This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frasca, F.
Right arrow Articles by Vigneri, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frasca, F.
Right arrow Articles by Vigneri, R.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, May 1999, p. 3278-3288, Vol. 19, No. 5
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

F. Frasca,1 G. Pandini,1 P. Scalia,1 L. Sciacca,1 R. Mineo,1 A. Costantino,1 I. D. Goldfine,2 A. Belfiore,3 and R. Vigneri1,*

Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania,1 and Cattedra di Endocrinologia, University of Catanzaro, Policlinico Mater Domini, Catanzaro,3 Italy, and Division of Diabetes and Endocrine Research, University of California, San Francisco, California 941152

Received 22 September 1998/Returned for modification 25 October 1998/Accepted 25 January 1999

Insulin-like growth factor II (IGF-II) is a peptide growth factor that is homologous to both insulin-like growth factor I (IGF-I) and insulin and plays an important role in embryonic development and carcinogenesis. IGF-II is believed to mediate its cellular signaling via the transmembrane tyrosine kinase type 1 insulin-like growth factor receptor (IGF-I-R), which is also the receptor for IGF-I. Earlier studies with both cultured cells and transgenic mice, however, have suggested that in the embryo the insulin receptor (IR) may also be a receptor for IGF-II. In most cells and tissues, IR binds IGF-II with relatively low affinity. The IR is expressed in two isoforms (IR-A and IR-B) differing by 12 amino acids due to the alternative splicing of exon 11. In the present study we found that IR-A but not IR-B bound IGF-II with an affinity close to that of insulin. Moreover, IGF-II bound to IR-A with an affinity equal to that of IGF-II binding to the IGF-I-R. Activation of IR-A by insulin led primarily to metabolic effects, whereas activation of IR-A by IGF-II led primarily to mitogenic effects. These differences in the biological effects of IR-A when activated by either IGF-II or insulin were associated with differential recruitment and activation of intracellular substrates. IR-A was preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney and had a relatively increased proportion of isoform A. IR-A expression was also increased in several tumors including those of the breast and colon. These data indicate, therefore, that there are two receptors for IGF-II, both IGF-I-R and IR-A. Further, they suggest that interaction of IGF-II with IR-A may play a role both in fetal growth and cancer biology.

* Corresponding author. Mailing address: Cattedra di Endocrinologia, Ospedale Garibaldi, 95123 Catania, Italy. Phone: 39-095-32 62 90. Fax: 39-095-715 80 72. E-mail: segmeint{at}mbox.unict.it.

Molecular and Cellular Biology, May 1999, p. 3278-3288, Vol. 19, No. 5
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chisalita, S I, Johansson, G S, Liefvendahl, E, Back, K, Arnqvist, H J (2009). Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2. J Mol Endocrinol 43: 231-239 [Abstract] [Full Text]  
  • Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., Vigneri, R. (2009). Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease. Endocr. Rev. 30: 586-623 [Abstract] [Full Text]  
  • Wahner Hendrickson, A. E., Haluska, P., Schneider, P. A., Loegering, D. A., Peterson, K. L., Attar, R., Smith, B. D., Erlichman, C., Gottardis, M., Karp, J. E., Carboni, J. M., Kaufmann, S. H. (2009). Expression of Insulin Receptor Isoform A and Insulin-like Growth Factor-1 Receptor in Human Acute Myelogenous Leukemia: Effect of the Dual-Receptor Inhibitor BMS-536924 In vitro. Cancer Res. 69: 7635-7643 [Abstract] [Full Text]  
  • Rowzee, A. M., Ludwig, D. L., Wood, T. L. (2009). Insulin-Like Growth Factor Type 1 Receptor and Insulin Receptor Isoform Expression and Signaling in Mammary Epithelial Cells. Endocrinology 150: 3611-3619 [Abstract] [Full Text]  
  • Sacco, A., Morcavallo, A., Pandini, G., Vigneri, R., Belfiore, A. (2009). Differential Signaling Activation by Insulin and Insulin-Like Growth Factors I and II upon Binding to Insulin Receptor Isoform A. Endocrinology 150: 3594-3602 [Abstract] [Full Text]  
  • Cornu, M., Yang, J.-Y., Jaccard, E., Poussin, C., Widmann, C., Thorens, B. (2009). Glucagon-Like Peptide-1 Protects {beta}-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop. Diabetes 58: 1816-1825 [Abstract] [Full Text]  
  • Berlato, C., Doppler, W. (2009). Selective Response to Insulin Versus Insulin-Like Growth Factor-I and -II and Up-Regulation of Insulin Receptor Splice Variant B in the Differentiated Mouse Mammary Epithelium. Endocrinology 150: 2924-2933 [Abstract] [Full Text]  
  • Sabbatini, P., Rowand, J. L., Groy, A., Korenchuk, S., Liu, Q., Atkins, C., Dumble, M., Yang, J., Anderson, K., Wilson, B. J., Emmitte, K. A., Rabindran, S. K., Kumar, R. (2009). Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase. Clin. Cancer Res. 15: 3058-3067 [Abstract] [Full Text]  
  • Alvino, C. L., McNeil, K. A., Ong, S. C., Delaine, C., Booker, G. W., Wallace, J. C., Whittaker, J., Forbes, B. E. (2009). A Novel Approach to Identify Two Distinct Receptor Binding Surfaces of Insulin-like Growth Factor II. J. Biol. Chem. 284: 7656-7664 [Abstract] [Full Text]  
  • Avnet, S., Sciacca, L., Salerno, M., Gancitano, G., Cassarino, M. F., Longhi, A., Zakikhani, M., Carboni, J. M., Gottardis, M., Giunti, A., Pollak, M., Vigneri, R., Baldini, N. (2009). Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma. Cancer Res. 69: 2443-2452 [Abstract] [Full Text]  
  • Ganeff, C., Chatel, G., Munaut, C., Frankenne, F., Foidart, J.-M., Winkler, R. (2009). The IGF system in in-vitro human decidualization. Mol Hum Reprod 15: 27-38 [Abstract] [Full Text]  
  • Haluska, P., Carboni, J. M., TenEyck, C., Attar, R. M., Hou, X., Yu, C., Sagar, M., Wong, T. W., Gottardis, M. M., Erlichman, C. (2008). HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Molecular Cancer Therapeutics 7: 2589-2598 [Abstract] [Full Text]  
  • Piao, W., Wang, Y., Adachi, Y., Yamamoto, H., Li, R., Imsumran, A., Li, H., Maehata, T., Ii, M., Arimura, Y., Lee, C.-T., Shinomura, Y., Carbone, D. P., Imai, K. (2008). Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Molecular Cancer Therapeutics 7: 1483-1493 [Abstract] [Full Text]  
  • Masnikosa, R., Nikolic, A., Nedic, O. (2008). Affinity Modulation of Human Placental Insulin and Insulin-Like Growth Factor Receptors by Lectins. J Biochem 143: 813-820 [Abstract] [Full Text]  
  • Sachdev, D., Yee, D. (2008). Disrupting Insulin-Like Growth Factor Signaling as a Potential Cancer Therapy. aacredbook 2008: 39-58 [Abstract] [Full Text]  
  • Nevado, C., Benito, M., Valverde, A. M. (2008). Role of Insulin Receptor and Balance in Insulin Receptor Isoforms A and B in Regulation of Apoptosis in Simian Virus 40-immortalized Neonatal Hepatocytes. Mol. Biol. Cell 19: 1185-1198 [Abstract] [Full Text]  
  • Navarrete Santos, A., Ramin, N., Tonack, S., Fischer, B. (2008). Cell Lineage-Specific Signaling of Insulin and Insulin-Like Growth Factor I in Rabbit Blastocysts. Endocrinology 149: 515-524 [Abstract] [Full Text]  
  • Gauguin, L., Klaproth, B., Sajid, W., Andersen, A. S., McNeil, K. A., Forbes, B. E., De Meyts, P. (2008). Structural Basis for the Lower Affinity of the Insulin-like Growth Factors for the Insulin Receptor. J. Biol. Chem. 283: 2604-2613 [Abstract] [Full Text]  
  • Kusada, Y., Morizono, T., Matsumoto-Takasaki, A., Sakai, K., Sato, S., Asanuma, H., Takayanagi, A., Fujita-Yamaguchi, Y. (2008). Construction and Characterization of Single-chain Antibodies Against Human Insulin-like Growth Factor-I Receptor from Hybridomas Producing 1H7 or 3B7 Monoclonal Antibody. J Biochem 143: 9-19 [Abstract] [Full Text]  
  • Kaneda, A., Wang, C. J., Cheong, R., Timp, W., Onyango, P., Wen, B., Iacobuzio-Donahue, C. A., Ohlsson, R., Andraos, R., Pearson, M. A., Sharov, A. A., Longo, D. L., Ko, M. S. H., Levchenko, A., Feinberg, A. P. (2007). Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc. Natl. Acad. Sci. USA 104: 20926-20931 [Abstract] [Full Text]  
  • de Groot, J. W. B, Rikhof, B., van Doorn, J., Bilo, H. J G, Alleman, M. A, Honkoop, A. H, van der Graaf, W. T A (2007). Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases. Endocr Relat Cancer 14: 979-993 [Abstract] [Full Text]  
  • Jensen, M., Hansen, B., De Meyts, P., Schaffer, L., Urso, B. (2007). Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses. J. Biol. Chem. 282: 35179-35186 [Abstract] [Full Text]  
  • Shields, S.-K., Nicola, C., Chakraborty, C. (2007). Rho Guanosine 5'-Triphosphatases Differentially Regulate Insulin-Like Growth Factor I (IGF-I) Receptor-Dependent and -Independent Actions of IGF-II on Human Trophoblast Migration. Endocrinology 148: 4906-4917 [Abstract] [Full Text]  
  • El-Shewy, H. M., Lee, M.-H., Obeid, L. M., Jaffa, A. A., Luttrell, L. M. (2007). The Insulin-like Growth Factor Type 1 and Insulin-like Growth Factor Type 2/Mannose-6-phosphate Receptors Independently Regulate ERK1/2 Activity in HEK293 Cells. J. Biol. Chem. 282: 26150-26157 [Abstract] [Full Text]  
  • Diaz, L.E., Chuan, Y-C., Lewitt, M., Fernandez-Perez, L., Carrasco-Rodriguez, S., Sanchez-Gomez, M., Flores-Morales, A. (2007). IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Mol Hum Reprod 13: 567-576 [Abstract] [Full Text]  
  • Denley, A., Carroll, J. M., Brierley, G. V., Cosgrove, L., Wallace, J., Forbes, B., Roberts, C. T. Jr. (2007). Differential Activation of Insulin Receptor Substrates 1 and 2 by Insulin-Like Growth Factor-Activated Insulin Receptors. Mol. Cell. Biol. 27: 3569-3577 [Abstract] [Full Text]  
  • Uhles, S., Moede, T., Leibiger, B., Berggren, P.-O., Leibiger, I. B. (2007). Selective gene activation by spatial segregation of insulin receptor B signaling. FASEB J. 21: 1609-1621 [Abstract] [Full Text]  
  • Samani, A. A., Yakar, S., LeRoith, D., Brodt, P. (2007). The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights. Endocr. Rev. 28: 20-47 [Abstract] [Full Text]  
  • Sachdev, D., Yee, D. (2007). Disrupting insulin-like growth factor signaling as a potential cancer therapy. Molecular Cancer Therapeutics 6: 1-12 [Abstract] [Full Text]  
  • Zhang, H., Yee, D. (2006). Is the type I insulin-like growth factor receptor a therapeutic target in endometrial cancer?. Clin. Cancer Res. 12: 6323-6325 [Full Text]  
  • Blanquart, C., Gonzalez-Yanes, C., Issad, T. (2006). Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer. Mol. Pharmacol. 70: 1802-1811 [Abstract] [Full Text]  
  • Slaaby, R., Schaffer, L., Lautrup-Larsen, I., Andersen, A. S., Shaw, A. C., Mathiasen, I. S., Brandt, J. (2006). Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant. J. Biol. Chem. 281: 25869-25874 [Abstract] [Full Text]  
  • Veldhuis, J. D., Roemmich, J. N., Richmond, E. J., Bowers, C. Y. (2006). Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition. Endocr. Rev. 27: 101-140 [Abstract] [Full Text]  
  • Sachdev, D., Singh, R., Fujita-Yamaguchi, Y., Yee, D. (2006). Down-regulation of Insulin Receptor by Antibodies against the Type I Insulin-Like Growth Factor Receptor: Implications for Anti-Insulin-Like Growth Factor Therapy in Breast Cancer. Cancer Res. 66: 2391-2402 [Abstract] [Full Text]  
  • Lu, L., Katsaros, D., Wiley, A., Rigault de la Longrais, I. A., Risch, H. A., Puopolo, M., Yu, H. (2006). The Relationship of Insulin-Like Growth Factor-II, Insulin-Like Growth Factor Binding Protein-3, and Estrogen Receptor-{alpha} Expression to Disease Progression in Epithelial Ovarian Cancer. Clin. Cancer Res. 12: 1208-1214 [Abstract] [Full Text]  
  • Denley, A., Brierley, G. V., Carroll, J. M., Lindenberg, A., Booker, G. W., Cosgrove, L. J., Wallace, J. C., Forbes, B. E., Roberts, C. T. Jr. (2006). Differential Activation of Insulin Receptor Isoforms by Insulin-Like Growth Factors Is Determined by the C Domain. Endocrinology 147: 1029-1036 [Abstract] [Full Text]  
  • Hawkes, C., Jhamandas, J. H., Harris, K. H., Fu, W., MacDonald, R. G., Kar, S. (2006). Single Transmembrane Domain Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor Regulates Central Cholinergic Function by Activating a G-Protein-Sensitive, Protein Kinase C-Dependent Pathway. J. Neurosci. 26: 585-596 [Abstract] [Full Text]  
  • Espelund, U., Bruun, J. M., Richelsen, B., Flyvbjerg, A., Frystyk, J. (2005). Pro- and mature IGF-II during diet-induced weight loss in obese subjects. Eur J Endocrinol 153: 861-869 [Abstract] [Full Text]  
  • Russo, V. C., Gluckman, P. D., Feldman, E. L., Werther, G. A. (2005). The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain. Endocr. Rev. 26: 916-943 [Abstract] [Full Text]  
  • Miller, B. S., Yee, D. (2005). Type I Insulin-like Growth Factor Receptor as a Therapeutic Target in Cancer. Cancer Res. 65: 10123-10127 [Abstract] [Full Text]  
  • Goodwin, P. J., Ennis, M., Fantus, I. G., Pritchard, K. I., Trudeau, M. E., Koo, J., Hood, N. (2005). Is Leptin a Mediator of Adverse Prognostic Effects of Obesity in Breast Cancer?. JCO 23: 6037-6042 [Abstract] [Full Text]  
  • Hartmann, W., Koch, A., Brune, H., Waha, A., Schuller, U., Dani, I., Denkhaus, D., Langmann, W., Bode, U., Wiestler, O. D., Schilling, K., Pietsch, T. (2005). Insulin-Like Growth Factor II Is Involved in the Proliferation Control of Medulloblastoma and Its Cerebellar Precursor Cells. Am. J. Pathol. 166: 1153-1162 [Abstract] [Full Text]  
  • Pandini, G., Mineo, R., Frasca, F., Roberts, C. T. Jr., Marcelli, M., Vigneri, R., Belfiore, A. (2005). Androgens Up-regulate the Insulin-like Growth Factor-I Receptor in Prostate Cancer Cells. Cancer Res. 65: 1849-1857 [Abstract] [Full Text]  
  • Serrano, R, Villar, M, Martinez, C, Carrascosa, J M, Gallardo, N, Andres, A (2005). Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue. J Mol Endocrinol 34: 153-161 [Abstract] [Full Text]  
  • Ibrahim, Y. H., Yee, D. (2005). Insulin-Like Growth Factor-I and Breast Cancer Therapy. Clin. Cancer Res. 11: 944s-950s [Abstract] [Full Text]  
  • Venables, J. P. (2004). Aberrant and Alternative Splicing in Cancer. Cancer Res. 64: 7647-7654 [Abstract] [Full Text]  
  • Denley, A., Bonython, E. R., Booker, G. W., Cosgrove, L. J., Forbes, B. E., Ward, C. W., Wallace, J. C. (2004). Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR. Mol. Endocrinol. 18: 2502-2512 [Abstract] [Full Text]  
  • Phy, J. L., Conover, C. A., Abbott, D. H., Zschunke, M. A., Walker, D. L., Session, D. R., Tummon, I. S., Thornhill, A. R., Lesnick, T. G., Dumesic, D. A. (2004). Insulin and Messenger Ribonucleic Acid Expression of Insulin Receptor Isoforms in Ovarian Follicles from Nonhirsute Ovulatory Women and Polycystic Ovary Syndrome Patients. J. Clin. Endocrinol. Metab. 89: 3561-3566 [Abstract] [Full Text]  
  • Watson, R. T., Kanzaki, M., Pessin, J. E. (2004). Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes. Endocr. Rev. 25: 177-204 [Abstract] [Full Text]  
  • NANDI, A., KITAMURA, Y., KAHN, C. R., ACCILI, D. (2004). Mouse Models of Insulin Resistance. Physiol. Rev. 84: 623-647 [Abstract] [Full Text]  
  • Bloomgarden, Z. T. (2004). Definitions of the Insulin Resistance Syndrome: The 1st World Congress on the Insulin Resistance Syndrome. Diabetes Care 27: 824-830 [Full Text]  
  • White, M. F. (2003). Insulin Signaling in Health and Disease. Science 302: 1710-1711 [Abstract] [Full Text]  
  • Pandini, G., Medico, E., Conte, E., Sciacca, L., Vigneri, R., Belfiore, A. (2003). Differential Gene Expression Induced by Insulin and Insulin-like Growth Factor-II through the Insulin Receptor Isoform A. J. Biol. Chem. 278: 42178-42189 [Abstract] [Full Text]  
  • Reiter, C. E. N., Sandirasegarane, L., Wolpert, E. B., Klinger, M., Simpson, I. A., Barber, A. J., Antonetti, D. A., Kester, M., Gardner, T. W. (2003). Characterization of insulin signaling in rat retina in vivo and ex vivo. Am. J. Physiol. Endocrinol. Metab. 285: E763-E774 [Abstract] [Full Text]  
  • Entingh, A. J., Taniguchi, C. M., Kahn, C. R. (2003). Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor. J. Biol. Chem. 278: 33377-33383 [Abstract] [Full Text]  
  • Okamoto, H., Accili, D. (2003). In Vivo Mutagenesis of the Insulin Receptor. J. Biol. Chem. 278: 28359-28362 [Abstract] [Full Text]  
  • Sciacca, L., Prisco, M., Wu, A., Belfiore, A., Vigneri, R., Baserga, R. (2003). Signaling Differences from the A and B Isoforms of the Insulin Receptor (IR) in 32D Cells in the Presence or Absence of IR Substrate-1. Endocrinology 144: 2650-2658 [Abstract] [Full Text]  
  • Hovey, R. C., Harris, J., Hadsell, D. L., Lee, A. V., Ormandy, C. J., Vonderhaar, B. K. (2003). Local Insulin-Like Growth Factor-II Mediates Prolactin-Induced Mammary Gland Development. Mol. Endocrinol. 17: 460-471 [Abstract] [Full Text]  
  • Hassan, A. B. (2003). Keys to the Hidden Treasures of the Mannose 6-Phosphate/Insulin-Like Growth Factor 2 Receptor. Am. J. Pathol. 162: 3-6 [Full Text]  
  • Firth, S. M., Baxter, R. C. (2002). Cellular Actions of the Insulin-Like Growth Factor Binding Proteins. Endocr. Rev. 23: 824-854 [Abstract] [Full Text]  
  • Whittaker, J., Sorensen, H., Gadsboll, V. L., Hinrichsen, J. (2002). Comparison of the Functional Insulin Binding Epitopes of the A and B Isoforms of the Insulin Receptor. J. Biol. Chem. 277: 47380-47384 [Abstract] [Full Text]  
  • Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., Belfiore, A. (2002). Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved. J. Biol. Chem. 277: 39684-39695 [Abstract] [Full Text]  
  • Kido, Y., Nakae, J., Hribal, M. L., Xuan, S., Efstratiadis, A., Accili, D. (2002). Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J. Biol. Chem. 277: 36740-36747 [Abstract] [Full Text]  
  • Kalli, K. R., Falowo, O. I., Bale, L. K., Zschunke, M. A., Roche, P. C., Conover, C. A. (2002). Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling. Endocrinology 143: 3259-3267 [Abstract] [Full Text]  
  • White, M. F. (2002). IRS proteins and the common path to diabetes. Am. J. Physiol. Endocrinol. Metab. 283: E413-E422 [Abstract] [Full Text]  
  • Duvillie, B., Currie, C., Chrones, T., Bucchini, D., Jami, J., Joshi, R. L., Hill, D. J. (2002). Increased Islet Cell Proliferation, Decreased Apoptosis, and Greater Vascularization Leading to {beta}-Cell Hyperplasia in Mutant Mice Lacking Insulin. Endocrinology 143: 1530-1537 [Abstract] [Full Text]  
  • Hassan, A. B., Macaulay, V. M. (2002). The insulin-like growth factor system as a therapeutic target in colorectal cancer. Ann Oncol 13: 349-356 [Abstract] [Full Text]  
  • Eichhorn, J., Kayali, A. G., Resor, L., Austin, D. A., Rose, D. W., Webster, N. J. G. (2002). PLC-{gamma}1 Enzyme Activity Is Required for Insulin-Induced DNA Synthesis. Endocrinology 143: 655-664 [Abstract] [Full Text]  
  • Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M. E., Koo, J., Madarnas, Y., Hartwick, W., Hoffman, B., Hood, N. (2002). Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study. JCO 20: 42-51 [Abstract] [Full Text]  
  • Vella, V., Pandini, G., Sciacca, L., Mineo, R., Vigneri, R., Pezzino, V., Belfiore, A. (2002). A Novel Autocrine Loop Involving IGF-II and the Insulin Receptor Isoform-A Stimulates Growth of Thyroid Cancer. J. Clin. Endocrinol. Metab. 87: 245-254 [Abstract] [Full Text]  
  • Nakae, J., Kido, Y., Accili, D. (2001). Distinct and Overlapping Functions of Insulin and IGF-I Receptors. Endocr. Rev. 22: 818-835 [Abstract] [Full Text]  
  • Whittaker, J., Groth, A. V., Mynarcik, D. C., Pluzek, L., Gadsboll, V. L., Whittaker, L. J. (2001). Alanine Scanning Mutagenesis of a Type 1 Insulin-like Growth Factor Receptor Ligand Binding Site. J. Biol. Chem. 276: 43980-43986 [Abstract] [Full Text]  
  • Suryawan, A., Nguyen, H. V., Bush, J. A., Davis, T. A. (2001). Developmental changes in the feeding-induced activation of the insulin-signaling pathway in neonatal pigs. Am. J. Physiol. Endocrinol. Metab. 281: E908-E915 [Abstract] [Full Text]  
  • Kim, J. J., Park, B.-C., Kido, Y., Accili, D. (2001). Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes. Endocrinology 142: 3354-3360 [Abstract] [Full Text]  
  • Vella, V, Sciacca, L, Pandini, G, Mineo, R, Squatrito, S, Vigneri, R, Belfiore, A (2001). The IGF system in thyroid cancer: new concepts. Mol. Pathol. 54: 121-124 [Abstract] [Full Text]  
  • Butler, A. A., LeRoith, D. (2001). Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology. Endocrinology 142: 1685-1688 [Abstract] [Full Text]  
  • Lou, H., Gagel, R. F. (2001). Alternative Ribonucleic Acid Processing in Endocrine Systems. Endocr. Rev. 22: 205-225 [Abstract] [Full Text]  
  • Nakamura, T., Kishi, A., Nishio, Y., Maegawa, H., Egawa, K., Wong, N. C. W., Kojima, H., Fujimiya, M., Arai, R., Kashiwagi, A., Kikkawa, R. (2001). Insulin Production in a Neuroectodermal Tumor that Expresses Islet Factor-1, But Not Pancreatic-Duodenal Homeobox 1. J. Clin. Endocrinol. Metab. 86: 1795-1800 [Abstract] [Full Text]  
  • Costanzo, B. V., Trischitta, V., Di Paola, R., Spampinato, D., Pizzuti, A., Vigneri, R., Frittitta, L. (2001). The Q Allele Variant (GLN121) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS121). Diabetes 50: 831-836 [Abstract] [Full Text]  
  • Kido, Y., Nakae, J., Accili, D. (2001). The Insulin Receptor and Its Cellular Targets. J. Clin. Endocrinol. Metab. 86: 972-979 [Abstract] [Full Text]  
  • Mendez, E., Planas, J. V., Castillo, J., Navarro, I., Gutierrez, J. (2001). Identification of a Type II Insulin-Like Growth Factor Receptor in Fish Embryos. Endocrinology 142: 1090-1097 [Abstract] [Full Text]  
  • Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., Butler, A. (2001). The Somatomedin Hypothesis: 2001. Endocr. Rev. 22: 53-74 [Abstract] [Full Text]  
  • Louhio, H., Hovatta, O., Sjoberg, J., Tuuri, T. (2000). The effects of insulin, and insulin-like growth factors I and II on human ovarian follicles in long-term culture. Mol Hum Reprod 6: 694-698 [Abstract] [Full Text]  
  • Baxter, R. C. (2000). Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am. J. Physiol. Endocrinol. Metab. 278: E967-E976 [Abstract] [Full Text]  
  • Bayes-Genis, A., Conover, C. A., Schwartz, R. S. (2000). The Insulin-Like Growth Factor Axis : A Review of Atherosclerosis and Restenosis. Circ. Res. 86: 125-130 [Abstract] [Full Text]  
  • LeRoith, D. (1999). Insulin-like Growth Factors in Pediatric Health and Disease. J. Clin. Endocrinol. Metab. 84: 4355-4361 [Full Text]  
  • Miele, C., Rochford, J. J., Filippa, N., Giorgetti-Peraldi, S., Van Obberghen, E. (2000). Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways. J. Biol. Chem. 275: 21695-21702 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»