal Domain of Yeast Telomerase Reverse Transcriptase: Recruitment of Est3p to the Telomerase Complex. Mol. Biol. Cell 14: 1-13 [Abstract] [Full Text]  
  • Symington, L. S. (2002). Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair. Microbiol. Mol. Biol. Rev. 66: 630-670 [Abstract] [Full Text]  
  • Stavropoulos, D. J., Bradshaw, P. S., Li, X., Pasic, I., Truong, K., Ikura, M., Ungrin, M., Meyn, M. S. (2002). The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis. Hum Mol Genet 11: 3135-3144 [Abstract] [Full Text]  
  • Parenteau, J., Wellinger, R. J. (2002). Differential Processing of Leading- and Lagging-Strand Ends at Saccharomyces cerevisiae Telomeres Revealed by the Absence of Rad27p Nuclease. Genetics 162: 1583-1594 [Abstract] [Full Text]  
  • Newbold, R. F. (2002). The significance of telomerase activation and cellular immortalization in human cancer. Mutagenesis 17: 539-550 [Abstract] [Full Text]  
  • Seto, A. G., Livengood, A. J., Tzfati, Y., Blackburn, E. H., Cech, T. R. (2002). A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 16: 2800-2812 [Abstract] [Full Text]  
  • Melnikova, L., Georgiev, P. (2002). Enhancer of terminal gene conversion, a New Mutation in Drosophila melanogaster That Induces Telomere Elongation by Gene Conversion. Genetics 162: 1301-1312 [Abstract] [Full Text]  
  • Ira, G., Haber, J. E. (2002). Characterization of RAD51-Independent Break-Induced Replication That Acts Preferentially with Short Homologous Sequences. Mol. Cell. Biol. 22: 6384-6392 [Abstract] [Full Text]  
  • Tsai, Y.-L., Tseng, S.-F., Chang, S.-H., Lin, C.-C., Teng, S.-C. (2002). Involvement of Replicative Polymerases, Tel1p, Mec1p, Cdc13p, and the Ku Complex in Telomere-Telomere Recombination. Mol. Cell. Biol. 22: 5679-5687 [Abstract] [Full Text]  
  • Kolodner, R. D., Putnam, C. D., Myung, K. (2002). Maintenance of Genome Stability in Saccharomyces cerevisiae. Science 297: 552-557 [Abstract] [Full Text]  
  • Maser, R. S., DePinho, R. A. (2002). Connecting Chromosomes, Crisis, and Cancer. Science 297: 565-569 [Abstract] [Full Text]  
  • Ohya, T., Kawasaki, Y., Hiraga, S.-I., Kanbara, S., Nakajo, K., Nakashima, N., Suzuki, A., Sugino, A. (2002). The DNA Polymerase Domain of polepsilon Is Required for Rapid, Efficient, and Highly Accurate Chromosomal DNA Replication, Telomere Length Maintenance, and Normal Cell Senescence in Saccharomyces cerevisiae. J. Biol. Chem. 277: 28099-28108 [Abstract] [Full Text]  
  • Nautiyal, S., DeRisi, J. L., Blackburn, E. H. (2002). The genome-wide expression response to telomerase deletion in Saccharomycescerevisiae. Proc. Natl. Acad. Sci. USA 99: 9316-9321 [Abstract] [Full Text]  
  • Natarajan, S., McEachern, M. J. (2002). Recombinational Telomere Elongation Promoted by DNA Circles. Mol. Cell. Biol. 22: 4512-4521 [Abstract] [Full Text]  
  • DuBois, M. L., Haimberger, Z. W., McIntosh, M. W., Gottschling, D. E. (2002). A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae. Genetics 161: 995-1013 [Abstract] [Full Text]  
  • Choe, W., Budd, M., Imamura, O., Hoopes, L., Campbell, J. L. (2002). Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication. Mol. Cell. Biol. 22: 4202-4217 [Abstract] [Full Text]  
  • Craven, R. J., Greenwell, P. W., Dominska, M., Petes, T. D. (2002). Regulation of Genome Stability by TEL1 and MEC1, Yeast Homologs of the Mammalian ATM and ATR Genes. Genetics 161: 493-507 [Abstract] [Full Text]  
  • Samper, E., Fernandez, P., Eguia, R., Martin-Rivera, L., Bernad, A., Blasco, M. A., Aracil, M. (2002). Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 99: 2767-2775 [Abstract] [Full Text]  
  • Lewis, L. K., Karthikeyan, G., Westmoreland, J. W., Resnick, M. A. (2002). Differential Suppression of DNA Repair Deficiencies of Yeast rad50, mre11 and xrs2 Mutants by EXO1 and TLC1 (the RNA Component of Telomerase). Genetics 160: 49-62 [Abstract] [Full Text]  
  • McEachern, M. J., Underwood, D. H., Blackburn, E. H. (2002). Dynamics of Telomeric DNA Turnover in Yeast. Genetics 160: 63-73 [Abstract] [Full Text]  
  • Siriaco, G. M., Cenci, G., Haoudi, A., Champion, L. E., Zhou, C., Gatti, M., Mason, J. M. (2002). Telomere elongation (Tel), a New Mutation in Drosophila melanogaster That Produces Long Telomeres. Genetics 160: 235-245 [Abstract] [Full Text]  
  • Grossi, S., Bianchi, A., Damay, P., Shore, D. (2001). Telomere Formation by Rap1p Binding Site Arrays Reveals End-Specific Length Regulation Requirements and Active Telomeric Recombination. Mol. Cell. Biol. 21: 8117-8128 [Abstract] [Full Text]  
  • Scholes, D. T., Banerjee, M., Bowen, B., Curcio, M. J. (2001). Multiple Regulators of Ty1 Transposition in Saccharomyces cerevisiae Have Conserved Roles in Genome Maintenance. Genetics 159: 1449-1465 [Abstract] [Full Text]  
  • Bucholc, M., Park, Y., Lustig, A. J. (2001). Intrachromatid Excision of Telomeric DNA as a Mechanism for Telomere Size Control in Saccharomyces cerevisiae. Mol. Cell. Biol. 21: 6559-6573 [Abstract] [Full Text]  
  • Grobelny, J. V., Kulp-McEliece, M., Broccoli, D. (2001). Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway. Hum Mol Genet 10: 1953-1961 [Abstract] [Full Text]  
  • Kraus, E., Leung, W.-Y., Haber, J. E. (2001). Break-induced replication: A review and an example in budding yeast. Proc. Natl. Acad. Sci. USA 98: 8255-8262 [Abstract] [Full Text]  
  • Meier, B., Driller, L., Jaklin, S., Feldmann, H. M. (2001). New Function of CDC13 in Positive Telomere Length Regulation. Mol. Cell. Biol. 21: 4233-4245 [Abstract] [Full Text]  
  • Perrem, K., Colgin, L. M., Neumann, A. A., Yeager, T. R., Reddel, R. R. (2001). Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells. Mol. Cell. Biol. 21: 3862-3875 [Abstract] [Full Text]  
  • Ray, A., Runge, K. W. (2001). Yeast telomerase appears to frequently copy the entire template in vivo. Nucleic Acids Res 29: 2382-2394 [Abstract] [Full Text]  
  • Malkova, A., Signon, L., Schaefer, C. B., Naylor, M. L., Theis, J. F., Newlon, C. S., Haber, J. E. (2001). RAD51-independent break-induced replication to repair a broken chromosome depends on a distant enhancer site. Genes Dev. 15: 1055-1060 [Abstract] [Full Text]  
  • Signon, L., Malkova, A., Naylor, M. L., Klein, H., Haber, J. E. (2001). Genetic Requirements for RAD51- and RAD54-Independent Break-Induced Replication Repair of a Chromosomal Double-Strand Break. Mol. Cell. Biol. 21: 2048-2056 [Abstract] [Full Text]  
  • Chen, Q., Ijpma, A., Greider, C. W. (2001). Two Survivor Pathways That Allow Growth in the Absence of Telomerase Are Generated by Distinct Telomere Recombination Events. Mol. Cell. Biol. 21: 1819-1827 [Abstract] [Full Text]  
  • Cohen, H., Sinclair, D. A. (2001). Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. USA 10.1073/pnas.061579598v1 [Abstract] [Full Text]  
  • Gallego, M. E., White, C. I. (2001). RAD50 function is essential for telomere maintenance in Arabidopsis. Proc. Natl. Acad. Sci. USA 98: 1711-1716 [Abstract] [Full Text]  
  • Grandin, N., Damon, C., Charbonneau, M. (2000). Cdc13 Cooperates with the Yeast Ku Proteins and Stn1 To Regulate Telomerase Recruitment. Mol. Cell. Biol. 20: 8397-8408 [Abstract] [Full Text]  
  • Tomaska, L., Nosek, J., Makhov, A. M., Pastorakova, A., Griffith, J. D. (2000). Extragenomic double-stranded DNA circles in yeast with linear mitochondrial genomes: potential involvement in telomere maintenance. Nucleic Acids Res 28: 4479-4487 [Abstract] [Full Text]  


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