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Molecular and Cellular Biology, February 2000, p. 1419-1425, Vol. 20, No. 4
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Minimal Phenotype of Mice Homozygous for a Null Mutation in the Forkhead/Winged Helix Gene, Mf2

Tsutomu Kume,1 Keyu Deng,1 and Brigid L. M. Hogan2,*

Howard Hughes Medical Institute1 and Department of Cell Biology,2 Vanderbilt University Medical Center, Nashville, Tennessee 37232-2175

Received 11 November 1999/Accepted 17 November 1999

Mf2 (mesoderm/mesenchyme forkhead 2) encodes a forkhead/winged helix transcription factor expressed in numerous tissues of the mouse embryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous system, and developing kidney. We have generated mice homozygous for a null mutation in the Mf2 gene (Mf2lacZ) to examine its role during embryonic development. The lacZ allele also allows monitoring of Mf2 gene expression. Homozygous null mutants are viable and fertile and have no major developmental defects. Some mutants show renal abnormalities, including kidney hypoplasia and hydroureter, but the penetrance of this phenotype is only 40% or lower, depending on the genetic background. These data suggest that Mf2 can play a unique role in kidney development, but there is functional redundancy in this organ and other tissues with other forkhead/winged helix genes.

* Corresponding author. Mailing address: Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232-2175. Phone: (615) 343-6418. Fax: (615) 343-2033. E-mail: brigid.hogan{at}mcmail.vanderbilt.edu.

Molecular and Cellular Biology, February 2000, p. 1419-1425, Vol. 20, No. 4
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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