This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nawaz, Z.
Right arrow Articles by O'Malley, B. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nawaz, Z.
Right arrow Articles by O'Malley, B. W.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, February 1999, p. 1182-1189, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily

Zafar Nawaz,1 David M. Lonard,1 Carolyn L. Smith,1 Efrat Lev-Lehman,2 Sophia Y. Tsai,1 Ming-Jer Tsai,1 and Bert W. O'Malley1,*

Department of Cell Biology1 and Department of Molecular and Human Genetics,2 Baylor College of Medicine, Houston, Texas 77030

Received 6 August 1998/Returned for modification 9 September 1998/Accepted 27 October 1998

In this study, we found that the E6-associated protein (E6-AP/UBE3A) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (PR) in a hormone-dependent manner. E6-AP also coactivates the hormone-dependent transcriptional activities of the other members of the nuclear hormone receptor superfamily. Previously, it was shown that E6-AP serves the role of a ubiquitin-protein ligase (E3) in the presence of the E6 protein from human papillomavirus types 16 and 18. Our data show that the ubiquitin-protein ligase function of E6-AP is dispensable for its ability to coactivate nuclear hormone receptors, showing that E6-AP possesses two separable independent functions, as both a coactivator and a ubiquitin-protein ligase. Disruption of the maternal copy of E6-AP is correlated with Angelman syndrome (AS), a genetic neurological disorder characterized by severe mental retardation, seizures, speech impairment, and other symptoms. However, the exact mechanism by which the defective E6-AP gene causes AS remains unknown. To correlate the E6-AP coactivator function and ubiquitin-protein ligase functions with the AS phenotype, we expressed mutant forms of E6-AP isolated from AS patients and assessed the ability of each of these mutant proteins to coactivate PR or provide ubiquitin-protein ligase activity. This analysis revealed that in the majority of the AS patients examined, the ubiquitin-protein ligase function of E6-AP was defective whereas the coactivator function was intact. This finding suggests that the AS phenotype results from a defect in the ubiquitin-proteosome protein degradation pathway.


* Corresponding author. Mailing address: Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-6205. Fax: (713) 798-5599. E-mail: berto{at}bcm.tmc.edu.


Molecular and Cellular Biology, February 1999, p. 1182-1189, Vol. 19, No. 2
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Liu, S., Le May, C., Wong, W. P.S., Ward, R. D., Clegg, D. J., Marcelli, M., Korach, K. S., Mauvais-Jarvis, F. (2009). Importance of Extranuclear Estrogen Receptor-{alpha} and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival. Diabetes 58: 2292-2302 [Abstract] [Full Text]  
  • Adams, B. D., Cowee, D. M., White, B. A. (2009). The Role of miR-206 in the Epidermal Growth Factor (EGF) Induced Repression of Estrogen Receptor-{alpha} (ER{alpha}) Signaling and a Luminal Phenotype in MCF-7 Breast Cancer Cells. Mol. Endocrinol. 23: 1215-1230 [Abstract] [Full Text]  
  • Wang, Y., Zong, H., Chi, Y., Hong, Y., Yang, Y., Zou, W., Yun, X., Gu, J. (2009). Repression of Estrogen Receptor alpha by CDK11p58 Through Promoting its Ubiquitin-Proteasome Degradation. J Biochem 145: 331-343 [Abstract] [Full Text]  
  • Ma, Q., Fu, W., Li, P., Nicosia, S. V., Jenster, G., Zhang, X., Bai, W. (2009). FoxO1 Mediates PTEN Suppression of Androgen Receptor N- and C-Terminal Interactions and Coactivator Recruitment. Mol. Endocrinol. 23: 213-225 [Abstract] [Full Text]  
  • Johnsen, S. A., Gungor, C., Prenzel, T., Riethdorf, S., Riethdorf, L., Taniguchi-Ishigaki, N., Rau, T., Tursun, B., Furlow, J. D., Sauter, G., Scheffner, M., Pantel, K., Gannon, F., Bach, I. (2009). Regulation of Estrogen-Dependent Transcription by the LIM Cofactors CLIM and RLIM in Breast Cancer. Cancer Res. 69: 128-136 [Abstract] [Full Text]  
  • Shima, Y., Shima, T., Chiba, T., Irimura, T., Pandolfi, P. P., Kitabayashi, I. (2008). PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation. Mol. Cell. Biol. 28: 7126-7138 [Abstract] [Full Text]  
  • Fenne, I. S., Hoang, T., Hauglid, M., Sagen, J. V., Lien, E. A., Mellgren, G. (2008). Recruitment of Coactivator Glucocorticoid Receptor Interacting Protein 1 to an Estrogen Receptor Transcription Complex Is Regulated by the 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Protein Kinase. Endocrinology 149: 4336-4345 [Abstract] [Full Text]  
  • Miyajima, N., Maruyama, S., Bohgaki, M., Kano, S., Shigemura, M., Shinohara, N., Nonomura, K., Hatakeyama, S. (2008). TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells. Cancer Res. 68: 3486-3494 [Abstract] [Full Text]  
  • Picard, N., Charbonneau, C., Sanchez, M., Licznar, A., Busson, M., Lazennec, G., Tremblay, A. (2008). Phosphorylation of Activation Function-1 Regulates Proteasome-Dependent Nuclear Mobility and E6-Associated Protein Ubiquitin Ligase Recruitment to the Estrogen Receptor {beta}. Mol. Endocrinol. 22: 317-330 [Abstract] [Full Text]  
  • Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., Beaudet, A. L. (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Hum Mol Genet 17: 111-118 [Abstract] [Full Text]  
  • Yin, P., Lin, Z., Cheng, Y.-H., Marsh, E. E., Utsunomiya, H., Ishikawa, H., Xue, Q., Reierstad, S., Innes, J., Thung, S., Kim, J. J., Xu, E., Bulun, S. E. (2007). Progesterone Receptor Regulates Bcl-2 Gene Expression through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells. J. Clin. Endocrinol. Metab. 92: 4459-4466 [Abstract] [Full Text]  
  • Tian, Y., Kolb, R., Hong, J.-H., Carroll, J., Li, D., You, J., Bronson, R., Yaffe, M. B., Zhou, J., Benjamin, T. (2007). TAZ Promotes PC2 Degradation through a SCF{beta}-Trcp E3 Ligase Complex. Mol. Cell. Biol. 27: 6383-6395 [Abstract] [Full Text]  
  • Peterson, T. J., Karmakar, S., Pace, M. C., Gao, T., Smith, C. L. (2007). The Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Corepressor Is Required for Full Estrogen Receptor {alpha} Transcriptional Activity. Mol. Cell. Biol. 27: 5933-5948 [Abstract] [Full Text]  
  • Lonard, D. M., Lanz, R. B., O'Malley, B. W. (2007). Nuclear Receptor Coregulators and Human Disease. Endocr. Rev. 28: 575-587 [Abstract] [Full Text]  
  • Duong, V., Boulle, N., Daujat, S., Chauvet, J., Bonnet, S., Neel, H., Cavailles, V. (2007). Differential Regulation of Estrogen Receptor {alpha} Turnover and Transactivation by Mdm2 and Stress-Inducing Agents. Cancer Res. 67: 5513-5521 [Abstract] [Full Text]  
  • O'Malley, B. W. (2007). Coregulators: From Whence Came These "Master Genes". Mol. Endocrinol. 21: 1009-1013 [Abstract] [Full Text]  
  • Adams, B. D., Furneaux, H., White, B. A. (2007). The Micro-Ribonucleic Acid (miRNA) miR-206 Targets the Human Estrogen Receptor-{alpha} (ER{alpha}) and Represses ER{alpha} Messenger RNA and Protein Expression in Breast Cancer Cell Lines. Mol. Endocrinol. 21: 1132-1147 [Abstract] [Full Text]  
  • Tateishi, Y., Sonoo, R., Sekiya, Y.-i., Sunahara, N., Kawano, M., Wayama, M., Hirota, R., Kawabe, Y.-i., Murayama, A., Kato, S., Kimura, K., Yanagisawa, J. (2006). Turning Off Estrogen Receptor {beta}-Mediated Transcription Requires Estrogen-Dependent Receptor Proteolysis. Mol. Cell. Biol. 26: 7966-7976 [Abstract] [Full Text]  
  • Dhananjayan, S. C., Ramamoorthy, S., Khan, O. Y., Ismail, A., Sun, J., Slingerland, J., O'Malley, B. W., Nawaz, Z. (2006). WW Domain Binding Protein-2, an E6-Associated Protein Interacting Protein, Acts as a Coactivator of Estrogen and Progesterone Receptors. Mol. Endocrinol. 20: 2343-2354 [Abstract] [Full Text]  
  • Logan, I. R., Gaughan, L., McCracken, S. R. C., Sapountzi, V., Leung, H. Y., Robson, C. N. (2006). Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer.. Mol. Cell. Biol. 26: 6502-6510 [Abstract] [Full Text]  
  • Mani, A., Oh, A. S., Bowden, E. T., Lahusen, T., Lorick, K. L., Weissman, A. M., Schlegel, R., Wellstein, A., Riegel, A. T. (2006). E6AP Mediates Regulated Proteasomal Degradation of the Nuclear Receptor Coactivator Amplified in Breast Cancer 1 in Immortalized Cells.. Cancer Res. 66: 8680-8686 [Abstract] [Full Text]  
  • Alarid, E. T. (2006). Lives and Times of Nuclear Receptors. Mol. Endocrinol. 20: 1972-1981 [Abstract] [Full Text]  
  • von Mikecz, A. (2006). The nuclear ubiquitin-proteasome system. J. Cell Sci. 119: 1977-1984 [Abstract] [Full Text]  
  • Lyons, L. S., Burnstein, K. L. (2006). Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases during Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity. Mol. Endocrinol. 20: 1061-1072 [Abstract] [Full Text]  
  • Khan, O. Y., Fu, G., Ismail, A., Srinivasan, S., Cao, X., Tu, Y., Lu, S., Nawaz, Z. (2006). Multifunction Steroid Receptor Coactivator, E6-Associated Protein, Is Involved in Development of the Prostate Gland. Mol. Endocrinol. 20: 544-559 [Abstract] [Full Text]  
  • Li, L., Li, Z., Howley, P. M., Sacks, D. B. (2006). E6AP and Calmodulin Reciprocally Regulate Estrogen Receptor Stability. J. Biol. Chem. 281: 1978-1985 [Abstract] [Full Text]  
  • Horner-Glister, E, Maleki-Dizaji, M, Guerin, C J, Johnson, S M, Styles, J, White, I N H (2005). Influence of oestradiol and tamoxifen on oestrogen receptors-{alpha} and -{beta} protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells. J Mol Endocrinol 35: 421-432 [Abstract] [Full Text]  
  • Kim, J.J., Buzzio, O.L., Li, S., Lu, Z. (2005). Role of FOXO1A in the Regulation of Insulin-Like Growth Factor-Binding Protein-1 in Human Endometrial Cells: Interaction with Progesterone Receptor. Biol. Reprod. 73: 833-839 [Abstract] [Full Text]  
  • Valley, C. C., Metivier, R., Solodin, N. M., Fowler, A. M., Mashek, M. T., Hill, L., Alarid, E. T. (2005). Differential Regulation of Estrogen-Inducible Proteolysis and Transcription by the Estrogen Receptor {alpha} N Terminus. Mol. Cell. Biol. 25: 5417-5428 [Abstract] [Full Text]  
  • Wang, X., DeFranco, D. B. (2005). Alternative Effects of the Ubiquitin-Proteasome Pathway on Glucocorticoid Receptor Down-Regulation and Transactivation Are Mediated by CHIP, an E3 Ligase. Mol. Endocrinol. 19: 1474-1482 [Abstract] [Full Text]  
  • O'Malley, B. W. (2005). A Life-Long Search for the Molecular Pathways of Steroid Hormone Action. Mol. Endocrinol. 19: 1402-1411 [Abstract] [Full Text]  
  • Dong, X., Shylnova, O., Challis, J. R. G., Lye, S. J. (2005). Identification and Characterization of the Protein-associated Splicing Factor as a Negative Co-regulator of the Progesterone Receptor. J. Biol. Chem. 280: 13329-13340 [Abstract] [Full Text]  
  • Moore, J. M. R., Guy, R. K. (2005). Coregulator Interactions with the Thyroid Hormone Receptor. Mol. Cell. Proteomics 4: 475-482 [Abstract] [Full Text]  
  • Liu, X., Yuan, H., Fu, B., Disbrow, G. L., Apolinario, T., Tomaic, V., Kelley, M. L., Baker, C. C., Huibregtse, J., Schlegel, R. (2005). The E6AP Ubiquitin Ligase Is Required for Transactivation of the hTERT Promoter by the Human Papillomavirus E6 Oncoprotein. J. Biol. Chem. 280: 10807-10816 [Abstract] [Full Text]  
  • Narayanan, R., Adigun, A. A., Edwards, D. P., Weigel, N. L. (2005). Cyclin-Dependent Kinase Activity Is Required for Progesterone Receptor Function: Novel Role for Cyclin A/Cdk2 as a Progesterone Receptor Coactivator. Mol. Cell. Biol. 25: 264-277 [Abstract] [Full Text]  
  • Hoang, T., Fenne, I. S., Cook, C., Borud, B., Bakke, M., Lien, E. A., Mellgren, G. (2004). cAMP-dependent Protein Kinase Regulates Ubiquitin-Proteasome-mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. J. Biol. Chem. 279: 49120-49130 [Abstract] [Full Text]  
  • Narayanan, R., Sepulveda, V. A. T., Falzon, M., Weigel, N. L. (2004). The Functional Consequences of Cross-talk between the Vitamin D Receptor and ERK Signaling Pathways Are Cell-specific. J. Biol. Chem. 279: 47298-47310 [Abstract] [Full Text]  
  • Fan, M., Nakshatri, H., Nephew, K. P. (2004). Inhibiting Proteasomal Proteolysis Sustains Estrogen Receptor-{alpha} Activation. Mol. Endocrinol. 18: 2603-2615 [Abstract] [Full Text]  
  • Verma, S., Ismail, A., Gao, X., Fu, G., Li, X., O'Malley, B. W., Nawaz, Z. (2004). The Ubiquitin-Conjugating Enzyme UBCH7 Acts as a Coactivator for Steroid Hormone Receptors. Mol. Cell. Biol. 24: 8716-8726 [Abstract] [Full Text]  
  • Cooper, E. M., Hudson, A. W., Amos, J., Wagstaff, J., Howley, P. M. (2004). Biochemical Analysis of Angelman Syndrome-associated Mutations in the E3 Ubiquitin Ligase E6-associated Protein. J. Biol. Chem. 279: 41208-41217 [Abstract] [Full Text]  
  • Shao, W., Keeton, E. K., McDonnell, D. P., Brown, M. (2004). Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc. Natl. Acad. Sci. USA 101: 11599-11604 [Abstract] [Full Text]  
  • Wojcik, C., Di Napoli, M. (2004). Ubiquitin-Proteasome System and Proteasome Inhibition: New Strategies in Stroke Therapy. Stroke 35: 1506-1518 [Abstract] [Full Text]  
  • Curtin, D., Ferris, H. A., Hakli, M., Gibson, M., Janne, O. A., Palvimo, J. J., Shupnik, M. A. (2004). Small Nuclear RING Finger Protein Stimulates the Rat Luteinizing Hormone-{beta} Promoter by Interacting with Sp1 and Steroidogenic Factor-1 and Protects from Androgen Suppression. Mol. Endocrinol. 18: 1263-1276 [Abstract] [Full Text]  
  • Burgdorf, S., Leister, P., Scheidtmann, K. H. (2004). TSG101 Interacts with Apoptosis-antagonizing Transcription Factor and Enhances Androgen Receptor-mediated Transcription by Promoting Its Monoubiquitination. J. Biol. Chem. 279: 17524-17534 [Abstract] [Full Text]  
  • Nawaz, Z., O'Malley, B. W. (2004). Urban Renewal in the Nucleus: Is Protein Turnover by Proteasomes Absolutely Required for Nuclear Receptor-Regulated Transcription?. Mol. Endocrinol. 18: 493-499 [Abstract] [Full Text]  
  • Smith, C. L., O'Malley, B. W. (2004). Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators. Endocr. Rev. 25: 45-71 [Abstract] [Full Text]  
  • Lange, C. A. (2004). Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word?. Mol. Endocrinol. 18: 269-278 [Abstract] [Full Text]  
  • Lonard, D. M., Tsai, S. Y., O'Malley, B. W. (2004). Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins. Mol. Cell. Biol. 24: 14-24 [Abstract] [Full Text]  
  • Moraitis, A. N., Giguere, V. (2003). The Co-repressor Hairless Protects ROR{alpha} Orphan Nuclear Receptor from Proteasome-mediated Degradation. J. Biol. Chem. 278: 52511-52518 [Abstract] [Full Text]  
  • Li, X., O'Malley, B. W. (2003). Unfolding the Action of Progesterone Receptors. J. Biol. Chem. 278: 39261-39264 [Full Text]  
  • Marsaud, V., Gougelet, A., Maillard, S., Renoir, J.-M. (2003). Various Phosphorylation Pathways, Depending on Agonist and Antagonist Binding to Endogenous Estrogen Receptor {alpha} (ER{alpha}), Differentially Affect ER{alpha} Extractability, Proteasome-Mediated Stability, and Transcriptional Activity in Human Breast Cancer Cells. Mol. Endocrinol. 17: 2013-2027 [Abstract] [Full Text]  
  • Kinyamu, H. K., Archer, T. K. (2003). Estrogen Receptor-Dependent Proteasomal Degradation of the Glucocorticoid Receptor Is Coupled to an Increase in Mdm2 Protein Expression. Mol. Cell. Biol. 23: 5867-5881 [Abstract] [Full Text]  
  • Kasai, M., Guerrero-Santoro, J., Friedman, R., Leman, E. S., Getzenberg, R. H., DeFranco, D. B. (2003). The Group 3 LIM Domain Protein Paxillin Potentiates Androgen Receptor Transactivation in Prostate Cancer Cell Lines. Cancer Res. 63: 4927-4935 [Abstract] [Full Text]  
  • Agoulnik, I. U., Krause, W. C., Bingman, W. E. III, Rahman, H. T., Amrikachi, M., Ayala, G. E., Weigel, N. L. (2003). Repressors of Androgen and Progesterone Receptor Action. J. Biol. Chem. 278: 31136-31148 [Abstract] [Full Text]  
  • Benezra, M., Chevallier, N., Morrison, D. J., MacLachlan, T. K., El-Deiry, W. S., Licht, J. D. (2003). BRCA1 Augments Transcription by the NF-{kappa}B Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit. J. Biol. Chem. 278: 26333-26341 [Abstract] [Full Text]  
  • Asamitsu, K., Tetsuka, T., Kanazawa, S., Okamoto, T. (2003). RING Finger Protein AO7 Supports NF-{kappa}B-mediated Transcription by Interacting with the Transactivation Domain of the p65 Subunit. J. Biol. Chem. 278: 26879-26887 [Abstract] [Full Text]  
  • Veldman, T., Liu, X., Yuan, H., Schlegel, R. (2003). Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc. Natl. Acad. Sci. USA 100: 8211-8216 [Abstract] [Full Text]  
  • Yan, F., Gao, X., Lonard, D. M., Nawaz, Z. (2003). Specific Ubiquitin-Conjugating Enzymes Promote Degradation of Specific Nuclear Receptor Coactivators. Mol. Endocrinol. 17: 1315-1331 [Abstract] [Full Text]  
  • Dutertre, M., Smith, C. L. (2003). Ligand-Independent Interactions of p160/Steroid Receptor Coactivators and CREB-Binding Protein (CBP) with Estrogen Receptor-{alpha}: Regulation by Phosphorylation Sites in the A/B Region Depends on Other Receptor Domains. Mol. Endocrinol. 17: 1296-1314 [Abstract] [Full Text]  
  • Coleman, K. M., Dutertre, M., El-Gharbawy, A., Rowan, B. G., Weigel, N. L., Smith, C. L. (2003). Mechanistic Differences in the Activation of Estrogen Receptor-alpha (ERalpha )- and ERbeta -dependent Gene Expression by cAMP Signaling Pathway(s). J. Biol. Chem. 278: 12834-12845 [Abstract] [Full Text]  
  • Qiu, M., Olsen, A., Faivre, E., Horwitz, K. B., Lange, C. A. (2003). Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors. Mol. Endocrinol. 17: 628-642 [Abstract] [Full Text]  
  • Daikoku, T., Matsumoto, H., Gupta, R. A., Das, S. K., Gassmann, M., DuBois, R. N., Dey, S. K. (2003). Expression of Hypoxia-inducible Factors in the Peri-implantation Mouse Uterus Is Regulated in a Cell-specific and Ovarian Steroid Hormone-dependent Manner. EVIDENCE FOR DIFFERENTIAL FUNCTION OF HIFs DURING EARLY PREGNANCY. J. Biol. Chem. 278: 7683-7691 [Abstract] [Full Text]  
  • James, A. J., Agoulnik, I. U., Harris, J. M., Buchanan, G., Tilley, W. D., Marcelli, M., Lamb, D. J., Weigel, N. L. (2002). A Novel Androgen Receptor Mutant, A748T, Exhibits Hormone Concentration-Dependent Defects in Nuclear Accumulation and Activity Despite Normal Hormone-Binding Affinity. Mol. Endocrinol. 16: 2692-2705 [Abstract] [Full Text]  
  • Wang, X., Pongrac, J. L., DeFranco, D. B. (2002). Glucocorticoid Receptors in Hippocampal Neurons that Do Not Engage Proteasomes Escape from Hormone-Dependent Down-Regulation but Maintain Transactivation Activity. Mol. Endocrinol. 16: 1987-1998 [Abstract] [Full Text]  
  • Herzing, L. B.K., Cook, E. H. Jr, Ledbetter, D. H. (2002). Allele-specific expression analysis by RNA-FISH demonstrates preferential maternal expression of UBE3A and imprint maintenance within 15q11- q13 duplications. Hum Mol Genet 11: 1707-1718 [Abstract] [Full Text]  
  • Henderson, M. J., Russell, A. J., Hird, S., Munoz, M., Clancy, J. L., Lehrbach, G. M., Calanni, S. T., Jans, D. A., Sutherland, R. L., Watts, C. K. W. (2002). EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response. J. Biol. Chem. 277: 26468-26478 [Abstract] [Full Text]  
  • Conaway, R. C., Brower, C. S., Conaway, J. W. (2002). Emerging Roles of Ubiquitin in Transcription Regulation. Science 296: 1254-1258 [Abstract] [Full Text]  
  • Heinlein, C. A., Chang, C. (2002). Androgen Receptor (AR) Coregulators: An Overview. Endocr. Rev. 23: 175-200 [Abstract] [Full Text]  
  • Fan, M., Long, X., Bailey, J. A., Reed, C. A., Osborne, E., Gize, E. A., Kirk, E. A., Bigsby, R. M., Nephew, K. P. (2002). The Activating Enzyme of NEDD8 Inhibits Steroid Receptor Function. Mol. Endocrinol. 16: 315-330 [Abstract] [Full Text]  
  • Smith, C. L., DeVera, D. G., Lamb, D. J., Nawaz, Z., Jiang, Y.-H., Beaudet, A. L., O'Malley, B. W. (2002). Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction. Mol. Cell. Biol. 22: 525-535 [Abstract] [Full Text]  
  • Shen, T., Horwitz, K. B., Lange, C. A. (2001). Transcriptional Hyperactivity of Human Progesterone Receptors Is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294. Mol. Cell. Biol. 21: 6122-6131 [Abstract] [Full Text]  
  • Conneely, O. M. (2001). Perspective: Female Steroid Hormone Action. Endocrinology 142: 2194-2199 [Full Text]  
  • Tabb, A. L., Utsugi, T., Wooten-Kee, C. R., Sasaki, T., Edling, S. A., Gump, W., Kikuchi, Y., Ellis, S. R. (2001). Genes Encoding Ribosomal Proteins Rps0A/B of Saccharomyces cerevisiae Interact With TOM1 Mutants Defective in Ribosome Synthesis. Genetics 157: 1107-1116 [Abstract] [Full Text]  
  • Osborne, C. K., Fuqua, S. A. W. (2000). Selective Estrogen Receptor Modulators: Structure, Function, and Clinical Use. JCO 18: 3172-3186 [Abstract] [Full Text]  
  • Stenoien, D. L., Mancini, M. G., Patel, K., Allegretto*, E. A., Smith, C. L., Mancini, M. A. (2000). Subnuclear Trafficking of Estrogen Receptor-{alpha} and Steroid Receptor Coactivator-1. Mol. Endocrinol. 14: 518-534 [Abstract] [Full Text]  
  • Chauchereau, A., Georgiakaki, M., Perrin-Wolff, M., Milgrom, E., Loosfelt, H. (2000). JAB1 Interacts with Both the Progesterone Receptor and SRC-1. J. Biol. Chem. 275: 8540-8548 [Abstract] [Full Text]  
  • Li, J., O'Malley, B. W., Wong, J. (2000). p300 Requires Its Histone Acetyltransferase Activity and SRC-1 Interaction Domain To Facilitate Thyroid Hormone Receptor Activation in Chromatin. Mol. Cell. Biol. 20: 2031-2042 [Abstract] [Full Text]  
  • Glass, C. K., Rosenfeld, M. G. (2000). The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14: 121-141 [Full Text]  
  • Lee, Y.-K., Dell, H., Dowhan, D. H., Hadzopoulou-Cladaras, M., Moore, D. D. (2000). The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression. Mol. Cell. Biol. 20: 187-195 [Abstract] [Full Text]  
  • McKenna, N. J., Lanz, R. B., O’Malley, B. W. (1999). Nuclear Receptor Coregulators: Cellular and Molecular Biology. Endocr. Rev. 20: 321-344 [Abstract] [Full Text]  
  • Nawaz, Z., Lonard, D. M., Dennis, A. P., Smith, C. L., O'Malley, B. W. (1999). Proteasome-dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci. USA 96: 1858-1862 [Abstract] [Full Text]  
  • Webb, P., Nguyen, P., Valentine, C., Weatherman, R. V., Scanlan, T. S., Kushner, P. J. (2000). An Antiestrogen-responsive Estrogen Receptor-alpha Mutant (D351Y) Shows Weak AF-2 Activity in the Presence of Tamoxifen. J. Biol. Chem. 275: 37552-37558 [Abstract] [Full Text]  
  • Conkright, M. D., Wani, M. A., Lingrel, J. B (2001). Lung Kruppel-like Factor Contains an Autoinhibitory Domain That Regulates Its Transcriptional Activation by Binding WWP1, an E3 Ubiquitin Ligase. J. Biol. Chem. 276: 29299-29306 [Abstract] [Full Text]  
  • Zhao, H. H., Herrera, R. E., Coronado-Heinsohn, E., Yang, M. C., Ludes-Meyers, J. H., Seybold-Tilson, K. J., Nawaz, Z., Yee, D., Barr, F. G., Diab, S. G., Brown, P. H., Fuqua, S. A. W., Osborne, C. K. (2001). Forkhead Homologue in Rhabdomyosarcoma Functions as a Bifunctional Nuclear Receptor-interacting Protein with Both Coactivator and Corepressor Functions. J. Biol. Chem. 276: 27907-27912 [Abstract] [Full Text]  
  • Saville, B., Poukka, H., Wormke, M., Janne, O. A., Palvimo, J. J., Stoner, M., Samudio, I., Safe, S. (2002). Cooperative Coactivation of Estrogen Receptor alpha in ZR-75 Human Breast Cancer Cells by SNURF and TATA-binding Protein. J. Biol. Chem. 277: 2485-2497 [Abstract] [Full Text]  
  • Walters, M. R., Dutertre, M., Smith, C. L. (2002). SKF-82958 Is a Subtype-selective Estrogen Receptor-alpha (ERalpha ) Agonist That Induces Functional Interactions between ERalpha and AP-1. J. Biol. Chem. 277: 1669-1679 [Abstract] [Full Text]