The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

doi:10.1128/MCB.20.2.556-562.2000

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Molecular and Cellular Biology, January 2000, p. 556-562, Vol. 20, No. 2
0270-7306/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

Steven B. McMahon, Marcelo A. Wood, and Michael D. Cole^*

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014

Received 22 June 1999/Returned for modification 28 July 1999/Accepted 22 October 1999

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation; however, the biochemical andgenetic pathways leading to transformation remain undefined. Wedemonstrate here that the recently described c-Myc cofactor TRRAPrecruits histone acetylase activity, which is catalyzed by thehuman GCN5 protein. Since c-Myc function is inhibited by recruitmentof histone deacetylase activity through Mad family proteins, theseopposing biochemical activities are likely to be responsible forthe antagonistic biological effects of c-Myc and Mad on targetgenes and ultimately on cellulartransformation.

^* Corresponding author. Mailing address: Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014. Phone:(609) 258-5936. Fax: (609) 258-2759. E-mail: mcole{at}molbio.princeton.edu.

Present address: The Wistar Institute, Philadelphia, PA 19104-4268.

Molecular and Cellular Biology, January 2000, p. 556-562, Vol. 20, No. 2
0270-7306/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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