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Molecular and Cellular Biology, December 2000, p. 9018-9027, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

Robert A. Blake, Martin A. Broome, Xiangdong Liu, Jianming Wu, Mikhail Gishizky, Li Sun, and Sara A. Courtneidge*

SUGEN Inc., South San Francisco, California 94080

Received 3 April 2000/Returned for modification 18 May 2000/Accepted 7 September 2000

The use of small-molecule inhibitors to study molecular components of cellular signal transduction pathways provides a means of analysis complementary to currently used techniques, such as antisense, dominant-negative (interfering) mutants and constitutively activated mutants. We have identified and characterized a small-molecule inhibitor, SU6656, which exhibits selectivity for Src and other members of the Src family. A related inhibitor, SU6657, inhibits many kinases, including Src and the platelet-derived growth factor (PDGF) receptor. The use of SU6656 confirmed our previous findings that Src family kinases are required for both Myc induction and DNA synthesis in response to PDGF stimulation of NIH 3T3 fibroblasts. By comparing PDGF-stimulated tyrosine phosphorylation events in untreated and SU6656-treated cells, we found that some substrates (for example, c-Cbl, and protein kinase C delta ) were Src family substrates whereas others (for example, phospholipase C-gamma ) were not. One protein, the adaptor Shc, was a substrate for both Src family kinases (on tyrosines 239 and 240) and a distinct tyrosine kinase (on tyrosine 317, which is perhaps phosphorylated by the PDGF receptor itself). Microinjection experiments demonstrated that a Shc molecule carrying mutations of tyrosines 239 and 240, in conjunction with an SH2 domain mutation, interfered with PDGF-stimulated DNA synthesis. Deletion of the phosphotyrosine-binding domain also inhibited synthesis. These inhibitions were overcome by heterologous expression of Myc, supporting the hypothesis that Shc functions in the Src pathway. SU6656 should prove a useful additional tool for further dissecting the role of Src kinases in this and other signal transduction pathways.

* Corresponding author. Mailing address: SUGEN Inc., 230 East Grand Ave., South San Francisco, CA 94080. Phone: (650) 553-8612. Fax: (650) 553-8304. E-mail: sara-courtneidge{at}sugen.com.

Molecular and Cellular Biology, December 2000, p. 9018-9027, Vol. 20, No. 23
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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  • Crowder, R. J., Enomoto, H., Yang, M., Johnson, E. M. Jr., Milbrandt, J. (2004). Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth. J. Biol. Chem. 279: 42072-42081 [Abstract] [Full Text]  
  • Mamidipudi, V., Zhang, J., Lee, K. C., Cartwright, C. A. (2004). RACK1 Regulates G1/S Progression by Suppressing Src Kinase Activity. Mol. Cell. Biol. 24: 6788-6798 [Abstract] [Full Text]  
  • Anneren, C., Cowan, C. A., Melton, D. A. (2004). The Src Family of Tyrosine Kinases Is Important for Embryonic Stem Cell Self-renewal. J. Biol. Chem. 279: 31590-31598 [Abstract] [Full Text]  
  • Knoll, B., Drescher, U. (2004). Src Family Kinases Are Involved in EphA Receptor-Mediated Retinal Axon Guidance. J. Neurosci. 24: 6248-6257 [Abstract] [Full Text]  
  • Liu, Z., Falola, J., Zhu, X., Gu, Y., Kim, L. T., Sarosi, G. A., Anthony, T., Nwariaku, F. E. (2004). Antiproliferative Effects of Src Inhibition on Medullary Thyroid Cancer. J. Clin. Endocrinol. Metab. 89: 3503-3509 [Abstract] [Full Text]  
  • Reinehr, R., Becker, S., Hongen, A., Haussinger, D. (2004). The Src Family Kinase Yes Triggers Hyperosmotic Activation of the Epidermal Growth Factor Receptor and CD95. J. Biol. Chem. 279: 23977-23987 [Abstract] [Full Text]  
  • Woodring, P. J., Meisenhelder, J., Johnson, S. A., Zhou, G.-L., Field, J., Shah, K., Bladt, F., Pawson, T., Niki, M., Pandolfi, P. P., Wang, J. Y.J., Hunter, T. (2004). c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. JCB 165: 493-503 [Abstract] [Full Text]  
  • de Virgilio, M., Kiosses, W. B., Shattil, S. J. (2004). Proximal, selective, and dynamic interactions between integrin {alpha}IIb{beta}3 and protein tyrosine kinases in living cells. JCB 165: 305-311 [Abstract] [Full Text]  
  • Mason, J. M., Morrison, D. J., Bassit, B., Dimri, M., Band, H., Licht, J. D., Gross, I. (2004). Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop. Mol. Biol. Cell 15: 2176-2188 [Abstract] [Full Text]  
  • Kasirer-Friede, A., Cozzi, M. R., Mazzucato, M., De Marco, L., Ruggeri, Z. M., Shattil, S. J. (2004). Signaling through GP Ib-IX-V activates {alpha}IIb{beta}3 independently of other receptors. Blood 103: 3403-3411 [Abstract] [Full Text]  
  • Wrobel, C. N., Debnath, J., Lin, E., Beausoleil, S., Roussel, M. F., Brugge, J. S. (2004). Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. JCB 165: 263-273 [Abstract] [Full Text]  
  • Sharma-Walia, N., Naranatt, P. P., Krishnan, H. H., Zeng, L., Chandran, B. (2004). Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Envelope Glycoprotein gB Induces the Integrin-Dependent Focal Adhesion Kinase-Src-Phosphatidylinositol 3-Kinase-Rho GTPase Signal Pathways and Cytoskeletal Rearrangements. J. Virol. 78: 4207-4223 [Abstract] [Full Text]  
  • Brown, T. A., Yang, T. M., Zaitsevskaia, T., Xia, Y., Dunn, C. A., Sigle, R. O., Knudsen, B., Carter, W. G. (2004). Adhesion or Plasmin Regulates Tyrosine Phosphorylation of a Novel Membrane Glycoprotein p80/gp140/CUB Domain-containing Protein 1 in Epithelia. J. Biol. Chem. 279: 14772-14783 [Abstract] [Full Text]  


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