This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boyd, K. E.
Right arrow Articles by Farnham, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boyd, K. E.
Right arrow Articles by Farnham, P. J.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, December 1999, p. 8393-8399, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells

Kathryn E. Boyddagger and Peggy J. Farnham*

McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, Wisconsin 53706

Received 15 July 1999/Returned for modification 27 August 1999/Accepted 20 September 1999

Previously, we have used a chromatin cross-linking and immunoprecipitation protocol for the analysis of Myc and USF binding to the cad promoter. The adaptation of this technique for the study of mammalian transcription factors was a big step forward in the analysis of transcription factor family member specificity, allowing for the first time a definitive knowledge of which factor binds to a promoter region under normal physiological conditions. However, due to limitations of the assay, our previous studies could not definitively prove that both Myc and USF bound to the exact same site on the cad promoter, nor could we directly correlate loss of in vivo binding of a particular factor with loss of transcriptional activity. Therefore, we have further modified the chromatin immunoprecipitation protocol to alleviate these problems. We have now shown that it is possible to coexamine growth-regulated transcriptional activity and promoter occupancy by using stably integrated promoter constructs. We show that both Myc and USF bind to the exact same E box on the cad promoter, suggesting that competition between these two factors for a single site occurs in living cells. We also find that cad promoter constructs that retain USF binding but lose Myc binding in vivo no longer display an increase in transcriptional activity in mid- to late G1 phase of the cell cycle. Finally, we propose that cell cycle-regulated transcriptional activation of the cad promoter may be a stochastic, rather than a predetermined, process.

* Corresponding author. Mailing address: 1400 University Ave., McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706. Phone: (608) 262-2071. Fax: (608) 262-2824. E-mail: farnham{at}oncology.wisc.edu.

dagger Present address: Department of Pathology, Yale University, New Haven, Conn.

Molecular and Cellular Biology, December 1999, p. 8393-8399, Vol. 19, No. 12
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Sun, Y., Chin, Y. E., Weisiger, E., Malter, C., Tawara, I., Toubai, T., Gatza, E., Mascagni, P., Dinarello, C. A., Reddy, P. (2009). Cutting Edge: Negative Regulation of Dendritic Cells through Acetylation of the Nonhistone Protein STAT-3. J. Immunol. 182: 5899-5903 [Abstract] [Full Text]  
  • Pelka, P., Ablack, J. N. G., Torchia, J., Turnell, A. S., Grand, R. J. A., Mymryk, J. S. (2009). Transcriptional control by adenovirus E1A conserved region 3 via p300/CBP. Nucleic Acids Res 37: 1095-1106 [Abstract] [Full Text]  
  • Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. G., Tantin, D. (2009). A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev. 23: 208-222 [Abstract] [Full Text]  
  • Winter, H. Y., Dayaram, T., Marriott, S. J. (2007). Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat by the Ternary Complex Factor Elk-1. J. Virol. 81: 13075-13081 [Abstract] [Full Text]  
  • Liu, N.-C., Lin, W.-J., Kim, E., Collins, L. L., Lin, H.-Y., Yu, I-C., Sparks, J. D., Chen, L.-M., Lee, Y.-F., Chang, C. (2007). Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase Mediated Gluconeogenesis. Diabetes 56: 2901-2909 [Abstract] [Full Text]  
  • Filipponi, D., Hobbs, R. M., Ottolenghi, S., Rossi, P., Jannini, E. A., Pandolfi, P. P., Dolci, S. (2007). Repression of kit Expression by Plzf in Germ Cells. Mol. Cell. Biol. 27: 6770-6781 [Abstract] [Full Text]  
  • Sekiya, M., Yahagi, N., Matsuzaka, T., Takeuchi, Y., Nakagawa, Y., Takahashi, H., Okazaki, H., Iizuka, Y., Ohashi, K., Gotoda, T., Ishibashi, S., Nagai, R., Yamazaki, T., Kadowaki, T., Yamada, N., Osuga, J.-i., Shimano, H. (2007). SREBP-1-independent regulation of lipogenic gene expression in adipocytes. J. Lipid Res. 48: 1581-1591 [Abstract] [Full Text]  
  • Winter, H. Y., Marriott, S. J. (2007). Human T-Cell Leukemia Virus Type 1 Tax Enhances Serum Response Factor DNA Binding and Alters Site Selection. J. Virol. 81: 6089-6098 [Abstract] [Full Text]  
  • Thangavel, C., Shapiro, B. H. (2007). A Molecular Basis for the Sexually Dimorphic Response to Growth Hormone. Endocrinology 148: 2894-2903 [Abstract] [Full Text]  
  • Zhang, J., Warren, M. A., Shoemaker, S. F., Ip, M. M. (2007). NF{kappa}B1/p50 Is Not Required for Tumor Necrosis Factor-Stimulated Growth of Primary Mammary Epithelial Cells: Implications for NF{kappa}B2/p52 and RelB. Endocrinology 148: 268-278 [Abstract] [Full Text]  
  • Kajiyama, Y., Tian, J., Locker, J. (2006). Characterization of Distant Enhancers and Promoters in the Albumin-{alpha}-Fetoprotein Locus during Active and Silenced Expression. J. Biol. Chem. 281: 30122-30131 [Abstract] [Full Text]  
  • Brayman, M. J., Julian, J., Mulac-Jericevic, B., Conneely, O. M., Edwards, D. P., Carson, D. D. (2006). Progesterone Receptor Isoforms A and B Differentially Regulate MUC1 Expression in Uterine Epithelial Cells. Mol. Endocrinol. 20: 2278-2291 [Abstract] [Full Text]  
  • Nakerakanti, S. S., Kapanadze, B., Yamasaki, M., Markiewicz, M., Trojanowska, M. (2006). Fli1 and Ets1 Have Distinct Roles in Connective Tissue Growth Factor/CCN2 Gene Regulation and Induction of the Profibrotic Gene Program. J. Biol. Chem. 281: 25259-25269 [Abstract] [Full Text]  
  • Miao, F., Li, S., Chavez, V., Lanting, L., Natarajan, R. (2006). Coactivator-Associated Arginine Methyltransferase-1 Enhances Nuclear Factor-{kappa}B-Mediated Gene Transcription through Methylation of Histone H3 at Arginine 17. Mol. Endocrinol. 20: 1562-1573 [Abstract] [Full Text]  
  • Gordon, D. F., Tucker, E. A., Tundwal, K., Hall, H., Wood, W. M., Ridgway, E. C. (2006). MED220/Thyroid Receptor-Associated Protein 220 Functions as a Transcriptional Coactivator with Pit-1 and GATA-2 on the Thyrotropin-{beta} Promoter in Thyrotropes. Mol. Endocrinol. 20: 1073-1089 [Abstract] [Full Text]  
  • Wagner, K., Zhang, P., Rosenbauer, F., Drescher, B., Kobayashi, S., Radomska, H. S., Kutok, J. L., Gilliland, D. G., Krauter, J., Tenen, D. G. (2006). Absence of the transcription factor CCAAT enhancer binding protein {alpha} results in loss of myeloid identity in bcr/abl-induced malignancy. Proc. Natl. Acad. Sci. USA 103: 6338-6343 [Abstract] [Full Text]  
  • Sharma, V., Hays, W. R., Wood, W. M., Pugazhenthi, U., St. Germain, D. L., Bianco, A. C., Krezel, W., Chambon, P., Haugen, B. R. (2006). Effects of Rexinoids on Thyrotrope Function and the Hypothalamic-Pituitary-Thyroid Axis. Endocrinology 147: 1438-1451 [Abstract] [Full Text]  
  • Eloranta, J. J., Jung, D., Kullak-Ublick, G. A. (2006). The Human Na+-Taurocholate Cotransporting Polypeptide Gene Is Activated by Glucocorticoid Receptor and Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator-1{alpha}, and Suppressed by Bile Acids via a Small Heterodimer Partner-Dependent Mechanism. Mol. Endocrinol. 20: 65-79 [Abstract] [Full Text]  
  • Geng, C.-d., Vedeckis, W. V. (2005). c-Myb and Members of the c-Ets Family of Transcription Factors Act as Molecular Switches to Mediate Opposite Steroid Regulation of the Human Glucocorticoid Receptor 1A Promoter. J. Biol. Chem. 280: 43264-43271 [Abstract] [Full Text]  
  • Zhu, Q., Pearson-White, S., Luo, K. (2005). Requirement for the SnoN Oncoprotein in Transforming Growth Factor {beta}-Induced Oncogenic Transformation of Fibroblast Cells. Mol. Cell. Biol. 25: 10731-10744 [Abstract] [Full Text]  
  • Chen, W.-Y., Juan, L.-J., Chung, B.-c. (2005). SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding. Mol. Cell. Biol. 25: 10442-10453 [Abstract] [Full Text]  
  • Chang, C.-W., Chuang, H.-C., Yu, C., Yao, T.-P., Chen, H. (2005). Stimulation of GCMa Transcriptional Activity by Cyclic AMP/Protein Kinase A Signaling Is Attributed to CBP-Mediated Acetylation of GCMa. Mol. Cell. Biol. 25: 8401-8414 [Abstract] [Full Text]  
  • Nguyen, T., Sherratt, P. J., Nioi, P., Yang, C. S., Pickett, C. B. (2005). Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1. J. Biol. Chem. 280: 32485-32492 [Abstract] [Full Text]  
  • Huan, C., Sashital, D., Hailemariam, T., Kelly, M. L., Roman, C. A. J. (2005). Renal Carcinoma-associated Transcription Factors TFE3 and TFEB Are Leukemia Inhibitory Factor-responsive Transcription Activators of E-cadherin. J. Biol. Chem. 280: 30225-30235 [Abstract] [Full Text]  
  • Tripathi, M. K., Misra, S., Khedkar, S. V., Hamilton, N., Irvin-Wilson, C., Sharan, C., Sealy, L., Chaudhuri, G. (2005). Regulation of BRCA2 Gene Expression by the SLUG Repressor Protein in Human Breast Cells. J. Biol. Chem. 280: 17163-17171 [Abstract] [Full Text]  
  • Ghosh, D., Sachdev, S., Hannink, M., Roberts, R. M. (2005). Coordinate Regulation of Basal and Cyclic 5'-Adenosine Monophosphate (cAMP)-Activated Expression of Human Chorionic Gonadotropin-{alpha} by Ets-2 and cAMP-Responsive Element Binding Protein. Mol. Endocrinol. 19: 1049-1066 [Abstract] [Full Text]  
  • Wu, J., Iwata, F., Grass, J. A., Osborne, C. S., Elnitski, L., Fraser, P., Ohneda, O., Yamamoto, M., Bresnick, E. H. (2005). Molecular Determinants of NOTCH4 Transcription in Vascular Endothelium. Mol. Cell. Biol. 25: 1458-1474 [Abstract] [Full Text]  
  • Jackers, P., Szalai, G., Moussa, O., Watson, D. K. (2004). Ets-dependent Regulation of Target Gene Expression during Megakaryopoiesis. J. Biol. Chem. 279: 52183-52190 [Abstract] [Full Text]  
  • Daniel, R., Ramcharan, J., Rogakou, E., Taganov, K. D., Greger, J. G., Bonner, W., Nussenzweig, A., Katz, R. A., Skalka, A. M. (2004). Histone H2AX Is Phosphorylated at Sites of Retroviral DNA Integration but Is Dispensable for Postintegration Repair. J. Biol. Chem. 279: 45810-45814 [Abstract] [Full Text]  
  • Yu, J., He, S., Friedman, J. S., Akimoto, M., Ghosh, D., Mears, A. J., Hicks, D., Swaroop, A. (2004). Altered Expression of Genes of the Bmp/Smad and Wnt/Calcium Signaling Pathways in the Cone-only Nrl-/- Mouse Retina, Revealed by Gene Profiling Using Custom cDNA Microarrays. J. Biol. Chem. 279: 42211-42220 [Abstract] [Full Text]  
  • Stanhope-Baker, P., Kessler, P. M., Li, W., Agarwal, M. L., Williams, B. R. G. (2004). The Wilms Tumor Suppressor-1 Target Gene Podocalyxin Is Transcriptionally Repressed by p53. J. Biol. Chem. 279: 33575-33585 [Abstract] [Full Text]  
  • FitzGerald, P. C., Shlyakhtenko, A., Mir, A. A., Vinson, C. (2004). Clustering of DNA Sequences in Human Promoters. Genome Res 14: 1562-1574 [Abstract] [Full Text]  
  • Jeong, K.-H., Chin, W. W., Kaiser, U. B. (2004). Essential Role of the Homeodomain for Pituitary Homeobox 1 Activation of Mouse Gonadotropin-Releasing Hormone Receptor Gene Expression through Interactions with c-Jun and DNA. Mol. Cell. Biol. 24: 6127-6139 [Abstract] [Full Text]  
  • Murtagh, J., McArdle, E., Gilligan, E., Thornton, L., Furlong, F., Martin, F. (2004). Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling. JCB 166: 133-143 [Abstract] [Full Text]  
  • Zhang, X., Wharton, W., Yuan, Z., Tsai, S.-C., Olashaw, N., Seto, E. (2004). Activation of the Growth-Differentiation Factor 11 Gene by the Histone Deacetylase (HDAC) Inhibitor Trichostatin A and Repression by HDAC3. Mol. Cell. Biol. 24: 5106-5118 [Abstract] [Full Text]  
  • Halmos, B., Basseres, D. S., Monti, S., D'Alo, F., Dayaram, T., Ferenczi, K., Wouters, B. J., Huettner, C. S., Golub, T. R., Tenen, D. G. (2004). A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3{beta} as a Novel Tumor Suppressor in Lung Cancer. Cancer Res. 64: 4137-4147 [Abstract] [Full Text]  
  • Rosenbauer, F., Wagner, K., Zhang, P., Knobeloch, K.-P., Iwama, A., Tenen, D. G. (2004). pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood 103: 4294-4301 [Abstract] [Full Text]  
  • Miao, F., Gonzalo, I. G., Lanting, L., Natarajan, R. (2004). In Vivo Chromatin Remodeling Events Leading to Inflammatory Gene Transcription under Diabetic Conditions. J. Biol. Chem. 279: 18091-18097 [Abstract] [Full Text]  
  • del Castillo-Olivares, A., Campos, J. A., Pandak, W. M., Gil, G. (2004). The Role of {alpha}1-Fetoprotein Transcription Factor/LRH-1 in Bile Acid Biosynthesis: A KNOWN NUCLEAR RECEPTOR ACTIVATOR THAT CAN ACT AS A SUPPRESSOR OF BILE ACID BIOSYNTHESIS. J. Biol. Chem. 279: 16813-16821 [Abstract] [Full Text]  
  • Chen, G. K., Sale, S., Tan, T., Ermoian, R. P., Sikic, B. I. (2004). CCAAT/Enhancer-Binding Protein {beta} (Nuclear Factor for Interleukin 6) Transactivates the Human MDR1 Gene by Interaction with an Inverted CCAAT Box in Human Cancer Cells. Mol. Pharmacol. 65: 906-916 [Abstract] [Full Text]  
  • Hussein, S. M., Duff, E. K., Sirard, C. (2003). Smad4 and {beta}-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2. J. Biol. Chem. 278: 48805-48814 [Abstract] [Full Text]  
  • Shan, B., Xu, J., Zhuo, Y., Morris, C. A., Morris, G. F. (2003). Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation. J. Biol. Chem. 278: 44009-44017 [Abstract] [Full Text]  
  • Rodriguez, C. I., Girones, N., Fresno, M. (2003). Cha, a Basic Helix-Loop-Helix Transcription Factor Involved in the Regulation of Upstream Stimulatory Factor Activity. J. Biol. Chem. 278: 43135-43145 [Abstract] [Full Text]  
  • Heckman, C. A., Cao, T., Somsouk, L., Duan, H., Mehew, J. W., Zhang, C.-y., Boxer, L. M. (2003). Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2. Cancer Res. 63: 6666-6673 [Abstract] [Full Text]  
  • Szentirmay, M. N., Yang, H.-X., Pawar, S. A., Vinson, C., Sawadogo, M. (2003). The IGF2 Receptor Is a USF2-specific Target in Nontumorigenic Mammary Epithelial Cells but Not in Breast Cancer Cells. J. Biol. Chem. 278: 37231-37240 [Abstract] [Full Text]  
  • McMurray, H. R., McCance, D. J. (2003). Human Papillomavirus Type 16 E6 Activates TERT Gene Transcription through Induction of c-Myc and Release of USF-Mediated Repression. J. Virol. 77: 9852-9861 [Abstract] [Full Text]  
  • Zheng, Q., Zhou, G., Morello, R., Chen, Y., Garcia-Rojas, X., Lee, B. (2003). Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. JCB 162: 833-842 [Abstract] [Full Text]  
  • Latasa, M.-J., Griffin, M. J., Moon, Y. S., Kang, C., Sul, H. S. (2003). Occupancy and Function of the -150 Sterol Regulatory Element and -65 E-Box in Nutritional Regulation of the Fatty Acid Synthase Gene in Living Animals. Mol. Cell. Biol. 23: 5896-5907 [Abstract] [Full Text]  
  • Li, X., Wong, J., Tsai, S. Y., Tsai, M.-J., O'Malley, B. W. (2003). Progesterone and Glucocorticoid Receptors Recruit Distinct Coactivator Complexes and Promote Distinct Patterns of Local Chromatin Modification. Mol. Cell. Biol. 23: 3763-3773 [Abstract] [Full Text]  
  • Khan, S., Abdelrahim, M., Samudio, I., Safe, S. (2003). Estrogen Receptor/Sp1 Complexes Are Required for Induction of cad Gene Expression by 17{beta}-Estradiol in Breast Cancer Cells. Endocrinology 144: 2325-2335 [Abstract] [Full Text]  
  • Hao, H., Qi, H., Ratnam, M. (2003). Modulation of the folate receptor type {beta} gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. Blood 101: 4551-4560 [Abstract] [Full Text]  
  • Khanna-Gupta, A., Zibello, T., Sun, H., Gaines, P., Berliner, N. (2003). Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBPalpha and C/EBPepsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression. Blood 101: 3460-3468 [Abstract] [Full Text]  
  • de Belle, I., Wu, J.-X., Sperandio, S., Mercola, D., Adamson, E. D. (2003). In Vivo Cloning and Characterization of a New Growth Suppressor Protein TOE1 as a Direct Target Gene of Egr1. J. Biol. Chem. 278: 14306-14312 [Abstract] [Full Text]  
  • Strieder, V., Lutz, W. (2003). E2F Proteins Regulate MYCN Expression in Neuroblastomas. J. Biol. Chem. 278: 2983-2989 [Abstract] [Full Text]  
  • Yu, C., Shen, K., Lin, M., Chen, P., Lin, C., Chang, G.-D., Chen, H. (2002). GCMa Regulates the Syncytin-mediated Trophoblastic Fusion. J. Biol. Chem. 277: 50062-50068 [Abstract] [Full Text]  
  • Mo, X., Dynan, W. S. (2002). Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites. Mol. Cell. Biol. 22: 8088-8099 [Abstract] [Full Text]  
  • Kajiyama, Y., Tian, J., Locker, J. (2002). Regulation of {alpha}-Fetoprotein Expression by Nkx2.8. Mol. Cell. Biol. 22: 6122-6130 [Abstract] [Full Text]  
  • Hempen, P. M., Phillips, K. M., Conway, P. S., Sandoval, K. H., Schneeman, T. A., Wu, H.-J., Kaetzel, C. S. (2002). Transcriptional Regulation of the Human Polymeric Ig Receptor Gene: Analysis of Basal Promoter Elements. J. Immunol. 169: 1912-1921 [Abstract] [Full Text]  
  • Qin, C., Nguyen, T., Stewart, J., Samudio, I., Burghardt, R., Safe, S. (2002). Estrogen Up-Regulation of p53 Gene Expression in MCF-7 Breast Cancer Cells Is Mediated by Calmodulin Kinase IV-Dependent Activation of a Nuclear Factor {kappa}B/CCAAT-Binding Transcription Factor-1 Complex. Mol. Endocrinol. 16: 1793-1809 [Abstract] [Full Text]  
  • Yaekashiwa, M., Wang, L.-H. (2002). Transcriptional Control of the Human Thromboxane Synthase Gene in Vivo and in Vitro. J. Biol. Chem. 277: 22497-22508 [Abstract] [Full Text]  
  • Sharma, D., Fondell, J. D. (2002). Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Proc. Natl. Acad. Sci. USA 99: 7934-7939 [Abstract] [Full Text]  
  • Qiu, P., Li, L. (2002). Histone Acetylation and Recruitment of Serum Responsive Factor and CREB-Binding Protein Onto SM22 Promoter During SM22 Gene Expression. Circ. Res. 90: 858-865 [Abstract] [Full Text]  
  • Levens, D. (2002). Disentangling the MYC web. Proc. Natl. Acad. Sci. USA 99: 5757-5759 [Full Text]  
  • Chakrabarti, S. K., James, J. C., Mirmira, R. G. (2002). Quantitative Assessment of Gene Targeting in Vitro and in Vivo by the Pancreatic Transcription Factor, Pdx1. IMPORTANCE OF CHROMATIN STRUCTURE IN DIRECTING PROMOTER BINDING. J. Biol. Chem. 277: 13286-13293 [Abstract] [Full Text]  
  • Mach, C. M., Hargrove, B. W., Kunkel, G. R. (2002). The Small RNA Gene Activator Protein, SphI Postoctamer Homology-binding Factor/Selenocysteine tRNA Gene Transcription Activating Factor, Stimulates Transcription of the Human Interferon Regulatory Factor-3 Gene. J. Biol. Chem. 277: 4853-4858 [Abstract] [Full Text]  
  • Manabe, I., Owens, G. K. (2001). The Smooth Muscle Myosin Heavy Chain Gene Exhibits Smooth Muscle Subtype-selective Modular Regulation in Vivo. J. Biol. Chem. 276: 39076-39087 [Abstract] [Full Text]  
  • Eisenman, R. N. (2001). Deconstructing Myc. Genes Dev. 15: 2023-2030 [Full Text]  
  • Frank, S. R., Schroeder, M., Fernandez, P., Taubert, S., Amati, B. (2001). Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15: 2069-2082 [Abstract] [Full Text]  
  • Párrizas, M., Maestro, M. A., Boj, S. F., Paniagua, A., Casamitjana, R., Gomis, R., Rivera, F., Ferrer, J. (2001). Hepatic Nuclear Factor 1-{alpha} Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets. Mol. Cell. Biol. 21: 3234-3243 [Abstract] [Full Text]  
  • Samoylenko, A., Roth, U., Jungermann, K., Kietzmann, T. (2001). The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site. Blood 97: 2657-2666 [Abstract] [Full Text]  
  • Baudino, T. A., Cleveland, J. L. (2001). The Max Network Gone Mad. Mol. Cell. Biol. 21: 691-702 [Full Text]  
  • Forsberg, E. C., Downs, K. M., Bresnick, E. H. (2000). Direct interaction of NF-E2 with hypersensitive site 2 of the beta -globin locus control region in living cells. Blood 96: 334-339 [Abstract] [Full Text]  
  • Jacquemin, P., Durviaux, S. M., Jensen, J., Godfraind, C., Gradwohl, G., Guillemot, F., Madsen, O. D., Carmeliet, P., Dewerchin, M., Collen, D., Rousseau, G. G., Lemaigre, F. P. (2000). Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3. Mol. Cell. Biol. 20: 4445-4454 [Abstract] [Full Text]  
  • Harris, V. K., Coticchia, C. M., List, H.-J., Wellstein, A., Riegel, A. T. (2000). Mitogen-induced Expression of the Fibroblast Growth Factor-binding Protein Is Transcriptionally Repressed through a Non-canonical E-box Element. J. Biol. Chem. 275: 28539-28548 [Abstract] [Full Text]  
  • Qiu, P., Li, L. (2002). Histone Acetylation and Recruitment of Serum Responsive Factor and CREB-Binding Protein Onto SM22 Promoter During SM22 Gene Expression. Circ. Res. 90: 858-865 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»