Stem-Loop Binding Protein, the Protein That Binds the 3' End of Histone mRNA, Is Cell Cycle Regulated by Both Translational and Posttranslational Mechanisms

doi:10.1128/MCB.20.12.4188-4198.2000

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Molecular and Cellular Biology, June 2000, p. 4188-4198, Vol. 20, No. 12
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Stem-Loop Binding Protein, the Protein That Binds the 3' End of Histone mRNA, Is Cell Cycle Regulated by Both Translational and Posttranslational Mechanisms

Michael L. Whitfield,¹ Lian-Xing Zheng,¹ Amy Baldwin,² Tomohiko Ohta,³^, Myra M. Hurt,² and William F. Marzluff¹^,³^,⁴^,^*

Department of Biochemistry and Biophysics,¹ Program in Molecular Biology and Biotechnology,⁴ and Lineberger Comprehensive Cancer Center,³ University of North Carolina, Chapel Hill, North Carolina, and Department of Biological Sciences, Florida State University, Tallahassee, Florida²

Received 8 March 2000/Accepted 23 March 2000

The expression of the replication-dependent histone mRNAs is tightly regulated during the cell cycle. As cells progress fromG₁ to S phase, histone mRNA levels increase 35-fold, and theydecrease again during G₂ phase. Replication-dependent histonemRNAs are the only metazoan mRNAs that lack polyadenylated tails,ending instead in a conserved stem-loop. Much of the cell cycleregulation is posttranscriptional and is mediated by the 3' stem-loop.A 31-kDa stem-loop binding protein (SLBP) binds the 3' end ofhistone mRNA. The SLBP is necessary for pre-mRNA processing andaccompanies the histone mRNA to the cytoplasm, where it is a componentof the histone messenger RNP. We used synchronous CHO cells selectedby mitotic shakeoff and HeLa cells synchronized at the G₁/S orthe M/G₁ boundary to study the regulation of SLBP during the cellcycle. In each system the amount of SLBP is regulated during thecell cycle, increasing 10- to 20-fold in the late G₁ and thendecreasing in the S/G₂ border. SLBP mRNA levels are constant duringthe cell cycle. SLBP is regulated at the level of translationas cells progress from G₁ to S phase, and the protein is rapidlydegraded as they progress into G₂. Regulation of SLBP may accountfor the posttranscriptional component of the cell cycle regulationof histonemRNA.

^* Corresponding author. Mailing address: Program in Molecular Biology and Biotechnology, CB# 7100, University of North Carolina,Chapel Hill, NC 27599. Phone: (919) 962-8920. Fax: (919) 966-6821.E-mail: marzluff{at}med.unc.edu.

On leave from Department of Surgery, St. Marianna University School of Medicine, Kawasaki 216,Japan.

Molecular and Cellular Biology, June 2000, p. 4188-4198, Vol. 20, No. 12
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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