This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Babic, A. M.
Right arrow Articles by Lau, L. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Babic, A. M.
Right arrow Articles by Lau, L. F.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, April 1999, p. 2958-2966, Vol. 19, No. 4
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin alpha vbeta 3, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo

Alexander M. Babic, Chih-Chiun Chen, and Lester F. Lau*

Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607-7170

Received 18 September 1998/Returned for modification 11 December 1998/Accepted 21 December 1998

Fisp12 was first identified as a secreted protein encoded by a growth factor-inducible immediate-early gene in mouse fibroblasts, whereas its human ortholog, CTGF (connective tissue growth factor), was identified as a mitogenic activity in conditioned media of human umbilical vein endothelial cells. Fisp12/CTGF is a member of a family of secreted proteins that includes CYR61, Nov, Elm-1, Cop-1/WISP-2, and WISP-3. Fisp12/CTGF has been shown to promote cell adhesion and mitogenesis in both fibroblasts and endothelial cells and to stimulate cell migration in fibroblasts. These findings, together with the localization of Fisp12/CTGF in angiogenic tissues, as well as in atherosclerotic plaques, suggest a possible role for Fisp12/CTGF in the regulation of vessel growth during development, wound healing, and vascular disease. In this study, we show that purified Fisp12 (mCTGF) protein promotes the adhesion of microvascular endothelial cells through the integrin receptor alpha vbeta 3. Furthermore, Fisp12 stimulates the migration of microvascular endothelial cells in culture, also through an integrin-alpha vbeta 3-dependent mechanism. In addition, the presence of Fisp12 promotes endothelial cell survival when cells are plated on laminin and deprived of growth factors, a condition that otherwise induces apoptosis. In vivo, Fisp12 induces neovascularization in rat corneal micropocket implants. These results demonstrate that Fisp12 is a novel angiogenic inducer and suggest a direct role for Fisp12 in the adhesion, migration, and survival of endothelial cells during blood vessel growth. Taken together with the recent finding that the related protein CYR61 also induces angiogenesis, we suggest that Fisp12/mCTGF and CYR61 comprise prototypes of a new family of angiogenic regulators that function, at least in part, through integrin-alpha vbeta 3-dependent pathways.

* Corresponding author. Mailing address: Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Ave., Chicago, IL 60607-7170. Phone: (312) 996-6978. Fax: (312) 996-7034. E-mail: lflau{at}uic.edu.

Molecular and Cellular Biology, April 1999, p. 2958-2966, Vol. 19, No. 4
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Franzen, C. A., Chen, C.-C., Todorovic, V., Juric, V., Monzon, R. I., Lau, L. F. (2009). Matrix Protein CCN1 Is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced Apoptosis. Mol Cancer Res 7: 1045-1055 [Abstract] [Full Text]  
  • Juric, V., Chen, C.-C., Lau, L. F. (2009). Fas-Mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo. Mol. Cell. Biol. 29: 3266-3279 [Abstract] [Full Text]  
  • Droppelmann, C. A., Gutierrez, J., Vial, C., Brandan, E. (2009). Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin. J. Biol. Chem. 284: 13551-13561 [Abstract] [Full Text]  
  • Wang, M.-Y., Chen, P.-S., Prakash, E., Hsu, H.-C., Huang, H.-Y., Lin, M.-T., Chang, K.-J., Kuo, M.-L. (2009). Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1. Cancer Res. 69: 3482-3491 [Abstract] [Full Text]  
  • Crawford, L. A., Guney, M. A., Oh, Y. A., DeYoung, R. A., Valenzuela, D. M., Murphy, A. J., Yancopoulos, G. D., Lyons, K. M., Brigstock, D. R., Economides, A., Gannon, M. (2009). Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis. Mol. Endocrinol. 23: 324-336 [Abstract] [Full Text]  
  • Priyanka, S., Jayaram, P., Sridaran, R., Medhamurthy, R. (2009). Genome-Wide Gene Expression Analysis Reveals a Dynamic Interplay between Luteotropic and Luteolytic Factors in the Regulation of Corpus Luteum Function in the Bonnet Monkey (Macaca radiata). Endocrinology 150: 1473-1484 [Abstract] [Full Text]  
  • Bennewith, K. L., Huang, X., Ham, C. M., Graves, E. E., Erler, J. T., Kambham, N., Feazell, J., Yang, G. P., Koong, A., Giaccia, A. J. (2009). The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth. Cancer Res. 69: 775-784 [Abstract] [Full Text]  
  • Walsh, C. T., Radeff-Huang, J., Matteo, R., Hsiao, A., Subramaniam, S., Stupack, D., Brown, J. H. (2008). Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J. 22: 4011-4021 [Abstract] [Full Text]  
  • Mukudai, Y., Kubota, S., Kawaki, H., Kondo, S., Eguchi, T., Sumiyoshi, K., Ohgawara, T., Shimo, T., Takigawa, M. (2008). Posttranscriptional Regulation of Chicken ccn2 Gene Expression by Nucleophosmin/B23 during Chondrocyte Differentiation. Mol. Cell. Biol. 28: 6134-6147 [Abstract] [Full Text]  
  • He, S., Chen, Y., Khankan, R., Barron, E., Burton, R., Zhu, D., Ryan, S. J., Oliver, N., Hinton, D. R. (2008). Connective Tissue Growth Factor as a Mediator of Intraocular Fibrosis. IOVS 49: 4078-4088 [Abstract] [Full Text]  
  • Smerdel-Ramoya, A., Zanotti, S., Stadmeyer, L., Durant, D., Canalis, E. (2008). Skeletal Overexpression of Connective Tissue Growth Factor Impairs Bone Formation and Causes Osteopenia. Endocrinology 149: 4374-4381 [Abstract] [Full Text]  
  • Walsh, C. T., Stupack, D., Brown, J. H. (2008). G Protein-Coupled Receptors Go Extracellular: RhoA Integrates the Integrins. Mol. Interv. 8: 165-173 [Abstract] [Full Text]  
  • Oka, M., Kubota, S., Kondo, S., Eguchi, T., Kuroda, C., Kawata, K., Minagi, S., Takigawa, M. (2007). Gene Expression and Distribution of Connective Tissue Growth Factor (CCN2/CTGF) During Secondary Ossification Center Formation. J. Histochem. Cytochem. 55: 1245-1255 [Abstract] [Full Text]  
  • Kuiper, E. J., Roestenberg, P., Ehlken, C., Lambert, V., van Treslong-de Groot, H. B., Lyons, K. M., Agostini, H.-J. T., Rakic, J.-M., Klaassen, I., Van Noorden, C. J.F., Goldschmeding, R., Schlingemann, R. O. (2007). Angiogenesis Is Not Impaired in Connective Tissue Growth Factor (CTGF) Knock-out Mice. J. Histochem. Cytochem. 55: 1139-1147 [Abstract] [Full Text]  
  • Chen, P.-S., Wang, M.-Y., Wu, S.-N., Su, J.-L., Hong, C.-C., Chuang, S.-E., Chen, M.-W., Hua, K.-T., Wu, Y.-L., Cha, S.-T., Babu, M. S., Chen, C.-N., Lee, P.-H., Chang, K.-J., Kuo, M.-L. (2007). CTGF enhances the motility of breast cancer cells via an integrin-{alpha}vbeta3-ERK1/2-dependent S100A4-upregulated pathway. J. Cell Sci. 120: 2053-2065 [Abstract] [Full Text]  
  • Furlong, F., Crean, J., Thornton, L., O'Leary, R., Murphy, M., Martin, F. (2007). Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose. Am. J. Physiol. Renal Physiol. 292: F1691-F1700 [Abstract] [Full Text]  
  • Wu, S., Peng, J., Duncan, M. R., Kasisomayajula, K., Grotendorst, G., Bancalari, E. (2007). ALK-5 Mediates Endogenous and TGF-beta1-Induced Expression of Connective Tissue Growth Factor in Embryonic Lung. Am. J. Respir. Cell Mol. Bio. 36: 552-561 [Abstract] [Full Text]  
  • Kita, T., Hata, Y., Miura, M., Kawahara, S., Nakao, S., Ishibashi, T. (2007). Functional Characteristics of Connective Tissue Growth Factor on Vitreoretinal Cells. Diabetes 56: 1421-1428 [Abstract] [Full Text]  
  • Leask, A., Abraham, D. J. (2006). All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J. Cell Sci. 119: 4803-4810 [Abstract] [Full Text]  
  • Kuiper, E. J., de Smet, M. D., van Meurs, J. C., Tan, H. S., Tanck, M. W. T., Oliver, N., van Nieuwenhoven, F. A., Goldschmeding, R., Schlingemann, R. O. (2006). Association of Connective Tissue Growth Factor With Fibrosis in Vitreoretinal Disorders in the Human Eye. Arch Ophthalmol 124: 1457-1462 [Abstract] [Full Text]  
  • Crean, J. K., Furlong, F., Mitchell, D., McArdle, E., Godson, C., Martin, F. (2006). Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27Kip-1. FASEB J. 20: 1712-1714 [Abstract] [Full Text]  
  • Chaqour, B., Yang, R., Sha, Q. (2006). Mechanical Stretch Modulates the Promoter Activity of the Profibrotic Factor CCN2 through Increased Actin Polymerization and NF-{kappa}B Activation. J. Biol. Chem. 281: 20608-20622 [Abstract] [Full Text]  
  • Chang, C.-C., Lin, M.-T., Lin, B.-R., Jeng, Y.-M., Chen, S.-T., Chu, C.-Y., Chen, R. J., Chang, K.-J., Yang, P.-C., Kuo, M.-L. (2006). Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis.. JNCI J Natl Cancer Inst 98: 984-995 [Abstract] [Full Text]  
  • Shi-wen, X., Stanton, L. A., Kennedy, L., Pala, D., Chen, Y., Howat, S. L., Renzoni, E. A., Carter, D. E., Bou-Gharios, G., Stratton, R. J., Pearson, J. D., Beier, F., Lyons, K. M., Black, C. M., Abraham, D. J., Leask, A. (2006). CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-beta1 in Embryonic Fibroblasts. J. Biol. Chem. 281: 10715-10726 [Abstract] [Full Text]  
  • Sohn, M., Tan, Y., Wang, B., Klein, R. L., Trojanowska, M., Jaffa, A. A. (2006). Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 290: H1624-H1634 [Abstract] [Full Text]  
  • Klein, C., Bauersachs, S., Ulbrich, S. E., Einspanier, R., Meyer, H. H.D., Schmidt, S. E.M., Reichenbach, H.-D., Vermehren, M., Sinowatz, F., Blum, H., Wolf, E. (2006). Monozygotic Twin Model Reveals Novel Embryo-Induced Transcriptome Changes of Bovine Endometrium in the Preattachment Period. Biol. Reprod. 74: 253-264 [Abstract] [Full Text]  
  • Kondo, S., Tanaka, N., Kubota, S., Mukudai, Y., Yosimichi, G., Sugahara, T., Takigawa, M. (2006). Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells. Molecular Cancer Therapeutics 5: 129-137 [Abstract] [Full Text]  
  • Todorovicc, V., Chen, C.-C., Hay, N., Lau, L. F. (2005). The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. JCB 171: 559-568 [Abstract] [Full Text]  
  • Yang, F., Tuxhorn, J. A., Ressler, S. J., McAlhany, S. J., Dang, T. D., Rowley, D. R. (2005). Stromal Expression of Connective Tissue Growth Factor Promotes Angiogenesis and Prostate Cancer Tumorigenesis. Cancer Res. 65: 8887-8895 [Abstract] [Full Text]  
  • Ben-Shlomo, I., Hsueh, A. J. W. (2005). Three's Company: Two or More Unrelated Receptors Pair with the Same Ligand. Mol. Endocrinol. 19: 1097-1109 [Abstract] [Full Text]  
  • Lin, C. G., Chen, C.-C., Leu, S.-J., Grzeszkiewicz, T. M., Lau, L. F. (2005). Integrin-dependent Functions of the Angiogenic Inducer NOV (CCN3): IMPLICATION IN WOUND HEALING. J. Biol. Chem. 280: 8229-8237 [Abstract] [Full Text]  
  • Mukudai, Y., Kubota, S., Eguchi, T., Kondo, S., Nakao, K., Takigawa, M. (2005). Regulation of Chicken ccn2 Gene by Interaction between RNA cis-Element and Putative trans-Factor during Differentiation of Chondrocytes. J. Biol. Chem. 280: 3166-3177 [Abstract] [Full Text]  
  • Wahab, N. A., Weston, B. S., Mason, R. M. (2005). Connective Tissue Growth Factor CCN2 Interacts with and Activates the Tyrosine Kinase Receptor TrkA. J. Am. Soc. Nephrol. 16: 340-351 [Abstract] [Full Text]  
  • Luo, Q., Kang, Q., Si, W., Jiang, W., Park, J. K., Peng, Y., Li, X., Luu, H. H., Luo, J., Montag, A. G., Haydon, R. C., He, T.-C. (2004). Connective Tissue Growth Factor (CTGF) Is Regulated by Wnt and Bone Morphogenetic Proteins Signaling in Osteoblast Differentiation of Mesenchymal Stem Cells. J. Biol. Chem. 279: 55958-55968 [Abstract] [Full Text]  
  • Chen, Y., Abraham, D. J., Shi-wen, X., Pearson, J. D., Black, C. M., Lyons, K. M., Leask, A. (2004). CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin. Mol. Biol. Cell 15: 5635-5646 [Abstract] [Full Text]  
  • Chen, N., Leu, S.-J., Todorovic, V., Lam, S. C.-T., Lau, L. F. (2004). Identification of a Novel Integrin {alpha}v{beta}3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells. J. Biol. Chem. 279: 44166-44176 [Abstract] [Full Text]  
  • Kuiper, E J, Witmer, A N, Klaassen, I, Oliver, N, Goldschmeding, R, Schlingemann, R O (2004). Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol 88: 1082-1087 [Abstract] [Full Text]  
  • Yokoi, H., Mukoyama, M., Nagae, T., Mori, K., Suganami, T., Sawai, K., Yoshioka, T., Koshikawa, M., Nishida, T., Takigawa, M., Sugawara, A., Nakao, K. (2004). Reduction in Connective Tissue Growth Factor by Antisense Treatment Ameliorates Renal Tubulointerstitial Fibrosis. J. Am. Soc. Nephrol. 15: 1430-1440 [Abstract] [Full Text]  
  • Absenger, Y., Hess-Stumpp, H., Kreft, B., Kratzschmar, J., Haendler, B., Schutze, N., Regidor, P.-A., Winterhager, E. (2004). Cyr61, a deregulated gene in endometriosis. Mol Hum Reprod 10: 399-407 [Abstract] [Full Text]  
  • Trackman, P. C., Kantarci, A. (2004). CONNECTIVE TISSUE METABOLISM AND GINGIVAL OVERGROWTH. CROBM 15: 165-175 [Abstract] [Full Text]  
  • LEASK, A., ABRAHAM, D. J. (2004). TGF-{beta} signaling and the fibrotic response. FASEB J. 18: 816-827 [Abstract] [Full Text]  
  • Mercurio, S., Latinkic, B., Itasaki, N., Krumlauf, R., Smith, J. C. (2004). Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 131: 2137-2147 [Abstract] [Full Text]  
  • Lassila, M., Allen, T. J., Cao, Z., Thallas, V., Jandeleit-Dahm, K. A., Candido, R., Cooper, M. E. (2004). Imatinib Attenuates Diabetes-Associated Atherosclerosis. Arterioscler. Thromb. Vasc. Bio. 24: 935-942 [Abstract] [Full Text]  
  • Xie, D., Yin, D., Wang, H.-J., Liu, G.-T., Elashoff, R., Black, K., Koeffler, H. P. (2004). Levels of Expression of CYR61 and CTGF Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas. Clin. Cancer Res. 10: 2072-2081 [Abstract] [Full Text]  
  • Gao, R., Brigstock, D. R. (2004). Connective Tissue Growth Factor (CCN2) Induces Adhesion of Rat Activated Hepatic Stellate Cells by Binding of Its C-terminal Domain to Integrin {alpha}v{beta}3 and Heparan Sulfate Proteoglycan. J. Biol. Chem. 279: 8848-8855 [Abstract] [Full Text]  
  • Chang, C.-C., Shih, J.-Y., Jeng, Y.-M., Su, J.-L., Lin, B.-Z., Chen, S.-T., Chau, Y.-P., Yang, P.-C., Kuo, M.-L. (2004). Connective Tissue Growth Factor and Its Role in Lung Adenocarcinoma Invasion and Metastasis. JNCI J Natl Cancer Inst 96: 364-375 [Abstract] [Full Text]  
  • Croci, S., Landuzzi, L., Astolfi, A., Nicoletti, G., Rosolen, A., Sartori, F., Follo, M. Y., Oliver, N., De Giovanni, C., Nanni, P., Lollini, P.-L. (2004). Inhibition of Connective Tissue Growth Factor (CTGF/CCN2) Expression Decreases the Survival and Myogenic Differentiation of Human Rhabdomyosarcoma Cells. Cancer Res. 64: 1730-1736 [Abstract] [Full Text]  
  • Hinton, D. R., Spee, C., He, S., Weitz, S., Usinger, W., LaBree, L., Oliver, N., Lim, J. I. (2004). Accumulation of NH2-Terminal Fragment of Connective Tissue Growth Factor in the Vitreous of Patients With Proliferative Diabetic Retinopathy. Diabetes Care 27: 758-764 [Abstract] [Full Text]  
  • Mason, H. R., Lake, A. C., Wubben, J. E., Nowak, R. A., Castellot, J. J. Jr (2004). The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells. Mol Hum Reprod 10: 181-187 [Abstract] [Full Text]  
  • Tikellis, C., Cooper, M. E., Twigg, Stephen. M., Burns, W. C., Tolcos, M. (2004). Connective Tissue Growth Factor Is Up-Regulated in the Diabetic Retina: Amelioration by Angiotensin-Converting Enzyme Inhibition. Endocrinology 145: 860-866 [Abstract] [Full Text]  
  • Leu, S.-J., Liu, Y., Chen, N., Chen, C.-C., Lam, S. C.-T., Lau, L. F. (2003). Identification of a Novel Integrin {alpha}6{beta}1 Binding Site in the Angiogenic Inducer CCN1 (CYR61). J. Biol. Chem. 278: 33801-33808 [Abstract] [Full Text]  
  • Weston, G., Trajstman, A. C., Gargett, C. E., Manuelpillai, U., Vollenhoven, B. J., Rogers, P. A.W. (2003). Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium. Mol Hum Reprod 9: 541-549 [Abstract] [Full Text]  
  • He, S., Jin, M. L., Worpel, V., Hinton, D. R. (2003). A Role for Connective Tissue Growth Factor in the Pathogenesis of Choroidal Neovascularization. Arch Ophthalmol 121: 1283-1288 [Abstract] [Full Text]  
  • Schober, J. M., Lau, L. F., Ugarova, T. P., Lam, S. C.-T. (2003). Identification of a Novel Integrin {alpha}M{beta}2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions. J. Biol. Chem. 278: 25808-25815 [Abstract] [Full Text]  
  • WERNER, S., GROSE, R. (2003). Regulation of Wound Healing by Growth Factors and Cytokines. Physiol. Rev. 83: 835-870 [Abstract] [Full Text]  
  • Lin, C. G., Leu, S.-J., Chen, N., Tebeau, C. M., Lin, S.-X., Yeung, C.-Y., Lau, L. F. (2003). CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family. J. Biol. Chem. 278: 24200-24208 [Abstract] [Full Text]  
  • Ivkovic, S., Yoon, B. S., Popoff, S. N., Safadi, F. F., Libuda, D. E., Stephenson, R. C., Daluiski, A., Lyons, K. M. (2003). Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130: 2779-2791 [Abstract] [Full Text]  
  • Candido, R., Forbes, J. M., Thomas, M. C., Thallas, V., Dean, R. G., Burns, W. C., Tikellis, C., Ritchie, R. H., Twigg, S. M., Cooper, M. E., Burrell, L. M. (2003). A Breaker of Advanced Glycation End Products Attenuates Diabetes-Induced Myocardial Structural Changes. Circ. Res. 92: 785-792 [Abstract] [Full Text]  
  • Lake, A. C., Bialik, A., Walsh, K., Castellot, J. J. Jr (2003). CCN5 Is a Growth Arrest-Specific Gene That Regulates Smooth Muscle Cell Proliferation and Motility. Am. J. Pathol. 162: 219-231 [Abstract] [Full Text]  
  • Mo, F.-E, Muntean, A. G., Chen, C.-C., Stolz, D. B., Watkins, S. C., Lau, L. F. (2002). CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity. Mol. Cell. Biol. 22: 8709-8720 [Abstract] [Full Text]  
  • Twigg, S. M., Cao, Z., MCLennan, S. V., Burns, W. C., Brammar, G., Forbes, J. M., Cooper, M. E. (2002). Renal Connective Tissue Growth Factor Induction in Experimental Diabetes Is Prevented by Aminoguanidine. Endocrinology 143: 4907-4915 [Abstract] [Full Text]  
  • Cheon, Y.-P., Li, Q., Xu, X., DeMayo, F. J., Bagchi, I. C., Bagchi, M. K. (2002). A Genomic Approach to Identify Novel Progesterone Receptor Regulated Pathways in the Uterus during Implantation. Mol. Endocrinol. 16: 2853-2871 [Abstract] [Full Text]  
  • Crean, J. K. G., Finlay, D., Murphy, M., Moss, C., Godson, C., Martin, F., Brady, H. R. (2002). The Role of p42/44 MAPK and Protein Kinase B in Connective Tissue Growth Factor Induced Extracellular Matrix Protein Production, Cell Migration, and Actin Cytoskeletal Rearrangement in Human Mesangial Cells. J. Biol. Chem. 277: 44187-44194 [Abstract] [Full Text]  
  • Gore-Hyer, E., Shegogue, D., Markiewicz, M., Lo, S., Hazen-Martin, D., Greene, E. L., Grotendorst, G., Trojanowska, M. (2002). TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am. J. Physiol. Renal Physiol. 283: F707-F716 [Abstract] [Full Text]  
  • Harlow, C. R., Davidson, L., Burns, K. H., Yan, C., Matzuk, M. M., Hillier, S. G. (2002). FSH and TGF-{beta} Superfamily Members Regulate Granulosa Cell Connective Tissue Growth Factor Gene Expression in Vitro and in Vivo. Endocrinology 143: 3316-3325 [Abstract] [Full Text]  
  • Burns, K. H., Owens, G. E., Fernandez, J. M., Nilson, J. H., Matzuk, M. M. (2002). Characterization of Integrin Expression in the Mouse Ovary. Biol. Reprod. 67: 743-751 [Abstract] [Full Text]  
  • Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V., Schultz, P. G. (2002). Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc. Natl. Acad. Sci. USA 99: 11181-11186 [Abstract] [Full Text]  
  • Sakamoto, K., Yamaguchi, S., Ando, R., Miyawaki, A., Kabasawa, Y., Takagi, M., Li, C. L., Perbal, B., Katsube, K.-i. (2002). The Nephroblastoma Overexpressed Gene (NOV/ccn3) Protein Associates with Notch1 Extracellular Domain and Inhibits Myoblast Differentiation via Notch Signaling Pathway. J. Biol. Chem. 277: 29399-29405 [Abstract] [Full Text]  
  • Candido, R., Jandeleit-Dahm, K. A., Cao, Z., Nesteroff;, S. P., Burns, W. C., Twigg, S. M., Dilley, R. J., Cooper, M. E., Allen, T. J. (2002). Prevention of Accelerated Atherosclerosis by Angiotensin-Converting Enzyme Inhibition in Diabetic Apolipoprotein E-Deficient Mice. Circulation 106: 246-253 [Abstract] [Full Text]  
  • Hilfiker, A., Hilfiker-Kleiner, D., Fuchs, M., Kaminski, K., Lichtenberg, A., Rothkotter, H.-J., Schieffer, B., Drexler, H. (2002). Expression of CYR61, an Angiogenic Immediate Early Gene, in Arteriosclerosis and Its Regulation by Angiotensin II. Circulation 106: 254-260 [Abstract] [Full Text]  
  • Moussad, E E-D A, Rageh, M A E, Wilson, A K, Geisert, R D, Brigstock, D R (2002). Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor {beta} type 1 (TGF-{beta}1) at the utero-placental interface during early pregnancy in the pig. Mol. Pathol. 55: 186-192 [Abstract] [Full Text]  
  • Schober, J. M., Chen, N., Grzeszkiewicz, T. M., Jovanovic, I., Emeson, E. E., Ugarova, T. P., Ye, R. D., Lau, L. F., Lam, S. C.-T. (2002). Identification of integrin alpha Mbeta 2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99: 4457-4465 [Abstract] [Full Text]  
  • Kondo, S., Kubota, S., Shimo, T., Nishida, T., Yosimichi, G., Eguchi, T., Sugahara, T., Takigawa, M. (2002). Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. Carcinogenesis 23: 769-776 [Abstract] [Full Text]  
  • Yokoi, H., Mukoyama, M., Sugawara, A., Mori, K., Nagae, T., Makino, H., Suganami, T., Yahata, K., Fujinaga, Y., Tanaka, I., Nakao, K. (2002). Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am. J. Physiol. Renal Physiol. 282: F933-F942 [Abstract] [Full Text]  
  • Twigg, S. M., Joly, A. H., Chen, M. M., Tsubaki, J., Kim, H.-S., Hwa, V., Oh, Y., Rosenfeld, R. G. (2002). Connective Tissue Growth Factor/IGF-Binding Protein-Related Protein-2 Is a Mediator in the Induction of Fibronectin by Advanced Glycosylation End-Products in Human Dermal Fibroblasts. Endocrinology 143: 1260-1269 [Abstract] [Full Text]  
  • Su, F., Overholtzer, M., Besser, D., Levine, A. J. (2002). WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 16: 46-57 [Abstract] [Full Text]  
  • Chen, C.-C., Mo, F.-E, Lau, L. F. (2001). The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts. J. Biol. Chem. 276: 47329-47337 [Abstract] [Full Text]  
  • Xie, D., Nakachi, K., Wang, H., Elashoff, R., Koeffler, H. P. (2001). Elevated Levels of Connective Tissue Growth Factor, WISP-1, and CYR61 in Primary Breast Cancers Associated with More Advanced Features. Cancer Res. 61: 8917-8923 [Abstract] [Full Text]  
  • Folger, P. A., Zekaria, D., Grotendorst, G., Masur, S. K. (2001). Transforming Growth Factor-{beta}-Stimulated Connective Tissue Growth Factor Expression during Corneal Myofibroblast Differentiation. IOVS 42: 2534-2541 [Abstract] [Full Text]  
  • Gupta, N, Wang, H, McLeod, T L, Naus, C C G, Kyurkchiev, S, Advani, S, Yu, J, Perbal, B, Weichselbaum, R R (2001). Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Mol. Pathol. 54: 293-299 [Abstract] [Full Text]  
  • Blom, I. E., van Dijk, A. J., Wieten, L., Duran, K., Ito, Y., Kleij, L., deNichilo, M., Rabelink, T. J., Weening, J. J., Aten, J., Goldschmeding, R. (2001). In vitro evidence for differential involvement of CTGF, TGF{beta}, and PDGF-BB in mesangial response to injury. Nephrol Dial Transplant 16: 1139-1148 [Abstract] [Full Text]  
  • de Veer, M. J., Holko, M., Frevel, M., Walker, E., Der, S., Paranjape, J. M., Silverman, R. H., Williams, B. R. G. (2001). Functional classification of interferon-stimulated genes identified using microarrays. J. Leukoc. Biol. 69: 912-920 [Abstract] [Full Text]  
  • Twigg, S. M., Chen, M. M., Joly, A. H., Chakrapani, S. D., Tsubaki, J., Kim, H.-S., Oh, Y., Rosenfeld, R. G. (2001). Advanced Glycosylation End Products Up-Regulate Connective Tissue Growth Factor (Insulin-Like Growth Factor-Binding Protein-Related Protein 2) in Human Fibroblasts: A Potential Mechanism for Expansion of Extracellular Matrix in Diabetes Mellitus. Endocrinology 142: 1760-1769 [Abstract] [Full Text]  
  • Perbal, B (2001). NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol. Pathol. 54: 57-79 [Abstract] [Full Text]  
  • Slee, R. B., Hillier, S. G., Largue, P., Harlow, C. R., Miele, G., Clinton, M. (2001). Differentiation-Dependent Expression of Connective Tissue Growth Factor and Lysyl Oxidase Messenger Ribonucleic Acids in Rat Granulosa Cells. Endocrinology 142: 1082-1089 [Abstract] [Full Text]  
  • Grotendorst, G. R., Lau, L. F., Perbal, B. (2001). CCN Proteins Are Distinct from, and Should Not Be Considered Members of, the Insulin-Like Growth Factor-Binding Protein Superfamily. J. Clin. Endocrinol. Metab. 86: 944-945 [Full Text]  
  • Gonzales, M., Weksler, B., Tsuruta, D., Goldman, R. D., Yoon, K. J., Hopkinson, S. B., Flitney, F. W., Jones, J. C. R. (2001). Structure and Function of a Vimentin-associated Matrix Adhesion in Endothelial Cells. Mol. Biol. Cell 12: 85-100 [Abstract] [Full Text]  
  • Uzumcu, M., Homsi, M.F.A., Ball, D.K., Coskun, S., Jaroudi, K., Hollanders, J.M.G., Brigstock, D.R. (2000). Localization of connective tissue growth factor in human uterine tissues. Mol Hum Reprod 6: 1093-1098 [Abstract] [Full Text]  
  • Pereira, R. C., Durant, D., Canalis, E. (2000). Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. Am. J. Physiol. Endocrinol. Metab. 279: E570-E576 [Abstract] [Full Text]  
  • Ellis, P. D., Chen, Q., Barker, P. J., Metcalfe, J. C., Kemp, P. R. (2000). Nov Gene Encodes Adhesion Factor for Vascular Smooth Muscle Cells and Is Dynamically Regulated in Response to Vascular Injury. Arterioscler. Thromb. Vasc. Bio. 20: 1912-1919 [Abstract] [Full Text]  
  • Wandji, S.-A., Gadsby, J. E., Barber, J. A., Hammond, J. M. (2000). Messenger Ribonucleic Acids for MAC25 and Connective Tissue Growth Factor (CTGF) Are Inversely Regulated during Folliculogenesis and Early Luteogenesis. Endocrinology 141: 2648-2657 [Abstract] [Full Text]  
  • Frazier, K. S., Paredes, A., Dube, P., Styer, E. (2000). Connective Tissue Growth Factor Expression in the Rat Remnant Kidney Model and Association with Tubular Epithelial Cells Undergoing Transdifferentiation. Vet Pathol 37: 328-335 [Abstract] [Full Text]  
  • Grotendorst, G. R., Lau, L. F., Perbal, B. (2000). CCN Proteins Are Distinct from and Should Not Be Considered Members of the Insulin-Like Growth Factor-Binding Protein Superfamily. Endocrinology 141: 2254-2256 [Full Text]  
  • Goldschmeding, R., Aten, J., Ito, Y., Blom, I., Rabelink, T., Weening, J. J. (2000). Connective tissue growth factor: just another factor in renal fibrosis?. Nephrol Dial Transplant 15: 296-299 [Full Text]  
  • Xu, L., Corcoran, R. B., Welsh, J. W., Pennica, D., Levine, A. J. (2000). WISP-1 is a Wnt-1- and beta -catenin-responsive oncogene. Genes Dev. 14: 585-595 [Abstract] [Full Text]  
  • Camerer, E., Gjernes, E., Wiiger, M., Pringle, S., Prydz, H. (2000). Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression. J. Biol. Chem. 275: 6580-6585 [Abstract] [Full Text]  
  • Nakanishi, T., Nishida, T., Shimo, T., Kobayashi, K., Kubo, T., Tamatani, T., Tezuka, K., Takigawa, M. (2000). Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture. Endocrinology 141: 264-273 [Abstract] [Full Text]  
  • Hishikawa, K., Oemar, B. S., Tanner, F. C., Nakaki, T., Luscher, T. F., Fujii, T. (1999). Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7. J. Biol. Chem. 274: 37461-37466 [Abstract] [Full Text]  
  • Jedsadayanmata, A., Chen, C.-C., Kireeva, M. L., Lau, L. F., Lam, S. C.-T. (1999). Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin alpha IIbbeta 3. J. Biol. Chem. 274: 24321-24327 [Abstract] [Full Text]  
  • Chen, N., Chen, C.-C., Lau, L. F. (2000). Adhesion of Human Skin Fibroblasts to Cyr61 Is Mediated through Integrin alpha 6beta 1 and Cell Surface Heparan Sulfate Proteoglycans. J. Biol. Chem. 275: 24953-24961 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»