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 Previous Article

Mol Cell Biol. 1982 October; 2(10): 1295-1298

Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.

B F Cheetham, D C Shaw and A J Bellett

ABSTRACT

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.

Mol Cell Biol. 1982 October; 2(10): 1295-1298






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