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Molecular and Cellular Biology, June 1999, p. 4495-4502, Vol. 19, No. 6
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors

Jian-rong Lu,1 Timothy A. McKinsey,1 Hongtao Xu,1 Da-zhi Wang,1 James A. Richardson,2 and Eric N. Olson1,*

Departments of Molecular Biology and Oncology1 and Pathology,2 University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9148

Received 8 December 1998/Returned for modification 29 January 1999/Accepted 11 February 1999

Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages and are required for proliferation and differentiation of multiple hematopoietic cell types, whereas GATA-4, -5, and -6 are expressed in the heart, where they activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype zinc finger protein that interacts with GATA-1 and serves as a cofactor for GATA-1-mediated transcription. FOG is coexpressed with GATA-1 in developing erythroid and megakaryocyte cell lineages and cooperates with GATA-1 to control erythropoiesis. We describe a novel FOG-related factor, FOG-2, that is expressed predominantly in the developing and adult heart, brain, and testis. FOG-2 interacts with GATA factors, and interaction of GATA-4 and FOG-2 results in either synergistic activation or repression of GATA-dependent cardiac promoters, depending on the specific promoter and the cell type in which they are tested. The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expression by GATA transcription factors.

* Corresponding author. Mailing address: Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75235-9148. Phone: (214) 648-1187. Fax: (214) 648-1196. E-mail: eolson{at}hamon.swmed.edu.

Molecular and Cellular Biology, June 1999, p. 4495-4502, Vol. 19, No. 6
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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