This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bonizzi, G.
Right arrow Articles by Bours, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonizzi, G.
Right arrow Articles by Bours, V.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, March 1999, p. 1950-1960, Vol. 19, No. 3
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Reactive Oxygen Intermediate-Dependent NF-kappa B Activation by Interleukin-1beta Requires 5-Lipoxygenase or NADPH Oxidase Activity

Giuseppina Bonizzi,1 Jacques Piette,2 Sonia Schoonbroodt,2 Roland Greimers,3 Laurence Havard,1 Marie-Paule Merville,1 and Vincent Bours1,*

Laboratory of Medical Chemistry/Medical Oncology,1 Laboratory of Fundamental Virology,2 and Laboratory of Pathology,3 University of Liège, Liège, Belgium

Received 16 July 1998/Returned for modification 26 August 1998/Accepted 30 November 1998

We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappa B activation by proinflammatory cytokines was cell specific. However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase. 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells. Stimulation of lymphoid cells with interleukin-1beta (IL-1beta ) led to ROI production and NF-kappa B activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappa B activation in these cells. IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappa B induction was not influenced by 5-LOX inhibitors. However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappa B activation. In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity. This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappa B activation by IL-1beta in epithelial cells. In conclusion, three different cell-specific pathways lead to NF-kappa B activation by IL-1beta : a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.

* Corresponding author. Mailing address: Medical Oncology, CHU B35, Sart-Tilman, Université de Liège, 4000 Liège, Belgium. Phone: 32-4-3662482. Fax: 32-4-3664534. E-mail: vbours{at}ulg.ac.be.

Molecular and Cellular Biology, March 1999, p. 1950-1960, Vol. 19, No. 3
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Barros, P., Jordan, P., Matos, P. (2009). Rac1 Signaling Modulates BCL-6-Mediated Repression of Gene Transcription. Mol. Cell. Biol. 29: 4156-4166 [Abstract] [Full Text]  
  • Janssen-Heininger, Y. M. W., Poynter, M. E., Aesif, S. W., Pantano, C., Ather, J. L., Reynaert, N. L., Ckless, K., Anathy, V., van der Velden, J., Irvin, C. G., van der Vliet, A. (2009). Nuclear Factor {kappa}B, Airway Epithelium, and Asthma: Avenues for Redox Control. Proc Am Thorac Soc 6: 249-255 [Abstract] [Full Text]  
  • Ahmad, R., Sylvester, J., Ahmad, M., Zafarullah, M. (2009). Adaptor Proteins and Ras Synergistically Regulate IL-1-Induced ADAMTS-4 Expression in Human Chondrocytes. J. Immunol. 182: 5081-5087 [Abstract] [Full Text]  
  • Singh, J., Khan, M., Singh, I. (2009). Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. J. Lipid Res. 50: 135-147 [Abstract] [Full Text]  
  • Kang, Y.-M., Ma, Y., Elks, C., Zheng, J.-P., Yang, Z.-M., Francis, J. (2008). Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-{kappa}B. Cardiovasc Res 79: 671-678 [Abstract] [Full Text]  
  • Taccone-Gallucci, M., Manca-di-Villahermosa, S., Maccarrone, M., Peters-Golden, M., Henderson, W. R. Jr. (2008). Leukotrienes. NEJM 358: 746-746 [Full Text]  
  • Chung, S. W., Toriba, A., Chung, H. Y., Yu, B. P., Kameda, T., Tang, N., Kizu, R., Hayakawa, K. (2008). Activation of 5-Lipoxygenase and NF-{kappa}B in the Action of Acenaphthenequinone by Modulation of Oxidative Stress. Toxicol Sci 101: 152-158 [Abstract] [Full Text]  
  • Gauss, K. A., Nelson-Overton, L. K., Siemsen, D. W., Gao, Y., DeLeo, F. R., Quinn, M. T. (2007). Role of NF-{kappa}B in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-{alpha}. J. Leukoc. Biol. 82: 729-741 [Abstract] [Full Text]  
  • Yu, Y., Zhang, Z.-H., Wei, S.-G., Chu, Y., Weiss, R. M., Heistad, D. D., Felder, R. B. (2007). Central Gene Transfer of Interleukin-10 Reduces Hypothalamic Inflammation and Evidence of Heart Failure in Rats After Myocardial Infarction. Circ. Res. 101: 304-312 [Abstract] [Full Text]  
  • Zmijewski, J. W., Zhao, X., Xu, Z., Abraham, E. (2007). Exposure to hydrogen peroxide diminishes NF-{kappa}B activation, I{kappa}B-{alpha} degradation, and proteasome activity in neutrophils. Am. J. Physiol. Cell Physiol. 293: C255-C266 [Abstract] [Full Text]  
  • Bedard, K., Krause, K.-H. (2007). The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology. Physiol. Rev. 87: 245-313 [Abstract] [Full Text]  
  • Mohan, S., Koyoma, K., Thangasamy, A., Nakano, H., Glickman, R. D., Mohan, N. (2007). Low shear stress preferentially enhances IKK activity through selective sources of ROS for persistent activation of NF-{kappa}B in endothelial cells. Am. J. Physiol. Cell Physiol. 292: C362-C371 [Abstract] [Full Text]  
  • Cieslik, K. A., Deng, W.-G., Wu, K. K. (2006). Essential Role of C-Rel in Nitric-Oxide Synthase-2 Transcriptional Activation: Time-Dependent Control by Salicylate. Mol. Pharmacol. 70: 2004-2014 [Abstract] [Full Text]  
  • Daniel, D. S., Dai, G., Singh, C. R., Lindsey, D. R., Smith, A. K., Dhandayuthapani, S., Hunter, R. L. Jr, Jagannath, C. (2006). The Reduced Bactericidal Function of Complement C5-Deficient Murine Macrophages Is Associated with Defects in the Synthesis and Delivery of Reactive Oxygen Radicals to Mycobacterial Phagosomes. J. Immunol. 177: 4688-4698 [Abstract] [Full Text]  
  • Xu, Y., Shao, Y., Voorhees, J. J., Fisher, G. J. (2006). Oxidative Inhibition of Receptor-type Protein-tyrosine Phosphatase {kappa} by Ultraviolet Irradiation Activates Epidermal Growth Factor Receptor in Human Keratinocytes. J. Biol. Chem. 281: 27389-27397 [Abstract] [Full Text]  
  • Matos, P., Jordan, P. (2006). Rac1, but Not Rac1B, Stimulates RelB-mediated Gene Transcription in Colorectal Cancer Cells. J. Biol. Chem. 281: 13724-13732 [Abstract] [Full Text]  
  • Liu, M., Vakharia, V. N. (2006). Nonstructural protein of infectious bursal disease virus inhibits apoptosis at the early stage of virus infection.. J. Virol. 80: 3369-3377 [Abstract] [Full Text]  
  • Anrather, J., Racchumi, G., Iadecola, C. (2006). NF-{kappa}B Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91phox. J. Biol. Chem. 281: 5657-5667 [Abstract] [Full Text]  
  • Li, Q., Engelhardt, J. F. (2006). Interleukin-1beta Induction of NF{kappa}B Is Partially Regulated by H2O2-mediated Activation of NF{kappa}B-inducing Kinase. J. Biol. Chem. 281: 1495-1505 [Abstract] [Full Text]  
  • Lee, N. K., Choi, Y. G., Baik, J. Y., Han, S. Y., Jeong, D.-w., Bae, Y. S., Kim, N., Lee, S. Y. (2005). A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106: 852-859 [Abstract] [Full Text]  
  • Higashi, Y., Peng, T., Du, J., Sukhanov, S., Li, Y., Itabe, H., Parthasarathy, S., Delafontaine, P. (2005). A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor. J. Lipid Res. 46: 1266-1277 [Abstract] [Full Text]  
  • Ye, Y. N., Liu, E. S. L., Shin, V. Y., Wu, W. K. K., Cho, C. H. (2004). The Modulating Role of Nuclear Factor-{kappa}B in the Action of {alpha}7-Nicotinic Acetylcholine Receptor and Cross-Talk between 5-Lipoxygenase and Cyclooxygenase-2 in Colon Cancer Growth Induced by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Exp. Ther. 311: 123-130 [Abstract] [Full Text]  
  • Largo, R, Diez-Ortego, I, Sanchez-Pernaute, O, Lopez-Armada, M J, Alvarez-Soria, M A, Egido, J, Herrero-Beaumont, G (2004). EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1{beta} in synovial fibroblasts. Ann Rheum Dis 63: 1197-1204 [Abstract] [Full Text]  
  • Chou, W.-C., Jie, C., Kenedy, A. A., Jones, R. J., Trush, M. A., Dang, C. V. (2004). Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc. Natl. Acad. Sci. USA 101: 4578-4583 [Abstract] [Full Text]  
  • Strassheim, D., Asehnoune, K., Park, J.-S., Kim, J.-Y., He, Q., Richter, D., Mitra, S., Arcaroli, J., Kuhn, K., Abraham, E. (2004). Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-{kappa}B, and cytokine expression. Am. J. Physiol. Cell Physiol. 286: C683-C692 [Abstract] [Full Text]  
  • Werner, E. (2004). GTPases and reactive oxygen species: switches for killing and signaling. J. Cell Sci. 117: 143-153 [Abstract] [Full Text]  
  • Ha, Y. J., Lee, J. R. (2004). Role of TNF Receptor-Associated Factor 3 in the CD40 Signaling by Production of Reactive Oxygen Species through Association with p40phox, a Cytosolic Subunit of Nicotinamide Adenine Dinucleotide Phosphate Oxidase. J. Immunol. 172: 231-239 [Abstract] [Full Text]  
  • Teufelhofer, O., Weiss, R.-M., Parzefall, W., Schulte-Hermann, R., Micksche, M., Berger, W., Elbling, L. (2003). Promyelocytic HL60 Cells Express NADPH Oxidase and Are Excellent Targets in a Rapid Spectrophotometric Microplate Assay for Extracellular Superoxide. Toxicol Sci 76: 376-383 [Abstract] [Full Text]  
  • Bernotti, S., Seidman, E., Sinnett, D., Brunet, S., Dionne, S., Delvin, E., Levy, E. (2003). Inflammatory reaction without endogenous antioxidant response in Caco-2 cells exposed to iron/ascorbate-mediated lipid peroxidation. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G898-G906 [Abstract] [Full Text]  
  • Saha, D., Sekhar, K. R., Cao, C., Morrow, J. D., Choy, H., Freeman, M. L. (2003). The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity. Cancer Res. 63: 6920-6927 [Abstract] [Full Text]  
  • Barbieri, S. S., Eligini, S., Brambilla, M., Tremoli, E., Colli, S. (2003). Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation: critical role of NADPH oxidase. Cardiovasc Res 60: 187-197 [Abstract] [Full Text]  
  • Xiong, S., She, H., Takeuchi, H., Han, B., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., Tsukamoto, H. (2003). Signaling Role of Intracellular Iron in NF-kappa B Activation. J. Biol. Chem. 278: 17646-17654 [Abstract] [Full Text]  
  • Gu, Y., Xu, Y. C., Wu, R. F., Nwariaku, F. E., Souza, R. F., Flores, S. C., Terada, L. S. (2003). p47phox Participates in Activation of RelA in Endothelial Cells. J. Biol. Chem. 278: 17210-17217 [Abstract] [Full Text]  
  • Maccarrone, M., Battista, N., Meloni, M., Bari, M., Galleri, G., Pippia, P., Cogoli, A., Finazzi-Agro, A. (2003). Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. J. Leukoc. Biol. 73: 472-481 [Abstract] [Full Text]  
  • Jeong, D.-w., Yoo, M.-H., Kim, T. S., Kim, J.-H., Kim, I. Y. (2002). Protection of Mice from Allergen-induced Asthma by Selenite. PREVENTION OF EOSINOPHIL INFILTRATION BY INHIBITION OF NF-kappa B ACTIVATION. J. Biol. Chem. 277: 17871-17876 [Abstract] [Full Text]  
  • Karnoub, A. E., Der, C. J., Campbell, S. L. (2001). The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation. Mol. Cell. Biol. 21: 2847-2857 [Abstract] [Full Text]  
  • Thannickal, V. J., Fanburg, B. L. (2000). Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L1005-L1028 [Abstract] [Full Text]  
  • Jan, J.-T., Chen, B.-H., Ma, S.-H., Liu, C.-I, Tsai, H.-P., Wu, H.-C., Jiang, S.-Y., Yang, K.-D., Shaio, M.-F. (2000). Potential Dengue Virus-Triggered Apoptotic Pathway in Human Neuroblastoma Cells: Arachidonic Acid, Superoxide Anion, and NF-kappa B Are Sequentially Involved. J. Virol. 74: 8680-8691 [Abstract] [Full Text]  
  • El-Kadi, A. O. S., Bleau, A.-M., Dumont, I., Maurice, H., du Souich, P. (2000). Role of Reactive Oxygen Intermediates in the Decrease of Hepatic Cytochrome P450 Activity by Serum of Humans and Rabbits with an Acute Inflammatory Reaction. Drug Metab. Dispos. 28: 1112-1120 [Abstract] [Full Text]  
  • Jeon, K.-I., Jeong, J.-Y., Jue, D.-M. (2000). Thiol-Reactive Metal Compounds Inhibit NF-{kappa}B Activation by Blocking I{kappa}B Kinase. J. Immunol. 164: 5981-5989 [Abstract] [Full Text]  
  • Jefferies, C. A., O'Neill, L. A. J. (2000). Rac1 Regulates Interleukin 1-induced Nuclear Factor kappa B Activation in an Inhibitory Protein kappa Balpha -independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression. J. Biol. Chem. 275: 3114-3120 [Abstract] [Full Text]  
  • Anthonsen, M. W., Solhaug, A., Johansen, B. (2001). Functional Coupling between Secretory and Cytosolic Phospholipase A2 Modulates Tumor Necrosis Factor-alpha - and Interleukin-1beta -induced NF-kappa B Activation. J. Biol. Chem. 276: 30527-30536 [Abstract] [Full Text]  
  • Bureau, C., Bernad, J., Chaouche, N., Orfila, C., Beraud, M., Gonindard, C., Alric, L., Vinel, J.-P., Pipy, B. (2001). Nonstructural 3 Protein of Hepatitis C Virus Triggers an Oxidative Burst in Human Monocytes via Activation of NADPH Oxidase. J. Biol. Chem. 276: 23077-23083 [Abstract] [Full Text]  
  • Korn, S. H., Wouters, E. F. M., Vos, N., Janssen-Heininger, Y. M. W. (2001). Cytokine-induced Activation of Nuclear Factor-kappa B Is Inhibited by Hydrogen Peroxide through Oxidative Inactivation of Ikappa B Kinase. J. Biol. Chem. 276: 35693-35700 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»