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Molecular and Cellular Biology, January 2000, p. 363-371, Vol. 20, No. 1
Departments of Internal Medicine and of Cell
Biology and Physiology1 and Department
of Surgery,2 Washington University School
of Medicine, St. Louis, Missouri 63110
Received 27 July 1999/Returned for modification 13 September
1999/Accepted 5 October 1999
E2F is a family of transcription factors that regulates the cell
cycle. It is widely accepted that E2F-mediated transactivation of a set
of genes is the critical activity that governs cellular progression
through G1 into S phase. In contrast to this hypothesis, we
demonstrate that E2F actually suppresses the onset of S phase in two
cell types when the cells are arrested by gamma irradiation. Our
findings indicate that in these cells, the critical event triggering
progression from G0/G1 arrest into S phase is
the release of E2F-mediated transrepression of cell cycle genes, not
transactivation by E2F. Furthermore, our data suggest that E2F-mediated
transactivation is not necessary for the G1/S-phase
transition in these cells.
0270-7306/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
E2F Is Required To Prevent Inappropriate S-Phase
Entry of Mammalian Cells
*
Corresponding author. Mailing address: Departments of
Internal Medicine and of Cell Biology and Physiology, Washington
University School of Medicine, 660 South Euclid Ave., Campus Box 8052, St. Louis, MO 63110. Phone: (314) 362-8964. Fax: (314) 362-8963. E-mail: weintrau{at}im.wustl.edu.
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