Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog

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Molecular and Cellular Biology, February 1999, p. 1049-1055, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Selective Interaction of Vitamin D Receptor with Transcriptional Coactivators by a Vitamin D Analog

Ken-Ichi Takeyama,¹ Yoshikazu Masuhiro,¹ Hiroaki Fuse,¹ Hideki Endoh,¹ Akiko Murayama,¹ Sachiko Kitanaka,¹ Miyuki Suzawa,¹ Junn Yanagisawa,¹ and Shigeaki Kato¹^,²^,^*

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113,¹ and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Saitama 332,² Japan

Received 20 July 1998/Returned for modification 8 September 1998/Accepted 6 November 1998

The nuclear vitamin D receptor (VDR) is a member of a nuclear receptor superfamily and acts as a ligand-dependent transcriptionfactor. A family of cotranscriptional activators (SRC-1, TIF2,and AIB-1) interacts with and activates the transactivation functionof nuclear receptors in a ligand-dependent way. We examined interactionof VDR with these coactivators that was induced by several vitaminD analogs, since they exert differential subsets of the biologicalaction of vitamin D through unknown mechanisms. Unlike other vitaminD analogs tested, OCT (22-oxa-1 $alpha$ ,25-dihydroxyvitamin D₃) inducedinteraction of VDR with TIF2 but not with SRC-1 or AIB-1. Consistentwith these interactions, only TIF2 was able to potentiate thetransactivation function of VDR bound to OCT. Thus, the presentfindings suggest that the structure of VDR is altered in a vitaminD analog-specific way, resulting in selective interactions ofVDR with coactivators. Such selective interaction of coactivatorswith VDR may specify the array of biological actions of a vitaminD analog like OCT, possibly through activating a particular setof target genepromoters.

^* Corresponding author. Mailing address: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1-1-1,Bunkyo-ku, Tokyo 113, Japan. Phone: 81-3-5802-8632. Fax: 81-3-5684-8342.E-mail: uskato{at}hongo.ecc.u-tokyo.ac.jp.

Molecular and Cellular Biology, February 1999, p. 1049-1055, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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