This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kishida, S.
Right arrow Articles by Kikuchi, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kishida, S.
Right arrow Articles by Kikuchi, A.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, June 1999, p. 4414-4422, Vol. 19, No. 6
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate beta -Catenin Stability

Shosei Kishida,1,2 Hideki Yamamoto,1 Shin-ichiro Hino,1 Satoshi Ikeda,1 Michiko Kishida,1 and Akira Kikuchi1,*

Department of Biochemistry, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551,1 and PRESTO, Japan Science and Technology Corporation, Hiroshima,2 Japan

Received 28 December 1998/Returned for modification 4 February 1999/Accepted 3 March 1999

The N-terminal region of Dvl-1 (a mammalian Dishevelled homolog) shares 37% identity with the C-terminal region of Axin, and this related region is named the DIX domain. The functions of the DIX domains of Dvl-1 and Axin were investigated. By yeast two-hybrid screening, the DIX domain of Dvl-1 was found to interact with Dvl-3, a second mammalian Dishevelled relative. The DIX domains of Dvl-1 and Dvl-3 directly bound one another. Furthermore, Dvl-1 formed a homo-oligomer. Axin also formed a homo-oligomer, and its DIX domain was necessary. The N-terminal region of Dvl-1, including its DIX domain, bound to Axin directly. Dvl-1 inhibited Axin-promoted glycogen synthase kinase 3beta -dependent phosphorylation of beta -catenin, and the DIX domain of Dvl-1 was required for this inhibitory activity. Expression of Dvl-1 in L cells induced the nuclear accumulation of beta -catenin, and deletion of the DIX domain abolished this activity. Although expression of Axin in SW480 cells caused the degradation of beta -catenin and reduced the cell growth rate, expression of an Axin mutant that lacks the DIX domain did not affect the level of beta -catenin or the growth rate. These results indicate that the DIX domains of Dvl-1 and Axin are important for protein-protein interactions and that they are necessary for the ability of Dvl-1 and Axin to regulate the stability of beta -catenin.

* Corresponding author. Mailing address: Department of Biochemistry, Hiroshima University School of Medicine, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Phone: 81-82-257-5130. Fax: 81-82-257-5134. E-mail: akikuchi{at}mcai.med.hiroshima-u.ac.jp.

Molecular and Cellular Biology, June 1999, p. 4414-4422, Vol. 19, No. 6
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chia, I. V., Kim, M. J., Itoh, K., Sokol, S. Y., Costantini, F. (2009). Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis. Genetics 181: 1359-1368 [Abstract] [Full Text]  
  • Kim, M. J., Chia, I. V., Costantini, F. (2008). SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. FASEB J. 22: 3785-3794 [Abstract] [Full Text]  
  • Carmon, K. S., Loose, D. S. (2008). Secreted Frizzled-Related Protein 4 Regulates Two Wnt7a Signaling Pathways and Inhibits Proliferation in Endometrial Cancer Cells. Mol Cancer Res 6: 1017-1028 [Abstract] [Full Text]  
  • Lu, Z., Liu, W., Huang, H., He, Y., Han, Y., Rui, Y., Wang, Y., Li, Q., Ruan, K., Ye, Z., Low, B. C., Meng, A., Lin, S.-C. (2008). Protein Encoded by the AxinFu Allele Effectively Down-regulates Wnt Signaling but Exerts a Dominant Negative Effect on c-Jun N-terminal Kinase Signaling. J. Biol. Chem. 283: 13132-13139 [Abstract] [Full Text]  
  • Hayward, P., Kalmar, T., Martinez Arias, A. (2008). Wnt/Notch signalling and information processing during development. Development 135: 411-424 [Abstract] [Full Text]  
  • Bikkavilli, R. K., Feigin, M. E., Malbon, C. C. (2008). G{alpha}o mediates WNT-JNK signaling through Dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J. Cell Sci. 121: 234-245 [Abstract] [Full Text]  
  • Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., Wynshaw-Boris, A., Hsieh, J.-C., He, X. (2008). Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development 135: 367-375 [Abstract] [Full Text]  
  • Eisinger, A. L., Nadauld, L. D., Shelton, D. N., Prescott, S. M., Stafforini, D. M., Jones, D. A. (2007). Retinoic Acid Inhibits beta-Catenin through Suppression of Cox-2: A ROLE FOR TRUNCATED ADENOMATOUS POLYPOSIS COLI. J. Biol. Chem. 282: 29394-29400 [Abstract] [Full Text]  
  • Schlessinger, K., McManus, E. J., Hall, A. (2007). Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. JCB 178: 355-361 [Abstract] [Full Text]  
  • Schwarz-Romond, T., Metcalfe, C., Bienz, M. (2007). Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell Sci. 120: 2402-2412 [Abstract] [Full Text]  
  • Bilic, J., Huang, Y.-L., Davidson, G., Zimmermann, T., Cruciat, C.-M., Bienz, M., Niehrs, C. (2007). Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation. Science 316: 1619-1622 [Abstract] [Full Text]  
  • Guo, Z., Dose, M., Kovalovsky, D., Chang, R., O'Neil, J., Look, A. T., von Boehmer, H., Khazaie, K., Gounari, F. (2007). {beta}-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood 109: 5463-5472 [Abstract] [Full Text]  
  • Bryja, V., Gradl, D., Schambony, A., Arenas, E., Schulte, G. (2007). beta-Arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proc. Natl. Acad. Sci. USA 104: 6690-6695 [Abstract] [Full Text]  
  • Kishida, S., Hamao, K., Inoue, M., Hasegawa, M., Matsuura, Y., Mikoshiba, K., Fukuda, M., Kikuchi, A. (2007). Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.. GENES CELLS 12: 49-61 [Abstract] [Full Text]  
  • Kim, S., Xu, X., Hecht, A., Boyer, T. G. (2006). Mediator Is a Transducer of Wnt/beta-Catenin Signaling. J. Biol. Chem. 281: 14066-14075 [Abstract] [Full Text]  
  • Kobayashi, T., Hino, S.-i., Oue, N., Asahara, T., Zollo, M., Yasui, W., Kikuchi, A. (2006). Glycogen Synthase Kinase 3 and h-prune Regulate Cell Migration by Modulating Focal Adhesions. Mol. Cell. Biol. 26: 898-911 [Abstract] [Full Text]  
  • Lu, D., Cottam, H. B., Corr, M., Carson, D. A. (2005). Repression of {beta}-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc. Natl. Acad. Sci. USA 102: 18567-18571 [Abstract] [Full Text]  
  • Smalley, M. J., Signoret, N., Robertson, D., Tilley, A., Hann, A., Ewan, K., Ding, Y., Paterson, H., Dale, T. C. (2005). Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. J. Cell Sci. 118: 5279-5289 [Abstract] [Full Text]  
  • Schwarz-Romond, T., Merrifield, C., Nichols, B. J., Bienz, M. (2005). The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J. Cell Sci. 118: 5269-5277 [Abstract] [Full Text]  
  • Hino, S.-i., Tanji, C., Nakayama, K. I., Kikuchi, A. (2005). Phosphorylation of {beta}-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes {beta}-Catenin through Inhibition of Its Ubiquitination. Mol. Cell. Biol. 25: 9063-9072 [Abstract] [Full Text]  
  • Wallingford, J. B., Habas, R. (2005). The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity. Development 132: 4421-4436 [Abstract] [Full Text]  
  • Xu, X.-M., Zhou, Y.-Q., Wang, M.-H. (2005). Mechanisms of Cytoplasmic {beta}-Catenin Accumulation and Its Involvement in Tumorigenic Activities Mediated by Oncogenic Splicing Variant of the Receptor Originated from Nantes Tyrosine Kinase. J. Biol. Chem. 280: 25087-25094 [Abstract] [Full Text]  
  • Chia, I. V., Costantini, F. (2005). Mouse Axin and Axin2/Conductin Proteins Are Functionally Equivalent In Vivo. Mol. Cell. Biol. 25: 4371-4376 [Abstract] [Full Text]  
  • Ihara, M., Yamamoto, H., Kikuchi, A. (2005). SUMO-1 Modification of PIASy, an E3 Ligase, Is Necessary for PIASy-Dependent Activation of Tcf-4. Mol. Cell. Biol. 25: 3506-3518 [Abstract] [Full Text]  
  • Salahshor, S, Woodgett, J R (2005). The links between axin and carcinogenesis. J. Clin. Pathol. 58: 225-236 [Abstract] [Full Text]  
  • Luo, W., Zou, H., Jin, L., Lin, S., Li, Q., Ye, Z., Rui, H., Lin, S.-C. (2005). Axin Contains Three Separable Domains That Confer Intramolecular, Homodimeric, and Heterodimeric Interactions Involved in Distinct Functions. J. Biol. Chem. 280: 5054-5060 [Abstract] [Full Text]  
  • Creyghton, M. P., Roel, G., Eichhorn, P. J.A., Hijmans, E. M., Maurer, I., Destree, O., Bernards, R. (2005). PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev. 19: 376-386 [Abstract] [Full Text]  
  • Fearnhead, N. S., Wilding, J. L., Winney, B., Tonks, S., Bartlett, S., Bicknell, D. C., Tomlinson, I. P. M., Mortensen, N. J. McC., Bodmer, W. F. (2004). Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. Proc. Natl. Acad. Sci. USA 101: 15992-15997 [Abstract] [Full Text]  
  • Hikasa, H., Sokol, S. Y. (2004). The involvement of Frodo in TCF-dependent signaling and neural tissue development. Development 131: 4725-4734 [Abstract] [Full Text]  
  • Wong, C. K., Luo, W., Deng, Y., Zou, H., Ye, Z., Lin, S.-C. (2004). The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms. J. Biol. Chem. 279: 39366-39373 [Abstract] [Full Text]  
  • Yukita, A., Michiue, T., Fukui, A., Sakurai, K., Yamamoto, H., Ihara, M., Kikuchi, A., Asashima, M. (2004). XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/{beta}-catenin signalling. GENES CELLS 9: 723-736 [Abstract] [Full Text]  
  • Weitzel, H. E., Illies, M. R., Byrum, C. A., Xu, R., Wikramanayake, A. H., Ettensohn, C. A. (2004). Differential stability of {beta}-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled. Development 131: 2947-2956 [Abstract] [Full Text]  
  • Papadopoulou, D., Bianchi, M. W., Bourouis, M. (2004). Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster. Mol. Cell. Biol. 24: 4909-4919 [Abstract] [Full Text]  
  • Kishida, S., Yamamoto, H., Kikuchi, A. (2004). Wnt-3a and Dvl Induce Neurite Retraction by Activating Rho-Associated Kinase. Mol. Cell. Biol. 24: 4487-4501 [Abstract] [Full Text]  
  • He, X., Semenov, M., Tamai, K., Zeng, X. (2004). LDL receptor-related proteins 5 and 6 in Wnt/{beta}-catenin signaling: Arrows point the way. Development 131: 1663-1677 [Abstract] [Full Text]  
  • Cong, F., Varmus, H. (2004). Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of {beta}-catenin. Proc. Natl. Acad. Sci. USA 101: 2882-2887 [Abstract] [Full Text]  
  • Wiechens, N., Heinle, K., Englmeier, L., Schohl, A., Fagotto, F. (2004). Nucleo-cytoplasmic Shuttling of Axin, a Negative Regulator of the Wnt-{beta}-Catenin Pathway. J. Biol. Chem. 279: 5263-5267 [Abstract] [Full Text]  
  • Cobas, M., Wilson, A., Ernst, B., Mancini, S. J.C., MacDonald, H. R., Kemler, R., Radtke, F. (2004). {beta}-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis. JEM 199: 221-229 [Abstract] [Full Text]  
  • Feng, Y., Lee, N., Fearon, E. R. (2003). TIP49 Regulates {beta}-Catenin-Mediated Neoplastic Transformation and T-Cell Factor Target Gene Induction via Effects on Chromatin Remodeling. Cancer Res. 63: 8726-8734 [Abstract] [Full Text]  
  • Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kuhl, M., Moon, R. T. (2003). Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. JCB 161: 769-777 [Abstract] [Full Text]  
  • Hino, S.-i., Michiue, T., Asashima, M., Kikuchi, A. (2003). Casein Kinase Iepsilon Enhances the Binding of Dvl-1 to Frat-1 and Is Essential for Wnt-3a-induced Accumulation of beta -Catenin. J. Biol. Chem. 278: 14066-14073 [Abstract] [Full Text]  
  • Lyu, J., Costantini, F., Jho, E.-h., Joo, C.-k. (2003). Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells. J. Biol. Chem. 278: 13487-13495 [Abstract] [Full Text]  
  • Hamblet, N. S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K. R., Sussman, D. J., Wynshaw-Boris, A. (2003). Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129: 5827-5838 [Abstract] [Full Text]  
  • Tanji, C., Yamamoto, H., Yorioka, N., Kohno, N., Kikuchi, K., Kikuchi, A. (2002). A-Kinase Anchoring Protein AKAP220 Binds to Glycogen Synthase Kinase-3beta (GSK-3beta ) and Mediates Protein Kinase A-dependent Inhibition of GSK-3beta. J. Biol. Chem. 277: 36955-36961 [Abstract] [Full Text]  
  • Karasawa, T., Yokokura, H., Kitajewski, J., Lombroso, P. J. (2002). Frizzled-9 Is Activated by Wnt-2 and Functions in Wnt/beta -Catenin Signaling. J. Biol. Chem. 277: 37479-37486 [Abstract] [Full Text]  
  • Kusano, S., Raab-Traub, N. (2002). I-mfa Domain Proteins Interact with Axin and Affect Its Regulation of the Wnt and c-Jun N-Terminal Kinase Signaling Pathways. Mol. Cell. Biol. 22: 6393-6405 [Abstract] [Full Text]  
  • Hanai, J.-i., Gloy, J., Karumanchi, S. A., Kale, S., Tang, J., Hu, G., Chan, B., Ramchandran, R., Jha, V., Sukhatme, V. P., Sokol, S. (2002). Endostatin is a potential inhibitor of Wnt signaling. JCB 158: 529-539 [Abstract] [Full Text]  
  • Chung, E. J., Hwang, S.-G., Nguyen, P., Lee, S., Kim, J.-S., Kim, J. W., Henkart, P. A., Bottaro, D. P., Soon, L., Bonvini, P., Lee, S.-J., Karp, J. E., Oh, H. J., Rubin, J. S., Trepel, J. B. (2002). Regulation of leukemic cell adhesion, proliferation, and survival by beta -catenin. Blood 100: 982-990 [Abstract] [Full Text]  
  • Anderson, C. B., Neufeld, K. L., White, R. L. (2002). Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. USA 99: 8683-8688 [Abstract] [Full Text]  
  • Kadoya, T., Yamamoto, H., Suzuki, T., Yukita, A., Fukui, A., Michiue, T., Asahara, T., Tanaka, K., Asashima, M., Kikuchi, A. (2002). Desumoylation Activity of Axam, a Novel Axin-Binding Protein, Is Involved in Downregulation of {beta}-Catenin. Mol. Cell. Biol. 22: 3803-3819 [Abstract] [Full Text]  
  • Penton, A., Wodarz, A., Nusse, R. (2002). A Mutational Analysis of dishevelled in Drosophila Defines Novel Domains in the Dishevelled Protein as Well as Novel Suppressing Alleles of axin. Genetics 161: 747-762 [Abstract] [Full Text]  
  • Korswagen, H. C., Coudreuse, D. Y.M., Betist, M. C., van de Water, S., Zivkovic, D., Clevers, H. C. (2002). The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 16: 1291-1302 [Abstract] [Full Text]  
  • Zhang, Y., Qiu, W.-J., Chan, S. C., Han, J., He, X., Lin, S.-C. (2002). Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways. J. Biol. Chem. 277: 17706-17712 [Abstract] [Full Text]  
  • Ferkey, D. M., Kimelman, D. (2002). Glycogen Synthase Kinase-3beta Mutagenesis Identifies a Common Binding Domain for GBP and Axin. J. Biol. Chem. 277: 16147-16152 [Abstract] [Full Text]  
  • Amit, S., Hatzubai, A., Birman, Y., Andersen, J. S., Ben-Shushan, E., Mann, M., Ben-Neriah, Y., Alkalay, I. (2002). Axin-mediated CKI phosphorylation of beta -catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16: 1066-1076 [Abstract] [Full Text]  
  • Jho, E.-h., Zhang, T., Domon, C., Joo, C.-K., Freund, J.-N., Costantini, F. (2002). Wnt/{beta}-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway. Mol. Cell. Biol. 22: 1172-1183 [Abstract] [Full Text]  
  • Kobayashi, M., Kishida, S., Fukui, A., Michiue, T., Miyamoto, Y., Okamoto, T., Yoneda, Y., Asashima, M., Kikuchi, A. (2002). Nuclear Localization of Duplin, a beta -Catenin-binding Protein, Is Essential for Its Inhibitory Activity on the Wnt Signaling Pathway. J. Biol. Chem. 277: 5816-5822 [Abstract] [Full Text]  
  • Chong, J. M., Uren, A., Rubin, J. S., Speicher, D. W. (2002). Disulfide Bond Assignments of Secreted Frizzled-related Protein-1 Provide Insights about Frizzled Homology and Netrin Modules. J. Biol. Chem. 277: 5134-5144 [Abstract] [Full Text]  
  • Killick, R., Pollard, C. C., Asuni, A. A., Mudher, A. K., Richardson, J. C., Rupniak, H. T., Sheppard, P. W., Varndell, I. M., Brion, J.-P., Levey, A. I., Levy, O. A., Vestling, M., Cowburn, R., Lovestone, S., Anderton, B. H. (2001). Presenilin 1 Independently Regulates beta -Catenin Stability and Transcriptional Activity. J. Biol. Chem. 276: 48554-48561 [Abstract] [Full Text]  
  • Chen, W., Hu, L. A., Semenov, M. V., Yanagawa, S., Kikuchi, A., Lefkowitz, R. J., Miller, W. E. (2001). beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. USA 10.1073/pnas.211572798v1 [Abstract] [Full Text]  
  • Rubinfeld, B., Tice, D. A., Polakis, P. (2001). Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1epsilon. J. Biol. Chem. 276: 39037-39045 [Abstract] [Full Text]  
  • Dahmen, R. P., Koch, A., Denkhaus, D., Tonn, J. C., Sorensen, N., Berthold, F., Behrens, J., Birchmeier, W., Wiestler, O. D., Pietsch, T. (2001). Deletions of AXIN1, a Component of the WNT/wingless Pathway, in Sporadic Medulloblastomas. Cancer Res. 61: 7039-7043 [Abstract] [Full Text]  
  • Furuhashi, M., Yagi, K., Yamamoto, H., Furukawa, Y., Shimada, S., Nakamura, Y., Kikuchi, A., Miyazono, K., Kato, M. (2001). Axin Facilitates Smad3 Activation in the Transforming Growth Factor {beta} Signaling Pathway. Mol. Cell. Biol. 21: 5132-5141 [Abstract] [Full Text]  
  • Heisenberg, C.-P., Houart, C., Take-uchi, M., Rauch, G.-J., Young, N., Coutinho, P., Masai, I., Caneparo, L., Concha, M. L., Geisler, R., Dale, T. C., Wilson, S. W., Stemple, D. L. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes Dev. 15: 1427-1434 [Abstract] [Full Text]  
  • Fearnhead, N. S., Britton, M. P., Bodmer, W. F. (2001). The ABC of APC. Hum Mol Genet 10: 721-733 [Abstract] [Full Text]  
  • Reinacher-Schick, A., Gumbiner, B. M. (2001). Apical Membrane Localization of the Adenomatous Polyposis Coli Tumor Suppressor Protein and Subcellular Distribution of the {beta}-Catenin Destruction Complex in Polarized Epithelial Cells. JCB 152: 491-502 [Abstract] [Full Text]  
  • Herman, M (2001). C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity. Development 128: 581-590 [Abstract]  
  • Hino, S.-i., Kishida, S., Michiue, T., Fukui, A., Sakamoto, I., Takada, S., Asashima, M., Kikuchi, A. (2001). Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein. Mol. Cell. Biol. 21: 330-342 [Abstract] [Full Text]  
  • Polakis, P. (2000). Wnt signaling and cancer. Genes Dev. 14: 1837-1851 [Full Text]  
  • Tada, M., Smith, J. C. (2000). Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127: 2227-2238 [Abstract]  
  • Itoh, K., Antipova, A., Ratcliffe, M. J., Sokol, S. (2000). Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction. Mol. Cell. Biol. 20: 2228-2238 [Abstract] [Full Text]  
  • Farr, G. H. , III, Ferkey, D. M., Yost, C., Pierce, S. B., Weaver, C., Kimelman, D. (2000). Interaction among GSK-3, GBP, Axin, and APC in Xenopus Axis Specification. JCB 148: 691-702 [Abstract] [Full Text]  
  • Strovel, E. T., Wu, D., Sussman, D. J. (2000). Protein Phosphatase 2Calpha Dephosphorylates Axin and Activates LEF-1-dependent Transcription. J. Biol. Chem. 275: 2399-2403 [Abstract] [Full Text]  
  • Zhurinsky, J, Shtutman, M, Ben-Ze'ev, A (2000). Plakoglobin and beta-catenin: protein interactions, regulation and biological roles. J. Cell Sci. 113: 3127-3139 [Abstract]  
  • Zhang, Y., Neo, S. Y., Wang, X., Han, J., Lin, S.-C. (1999). Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling. J. Biol. Chem. 274: 35247-35254 [Abstract] [Full Text]  
  • Kodama, S., Ikeda, S., Asahara, T., Kishida, M., Kikuchi, A. (1999). Axin Directly Interacts with Plakoglobin and Regulates Its Stability. J. Biol. Chem. 274: 27682-27688 [Abstract] [Full Text]  
  • McCartney, B. M., Dierick, H. A., Kirkpatrick, C., Moline, M. M., Baas, A., Peifer, M., Bejsovec, A. (1999). Drosophila APC2 Is a Cytoskeletally-associated Protein that Regulates Wingless Signaling in the Embryonic Epidermis. JCB 146: 1303-1318 [Abstract] [Full Text]  
  • Ratcliffe, M. J., Itoh, K., Sokol, S. Y. (2000). A Positive Role for the PP2A Catalytic Subunit in Wnt Signal Transduction. J. Biol. Chem. 275: 35680-35683 [Abstract] [Full Text]  
  • Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S.-F., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., Perrella, M. A., Lee, M.-E. (2001). Akt Participation in the Wnt Signaling Pathway through Dishevelled. J. Biol. Chem. 276: 17479-17483 [Abstract] [Full Text]  
  • Zhang, Y., Neo, S. Y., Han, J., Lin, S.-C. (2000). Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase. J. Biol. Chem. 275: 25008-25014 [Abstract] [Full Text]  
  • Hinoi, T., Yamamoto, H., Kishida, M., Takada, S., Kishida, S., Kikuchi, A. (2000). Complex Formation of Adenomatous Polyposis Coli Gene Product and Axin Facilitates Glycogen Synthase Kinase-3beta -dependent Phosphorylation of beta -Catenin and Down-regulates beta -Catenin. J. Biol. Chem. 275: 34399-34406 [Abstract] [Full Text]  
  • Sakamoto, I., Kishida, S., Fukui, A., Kishida, M., Yamamoto, H., Hino, S.-i., Michiue, T., Takada, S., Asashima, M., Kikuchi, A. (2000). A Novel beta -Catenin-binding Protein Inhibits beta -Catenin-dependent Tcf Activation and Axis Formation. J. Biol. Chem. 275: 32871-32878 [Abstract] [Full Text]  
  • Kadoya, T., Kishida, S., Fukui, A., Hinoi, T., Michiue, T., Asashima, M., Kikuchi, A. (2000). Inhibition of Wnt Signaling Pathway by a Novel Axin-binding Protein. J. Biol. Chem. 275: 37030-37037 [Abstract] [Full Text]  
  • Yamamoto, H., Hinoi, T., Michiue, T., Fukui, A., Usui, H., Janssens, V., Van Hoof, C., Goris, J., Asashima, M., Kikuchi, A. (2001). Inhibition of the Wnt Signaling Pathway by the PR61 Subunit of Protein Phosphatase 2A. J. Biol. Chem. 276: 26875-26882 [Abstract] [Full Text]  
  • Kishida, M., Hino, S.-i., Michiue, T., Yamamoto, H., Kishida, S., Fukui, A., Asashima, M., Kikuchi, A. (2001). Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iepsilon. J. Biol. Chem. 276: 33147-33155 [Abstract] [Full Text]  
  • Chen, W., Hu, L. A., Semenov, M. V., Yanagawa, S., Kikuchi, A., Lefkowitz, R. J., Miller, W. E. (2001). beta -Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. USA 98: 14889-14894 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»