Two Novel Drosophila TAFIIs Have Homology with Human TAFII30 and Are Differentially Regulated during Development

doi:10.1128/MCB.20.5.1639-1648.2000

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Georgieva, S.
	Articles by Tora, L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Georgieva, S.
	Articles by Tora, L.

Previous Article | Next Article

Molecular and Cellular Biology, March 2000, p. 1639-1648, Vol. 20, No. 5
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Two Novel Drosophila TAF_IIs Have Homology with Human TAF_II30 and Are Differentially Regulated during Development

Sofia Georgieva,¹^,²^,³ Doris B. Kirschner,¹ Tereza Jagla,⁴ Elena Nabirochkina,²^,³ Susanne Hanke,⁵ Heide Schenkel,⁵ Cécilia de Lorenzo,⁵ Pradip Sinha,⁶ Krysztof Jagla,⁴ Bernard Mechler,⁵ and Làszlò Tora¹^,^*

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, F-67404 Illkirch Cedex, CU de Strasbourg,¹ and INSERM U.384, 63001 Clermont Ferrand Cedex,⁴ France; Institute of Gene Biology, Russian Academy of Sciences,² and University of Oslo, Center of Medical Studies,³ Moscow, Russia; Department of Development Genetics, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany⁵; and Drosophila Stock Center, School of Life Sciences, Devi Ahilya, Vishwavidyala, Vigyan Bhawan, Indore 452-001, India⁶

Received 26 July 1999/Returned for modification 31 August 1999/Accepted 18 November 1999

TFIID is a multiprotein complex composed of the TATA binding protein (TBP) and TBP-associated factors (TAF_IIs). The bindingof TFIID to the promoter is the first step of RNA polymerase IIpreinitiation complex assembly on protein-coding genes. Yeast(y) and human (h) TFIID complexes contain 10 to 13 TAF_IIs. Biochemicalstudies suggested that the Drosophila (d) TFIID complexes containonly eight TAF_IIs, leaving a number of yeast and human TAF_IIs(e.g., hTAF_II55, hTAF_II30, and hTAF_II18) without known Drosophilahomologues. We demonstrate that Drosophila has not one but twohTAF_II30 homologues, dTAF_II16 and dTAF_II24, which are encodedby two adjacent genes. These two genes are localized in a head-to-headorientation, and their 5' extremities overlap. We show that thesenovel dTAF_IIs are expressed and that they are both associatedwith TBP and other bona fide dTAF_IIs in dTFIID complexes. dTAF_II24,but not dTAF_II16, was also found to be associated with the histoneacetyltransferase (HAT) dGCN5. Thus, dTAF_II16 and dTAF_II24 arefunctional homologues of hTAF_II30, and this is the first demonstrationthat a TAF_II-GCN5-HAT complex exists in Drosophila. The two dTAF_IIsare differentially expressed during embryogenesis and can be detectedin both nuclei and cytoplasm of the cells. These results togetherindicate that dTAF_II16 and dTAF_II24 may have similar but not identicalfunctions.

^* Corresponding author. Mailing address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP,BP 163, F67404 Illkirch Cedex, CU de Strasbourg, France. Phone:33 388 65 34 44. Fax: 33 388 65 32 01. E-mail: laszlo{at}igbmc.u-strasbg.fr.

Molecular and Cellular Biology, March 2000, p. 1639-1648, Vol. 20, No. 5
0270-7306/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

Prince, F., Katsuyama, T., Oshima, Y., Plaza, S., Resendez-Perez, D., Berry, M., Kurata, S., Gehring, W. J. (2008). The YPWM motif links Antennapedia to the basal transcriptional machinery. Development 135: 1669-1679 [Abstract] [Full Text]
Tamada, Y., Nakamori, K., Nakatani, H., Matsuda, K., Hata, S., Furumoto, T., Izui, K. (2007). Temporary Expression of the TAF10 Gene and its Requirement for Normal Development of Arabidopsis thaliana. Plant Cell Physiol 48: 134-146 [Abstract] [Full Text]
Ciurciu, A., Komonyi, O., Pankotai, T., Boros, I. M. (2006). The Drosophila Histone Acetyltransferase Gcn5 and Transcriptional Adaptor Ada2a Are Involved in Nucleosomal Histone H4 Acetylation. Mol. Cell. Biol. 26: 9413-9423 [Abstract] [Full Text]
Kopytova, D. V., Krasnov, A. N., Kopantceva, M. R., Nabirochkina, E. N., Nikolenko, J. V., Maksimenko, O., Kurshakova, M. M., Lebedeva, L. A., Yerokhin, M. M., Simonova, O. B., Korochkin, L. I., Tora, L., Georgiev, P. G., Georgieva, S. G. (2006). Two Isoforms of Drosophila TRF2 Are Involved in Embryonic Development, Premeiotic Chromatin Condensation, and Proper Differentiation of Germ Cells of Both Sexes.. Mol. Cell. Biol. 26: 7492-7505 [Abstract] [Full Text]
Gao, X., Ren, F., Lu, Y.-T. (2006). The Arabidopsis Mutant stg1 Identifies a Function for TBP-Associated Factor 10 in Plant Osmotic Stress Adaptation. Plant Cell Physiol 47: 1285-1294 [Abstract] [Full Text]
Lebedeva, L. A., Nabirochkina, E. N., Kurshakova, M. M., Robert, F., Krasnov, A. N., Evgen'ev, M. B., Kadonaga, J. T., Georgieva, S. G., Tora, L. (2005). Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation. Proc. Natl. Acad. Sci. USA 102: 18087-18092 [Abstract] [Full Text]
Krasnov, A. N., Kurshakova, M. M., Ramensky, V. E., Mardanov, P. V., Nabirochkina, E. N., Georgieva, S. G. (2005). A retrocopy of a gene can functionally displace the source gene in evolution. Nucleic Acids Res 33: 6654-6661 [Abstract] [Full Text]
Pankotai, T., Komonyi, O., Bodai, L., Ujfaludi, Z., Muratoglu, S., Ciurciu, A., Tora, L., Szabad, J., Boros, I. (2005). The Homologous Drosophila Transcriptional Adaptors ADA2a and ADA2b Are both Required for Normal Development but Have Different Functions. Mol. Cell. Biol. 25: 8215-8227 [Abstract] [Full Text]
Frontini, M., Soutoglou, E., Argentini, M., Bole-Feysot, C., Jost, B., Scheer, E., Tora, L. (2005). TAF9b (Formerly TAF9L) Is a Bona Fide TAF That Has Unique and Overlapping Roles with TAF9. Mol. Cell. Biol. 25: 4638-4649 [Abstract] [Full Text]
Soutoglou, E., Demeny, M. A., Scheer, E., Fienga, G., Sassone-Corsi, P., Tora, L. (2005). The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners. Mol. Cell. Biol. 25: 4092-4104 [Abstract] [Full Text]
Furumoto, T., Tamada, Y., Izumida, A., Nakatani, H., Hata, S., Izui, K. (2005). Abundant Expression in Vascular Tissue of Plant TAF10, an Orthologous Gene for TATA Box-binding Protein-associated Factor 10, in Flaveria trinervia and Abnormal Morphology of Arabidopsis thaliana Transformants on its Overexpression. Plant Cell Physiol 46: 108-117 [Abstract] [Full Text]
Hiller, M., Chen, X., Pringle, M. J., Suchorolski, M., Sancak, Y., Viswanathan, S., Bolival, B., Lin, T.-Y., Marino, S., Fuller, M. T. (2004). Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development 131: 5297-5308 [Abstract] [Full Text]
Muratoglu, S., Georgieva, S., Papai, G., Scheer, E., Enunlu, I., Komonyi, O., Cserpan, I., Lebedeva, L., Nabirochkina, E., Udvardy, A., Tora, L., Boros, I. (2003). Two Different Drosophila ADA2 Homologues Are Present in Distinct GCN5 Histone Acetyltransferase-Containing Complexes. Mol. Cell. Biol. 23: 306-321 [Abstract] [Full Text]
Kobayashi, A., Akasaka, K., Kawaichi, M., Kokubo, T. (2002). Functional interaction between TATA and upstream CACGTG elements regulates the temporally specific expression of Otx mRNAs during early embryogenesis of the sea urchin, Hemicentrotus pulcherrimus. Nucleic Acids Res 30: 3034-3044 [Abstract] [Full Text]
Kirchner, J., Sanders, S. L., Klebanow, E., Weil, P. A. (2001). Molecular Genetic Dissection of TAF25, an Essential Yeast Gene Encoding a Subunit Shared by TFIID and SAGA Multiprotein Transcription Factors. Mol. Cell. Biol. 21: 6668-6680 [Abstract] [Full Text]
Gangloff, Y.-G., Pointud, J.-C., Thuault, S., Carre, L., Romier, C., Muratoglu, S., Brand, M., Tora, L., Couderc, J.-L., Davidson, I. (2001). The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger. Mol. Cell. Biol. 21: 5109-5121 [Abstract] [Full Text]
Georgieva, S., Nabirochkina, E., Dilworth, F. J., Eickhoff, H., Becker, P., Tora, L., Georgiev, P., Soldatov, A. (2001). The Novel Transcription Factor e(y)2 Interacts with TAFII40 and Potentiates Transcription Activation on Chromatin Templates. Mol. Cell. Biol. 21: 5223-5231 [Abstract] [Full Text]
Hiller, M. A., Lin, T.-Y., Wood, C., Fuller, M. T. (2001). Developmental regulation of transcription by a tissue-specific TAF homolog. Genes Dev. 15: 1021-1030 [Abstract] [Full Text]
Gangloff, Y.-G., Sanders, S. L., Romier, C., Kirschner, D., Weil, P. A., Tora, L., Davidson, I. (2001). Histone Folds Mediate Selective Heterodimerization of Yeast TAFII25 with TFIID Components yTAFII47 and yTAFII65 and with SAGA Component ySPT7. Mol. Cell. Biol. 21: 1841-1853 [Abstract] [Full Text]
Hernández-Hernández, A., Ferrús, A. (2001). Prodos Is a Conserved Transcriptional Regulator That Interacts with dTAFII16 in Drosophila melanogaster. Mol. Cell. Biol. 21: 614-623 [Abstract] [Full Text]
Aoyagi, N., Wassarman, D. A. (2000). Genes Encoding Drosophila melanogaster RNA Polymerase II General Transcription Factors: Diversity in TFIIA and TFIID Components Contributes to Gene-specific Transcriptional Regulation. J. Cell Biol. 150: F45-F50 [Abstract] [Full Text]
Sterner, D. E., Berger, S. L. (2000). Acetylation of Histones and Transcription-Related Factors. Microbiol. Mol. Biol. Rev. 64: 435-459 [Abstract] [Full Text]
Sanders, S. L., Weil, P. A. (2000). Identification of Two Novel TAF Subunits of the Yeast Saccharomyces cerevisiae TFIID Complex. J. Biol. Chem. 275: 13895-13900 [Abstract] [Full Text]

J. Bacteriol.	J. Virol.	Eukaryot. Cell

Microbiol. Mol. Biol. Rev.	Clin. Vaccine Immunol.	All ASM Journals