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Molecular and Cellular Biology, May 2000, p. 3705-3714, Vol. 20, No. 10
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/or gadd45 Genes

Martin L. Smith,1,* James M. Ford,2,dagger M. Christine Hollander,1 Rachel A. Bortnick,1 Sally A. Amundson,1 Young R. Seo,3 Chu-Xia Deng,4 Philip C. Hanawalt,2 and Albert J. Fornace Jr.1

Division of Basic Science, National Cancer Institute,1 and National Institute of Diabetes, Digestive, and Kidney Diseases,4 National Institutes of Health, Bethesda, Maryland 20892; Department of Biological Sciences, Stanford University, Stanford, California 943052; and Indiana University Cancer Center/Walther Oncology Center and Department of Microbiology, Indiana University School of Medicine, Indianapolis, Indiana 462023

Received 14 January 2000/Returned for modification 17 February 2000/Accepted 22 February 2000

Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the pathway for repair of UV-induced DNA damage. The global genomic repair (GGR) subpathway of NER, but not transcription-coupled repair (TCR), is mainly affected by p53 loss or inactivation. We have utilized mouse embryo fibroblasts (MEFs) lacking p53 genes or downstream effector genes of the p53 pathway, gadd45 (Gadd45a) or p21 (Cdkn1a), as well as MEFs lacking both gadd45 and p21 genes to address the potential contribution of these downstream effectors to p53-associated DNA repair. Loss of p53 or gadd45 had a pronounced effect on GGR, while p21 loss had only a marginal effect, determined by measurements of repair synthesis (unscheduled DNA synthesis), by immunoassays to detect removal of UV photoproducts from genomic DNA, and by assays determining strand-specific removal of CPDs from the mouse dhfr gene. Taken together, the evidence suggests a role for Gadd45, but relatively little role for p21, in DNA repair responses to UV radiation. Recent evidence suggests that Gadd45 binds to UV-damaged chromatin and may affect lesion accessibility. MEFs lacking p53 or gadd45 genes exhibited decreased colony-forming ability after UV radiation and cisplatin compared to wild-type MEFs, indicating their sensitivity to DNA damage. We provide evidence that Gadd45 affects chromatin remodelling of templates concurrent with DNA repair, thus indicating that Gadd45 may participate in the coupling between chromatin assembly and DNA repair.

* Corresponding author. Present address: Indiana University Cancer Center, Department of Microbiology and Walther Oncology Center, R4-155, Indiana University School of Medicine, Indianapolis, IN 46202.

dagger Present address: Departments of Medicine and Genetics, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305.

Molecular and Cellular Biology, May 2000, p. 3705-3714, Vol. 20, No. 10
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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  • Akutsu, N., Lin, R., Bastien, Y., Bestawros, A., Enepekides, D. J., Black, M. J., White, J. H. (2001). Regulation of Gene Expression by 1{{alpha}},25-Dihydroxyvitamin D3 and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells. Mol. Endocrinol. 15: 1127-1139 [Abstract] [Full Text]  
  • Cheung, K-J. Jr., Mitchell, D., Lin, P., Li, G. (2001). The Tumor Suppressor Candidate p33ING1 Mediates Repair of UV-Damaged DNA. Cancer Res. 61: 4974-4977 [Abstract] [Full Text]  
  • Lackinger, D., Eichhorn, U., Kaina, B. (2001). Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both. Mutagenesis 16: 233-241 [Abstract] [Full Text]  
  • Therrien, J.-P., Loignon, M., Drouin, R., Drobetsky, E. A. (2001). Ablation of p21waf1cip1 Expression Enhances the Capacity of p53-deficient Human Tumor Cells to Repair UVB-induced DNA Damage. Cancer Res. 61: 3781-3786 [Abstract] [Full Text]  
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