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Molecular and Cellular Biology, February 2000, p. 1419-1425, Vol. 20, No. 4
Howard Hughes Medical
Institute1 and Department of Cell
Biology,2 Vanderbilt University Medical
Center, Nashville, Tennessee 37232-2175
Received 11 November 1999/Accepted 17 November 1999
Mf2 (mesoderm/mesenchyme forkhead 2) encodes a
forkhead/winged helix transcription factor expressed in numerous
tissues of the mouse embryo, including paraxial mesoderm, somites,
branchial arches, vibrissae, developing central nervous system, and
developing kidney. We have generated mice homozygous for a null
mutation in the Mf2 gene (Mf2lacZ)
to examine its role during embryonic development. The lacZ
allele also allows monitoring of Mf2 gene expression.
Homozygous null mutants are viable and fertile and have no major
developmental defects. Some mutants show renal abnormalities, including
kidney hypoplasia and hydroureter, but the penetrance of this phenotype is only 40% or lower, depending on the genetic background. These data
suggest that Mf2 can play a unique role in kidney
development, but there is functional redundancy in this organ and other
tissues with other forkhead/winged helix genes.
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Minimal Phenotype of Mice Homozygous for a Null
Mutation in the Forkhead/Winged Helix Gene, Mf2
*
Corresponding author. Mailing address: Howard Hughes
Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN 37232-2175. Phone: (615) 343-6418. Fax:
(615) 343-2033. E-mail:
brigid.hogan{at}mcmail.vanderbilt.edu.
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