The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bevan, C. L.
	Articles by Parker, M. G.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bevan, C. L.
	Articles by Parker, M. G.

Previous Article | Next Article

Molecular and Cellular Biology, December 1999, p. 8383-8392, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1

Charlotte L. Bevan,¹^, Sue Hoare,¹ Frank Claessens,² David M. Heery,¹^, and Malcolm G. Parker¹^,^*

Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom,¹ and Afdeling Biochemie, Campus Gasthuisberg, 300 Leuven, Belgium²

Received 20 May 1999/Returned for modification 23 June 1999/Accepted 14 September 1999

The androgen receptor is unusual among nuclear receptors in that most, if not all, of its activity is mediated via the constitutiveactivation function in the N terminus. Here we demonstrate thatp160 coactivators such as SRC1 (steroid receptor coactivator 1)interact directly with the N terminus in a ligand-independentmanner via a conserved glutamine-rich region between residues1053 and 1123. Although SRC1 is capable of interacting with theligand-binding domain by means of LXXLL motifs, this interactionis not essential since an SRC1 mutant with no functional LXXLLmotifs retains its ability to potentiate androgen receptor activity.In contrast, mutants lacking the glutamine-rich region are inactive,indicating that this region is both necessary and sufficient forrecruitment of SRC1 to the androgen receptor. This recruitmentis in direct contrast to the recruitment of SRC1 to the estrogenreceptor, which requires interaction with the ligand-bindingdomain.

^* Corresponding author. Mailing address: Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, 44 Lincoln's InnFields, London WC2A 3PX, United Kingdom. Phone: 44 171 269 3280.Fax: 44 171 269 3094. E-mail: m.parker{at}icrf.icnet.uk.

Present address: Prostate Cancer Research Group, Department of Cancer Medicine, Imperial College School of Medicine, HammersmithHospital, London W12 0NN, UnitedKingdom.

Present address: Department of Biochemistry, University of Leicester, Leicester LE1 7RH, UnitedKingdom.

Molecular and Cellular Biology, December 1999, p. 8383-8392, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., Tindall, D. J. (2008). Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance. Cancer Res. 68: 5469-5477 [Abstract] [Full Text]
Kim, D.-H., Kim, G. S., Yun, C. H., Lee, Y. C. (2008). Functional Conservation of the Glutamine-Rich Domains of Yeast Gal11 and Human SRC-1 in the Transactivation of Glucocorticoid Receptor Tau 1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 28: 913-925 [Abstract] [Full Text]
Suh, J. H., Shong, M., Choi, H.-S., Lee, K. (2008). CR6-Interacting Factor 1 Represses the Transactivation of Androgen Receptor by Direct Interaction. Mol. Endocrinol. 22: 33-46 [Abstract] [Full Text]
Heemers, H. V., Tindall, D. J. (2007). Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex. Endocr. Rev. 28: 778-808 [Abstract] [Full Text]
Dehm, S. M., Tindall, D. J. (2007). Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer. Mol. Endocrinol. 21: 2855-2863 [Abstract] [Full Text]
Dehm, S. M., Regan, K. M., Schmidt, L. J., Tindall, D. J. (2007). Selective Role of an NH2-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion Independent Prostate Cancer Cells. Cancer Res. 67: 10067-10077 [Abstract] [Full Text]
Hodgson, M. C., Astapova, I., Hollenberg, A. N., Balk, S. P. (2007). Activity of Androgen Receptor Antagonist Bicalutamide in Prostate Cancer Cells Is Independent of NCoR and SMRT Corepressors. Cancer Res. 67: 8388-8395 [Abstract] [Full Text]
Mahajan, N. P., Liu, Y., Majumder, S., Warren, M. R., Parker, C. E., Mohler, J. L., Earp, H. S., Whang, Y. E. (2007). Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 104: 8438-8443 [Abstract] [Full Text]
Haelens, A., Tanner, T., Denayer, S., Callewaert, L., Claessens, F. (2007). The Hinge Region Regulates DNA Binding, Nuclear Translocation, and Transactivation of the Androgen Receptor. Cancer Res. 67: 4514-4523 [Abstract] [Full Text]
Lu, N. Z., Wardell, S. E., Burnstein, K. L., Defranco, D., Fuller, P. J., Giguere, V., Hochberg, R. B., McKay, L., Renoir, J.-M., Weigel, N. L., Wilson, E. M., McDonnell, D. P., Cidlowski, J. A. (2006). International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors. Pharmacol. Rev. 58: 782-797 [Full Text]
Zhou, D., Ye, J. j., Li, Y., Lui, K., Chen, S. (2006). The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha. Nucleic Acids Res 34: 5974-5986 [Abstract] [Full Text]
Fu, M., Liu, M., Sauve, A. A., Jiao, X., Zhang, X., Wu, X., Powell, M. J., Yang, T., Gu, W., Avantaggiati, M. L., Pattabiraman, N., Pestell, T. G., Wang, F., Quong, A. A., Wang, C., Pestell, R. G. (2006). Hormonal Control of Androgen Receptor Function through SIRT1. Mol. Cell. Biol. 26: 8122-8135 [Abstract] [Full Text]
Dehm, S. M., Tindall, D. J. (2006). Ligand-independent Androgen Receptor Activity Is Activation Function-2-independent and Resistant to Antiandrogens in Androgen Refractory Prostate Cancer Cells. J. Biol. Chem. 281: 27882-27893 [Abstract] [Full Text]
Chattopadhyay, S., Gong, E.-Y., Hwang, M., Park, E., Lee, H. J., Hong, C. Y., Choi, H.-S., Cheong, J.-H., Kwon, H. B., Lee, K. (2006). The CCAAT Enhancer-Binding Protein-{alpha} Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer Cells. Mol. Endocrinol. 20: 984-995 [Abstract] [Full Text]
Yoon, H.-G., Wong, J. (2006). The Corepressors Silencing Mediator of Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Are Involved in Agonist- and Antagonist-Regulated Transcription by Androgen Receptor. Mol. Endocrinol. 20: 1048-1060 [Abstract] [Full Text]
Butler, L. M., Centenera, M. M., Neufing, P. J., Buchanan, G., Choong, C. S. Y., Ricciardelli, C., Saint, K., Lee, M., Ochnik, A., Yang, M., Brown, M. P., Tilley, W. D. (2006). Suppression of Androgen Receptor Signaling in Prostate Cancer Cells by an Inhibitory Receptor Variant. Mol. Endocrinol. 20: 1009-1024 [Abstract] [Full Text]
Nishi, M., Kawata, M. (2006). Brain Corticosteroid Receptor Dynamics and Trafficking: Implications from Live Cell Imaging. Neuroscientist 12: 119-133 [Abstract]
Li, J., Fu, J., Toumazou, C., Yoon, H.-G., Wong, J. (2006). A Role of the Amino-Terminal (N) and Carboxyl-Terminal (C) Interaction in Binding of Androgen Receptor to Chromatin. Mol. Endocrinol. 20: 776-785 [Abstract] [Full Text]
Baek, S. H., Ohgi, K. A., Nelson, C. A., Welsbie, D., Chen, C., Sawyers, C. L., Rose, D. W., Rosenfeld, M. G. (2006). Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc. Natl. Acad. Sci. USA 103: 3100-3105 [Abstract] [Full Text]
Callewaert, L., Van Tilborgh, N., Claessens, F. (2006). Interplay between Two Hormone-Independent Activation Domains in the Androgen Receptor. Cancer Res. 66: 543-553 [Abstract] [Full Text]
Li, A. J., Lerner, D. L., Gapuzan, M.-E. R., Karlan, B. Y. (2005). AIB1 Polymorphisms Predict Aggressive Ovarian Cancer Phenotype. Cancer Epidemiol. Biomarkers Prev. 14: 2919-2922 [Abstract] [Full Text]
Song, L.-N., Gelmann, E. P. (2005). Interaction of {beta}-Catenin and TIF2/GRIP1 in Transcriptional Activation by the Androgen Receptor. J. Biol. Chem. 280: 37853-37867 [Abstract] [Full Text]
Lucey, M. J., Chen, D., Lopez-Garcia, J., Hart, S. M., Phoenix, F., Al-Jehani, R., Alao, J. P., White, R., Kindle, K. B., Losson, R., Chambon, P., Parker, M. G., Schar, P., Heery, D. M., Buluwela, L., Ali, S. (2005). T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif. Nucleic Acids Res 33: 6393-6404 [Abstract] [Full Text]
Chen, G., Nomura, M., Morinaga, H., Matsubara, E., Okabe, T., Goto, K., Yanase, T., Zheng, H., Lu, J., Nawata, H. (2005). Modulation of Androgen Receptor Transactivation by FoxH1: A NEWLY IDENTIFIED ANDROGEN RECEPTOR COREPRESSOR. J. Biol. Chem. 280: 36355-36363 [Abstract] [Full Text]
Rau, K-M, Kang, H-Y, Cha, T-L, Miller, S A, Hung, M-C (2005). The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers. Endocr Relat Cancer 12: 511-532 [Abstract] [Full Text]
Agoulnik, I. U., Vaid, A., Bingman, W. E. III, Erdeme, H., Frolov, A., Smith, C. L., Ayala, G., Ittmann, M. M., Weigel, N. L. (2005). Role of SRC-1 in the Promotion of Prostate Cancer Cell Growth and Tumor Progression. Cancer Res. 65: 7959-7967 [Abstract] [Full Text]
Ye, X., Han, S. J., Tsai, S. Y., DeMayo, F. J., Xu, J., Tsai, M.-J., O'Malley, B. W. (2005). Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc. Natl. Acad. Sci. USA 102: 9487-9492 [Abstract] [Full Text]
Hong, C. Y., Suh, J. H., Kim, K., Gong, E.-Y., Jeon, S. H., Ko, M., Seong, R. H., Kwon, H. B., Lee, K. (2005). Modulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways. Mol. Cell. Biol. 25: 4841-4852 [Abstract] [Full Text]
Wan, W., Farboud, B., Privalsky, M. L. (2005). Pituitary Resistance to Thyroid Hormone Syndrome Is Associated with T3 Receptor Mutants that Selectively Impair {beta}2 Isoform Function. Mol. Endocrinol. 19: 1529-1542 [Abstract] [Full Text]
Estebanez-Perpina, E., Moore, J. M. R., Mar, E., Delgado-Rodrigues, E., Nguyen, P., Baxter, J. D., Buehrer, B. M., Webb, P., Fletterick, R. J., Guy, R. K. (2005). The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor. J. Biol. Chem. 280: 8060-8068 [Abstract] [Full Text]
Burd, C. J., Petre, C. E., Moghadam, H., Wilson, E. M., Knudsen, K. E. (2005). Cyclin D1 Binding to the Androgen Receptor (AR) NH2-Terminal Domain Inhibits Activation Function 2 Association and Reveals Dual Roles for AR Corepression. Mol. Endocrinol. 19: 607-620 [Abstract] [Full Text]
Meijer, O. C., Kalkhoven, E., van der Laan, S., Steenbergen, P. J., Houtman, S. H., Dijkmans, T. F., Pearce, D., de Kloet, E. R. (2005). Steroid Receptor Coactivator-1 Splice Variants Differentially Affect Corticosteroid Receptor Signaling. Endocrinology 146: 1438-1448 [Abstract] [Full Text]
Hodgson, M. C., Astapova, I., Cheng, S., Lee, L. J., Verhoeven, M. C., Choi, E., Balk, S. P., Hollenberg, A. N. (2005). The Androgen Receptor Recruits Nuclear Receptor CoRepressor (N-CoR) in the Presence of Mifepristone via Its N and C Termini Revealing a Novel Molecular Mechanism for Androgen Receptor Antagonists. J. Biol. Chem. 280: 6511-6519 [Abstract] [Full Text]
Belandia, B., Powell, S. M., Garcia-Pedrero, J. M., Walker, M. M., Bevan, C. L., Parker, M. G. (2005). Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor Corepressor. Mol. Cell. Biol. 25: 1425-1436 [Abstract] [Full Text]
Hsu, C.-L., Chen, Y.-L., Ting, H.-J., Lin, W.-J., Yang, Z., Zhang, Y., Wang, L., Wu, C.-T., Chang, H.-C., Yeh, S., Pimplikar, S. W., Chang, C. (2005). Androgen Receptor (AR) NH2- and COOH-Terminal Interactions Result in the Differential Influences on the AR-Mediated Transactivation and Cell Growth. Mol. Endocrinol. 19: 350-361 [Abstract] [Full Text]
Umar, A., Berrevoets, C. A., Van, N. M., van Leeuwen, M., Verbiest, M., Kleijer, W. J., Dooijes, D., Grootegoed, J. A., Drop, S. L. S., Brinkmann, A. O. (2005). Functional Analysis of a Novel Androgen Receptor Mutation, Q902K, in an Individual with Partial Androgen Insensitivity. J. Clin. Endocrinol. Metab. 90: 507-515 [Abstract] [Full Text]
Qin, J., Gao, D.-m., Jiang, Q.-F., Zhou, Q., Kong, Y.-Y., Wang, Y., Xie, Y.-H. (2004). Prospero-Related Homeobox (Prox1) Is a Corepressor of Human Liver Receptor Homolog-1 and Suppresses the Transcription of the Cholesterol 7-{alpha}-Hydroxylase Gene. Mol. Endocrinol. 18: 2424-2439 [Abstract] [Full Text]
Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A. G. M., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C. J., Brinkmann, A. O., Pike, A. C. W., Trapman, J. (2004). Distinct Recognition Modes of FXXLF and LXXLL Motifs by the Androgen Receptor. Mol. Endocrinol. 18: 2132-2150 [Abstract] [Full Text]
Xu, P.-L., Liu, Y.-Q., Shan, S.-F., Kong, Y.-Y., Zhou, Q., Li, M., Ding, J.-P., Xie, Y.-H., Wang, Y. (2004). Molecular Mechanism for the Potentiation of the Transcriptional Activity of Human Liver Receptor Homolog 1 by Steroid Receptor Coactivator-1. Mol. Endocrinol. 18: 1887-1905 [Abstract] [Full Text]
Callewaert, L., Verrijdt, G., Haelens, A., Claessens, F. (2004). Differential Effect of Small Ubiquitin-Like Modifier (SUMO)-ylation of the Androgen Receptor in the Control of Cooperativity on Selective Versus Canonical Response Elements. Mol. Endocrinol. 18: 1438-1449 [Abstract] [Full Text]
Wang, Q., Udayakumar, T. S., Vasaitis, T. S., Brodie, A. M., Fondell, J. D. (2004). Mechanistic Relationship between Androgen Receptor Polyglutamine Tract Truncation and Androgen-dependent Transcriptional Hyperactivity in Prostate Cancer Cells. J. Biol. Chem. 279: 17319-17328 [Abstract] [Full Text]
Heinlein, C. A., Chang, C. (2004). Androgen Receptor in Prostate Cancer. Endocr. Rev. 25: 276-308 [Abstract] [Full Text]
Gregory, C. W., Fei, X., Ponguta, L. A., He, B., Bill, H. M., French, F. S., Wilson, E. M. (2004). Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer. J. Biol. Chem. 279: 7119-7130 [Abstract] [Full Text]
Goenka, S., Marlar, C., Schindler, U., Boothby, M. (2003). Differential Roles of C-terminal Activation Motifs in the Establishment of Stat6 Transcriptional Specificity. J. Biol. Chem. 278: 50362-50370 [Abstract] [Full Text]
Litterst, C. M., Kliem, S., Marilley, D., Pfitzner, E. (2003). NCoA-1/SRC-1 Is an Essential Coactivator of STAT5 That Binds to the FDL Motif in the {alpha}-Helical Region of the STAT5 Transactivation Domain. J. Biol. Chem. 278: 45340-45351 [Abstract] [Full Text]
Warnmark, A., Treuter, E., Wright, A. P. H., Gustafsson, J.-A. (2003). Activation Functions 1 and 2 of Nuclear Receptors: Molecular Strategies for Transcriptional Activation. Mol. Endocrinol. 17: 1901-1909 [Abstract] [Full Text]
Lee, D. K., Chang, C. (2003). Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication. J. Clin. Endocrinol. Metab. 88: 4043-4054 [Abstract] [Full Text]
Kasai, M., Guerrero-Santoro, J., Friedman, R., Leman, E. S., Getzenberg, R. H., DeFranco, D. B. (2003). The Group 3 LIM Domain Protein Paxillin Potentiates Androgen Receptor Transactivation in Prostate Cancer Cell Lines. Cancer Res. 63: 4927-4935 [Abstract] [Full Text]
Agoulnik, I. U., Krause, W. C., Bingman, W. E. III, Rahman, H. T., Amrikachi, M., Ayala, G. E., Weigel, N. L. (2003). Repressors of Androgen and Progesterone Receptor Action. J. Biol. Chem. 278: 31136-31148 [Abstract] [Full Text]
Evangelou, A., Letarte, M., Jurisica, I., Sultan, M., Murphy, K. J., Rosen, B., Brown, T. J. (2003). Loss of Coordinated Androgen Regulation in Nonmalignant Ovarian Epithelial Cells with BRCA1/2 Mutations and Ovarian Cancer Cells. Cancer Res. 63: 2416-2424 [Abstract] [Full Text]
Liu, G.-Z., Wang, H., Wang, Z. (2003). Identification of a Highly Conserved Domain in the Androgen Receptor That Suppresses the DNA-binding Domain-DNA Interactions. J. Biol. Chem. 278: 14956-14960 [Abstract] [Full Text]
Hu, X., Cherbas, L., Cherbas, P. (2003). Transcription Activation by the Ecdysone Receptor (EcR/USP): Identification of Activation Functions. Mol. Endocrinol. 17: 716-731 [Abstract] [Full Text]
Coulthard, V. H., Matsuda, S., Heery, D. M. (2003). An Extended LXXLL Motif Sequence Determines the Nuclear Receptor Binding Specificity of TRAP220. J. Biol. Chem. 278: 10942-10951 [Abstract] [Full Text]
Song, L.-N., Herrell, R., Byers, S., Shah, S., Wilson, E. M., Gelmann, E. P. (2003). {beta}-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription. Mol. Cell. Biol. 23: 1674-1687 [Abstract] [Full Text]
Callewaert, L., Verrijdt, G., Christiaens, V., Haelens, A., Claessens, F. (2003). Dual Function of an Amino-terminal Amphipatic Helix in Androgen Receptor-mediated Transactivation through Specific and Nonspecific Response Elements. J. Biol. Chem. 278: 8212-8218 [Abstract] [Full Text]
Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., Chen, J. D. (2003). Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT. J. Biol. Chem. 278: 5052-5061 [Abstract] [Full Text]
Li, P., Lee, H., Guo, S., Unterman, T. G., Jenster, G., Bai, W. (2003). AKT-Independent Protection of Prostate Cancer Cells from Apoptosis Mediated through Complex Formation between the Androgen Receptor and FKHR. Mol. Cell. Biol. 23: 104-118 [Abstract] [Full Text]
Christiaens, V., Bevan, C. L., Callewaert, L., Haelens, A., Verrijdt, G., Rombauts, W., Claessens, F. (2002). Characterization of the Two Coactivator-interacting Surfaces of the Androgen Receptor and Their Relative Role in Transcriptional Control*. J. Biol. Chem. 277: 49230-49237 [Abstract] [Full Text]
Wang, Q., Sharma, D., Ren, Y., Fondell, J. D. (2002). A Coregulatory Role for the TRAP-Mediator Complex in Androgen Receptor-mediated Gene Expression. J. Biol. Chem. 277: 42852-42858 [Abstract] [Full Text]
Reid, J., Murray, I., Watt, K., Betney, R., McEwan, I. J. (2002). The Androgen Receptor Interacts with Multiple Regions of the Large Subunit of General Transcription Factor TFIIF. J. Biol. Chem. 277: 41247-41253 [Abstract] [Full Text]
Ueda, T., Mawji, N. R., Bruchovsky, N., Sadar, M. D. (2002). Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells. J. Biol. Chem. 277: 38087-38094 [Abstract] [Full Text]
Martinez, E. D., Danielsen, M. (2002). Loss of Androgen Receptor Transcriptional Activity at the G1/S Transition. J. Biol. Chem. 277: 29719-29729 [Abstract] [Full Text]
Zhao, Y., Goto, K., Saitoh, M., Yanase, T., Nomura, M., Okabe, T., Takayanagi, R., Nawata, H. (2002). Activation Function-1 Domain of Androgen Receptor Contributes to the Interaction between Subnuclear Splicing Factor Compartment and Nuclear Receptor Compartment. IDENTIFICATION OF THE p102 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLE-BINDING PROTEIN AS A COACTIVATOR FOR THE RECEPTOR. J. Biol. Chem. 277: 30031-30039 [Abstract] [Full Text]
Masiello, D., Cheng, S., Bubley, G. J., Lu, M. L., Balk, S. P. (2002). Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor. J. Biol. Chem. 277: 26321-26326 [Abstract] [Full Text]
He, B., Lee, L. W., Minges, J. T., Wilson, E. M. (2002). Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction. J. Biol. Chem. 277: 25631-25639 [Abstract] [Full Text]
Cheng, S., Brzostek, S., Lee, S. R., Hollenberg, A. N., Balk, S. P. (2002). Inhibition of the Dihydrotestosterone-Activated Androgen Receptor by Nuclear Receptor Corepressor. Mol. Endocrinol. 16: 1492-1501 [Abstract] [Full Text]
Gelmann, E. P. (2002). Molecular Biology of the Androgen Receptor. JCO 20: 3001-3015 [Abstract] [Full Text]
Reid, J., Kelly, S. M., Watt, K., Price, N. C., McEwan, I. J. (2002). Conformational Analysis of the Androgen Receptor Amino-terminal Domain Involved in Transactivation. INFLUENCE OF STRUCTURE-STABILIZING SOLUTES AND PROTEIN-PROTEIN INTERACTIONS. J. Biol. Chem. 277: 20079-20086 [Abstract] [Full Text]
Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y. G., Chang, C., Hopp, T., Fuqua, S. A. W., Jaffray, E., Hay, R. T., Palvimo, J. J., Janne, O. A., Pestell, R. G. (2002). Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function. Mol. Cell. Biol. 22: 3373-3388 [Abstract] [Full Text]
Tan, J.-A., Hall, S. H., Hamil, K. G., Grossman, G., Petrusz, P., French, F. S. (2002). Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators. J. Biol. Chem. 277: 16993-17001 [Abstract] [Full Text]
Huang, Z.-Q., Li, J., Wong, J. (2002). AR Possesses an Intrinsic Hormone-Independent Transcriptional Activity. Mol. Endocrinol. 16: 924-937 [Abstract] [Full Text]
Heinlein, C. A., Chang, C. (2002). Androgen Receptor (AR) Coregulators: An Overview. Endocr. Rev. 23: 175-200 [Abstract] [Full Text]
Chang, C.-Y., McDonnell, D. P. (2002). Evaluation of Ligand-Dependent Changes in AR Structure Using Peptide Probes. Mol. Endocrinol. 16: 647-660 [Abstract] [Full Text]
Yi, P., Driscoll, M. D., Huang, J., Bhagat, S., Hilf, R., Bambara, R. A., Muyan, M. (2002). The Effects of Estrogen-Responsive Element- and Ligand-Induced Structural Changes on the Recruitment of Cofactors and Transcriptional Responses by ER{alpha} and ER{beta}. Mol. Endocrinol. 16: 674-693 [Abstract] [Full Text]
Saitoh, M., Takayanagi, R., Goto, K., Fukamizu, A., Tomura, A., Yanase, T., Nawata, H. (2002). The Presence of Both the Amino- and Carboxyl-Terminal Domains in the AR Is Essential for the Completion of a Transcriptionally Active Form with Coactivators and Intranuclear Compartmentalization Common to the Steroid Hormone Receptors: A Three-Dimensional Imaging Study. Mol. Endocrinol. 16: 694-706 [Abstract] [Full Text]
Ruse, M. D. Jr., Privalsky, M. L., Sladek, F. M. (2002). Competitive Cofactor Recruitment by Orphan Receptor Hepatocyte Nuclear Factor 4{alpha}1: Modulation by the F Domain. Mol. Cell. Biol. 22: 1626-1638 [Abstract] [Full Text]
Holter, E., Kotaja, N., Makela, S., Strauss, L., Kietz, S., Janne, O. A., Gustafsson, J.-A., Palvimo, J. J., Treuter, E. (2002). Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1. Mol. Endocrinol. 16: 515-528 [Abstract] [Full Text]
Ueda, T., Bruchovsky, N., Sadar, M. D. (2002). Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways. J. Biol. Chem. 277: 7076-7085 [Abstract] [Full Text]
Zhou, Z.-x., He, B., Hall, S. H., Wilson, E. M., French, F. S. (2002). Domain Interactions between Coregulator ARA70 and the Androgen Receptor (AR). Mol. Endocrinol. 16: 287-300 [Abstract] [Full Text]
Markus, S. M., Taneja, S. S., Logan, S. K., Li, W., Ha, S., Hittelman, A. B., Rogatsky, I., Garabedian, M. J. (2002). Identification and Characterization of ART-27, a Novel Coactivator for the Androgen Receptor N Terminus. Mol. Biol. Cell 13: 670-682 [Abstract] [Full Text]
Lee, S. R., Ramos, S. M., Ko, A., Masiello, D., Swanson, K. D., Lu, M. L., Balk, S. P. (2002). AR and ER Interaction with a p21-Activated Kinase (PAK6). Mol. Endocrinol. 16: 85-99 [Abstract] [Full Text]
Gaughan, L., Brady, M. E., Cook, S., Neal, D. E., Robson, C. N. (2001). Tip60 Is a Co-activator Specific for Class I Nuclear Hormone Receptors. J. Biol. Chem. 276: 46841-46848 [Abstract] [Full Text]
Litterst, C. M., Pfitzner, E. (2001). Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1. J. Biol. Chem. 276: 45713-45721 [Abstract] [Full Text]
He, B., Bowen, N. T., Minges, J. T., Wilson, E. M. (2001). Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 Coactivator Recruitment by Activation Function 2. J. Biol. Chem. 276: 42293-42301 [Abstract] [Full Text]
Tung, L., Shen, T., Abel, M. G., Powell, R. L., Takimoto, G. S., Sartorius, C. A., Horwitz, K. B. (2001). Mapping the Unique Activation Function 3 in the Progesterone B-receptor Upstream Segment. TWO LXXLL MOTIFS AND A TRYPTOPHAN RESIDUE ARE REQUIRED FOR ACTIVITY. J. Biol. Chem. 276: 39843-39851 [Abstract] [Full Text]
Hughes, I. A. (2001). Minireview: Sex Differentiation. Endocrinology 142: 3281-3287 [Abstract] [Full Text]
Yang, Z., Privalsky, M. L. (2001). Isoform-Specific Transcriptional Regulation by Thyroid Hormone Receptors: Hormone-Independent Activation Operates through a Steroid Receptor Mode of Coactivator Interaction. Mol. Endocrinol. 15: 1170-1185 [Abstract] [Full Text]
Rebbeck, T. R., Wang, Y., Kantoff, P. W., Krithivas, K., Neuhausen, S. L., Godwin, A. K., Daly, M. B., Narod, S. A., Brunet, J.-S., Vesprini, D., Garber, J. E., Lynch, H. T., Weber, B. L., Brown, M. (2001). Modification of BRCA1- and BRCA2-associated Breast Cancer Risk by AIB1 Genotype and Reproductive History. Cancer Res. 61: 5420-5424 [Abstract] [Full Text]
Aranda, A., Pascual, A. (2001). Nuclear Hormone Receptors and Gene Expression. Physiol. Rev. 81: 1269-1304 [Abstract] [Full Text]
Thompson, J., Saatcioglu, F., Janne, O. A., Palvimo, J. J. (2001). Disrupted Amino- and Carboxyl-Terminal Interactions of the Androgen Receptor Are Linked to Androgen Insensitivity. Mol. Endocrinol. 15: 923-935 [Abstract] [Full Text]
Grad, J. M., Lyons, L. S., Robins, D. M., Burnstein, K. L. (2001). The Androgen Receptor (AR) Amino-Terminus Imposes Androgen-Specific Regulation of AR Gene Expression via an Exonic Enhancer. Endocrinology 142: 1107-1116 [Abstract] [Full Text]
Sheppard, H. M., Harries, J. C., Hussain, S., Bevan, C., Heery, D. M. (2001). Analysis of the Steroid Receptor Coactivator 1 (SRC1)-CREB Binding Protein Interaction Interface and Its Importance for the Function of SRC1. Mol. Cell. Biol. 21: 39-50 [Abstract] [Full Text]
Tolón, R. M., Castillo, A. I., Jiménez-Lara, A. M., Aranda, A. (2000). Association with Ets-1 Causes Ligand- and AF2-Independent Activation of Nuclear Receptors. Mol. Cell. Biol. 20: 8793-8802 [Abstract] [Full Text]
Slagsvold, T., Kraus, I., Bentzen, T., Palvimo, J., Saatcioglu, F. (2000). Mutational Analysis of the Androgen Receptor AF-2 (Activation Function 2) Core Domain Reveals Functional and Mechanistic Differences of Conserved Residues Compared with Other Nuclear Receptors. Mol. Endocrinol. 14: 1603-1617 [Abstract] [Full Text]
Lim, J., Ghadessy, F. J., Abdullah, A. A. R., Pinsky, L., Trifiro, M., Yong, E. L. (2000). Human Androgen Receptor Mutation Disrupts Ternary Interactions between Ligand, Receptor Domains, and the Coactivator TIF2 (Transcription Intermediary Factor 2). Mol. Endocrinol. 14: 1187-1197 [Abstract] [Full Text]
Auger, A. P., Tetel, M. J., McCarthy, M. M. (2000). Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Proc. Natl. Acad. Sci. USA 97: 7551-7555 [Abstract] [Full Text]
Schoenmakers, E., Verrijdt, G., Peeters, B., Verhoeven, G., Rombauts, W., Claessens, F. (2000). Differences in DNA Binding Characteristics of the Androgen and Glucocorticoid Receptors Can Determine Hormone-specific Responses. J. Biol. Chem. 275: 12290-12297 [Abstract] [Full Text]
Belandia, B., Parker, M. G. (2000). Functional Interaction between the p160 Coactivator Proteins and the Transcriptional Enhancer Factor Family of Transcription Factors. J. Biol. Chem. 275: 30801-30805 [Abstract] [Full Text]
He, B., Kemppainen, J. A., Wilson, E. M. (2000). FXXLF and WXXLF Sequences Mediate the NH2-terminal Interaction with the Ligand Binding Domain of the Androgen Receptor. J. Biol. Chem. 275: 22986-22994 [Abstract] [Full Text]

J. Bacteriol.	J. Virol.	Eukaryot. Cell

Microbiol. Mol. Biol. Rev.	Clin. Vaccine Immunol.	All ASM Journals