8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

doi:10.1128/MCB.20.23.8720-8730.2000

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Molecular and Cellular Biology, December 2000, p. 8720-8730, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

8-Bromo-Cyclic AMP Induces Phosphorylation of Two Sites in SRC-1 That Facilitate Ligand-Independent Activation of the Chicken Progesterone Receptor and Are Critical for Functional Cooperation between SRC-1 and CREB Binding Protein

Brian G. Rowan, Nefretiti Garrison, Nancy L. Weigel,^* and Bert W. O'Malley

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Received 21 July 2000/Returned for modification 11 September 2000/Accepted 19 September 2000

Elevation of intracellular 8-bromo-cyclic AMP (cAMP) can activate certain steroid receptors and enhance the ligand-dependentactivation of most receptors. During ligand-independent activationof the chicken progesterone receptor (cPR_A) with the protein kinaseA (PKA) activator, 8-bromo-cAMP, we found no alteration in cPR_Aphosphorylation (W. Bai, B. G. Rowan, V. E. Allgood, B. W. O'Malley,and N. L. Weigel, J. Biol. Chem. 272:10457-10463, 1997). To determineif other receptor-associated cofactors were targets of cAMP-dependentsignaling pathways, we examined the phosphorylation of steroidreceptor coactivator 1 (SRC-1). We detected a 1.8-fold increasein SRC-1 phosphorylation in transfected COS-1 cells incubatedwith 8-bromo-cAMP. Phosphorylation was increased on two mitogen-activatedprotein kinase (MAPK) sites, threonine 1179 and serine 1185. PKAdid not phosphorylate these sites in vitro. However, blockageof PKA activity in COS-1 cells with the PKA inhibitor (PKI) preventedthe 8-bromo-cAMP-mediated phosphorylation of these sites. Incubationof COS-1 cells with 8-bromo-cAMP resulted in activation of theMAPK pathway, as determined by Western blotting with antibodiesto the phosphorylated (active) form of Erk-1/2, suggesting anindirect pathway to SRC-1 phosphorylation. Mutation of threonine1179 and serine 1185 to alanine in COS-1 cells coexpressing cPR_Aand the GRE₂E1bCAT reporter resulted in up to a 50% decrease incoactivation during both ligand-independent activation and ligand-dependentactivation. This was due, in part, to loss of functional cooperationbetween SRC-1 and CREB binding protein for coactivation of cPR_A.This is the first demonstration of cross talk between a signalingpathway and specific phosphorylation sites in a nuclear receptorcoactivator that can regulate steroid receptoractivation.

^* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, Baylor College of Medicine, One BaylorPlaza, Houston, TX 77030. Phone: (713) 798-6234. Fax: (713) 790-1275.E-mail: nweigel{at}bcm.tmc.edu.

Molecular and Cellular Biology, December 2000, p. 8720-8730, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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