This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boddy, M. N.
Right arrow Articles by Russell, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boddy, M. N.
Right arrow Articles by Russell, P.

 Previous Article  |  Next Article 

Molecular and Cellular Biology, December 2000, p. 8758-8766, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1

Michael N. Boddy,1 Antonia Lopez-Girona,1 Paul Shanahan,1 Heidrun Interthal,2 Wolf-Dietrich Heyer,3 and Paul Russell1,*

Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 920371; Department of Microbiology, University of Washington, Seattle, Washington 981952; and Division of Biological Sciences, Sections of Microbiology and Molecular & Cellular Biology, University of California, Davis, Davis, California 956163

Received 30 June 2000/Returned for modification 1 September 2000/Accepted 7 September 2000

Cds1, a serine/threonine kinase, enforces the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. Cds1 is required for survival of replicational stress caused by agents that stall replication forks, but how Cds1 performs these functions is largely unknown. Here we report that the forkhead-associated-1 (FHA1) protein-docking domain of Cds1 interacts with Mus81, an evolutionarily conserved damage tolerance protein. Mus81 has an endonuclease homology domain found in the XPF nucleotide excision repair protein. Inactivation of mus81 reveals a unique spectrum of phenotypes. Mus81 enables survival of deoxynucleotide triphosphate starvation, UV radiation, and DNA polymerase impairment. Mus81 is essential in the absence of Bloom's syndrome Rqh1 helicase and is required for productive meiosis. Genetic epistasis studies suggest that Mus81 works with recombination enzymes to properly replicate damaged DNA. Inactivation of Mus81 triggers a checkpoint-dependent delay of mitosis. We propose that Mus81 is involved in the recruitment of Cds1 to aberrant DNA structures where Cds1 modulates the activity of damage tolerance enzymes.

* Corresponding author. Mailing address: Departments of Molecular Biology and Cell Biology, 10550 North Torrey Pines Rd., MB-3, The Scripps Research Institute, La Jolla, CA 92037. Phone: (858) 784-8273. Fax: (858) 784-2265. E-mail: prussell{at}scripps.edu.

Molecular and Cellular Biology, December 2000, p. 8758-8766, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Geuting, V., Kobbe, D., Hartung, F., Durr, J., Focke, M., Puchta, H. (2009). Two Distinct MUS81-EME1 Complexes from Arabidopsis Process Holliday Junctions. Plant Physiol. 150: 1062-1071 [Abstract] [Full Text]  
  • Matulova, P., Marini, V., Burgess, R. C., Sisakova, A., Kwon, Y., Rothstein, R., Sung, P., Krejci, L. (2009). Cooperativity of Mus81{middle dot}Mms4 with Rad54 in the Resolution of Recombination and Replication Intermediates. J. Biol. Chem. 284: 7733-7745 [Abstract] [Full Text]  
  • Mankouri, H. W., Ngo, H.-P., Hickson, I. D. (2009). Esc2 and Sgs1 Act in Functionally Distinct Branches of the Homologous Recombination Repair Pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 20: 1683-1694 [Abstract] [Full Text]  
  • Willis, N., Rhind, N. (2009). Mus81, Rhp51(Rad51), and Rqh1 Form an Epistatic Pathway Required for the S-Phase DNA Damage Checkpoint. Mol. Biol. Cell 20: 819-833 [Abstract] [Full Text]  
  • Mazina, O. M., Mazin, A. V. (2008). Human Rad54 protein stimulates human Mus81-Eme1 endonuclease. Proc. Natl. Acad. Sci. USA 105: 18249-18254 [Abstract] [Full Text]  
  • Franchitto, A., Pirzio, L. M., Prosperi, E., Sapora, O., Bignami, M., Pichierri, P. (2008). Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. JCB 183: 241-252 [Abstract] [Full Text]  
  • Pebernard, S., Perry, J. J. P., Tainer, J. A., Boddy, M. N. (2008). Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holocomplex in Genome Stability. Mol. Biol. Cell 19: 4099-4109 [Abstract] [Full Text]  
  • Cromie, G. A., Hyppa, R. W., Smith, G. R. (2008). The Fission Yeast BLM Homolog Rqh1 Promotes Meiotic Recombination. Genetics 179: 1157-1167 [Abstract] [Full Text]  
  • Chang, J. H., Kim, J. J., Choi, J. M., Lee, J. H., Cho, Y. (2008). Crystal structure of the Mus81-Eme1 complex. Genes Dev. 22: 1093-1106 [Abstract] [Full Text]  
  • Ehmsen, K. T., Heyer, W.-D. (2008). Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease. Nucleic Acids Res 36: 2182-2195 [Abstract] [Full Text]  
  • Taylor, E. R., McGowan, C. H. (2008). Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc. Natl. Acad. Sci. USA 105: 3757-3762 [Abstract] [Full Text]  
  • Froget, B., Blaisonneau, J., Lambert, S., Baldacci, G. (2008). Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint. Mol. Biol. Cell 19: 445-456 [Abstract] [Full Text]  
  • Hashimoto, M., Taniguchi, M., Yoshino, S., Arai, S., Sato, K. (2008). S Phase-preferential Cre-recombination in Mammalian Cells Revealed by HIV-TAT-PTD-mediated Protein Transduction. J Biochem 143: 87-95 [Abstract] [Full Text]  
  • Hartung, F., Suer, S., Puchta, H. (2007). Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 104: 18836-18841 [Abstract] [Full Text]  
  • Inagaki, K., Ma, C., Storm, T. A., Kay, M. A., Nakai, H. (2007). The Role of DNA-PKcs and Artemis in Opening Viral DNA Hairpin Termini in Various Tissues in Mice. J. Virol. 81: 11304-11321 [Abstract] [Full Text]  
  • Nomura, Y., Adachi, N., Koyama, H. (2007). Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. GENES CELLS 12: 1111-1122 [Abstract] [Full Text]  
  • Pamidi, A., Cardoso, R., Hakem, A., Matysiak-Zablocki, E., Poonepalli, A., Tamblyn, L., Perez-Ordonez, B., Hande, M. P., Sanchez, O., Hakem, R. (2007). Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer. Cancer Res. 67: 8527-8535 [Abstract] [Full Text]  
  • Dovey, C. L., Russell, P. (2007). Mms22 Preserves Genomic Integrity During DNA Replication in Schizosaccharomyces pombe. Genetics 177: 47-61 [Abstract] [Full Text]  
  • Trowbridge, K., McKim, K., Brill, S. J., Sekelsky, J. (2007). Synthetic Lethality of Drosophila in the Absence of the MUS81 Endonuclease and the DmBlm Helicase Is Associated With Elevated Apoptosis. Genetics 176: 1993-2001 [Abstract] [Full Text]  
  • Hope, J. C., Cruzata, L. D., Duvshani, A., Mitsumoto, J., Maftahi, M., Freyer, G. A. (2007). Mus81-Eme1-Dependent and -Independent Crossovers Form in Mitotic Cells during Double-Strand Break Repair in Schizosaccharomyces pombe. Mol. Cell. Biol. 27: 3828-3838 [Abstract] [Full Text]  
  • Mimida, N., Kitamoto, H., Osakabe, K., Nakashima, M., Ito, Y., Heyer, W.-D., Toki, S., Ichikawa, H. (2007). Two Alternatively Spliced Transcripts Generated from OsMUS81, a Rice Homolog of Yeast MUS81, Are Up-Regulated by DNA-Damaging Treatments. Plant Cell Physiol 48: 648-654 [Abstract] [Full Text]  
  • Noguchi, C., Noguchi, E. (2007). Sap1 Promotes the Association of the Replication Fork Protection Complex With Chromatin and Is Involved in the Replication Checkpoint in Schizosaccharomyces pombe. Genetics 175: 553-566 [Abstract] [Full Text]  
  • Herzberg, K., Bashkirov, V. I., Rolfsmeier, M., Haghnazari, E., McDonald, W. H., Anderson, S., Bashkirova, E. V., Yates, J. R. III, Heyer, W.-D. (2006). Phosphorylation of Rad55 on Serines 2, 8, and 14 Is Required for Efficient Homologous Recombination in the Recovery of Stalled Replication Forks. Mol. Cell. Biol. 26: 8396-8409 [Abstract] [Full Text]  
  • Johnson-Schlitz, D., Engels, W. R. (2006). Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Proc. Natl. Acad. Sci. USA 103: 16840-16845 [Abstract] [Full Text]  
  • Raffa, G. D., Wohlschlegel, J., Yates, J. R. III, Boddy, M. N. (2006). SUMO-binding Motifs Mediate the Rad60-dependent Response to Replicative Stress and Self-association. J. Biol. Chem. 281: 27973-27981 [Abstract] [Full Text]  
  • Hartung, F., Suer, S., Bergmann, T., Puchta, H. (2006). The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A. Nucleic Acids Res 34: 4438-4448 [Abstract] [Full Text]  
  • Cobb, J. A., Bjergbaek, L. (2006). RecQ helicases: lessons from model organisms. Nucleic Acids Res 34: 4106-4114 [Abstract] [Full Text]  
  • Nitani, N., Nakamura, K.-i., Nakagawa, C., Masukata, H., Nakagawa, T. (2006). Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast. Genetics 174: 155-165 [Abstract] [Full Text]  
  • Andreassen, P. R., Ho, G. P.H., D'Andrea, A. D. (2006). DNA damage responses and their many interactions with the replication fork. Carcinogenesis 27: 883-892 [Abstract] [Full Text]  
  • Coulon, S., Noguchi, E., Noguchi, C., Du, L.-L., Nakamura, T. M., Russell, P. (2006). Rad22Rad52-dependent Repair of Ribosomal DNA Repeats Cleaved by Slx1-Slx4 Endonuclease. Mol. Biol. Cell 17: 2081-2090 [Abstract] [Full Text]  
  • Pebernard, S., Wohlschlegel, J., McDonald, W. H., Yates, J. R. III, Boddy, M. N. (2006). The nse5-nse6 dimer mediates DNA repair roles of the smc5-smc6 complex.. Mol. Cell. Biol. 26: 1617-1630 [Abstract] [Full Text]  
  • Hiyama, T., Katsura, M., Yoshihara, T., Ishida, M., Kinomura, A., Tonda, T., Asahara, T., Miyagawa, K. (2006). Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res 34: 880-892 [Abstract] [Full Text]  
  • Sheedy, D. M., Dimitrova, D., Rankin, J. K., Bass, K. L., Lee, K. M., Tapia-Alveal, C., Harvey, S. H., Murray, J. M., O'Connell, M. J. (2005). Brc1-Mediated DNA Repair and Damage Tolerance. Genetics 171: 457-468 [Abstract] [Full Text]  
  • Dendouga, N., Gao, H., Moechars, D., Janicot, M., Vialard, J., McGowan, C. H. (2005). Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis. Mol. Cell. Biol. 25: 7569-7579 [Abstract] [Full Text]  
  • Shima, H., Suzuki, M., Shinohara, M. (2005). Isolation and Characterization of Novel xrs2 Mutations in Saccharomyces cerevisiae. Genetics 170: 71-85 [Abstract] [Full Text]  
  • Kai, M., Boddy, M. N., Russell, P., Wang, T. S.-F. (2005). Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress. Genes Dev. 19: 919-932 [Abstract] [Full Text]  
  • Zhang, R., Sengupta, S., Yang, Q., Linke, S. P., Yanaihara, N., Bradsher, J., Blais, V., McGowan, C. H., Harris, C. C. (2005). BLM Helicase Facilitates Mus81 Endonuclease Activity in Human Cells. Cancer Res. 65: 2526-2531 [Abstract] [Full Text]  
  • Farah, J. A., Cromie, G., Steiner, W. W., Smith, G. R. (2005). A Novel Recombination Pathway Initiated by the Mre11/Rad50/Nbs1 Complex Eliminates Palindromes During Meiosis in Schizosaccharomyces pombe. Genetics 169: 1261-1274 [Abstract] [Full Text]  
  • Meister, P., Taddei, A., Vernis, L., Poidevin, M., Gasser, S. M., Baldacci, G. (2005). Temporal separation of replication and recombination requires the intra-S checkpoint. JCB 168: 537-544 [Abstract] [Full Text]  
  • Zhao, H., Russell, P. (2004). DNA Binding Domain in the Replication Checkpoint Protein Mrc1 of Schizosaccharomyces pombe. J. Biol. Chem. 279: 53023-53027 [Abstract] [Full Text]  
  • Komori, K., Hidaka, M., Horiuchi, T., Fujikane, R., Shinagawa, H., Ishino, Y. (2004). Cooperation of the N-terminal Helicase and C-terminal Endonuclease Activities of Archaeal Hef Protein in Processing Stalled Replication Forks. J. Biol. Chem. 279: 53175-53185 [Abstract] [Full Text]  
  • Morikawa, H., Morishita, T., Kawane, S., Iwasaki, H., Carr, A. M., Shinagawa, H. (2004). Rad62 Protein Functionally and Physically Associates with the Smc5/Smc6 Protein Complex and Is Required for Chromosome Integrity and Recombination Repair in Fission Yeast. Mol. Cell. Biol. 24: 9401-9413 [Abstract] [Full Text]  
  • Tomita, K., Kibe, T., Kang, H.-Y., Seo, Y.-S., Uritani, M., Ushimaru, T., Ueno, M. (2004). Fission Yeast Dna2 Is Required for Generation of the Telomeric Single-Strand Overhang. Mol. Cell. Biol. 24: 9557-9567 [Abstract] [Full Text]  
  • Pebernard, S., McDonald, W. H., Pavlova, Y., Yates, J. R. III, Boddy, M. N. (2004). Nse1, Nse2, and a Novel Subunit of the Smc5-Smc6 Complex, Nse3, Play a Crucial Role in Meiosis. Mol. Biol. Cell 15: 4866-4876 [Abstract] [Full Text]  
  • Kumar, S., Huberman, J. A. (2004). On the Slowing of S Phase in Response to DNA Damage in Fission Yeast. J. Biol. Chem. 279: 43574-43580 [Abstract] [Full Text]  
  • Doe, C. L., Osman, F., Dixon, J., Whitby, M. C. (2004). DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51. Nucleic Acids Res 32: 5570-5581 [Abstract] [Full Text]  
  • Noguchi, E., Noguchi, C., McDonald, W. H., Yates, J. R. III, Russell, P. (2004). Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast. Mol. Cell. Biol. 24: 8342-8355 [Abstract] [Full Text]  
  • Haghnazari, E., Heyer, W.-D. (2004). The DNA damage checkpoint pathways exert multiple controls on the efficiency and outcome of the repair of a double-stranded DNA gap. Nucleic Acids Res 32: 4257-4268 [Abstract] [Full Text]  
  • Tanaka, K., Russell, P. (2004). Cds1 Phosphorylation by Rad3-Rad26 Kinase Is Mediated by Forkhead-associated Domain Interaction with Mrc1. J. Biol. Chem. 279: 32079-32086 [Abstract] [Full Text]  
  • McPherson, J. P., Lemmers, B., Chahwan, R., Pamidi, A., Migon, E., Matysiak-Zablocki, E., Moynahan, M. E., Essers, J., Hanada, K., Poonepalli, A., Sanchez-Sweatman, O., Khokha, R., Kanaar, R., Jasin, M., Hande, M. P., Hakem, R. (2004). Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression. Science 304: 1822-1826 [Abstract] [Full Text]  
  • Doe, C. L., Whitby, M. C. (2004). The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast. Nucleic Acids Res 32: 1480-1491 [Abstract] [Full Text]  
  • Blais, V., Gao, H., Elwell, C. A., Boddy, M. N., Gaillard, P.-H. L., Russell, P., McGowan, C. H. (2004). RNA Interference Inhibition of Mus81 Reduces Mitotic Recombination in Human Cells. Mol. Biol. Cell 15: 552-562 [Abstract] [Full Text]  
  • Hollingsworth, N. M., Brill, S. J. (2004). The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions. Genes Dev. 18: 117-125 [Full Text]  
  • Coulon, S., Gaillard, P.-H. L., Chahwan, C., McDonald, W. H., Yates, J. R. III, Russell, P. (2004). Slx1-Slx4 Are Subunits of a Structure-specific Endonuclease That Maintains Ribosomal DNA in Fission Yeast. Mol. Biol. Cell 15: 71-80 [Abstract] [Full Text]  
  • Smith, G. R., Boddy, M. N., Shanahan, P., Russell, P. (2003). Fission Yeast Mus81{middle dot}Eme1 Holliday Junction Resolvase Is Required for Meiotic Crossing Over but Not for Gene Conversion. Genetics 165: 2289-2293 [Abstract] [Full Text]  
  • Gao, H., Chen, X.-B., McGowan, C. H. (2003). Mus81 Endonuclease Localizes to Nucleoli and to Regions of DNA Damage in Human S-phase Cells. Mol. Biol. Cell 14: 4826-4834 [Abstract] [Full Text]  
  • Zhao, H., Tanaka, K., Nogochi, E., Nogochi, C., Russell, P. (2003). Replication Checkpoint Protein Mrc1 Is Regulated by Rad3 and Tel1 in Fission Yeast. Mol. Cell. Biol. 23: 8395-8403 [Abstract] [Full Text]  
  • McDonald, W. H., Pavlova, Y., Yates, J. R. III, Boddy, M. N. (2003). Novel Essential DNA Repair Proteins Nse1 and Nse2 Are Subunits of the Fission Yeast Smc5-Smc6 Complex. J. Biol. Chem. 278: 45460-45467 [Abstract] [Full Text]  
  • Noguchi, E., Noguchi, C., Du, L.-L., Russell, P. (2003). Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1. Mol. Cell. Biol. 23: 7861-7874 [Abstract] [Full Text]  
  • Furuya, K., Carr, A. M. (2003). DNA checkpoints in fission yeast. J. Cell Sci. 116: 3847-3848 [Full Text]  
  • Bondar, T., Mirkin, E. V., Ucker, D. S., Walden, W. E., Mirkin, S. M., Raychaudhuri, P. (2003). Schizosaccharomyces pombe Ddb1 Is functionally Linked to the Replication Checkpoint Pathway. J. Biol. Chem. 278: 37006-37014 [Abstract] [Full Text]  
  • Chahwan, C., Nakamura, T. M., Sivakumar, S., Russell, P., Rhind, N. (2003). The Fission Yeast Rad32 (Mre11)-Rad50-Nbs1 Complex Is Required for the S-Phase DNA Damage Checkpoint. Mol. Cell. Biol. 23: 6564-6573 [Abstract] [Full Text]  
  • Boddy, M. N., Shanahan, P., McDonald, W. H., Lopez-Girona, A., Noguchi, E., Yates III, J. R., Russell, P. (2003). Replication Checkpoint Kinase Cds1 Regulates Recombinational Repair Protein Rad60. Mol. Cell. Biol. 23: 5939-5946 [Abstract] [Full Text]  
  • Tomita, K., Matsuura, A., Caspari, T., Carr, A. M., Akamatsu, Y., Iwasaki, H., Mizuno, K.-i., Ohta, K., Uritani, M., Ushimaru, T., Yoshinaga, K., Ueno, M. (2003). Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres. Mol. Cell. Biol. 23: 5186-5197 [Abstract] [Full Text]  
  • Ciccia, A., Constantinou, A., West, S. C. (2003). Identification and Characterization of the Human Mus81-Eme1 Endonuclease. J. Biol. Chem. 278: 25172-25178 [Abstract] [Full Text]  
  • Ogrunc, M., Sancar, A. (2003). Identification and Characterization of Human MUS81-MMS4 Structure-specific Endonuclease. J. Biol. Chem. 278: 21715-21720 [Abstract] [Full Text]  
  • Bastin-Shanower, S. A., Fricke, W. M., Mullen, J. R., Brill, S. J. (2003). The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10. Mol. Cell. Biol. 23: 3487-3496 [Abstract] [Full Text]  
  • de los Santos, T., Hunter, N., Lee, C., Larkin, B., Loidl, J., Hollingsworth, N. M. (2003). The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding Yeast. Genetics 164: 81-94 [Abstract] [Full Text]  
  • Whitby, M. C., Osman, F., Dixon, J. (2003). Cleavage of Model Replication Forks by Fission Yeast Mus81-Eme1 and Budding Yeast Mus81-Mms4. J. Biol. Chem. 278: 6928-6935 [Abstract] [Full Text]  
  • Bashkirov, V. I., Bashkirova, E. V., Haghnazari, E., Heyer, W.-D. (2003). Direct Kinase-to-Kinase Signaling Mediated by the FHA Phosphoprotein Recognition Domain of the Dun1 DNA Damage Checkpoint Kinase. Mol. Cell. Biol. 23: 1441-1452 [Abstract] [Full Text]  
  • Fabre, F., Chan, A., Heyer, W.-D., Gangloff, S. (2002). Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc. Natl. Acad. Sci. USA 99: 16887-16892 [Abstract] [Full Text]  
  • Chang, M., Bellaoui, M., Boone, C., Brown, G. W. (2002). A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. USA 99: 16934-16939 [Abstract] [Full Text]  
  • Symington, L. S. (2002). Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair. Microbiol. Mol. Biol. Rev. 66: 630-670 [Abstract] [Full Text]  
  • Williams, D. R., McIntosh, J. R. (2002). mcl1+, the Schizosaccharomyces pombe Homologue of CTF4, Is Important for Chromosome Replication, Cohesion, and Segregation. Eukaryot Cell 1: 758-773 [Abstract] [Full Text]  
  • Doe, C. L., Ahn, J. S., Dixon, J., Whitby, M. C. (2002). Mus81-Eme1 and Rqh1 Involvement in Processing Stalled and Collapsed Replication Forks. J. Biol. Chem. 277: 32753-32759 [Abstract] [Full Text]  
  • Carr, A. M. (2002). Checking That Replication Breakdown Is Not Terminal. Science 297: 557-558 [Abstract] [Full Text]  
  • O'Neill, T., Giarratani, L., Chen, P., Iyer, L., Lee, C.-H., Bobiak, M., Kanai, F., Zhou, B.-B., Chung, J. H., Rathbun, G. A. (2002). Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach. J. Biol. Chem. 277: 16102-16115 [Abstract] [Full Text]  
  • Osman, F., Tsaneva, I. R., Whitby, M. C., Doe, C. L. (2002). UV Irradiation Causes the Loss of Viable Mitotic Recombinants in Schizosaccharomyces pombe Cells Lacking the G2/M DNA Damage Checkpoint. Genetics 160: 891-908 [Abstract] [Full Text]  
  • Kaliraman, V., Mullen, J. R., Fricke, W. M., Bastin-Shanower, S. A., Brill, S. J. (2001). Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev. 15: 2730-2740 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»