This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vazquez, F.
Right arrow Articles by Sellers, W. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vazquez, F.
Right arrow Articles by Sellers, W. R.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, July 2000, p. 5010-5018, Vol. 20, No. 14
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Phosphorylation of the PTEN Tail Regulates Protein Stability and Function

Francisca Vazquez, Shivapriya Ramaswamy, Noriaki Nakamura, and William R. Sellers*

Department of Adult Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

Received 14 February 2000/Returned for modification 30 March 2000/Accepted 19 April 2000

The PTEN gene is a tumor suppressor localized in the frequently altered chromosomal region 10q23. The tumor suppressor function of the PTEN protein (PTEN) has been linked to its ability to dephosphorylate the lipid second-messenger phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate and, by doing so, to antagonize the phosphoinositide 3-kinase pathway. The PTEN protein consists of an amino-terminal phosphatase domain, a lipid binding C2 domain, and a 50-amino-acid C-terminal domain (the "tail") of unknown function. A number of studies have shown that the tail is dispensable for both phosphatase activity and blocking cell growth. Here, we show that the PTEN tail is necessary for maintaining protein stability and that it also acts to inhibit PTEN function. Thus, removing the tail results in a loss of stability but does not result in a loss of function because the resultant protein is more active. Furthermore, tail-dependent regulation of stability and activity is linked to the phosphorylation of three residues (S380, T382, and T383) within the tail. Therefore, the tail is likely to mediate the regulation of PTEN function through phosphorylation.

* Corresponding author. Mailing address: Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115. Phone: (617) 632-5261. Fax: (617) 632-5417. E-mail: William_Sellers{at}dfci.harvard.edu.

Molecular and Cellular Biology, July 2000, p. 5010-5018, Vol. 20, No. 14
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Song, P., Zhang, M., Wang, S., Xu, J., Choi, H. C., Zou, M.-H. (2009). Thromboxane A2 Receptor Activates a Rho-associated Kinase/LKB1/PTEN Pathway to Attenuate Endothelium Insulin Signaling. J. Biol. Chem. 284: 17120-17128 [Abstract] [Full Text]  
  • CHHABRA, A., VERMA, A., MEHTA, K. (2009). Tissue Transglutaminase Promotes or Suppresses Tumors Depending on Cell Context. Anticancer Res 29: 1909-1919 [Abstract] [Full Text]  
  • Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C., Ashford, M. L. J. (2009). Leptin-dependent Phosphorylation of PTEN Mediates Actin Restructuring and Activation of ATP-sensitive K+ Channels. J. Biol. Chem. 284: 9331-9340 [Abstract] [Full Text]  
  • Ross, A. H., Gericke, A. (2009). Phosphorylation keeps PTEN phosphatase closed for business. Proc. Natl. Acad. Sci. USA 106: 1297-1298 [Full Text]  
  • Rahdar, M., Inoue, T., Meyer, T., Zhang, J., Vazquez, F., Devreotes, P. N. (2009). A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc. Natl. Acad. Sci. USA 106: 480-485 [Abstract] [Full Text]  
  • Kim, J. W., Kang, K. H., Burrola, P., Mak, T. W., Lemke, G. (2008). Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. Genes Dev. 22: 3147-3157 [Abstract] [Full Text]  
  • Yamamoto, H., Shigematsu, H., Nomura, M., Lockwood, W. W., Sato, M., Okumura, N., Soh, J., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Date, H., Lam, W. L., Minna, J. D., Gazdar, A. F. (2008). PIK3CA Mutations and Copy Number Gains in Human Lung Cancers. Cancer Res. 68: 6913-6921 [Abstract] [Full Text]  
  • Bu, S., Kapanadze, B., Hsu, T., Trojanowska, M. (2008). Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-{beta}/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway. J. Biol. Chem. 283: 19593-19602 [Abstract] [Full Text]  
  • Xia, H., Diebold, D., Nho, R., Perlman, D., Kleidon, J., Kahm, J., Avdulov, S., Peterson, M., Nerva, J., Bitterman, P., Henke, C. (2008). Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis. JEM 205: 1659-1672 [Abstract] [Full Text]  
  • Fouladkou, F., Landry, T., Kawabe, H., Neeb, A., Lu, C., Brose, N., Stambolic, V., Rotin, D. (2008). The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc. Natl. Acad. Sci. USA 105: 8585-8590 [Abstract] [Full Text]  
  • Woiwode, A., Johnson, S. A. S., Zhong, S., Zhang, C., Roeder, R. G., Teichmann, M., Johnson, D. L. (2008). PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex. Mol. Cell. Biol. 28: 4204-4214 [Abstract] [Full Text]  
  • Chang, C.-J., Mulholland, D. J., Valamehr, B., Mosessian, S., Sellers, W. R., Wu, H. (2008). PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression. Mol. Cell. Biol. 28: 3281-3289 [Abstract] [Full Text]  
  • Dal Col, J., Zancai, P., Terrin, L., Guidoboni, M., Ponzoni, M., Pavan, A., Spina, M., Bergamin, S., Rizzo, S., Tirelli, U., De Rossi, A., Doglioni, C., Dolcetti, R. (2008). Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. Blood 111: 5142-5151 [Abstract] [Full Text]  
  • Song, P., Xie, Z., Wu, Y., Xu, J., Dong, Y., Zou, M.-H. (2008). Protein Kinase C{zeta}-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells. J. Biol. Chem. 283: 12446-12455 [Abstract] [Full Text]  
  • Verma, A., Guha, S., Wang, H., Fok, J. Y., Koul, D., Abbruzzese, J., Mehta, K. (2008). Tissue Transglutaminase Regulates Focal Adhesion Kinase/AKT Activation by Modulating PTEN Expression in Pancreatic Cancer Cells. Clin. Cancer Res. 14: 1997-2005 [Abstract] [Full Text]  
  • Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., Kubin, T., Braun, T., Bober, E. (2008). Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice. Circ. Res. 102: 703-710 [Abstract] [Full Text]  
  • Planchon, S. M., Waite, K. A., Eng, C. (2008). The nuclear affairs of PTEN. J. Cell Sci. 121: 249-253 [Abstract] [Full Text]  
  • Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J., Van Haastert, P. J.M. (2007). Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphate-mediated Chemotaxis. Mol. Biol. Cell 18: 4772-4779 [Abstract] [Full Text]  
  • Chow, J. Y.C., Quach, K. T., Cabrera, B. L., Cabral, J. A., Beck, S. E., Carethers, J. M. (2007). RAS/ERK modulates TGF{beta}-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis 28: 2321-2327 [Abstract] [Full Text]  
  • Song, P., Wu, Y., Xu, J., Xie, Z., Dong, Y., Zhang, M., Zou, M.-H. (2007). Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner. Circulation 116: 1585-1595 [Abstract] [Full Text]  
  • Jahn, T., Leifheit, E., Gooch, S., Sindhu, S., Weinberg, K. (2007). Lipid rafts are required for Kit survival and proliferation signals. Blood 110: 1739-1747 [Abstract] [Full Text]  
  • Odriozola, L., Singh, G., Hoang, T., Chan, A. M. (2007). Regulation of PTEN Activity by Its Carboxyl-terminal Autoinhibitory Domain. J. Biol. Chem. 282: 23306-23315 [Abstract] [Full Text]  
  • Kohli, R., Pan, X., Malladi, P., Wainwright, M. S., Whitington, P. F. (2007). Mitochondrial Reactive Oxygen Species Signal Hepatocyte Steatosis by Regulating the Phosphatidylinositol 3-Kinase Cell Survival Pathway. J. Biol. Chem. 282: 21327-21336 [Abstract] [Full Text]  
  • Kim, K. Y., Cho, H. S., Jung, W. H., Kim, S. S., Cheon, H. G. (2007). Phosphatase and Tensin Homolog Deleted on Chromosome 10 Suppression Is an Important Process in Peroxisome Proliferator-Activated Receptor-{gamma} Signaling in Adipocytes and Myotubes. Mol. Pharmacol. 71: 1554-1562 [Abstract] [Full Text]  
  • Liu, H.-Y., Collins, Q. F., Xiong, Y., Moukdar, F., Lupo, E. G. Jr., Liu, Z., Cao, W. (2007). Prolonged Treatment of Primary Hepatocytes with Oleate Induces Insulin Resistance through p38 Mitogen-activated Protein Kinase. J. Biol. Chem. 282: 14205-14212 [Abstract] [Full Text]  
  • Barber, D. F., Alvarado-Kristensson, M., Gonzalez-Garcia, A., Pulido, R., Carrera, A. C. (2006). PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase. Sci Signal 2006: pe49-pe49 [Abstract] [Full Text]  
  • Nho, R. S., Xia, H., Diebold, D., Kahm, J., Kleidon, J., White, E., Henke, C. A. (2006). PTEN Regulates Fibroblast Elimination during Collagen Matrix Contraction. J. Biol. Chem. 281: 33291-33301 [Abstract] [Full Text]  
  • Okahara, F., Itoh, K., Nakagawara, A., Murakami, M., Kanaho, Y., Maehama, T. (2006). Critical Role of PICT-1, a Tumor Suppressor Candidate, in Phosphatidylinositol 3,4,5-Trisphosphate Signals and Tumorigenic Transformation. Mol. Biol. Cell 17: 4888-4895 [Abstract] [Full Text]  
  • Okumura, K., Mendoza, M., Bachoo, R. M., DePinho, R. A., Cavenee, W. K., Furnari, F. B. (2006). PCAF Modulates PTEN Activity. J. Biol. Chem. 281: 26562-26568 [Abstract] [Full Text]  
  • Gil, A., Andres-Pons, A., Fernandez, E., Valiente, M., Torres, J., Cervera, J., Pulido, R. (2006). Nuclear Localization of PTEN by a Ran-dependent Mechanism Enhances Apoptosis: Involvement of an N-Terminal Nuclear Localization Domain and Multiple Nuclear Exclusion Motifs. Mol. Biol. Cell 17: 4002-4013 [Abstract] [Full Text]  
  • Balsara, R. D., Castellino, F. J., Ploplis, V. A. (2006). A Novel Function of Plasminogen Activator Inhibitor-1 in Modulation of the AKT Pathway in Wild-type and Plasminogen Activator Inhibitor-1-deficient Endothelial Cells. J. Biol. Chem. 281: 22527-22536 [Abstract] [Full Text]  
  • Wang, X. L., Zhang, L., Youker, K., Zhang, M.-X., Wang, J., LeMaire, S. A., Coselli, J. S., Shen, Y. H. (2006). Free Fatty Acids Inhibit Insulin Signaling-Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase.. Diabetes 55: 2301-2310 [Abstract] [Full Text]  
  • MacGlashan, D. Jr., Vilarino, N. (2006). Nonspecific Desensitization, Functional Memory, and the Characteristics of SHIP Phosphorylation following IgE-Mediated Stimulation of Human Basophils. J. Immunol. 177: 1040-1051 [Abstract] [Full Text]  
  • Tang, Y., Eng, C. (2006). p53 Down-Regulates Phosphatase and Tensin Homologue Deleted on Chromosome 10 Protein Stability Partially through Caspase-Mediated Degradation in Cells with Proteasome Dysfunction.. Cancer Res. 66: 6139-6148 [Abstract] [Full Text]  
  • Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M., Devreotes, P. N. (2006). Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.. Proc. Natl. Acad. Sci. USA 103: 3633-3638 [Abstract] [Full Text]  
  • Flaherty, D. M., Monick, M. M., Hinde, S. L. (2006). Human Alveolar Macrophages Are Deficient in PTEN: THE ROLE OF ENDOGENOUS OXIDANTS. J. Biol. Chem. 281: 5058-5064 [Abstract] [Full Text]  
  • Shen, Y. H., Zhang, L., Utama, B., Wang, J., Gan, Y., Wang, X., Wang, J., Chen, L., Vercellotti, G. M., Coselli, J. S., Mehta, J. L., Wang, X. L. (2006). Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Cardiovasc Res 69: 502-511 [Abstract] [Full Text]  
  • Ammoun, S., Johansson, L., Ekholm, M. E., Holmqvist, T., Danis, A. S., Korhonen, L., Sergeeva, O. A., Haas, H. L., Akerman, K. E. O., Kukkonen, J. P. (2006). OX1 Orexin Receptors Activate Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells via Multiple Mechanisms: The Role of Ca2+ Influx in OX1 Receptor Signaling. Mol. Endocrinol. 20: 80-99 [Abstract] [Full Text]  
  • Cai, Z., Semenza, G. L. (2005). PTEN Activity Is Modulated During Ischemia and Reperfusion: Involvement in the Induction and Decay of Preconditioning. Circ. Res. 97: 1351-1359 [Abstract] [Full Text]  
  • Tseng, Y.-T., Yano, N., Rojan, A., Stabila, J. P., McGonnigal, B. G., Ianus, V., Wadhawan, R., Padbury, J. F. (2005). Ontogeny of phosphoinositide 3-kinase signaling in developing heart: effect of acute {beta}-adrenergic stimulation. Am. J. Physiol. Heart Circ. Physiol. 289: H1834-H1842 [Abstract] [Full Text]  
  • Al-Khouri, A. M., Ma, Y., Togo, S. H., Williams, S., Mustelin, T. (2005). Cooperative Phosphorylation of the Tumor Suppressor Phosphatase and Tensin Homologue (PTEN) by Casein Kinases and Glycogen Synthase Kinase 3{beta}. J. Biol. Chem. 280: 35195-35202 [Abstract] [Full Text]  
  • Vogelmann, R., Nguyen-tat, M.-D., Giehl, K., Adler, G., Wedlich, D., Menke, A. (2005). TGF{beta}-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J. Cell Sci. 118: 4901-4912 [Abstract] [Full Text]  
  • Dave, B., Eason, R. R., Till, S.R., Geng, Y., Velarde, M. C., Badger, T. M., Simmen, R. C.M. (2005). The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis 26: 1793-1803 [Abstract] [Full Text]  
  • Pan, Q., Bao, L. W., Kleer, C. G., Sabel, M. S., Griffith, K. A., Teknos, T. N., Merajver, S. D. (2005). Protein Kinase C{varepsilon} Is a Predictive Biomarker of Aggressive Breast Cancer and a Validated Target for RNA Interference Anticancer Therapy. Cancer Res. 65: 8366-8371 [Abstract] [Full Text]  
  • Dickerson, E. B., Thomas, R., Fosmire, S. P., Lamerato-Kozicki, A. R., Bianco, S. R., Wojcieszyn, J. W., Breen, M., Helfand, S. C., Modiano, J. F. (2005). Mutations of Phosphatase and Tensin Homolog Deleted from Chromosome 10 in Canine Hemangiosarcoma. Vet Pathol 42: 618-632 [Abstract] [Full Text]  
  • Zhang, C., Comai, L., Johnson, D. L. (2005). PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex. Mol. Cell. Biol. 25: 6899-6911 [Abstract] [Full Text]  
  • Agrawal, S., Pilarski, R., Eng, C. (2005). Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN. Hum Mol Genet 14: 2459-2468 [Abstract] [Full Text]  
  • Mehenni, H., Lin-Marq, N., Buchet-Poyau, K., Reymond, A., Collart, M. A., Picard, D., Antonarakis, S. E. (2005). LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet 14: 2209-2219 [Abstract] [Full Text]  
  • Waite, K. A., Sinden, M. R., Eng, C. (2005). Phytoestrogen exposure elevates PTEN levels. Hum Mol Genet 14: 1457-1463 [Abstract] [Full Text]  
  • Ghias, K., Ma, C., Gandhi, V., Platanias, L. C., Krett, N. L., Rosen, S. T. (2005). 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: Role in induction of apoptosis in multiple myeloma. Molecular Cancer Therapeutics 4: 569-577 [Abstract] [Full Text]  
  • Okumura, K., Zhao, M., DePinho, R. A., Furnari, F. B., Cavenee, W. K. (2005). From the Cover: Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc. Natl. Acad. Sci. USA 102: 2703-2706 [Abstract] [Full Text]  
  • Huang, J., Niu, X.-L., Pippen, A. M., Annex, B. H., Kontos, C. D. (2005). Adenovirus-Mediated Intraarterial Delivery of PTEN Inhibits Neointimal Hyperplasia. Arterioscler. Thromb. Vasc. Bio. 25: 354-358 [Abstract] [Full Text]  
  • Seo, J. H., Ahn, Y., Lee, S.-R., Yeo, C. Y., Hur, K. C. (2005). The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway. Mol. Biol. Cell 16: 348-357 [Abstract] [Full Text]  
  • Okahara, F., Ikawa, H., Kanaho, Y., Maehama, T. (2004). Regulation of PTEN Phosphorylation and Stability by a Tumor Suppressor Candidate Protein. J. Biol. Chem. 279: 45300-45303 [Abstract] [Full Text]  
  • Min, Y. H., Cheong, J.-W., Lee, M. H., Kim, J. Y., Lee, S. T., Hahn, J. S., Ko, Y. W. (2004). Elevated S-Phase Kinase-Associated Protein 2 Protein Expression in Acute Myelogenous Leukemia: Its Association with Constitutive Phosphorylation of Phosphatase and Tensin Homologue Protein and Poor Prognosis. Clin. Cancer Res. 10: 5123-5130 [Abstract] [Full Text]  
  • Sansal, I., Sellers, W. R. (2004). The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway. JCO 22: 2954-2963 [Abstract] [Full Text]  
  • Huang, H., Muddiman, D. C., Tindall, D. J. (2004). Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells. J. Biol. Chem. 279: 13866-13877 [Abstract] [Full Text]  
  • Mourani, P. M., Garl, P. J., Wenzlau, J. M., Carpenter, T. C., Stenmark, K. R., Weiser-Evans, M. C.M. (2004). Unique, Highly Proliferative Growth Phenotype Expressed by Embryonic and Neointimal Smooth Muscle Cells Is Driven by Constitutive Akt, mTOR, and p70S6K Signaling and Is Actively Repressed by PTEN. Circulation 109: 1299-1306 [Abstract] [Full Text]  
  • Lee, J. H., Kim, K. Y., Lee, Y.-K., Park, S. Y., Kim, C. D., Lee, W. S., Rhim, B. Y., Hong, K. W. (2004). Cilostazol Prevents Focal Cerebral Ischemic Injury by Enhancing Casein Kinase 2 Phosphorylation and Suppression of Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation in Rats. J. Pharmacol. Exp. Ther. 308: 896-903 [Abstract] [Full Text]  
  • Raftopoulou, M., Etienne-Manneville, S., Self, A., Nicholls, S., Hall, A. (2004). Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN. Science 303: 1179-1181 [Abstract] [Full Text]  
  • Hsieh, A. C., Bo, R., Manola, J., Vazquez, F., Bare, O., Khvorova, A., Scaringe, S., Sellers, W. R. (2004). A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res 32: 893-901 [Abstract] [Full Text]  
  • Garl, P. J., Wenzlau, J. M., Walker, H. A., Whitelock, J. M., Costell, M., Weiser-Evans, M. C.M. (2004). Perlecan-Induced Suppression of Smooth Muscle Cell Proliferation Is Mediated Through Increased Activity of the Tumor Suppressor PTEN. Circ. Res. 94: 175-183 [Abstract] [Full Text]  
  • Orchiston, E. A., Bennett, D., Leslie, N. R., Clarke, R. G., Winward, L., Downes, C. P., Safrany, S. T. (2004). PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6-Pentakisphosphate (Ins(1,3,4,5,6)P5): EVIDENCE FOR Ins(1,3,4,5,6)P5 AS A PROLIFERATIVE SIGNAL. J. Biol. Chem. 279: 1116-1122 [Abstract] [Full Text]  
  • Kim, K. Y., Shin, H. K., Lee, J. H., Kim, C. D., Lee, W. S., Rhim, B. Y., Shin, Y. W., Hong, K. W. (2004). Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor-{alpha}-Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells. J. Pharmacol. Exp. Ther. 308: 97-104 [Abstract] [Full Text]  
  • Moe-Behrens, G. H. G., Klinger, F. G., Eskild, W., Grotmol, T., Haugen, T. B., De Felici, M. (2003). Akt/PTEN Signaling Mediates Estrogen-Dependent Proliferation of Primordial Germ Cells in Vitro. Mol. Endocrinol. 17: 2630-2638 [Abstract] [Full Text]  
  • Goberdhan, D. C.I., Wilson, C. (2003). PTEN: tumour suppressor, multifunctional growth regulator and more. Hum Mol Genet 12: R239-248 [Abstract] [Full Text]  
  • Lu, Y., Yu, Q., Liu, J. H., Zhang, J., Wang, H., Koul, D., McMurray, J. S., Fang, X., Yung, W.K. A., Siminovitch, K. A., Mills, G. B. (2003). Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades. J. Biol. Chem. 278: 40057-40066 [Abstract] [Full Text]  
  • Deleris, P., Bacqueville, D., Gayral, S., Carrez, L., Salles, J.-P., Perret, B., Breton-Douillon, M. (2003). SHIP-2 and PTEN Are Expressed and Active in Vascular Smooth Muscle Cell Nuclei, but Only SHIP-2 Is Associated with Nuclear Speckles. J. Biol. Chem. 278: 38884-38891 [Abstract] [Full Text]  
  • Guzeloglu-Kayisli, O., Kayisli, U. A., Al-Rejjal, R., Zheng, W., Luleci, G., Arici, A. (2003). Regulation of PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Expression by Estradiol and Progesterone in Human Endometrium. J. Clin. Endocrinol. Metab. 88: 5017-5026 [Abstract] [Full Text]  
  • Ducruet, A. P., Lazo, J. S. (2003). Regulation of Cdc25A Half-life in Interphase by Cyclin-dependent Kinase 2 Activity. J. Biol. Chem. 278: 31838-31842 [Abstract] [Full Text]  
  • Wu, W., Wang, X., Zhang, W., Reed, W., Samet, J. M., Whang, Y. E., Ghio, A. J. (2003). Zinc-induced PTEN Protein Degradation through the Proteasome Pathway in Human Airway Epithelial Cells. J. Biol. Chem. 278: 28258-28263 [Abstract] [Full Text]  
  • Su, J. D., Mayo, L. D., Donner, D. B., Durden, D. L. (2003). PTEN and Phosphatidylinositol 3'-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment. Cancer Res. 63: 3585-3592 [Abstract] [Full Text]  
  • Das, S., Dixon, J. E., Cho, W. (2003). Membrane-binding and activation mechanism of PTEN. Proc. Natl. Acad. Sci. USA 100: 7491-7496 [Abstract] [Full Text]  
  • Song, D. H., Dominguez, I., Mizuno, J., Kaut, M., Mohr, S. C., Seldin, D. C. (2003). CK2 Phosphorylation of the Armadillo Repeat Region of {beta}-Catenin Potentiates Wnt Signaling. J. Biol. Chem. 278: 24018-24025 [Abstract] [Full Text]  
  • Poser, S., Impey, S., Xia, Z., Storm, D. R. (2003). Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP. J. Neurosci. 23: 4420-4427 [Abstract] [Full Text]  
  • Waite, K. A., Eng, C. (2003). BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum Mol Genet 12: 679-684 [Abstract] [Full Text]  
  • Romieu-Mourez, R., Landesman-Bollag, E., Seldin, D. C., Sonenshein, G. E. (2002). Protein Kinase CK2 Promotes Aberrant Activation of Nuclear Factor-{kappa}B, Transformed Phenotype, and Survival of Breast Cancer Cells. Cancer Res. 62: 6770-6778 [Abstract] [Full Text]  
  • Kohlstedt, K., Shoghi, F., Muller-Esterl, W., Busse, R., Fleming, I. (2002). CK2 Phosphorylates the Angiotensin-Converting Enzyme and Regulates Its Retention in the Endothelial Cell Plasma Membrane. Circ. Res. 91: 749-756 [Abstract] [Full Text]  
  • Northcott, C. A., Poy, M. N., Najjar, S. M., Watts, S. W. (2002). Phosphoinositide 3-Kinase Mediates Enhanced Spontaneous and Agonist-Induced Contraction in Aorta of Deoxycorticosterone Acetate-Salt Hypertensive Rats. Circ. Res. 91: 360-369 [Abstract] [Full Text]  
  • Fox, J. A., Ung, K., Tanlimco, S. G., Jirik, F. R. (2002). Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1. J. Immunol. 169: 49-54 [Abstract] [Full Text]  
  • Birle, D., Bottini, N., Williams, S., Huynh, H., deBelle, I., Adamson, E., Mustelin, T. (2002). Negative Feedback Regulation of the Tumor Suppressor PTEN by Phosphoinositide-Induced Serine Phosphorylation. J. Immunol. 169: 286-291 [Abstract] [Full Text]  
  • Ermoian, R. P., Furniss, C. S., Lamborn, K. R., Basila, D., Berger, M. S., Gottschalk, A. R., Nicholas, M. K., Stokoe, D., Haas-Kogan, D. A. (2002). Dysregulation of PTEN and Protein Kinase B Is Associated with Glioma Histology and Patient Survival. Clin. Cancer Res. 8: 1100-1106 [Abstract] [Full Text]  
  • Mills, G. B., Lu, Y., Kohn, E. C. (2001). Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc. Natl. Acad. Sci. USA 98: 10031-10033 [Full Text]  
  • Ross, A. H., Lachyankar, M. B., Recht, L. D. (2001). PTEN: A Newly Identified Regulator of Neuronal Differentiation. Neuroscientist 7: 278-281 [Abstract]  
  • Tolkacheva, T., Boddapati, M., Sanfiz, A., Tsuchida, K., Kimmelman, A. C., Chan, A. M-L. (2001). Regulation of PTEN Binding to MAGI-2 by Two Putative Phosphorylation Sites at Threonine 382 and 383. Cancer Res. 61: 4985-4989 [Abstract] [Full Text]  
  • Simpson, L., Li, J., Liaw, D., Hennessy, I., Oliner, J., Christians, F., Parsons, R. (2001). PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2. Mol. Cell. Biol. 21: 3947-3958 [Abstract] [Full Text]  
  • Zhu, X., Kwon, C.-H., Schlosshauer, P. W., Ellenson, L. H., Baker, S. J. (2001). PTEN Induces G1 Cell Cycle Arrest and Decreases Cyclin D3 Levels in Endometrial Carcinoma Cells. Cancer Res. 61: 4569-4575 [Abstract] [Full Text]  
  • Maher, E. A., Furnari, F. B., Bachoo, R. M., Rowitch, D. H., Louis, D. N., Cavenee, W. K., DePinho, R. A. (2001). Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15: 1311-1333 [Full Text]  
  • Brognard, J., Clark, A. S., Ni, Y., Dennis, P. A. (2001). Akt/Protein Kinase B Is Constitutively Active in Non-Small Cell Lung Cancer Cells and Promotes Cellular Survival and Resistance to Chemotherapy and Radiation. Cancer Res. 61: 3986-3997 [Abstract] [Full Text]  
  • Wen, S., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K., Durden, D. L. (2001). PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA 10.1073/pnas.081063798v1 [Abstract] [Full Text]  
  • Yamada, K. M., Araki, M. (2001). Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J. Cell Sci. 114: 2375-2382 [Abstract] [Full Text]  
  • Nakamura, N., Ramaswamy, S., Vazquez, F., Signoretti, S., Loda, M., Sellers, W. R. (2000). Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN. Mol. Cell. Biol. 20: 8969-8982 [Abstract] [Full Text]  
  • Georgescu, M.-M., Kirsch, K. H., Kaloudis, P., Yang, H., Pavletich, N. P., Hanafusa, H. (2000). Stabilization and Productive Positioning Roles of the C2 Domain of PTEN Tumor Suppressor. Cancer Res. 60: 7033-7038 [Abstract] [Full Text]  
  • Vazquez, F., Grossman, S. R., Takahashi, Y., Rokas, M. V., Nakamura, N., Sellers, W. R. (2001). Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex. J. Biol. Chem. 276: 48627-48630 [Abstract] [Full Text]  
  • Torres, J., Pulido, R. (2001). The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus. IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION. J. Biol. Chem. 276: 993-998 [Abstract] [Full Text]  
  • Wen, S., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K., Durden, D. L. (2001). PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA 98: 4622-4627 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»