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Molecular and Cellular Biology, September 1999, p. 5923-5929, Vol. 19, No. 9
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

NF-kappa B Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

Cun-Yu Wang,1,* Denis C. Guttridge,2 Marty W. Mayo,2 and Albert S. Baldwin Jr.2,3,*

Laboratory of Molecular Signaling and Apoptotsis, School of Dentistry,1 Lineberger Comprehensive Cancer Center,2 and Department of Biology,3 University of North Carolina, Chapel Hill, North Carolina 27599

Received 18 March 1999/Returned for modification 28 April 1999/Accepted 9 June 1999

Recent evidence indicates that the transcription factor NF-kappa B is a major effector of inducible antiapoptotic mechanisms. For example, it was shown that NF-kappa B activation suppresses the activation of caspase 8, the apical caspase in tumor necrosis factor (TNF) receptor family signaling cascades, through the transcriptional regulation of certain TRAF and IAP proteins. However, it was unknown whether NF-kappa B controls other key regulatory mechanisms in apoptosis. Here we show that NF-kappa B activation suppresses mitochondrial release of cytochrome c through the activation of the Bcl-2 family member A1/Bfl-1. The restoration of A1 in NF-kappa B null cells diminished TNF-induced apoptosis by reducing the release of proapoptotic cytochrome c from mitochondria. In addition, A1 potently inhibited etoposide-induced apoptosis by inhibiting the release of cytochrome c and by blocking caspase 3 activation. Our findings demonstrate that A1 is an important antiapoptotic gene controlled by NF-kappa B and establish that the prosurvival function of NF-kappa B can be manifested at multiple levels.

* Corresponding author. Mailing address for Cun-Yu Wang: Dept. of Biological and Materials Science, School of Dentistry, Univ. of Michigan, 1011 N. University, Ann Arbor, MI 48109. Phone: (734) 763-5481. Fax: (734) 763-3453. E-mail: cywang{at}umich.edu. Mailing address for Albert S. Baldwin, Jr.: 22-000 Lineberger Comprehensive Cancer Center, CB# 7295, University of North Carolina, Chapel Hill, NC 27599. Phone: (919) 966-3652. Fax: (919) 966-0444.

Molecular and Cellular Biology, September 1999, p. 5923-5929, Vol. 19, No. 9
0270-7306/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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  • Lavon, I., Pikarsky, E., Gutkovich, E., Goldberg, I., Bar, J., Oren, M., Ben-Neriah, Y. (2003). Nuclear Factor-{kappa}B Protects the Liver against Genotoxic Stress and Functions Independently of p53. Cancer Res. 63: 25-30 [Abstract] [Full Text]  
  • Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M. R., Lin, A. (2002). The Absence of NF-{kappa}B-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis. Mol. Cell. Biol. 22: 8571-8579 [Abstract] [Full Text]  
  • Paris, R., Morales, A., Coll, O., Sanchez-Reyes, A., Garcia-Ruiz, C., Fernandez-Checa, J. C. (2002). Ganglioside GD3 Sensitizes Human Hepatoma Cells to Cancer Therapy. J. Biol. Chem. 277: 49870-49876 [Abstract] [Full Text]  
  • Reuther-Madrid, J. Y., Kashatus, D., Chen, S., Li, X., Westwick, J., Davis, R. J., Earp, H. S., Wang, C.-Y., Baldwin, A. S. Jr. (2002). The p65/RelA Subunit of NF-{kappa}B Suppresses the Sustained, Antiapoptotic Activity of Jun Kinase Induced by Tumor Necrosis Factor. Mol. Cell. Biol. 22: 8175-8183 [Abstract] [Full Text]  
  • Poulaki, V., Mitsiades, C. S., Joussen, A. M., Lappas, A., Kirchhof, B., Mitsiades, N. (2002). Constitutive Nuclear Factor-{kappa}B Activity Is Crucial for Human Retinoblastoma Cell Viability. Am. J. Pathol. 161: 2229-2240 [Abstract] [Full Text]  
  • Baumann, B., Bohnenstengel, F., Siegmund, D., Wajant, H., Weber, C., Herr, I., Debatin, K.-M., Proksch, P., Wirth, T. (2002). Rocaglamide Derivatives Are Potent Inhibitors of NF-kappa B Activation in T-cells. J. Biol. Chem. 277: 44791-44800 [Abstract] [Full Text]  
  • Munzert, G., Kirchner, D., Stobbe, H., Bergmann, L., Schmid, R. M., Dohner, H., Heimpel, H. (2002). Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood 100: 3749-3756 [Abstract] [Full Text]  
  • Planey, S. L., Derfoul, A., Steplewski, A., Robertson, N. M., Litwack, G. (2002). Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain. J. Biol. Chem. 277: 42188-42196 [Abstract] [Full Text]  
  • Regula, K. M., Ens, K., Kirshenbaum, L. A. (2002). IKKbeta Is Required for Bcl-2-mediated NF-kappa B Activation in Ventricular Myocytes. J. Biol. Chem. 277: 38676-38682 [Abstract] [Full Text]  
  • You, Z., Madrid, L. V., Saims, D., Sedivy, J., Wang, C.-Y. (2002). c-Myc Sensitizes Cells to Tumor Necrosis Factor-mediated Apoptosis by Inhibiting Nuclear Factor kappa B Transactivation. J. Biol. Chem. 277: 36671-36677 [Abstract] [Full Text]  
  • Sonis, S. T. (2002). THE BIOLOGIC ROLE FOR NUCLEAR FACTOR-KAPPAB IN DISEASE AND ITS POTENTIAL INVOLVEMENT IN MUCOSAL INJURY ASSOCIATED WITH ANTI-NEOPLASTIC THERAPY. CROBM 13: 380-389 [Abstract] [Full Text]  
  • Sakuma, H., Yamamoto, M., Okumura, M., Kojima, T., Maruyama, T., Yasuda, K. (2002). High glucose inhibits apoptosis in human coronary artery smooth muscle cells by increasing bcl-xL and bfl-1/A1. Am. J. Physiol. Cell Physiol. 283: C422-C428 [Abstract] [Full Text]  
  • Sanchez-Perez, I., Benitah, S. A., Martinez-Gomariz, M., Lacal, J. C., Perona, R. (2002). Cell Stress and MEKK1-mediated c-Jun Activation Modulate NFkappa B Activity and Cell Viability. Mol. Biol. Cell 13: 2933-2945 [Abstract] [Full Text]  
  • Zeng, Q., Chen, S., You, Z., Yang, F., Carey, T. E., Saims, D., Wang, C.-Y. (2002). Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NFkappa B. J. Biol. Chem. 277: 25203-25208 [Abstract] [Full Text]  
  • Werner, A. B., de Vries, E., Tait, S. W. G., Bontjer, I., Borst, J. (2002). Bcl-2 Family Member Bfl-1/A1 Sequesters Truncated Bid to Inhibit Its Collaboration with Pro-apoptotic Bak or Bax. J. Biol. Chem. 277: 22781-22788 [Abstract] [Full Text]  
  • Mitsiades, N., Mitsiades, C. S., Poulaki, V., Chauhan, D., Richardson, P. G., Hideshima, T., Munshi, N., Treon, S. P., Anderson, K. C. (2002). Biologic sequelae of nuclear factor-kappa B blockade in multiple myeloma: therapeutic applications. Blood 99: 4079-4086 [Abstract] [Full Text]  
  • Maxwell, J. R., Ruby, C., Kerkvliet, N. I., Vella, A. T. (2002). Contrasting the Roles of Costimulation and the Natural Adjuvant Lipopolysaccharide During the Induction of T Cell Immunity. J. Immunol. 168: 4372-4381 [Abstract] [Full Text]  
  • You, Z., Saims, D., Chen, S., Zhang, Z., Guttridge, D. C., Guan, K.-l., MacDougald, O. A., Brown, A. M.C., Evan, G., Kitajewski, J., Wang, C.-Y. (2002). Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. JCB 157: 429-440 [Abstract] [Full Text]  
  • Tumang, J. R., Negm, R. S., Solt, L. A., Schneider, T. J., Colarusso, T. P., Hastings, W. D., Woodland, R. T., Rothstein, T. L. (2002). BCR Engagement Induces Fas Resistance in Primary B Cells in the Absence of Functional Bruton's Tyrosine Kinase. J. Immunol. 168: 2712-2719 [Abstract] [Full Text]  
  • Chen, S., Fribley, A., Wang, C.-Y. (2002). Potentiation of Tumor Necrosis Factor-mediated Apoptosis of Oral Squamous Cell Carcinoma Cells by Adenovirus-mediated Gene Transfer of NF-{kappa}B Inhibitor. JDR 81: 98-102 [Abstract] [Full Text]  
  • Adams, J. (2002). Development of the Proteasome Inhibitor PS-341. The Oncologist 7: 9-16 [Abstract] [Full Text]  
  • Thomas, K. W., Monick, M. M., Staber, J. M., Yarovinsky, T., Carter, A. B., Hunninghake, G. W. (2002). Respiratory Syncytial Virus Inhibits Apoptosis and Induces NF-kappa B Activity through a Phosphatidylinositol 3-Kinase-dependent Pathway. J. Biol. Chem. 277: 492-501 [Abstract] [Full Text]  


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