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Molecular and Cellular Biology, July 2000, p. 4773-4781, Vol. 20, No. 13
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of DBP in the Circadian Oscillatory Mechanism

Shun Yamaguchi, Shigeru Mitsui, Lily Yan, Kazuhiro Yagita, Shigeru Miyake, and Hitoshi Okamura*

Department of Anatomy and Brain Science, Kobe University School of Medicine, Kobe 650-0017, Japan

Received 10 January 2000/Returned for modification 3 March 2000/Accepted 20 March 2000

Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and mCRY proteins, as is the case for mPer1. Thus, a clock-controlled dbp gene may play an important role in central clock oscillation.

* Corresponding author. Mailing address: Department of Anatomy and Brain Science, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. Phone: (81) 78 382 5340. Fax: (81) 78 382 5341. E-mail: okamurah{at}kobe-u.ac.jp.

Molecular and Cellular Biology, July 2000, p. 4773-4781, Vol. 20, No. 13
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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